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11778

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8554 (72.6%)
Target
6383 (54.2%)
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11778 (100.0%)

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Halaman 176 / 236
Pertuzumab Approved DB06366
biotech | CAS: 380610-27-5

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhThe median half-lif…
Vol. DistribusiThe average steady-…
KlirensThe median clearanc…
Genetik -
Peruvoside DB13756
small molecule | CAS: 1182-87-2

Deskripsi belum tersedia.

Kategori:
CardanolidesCardiac GlycosidesCardiac Therapy +7
Waktu Paruh-
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Genetik -
Petesicatib DB15297
small molecule | CAS: 1252637-35-6

Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).

Kategori:
Enzyme Inhibitors
Target Protein:
Cathepsin S
Waktu Paruh-
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Genetik -
Petrelintide DB19442
biotech | CAS: 2766385-23-1

Petrelintide is under investigation in clinical trial NCT06662539 (Once-weekly Petrelintide Versus Placebo for Obesity or Overweight With Co-morbidities).

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Pevonedistat DB11759
small molecule | CAS: 905579-51-3

Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others.

Kategori:
CycloparaffinsEnzyme Inhibitors
Target Protein:
NEDD8-activating enzyme E1 catalytic subunitUbiquitin-like protein NEDD8NEDD8-activating enzyme E1 regulatory subunit
Waktu Paruh-
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Genetik -
Pexacerfont DB12572
small molecule | CAS: 459856-18-9

Pexacerfont has been investigated for the treatment of Alcoholism, Anxiety Disorder, Alcohol Dependence, and Alcohol-Related Disorders.

Target Protein:
Corticotropin-releasing factor receptor 1
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Pexidartinib Approved DB12978
small molecule | CAS: 1029044-16-3

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +34
Target Protein:
Macrophage colony-stimulating factor 1 receptorMast/stem cell growth factor receptor KitReceptor-type tyrosine-protein kinase FLT3 +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Pexiganan DB16293
biotech | CAS: 147664-63-9

Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexmetinib DB16294
small molecule | CAS: 945614-12-0

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
Angiopoietin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00217830 DB12998
small molecule | CAS: 846032-02-8

PF-00217830 has been used in trials studying the treatment of Schizophrenia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
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PF-00356231 DB03367
small molecule | CAS: 766536-21-4

Deskripsi belum tersedia.

Target Protein:
Macrophage metalloelastase
Waktu Paruh-
Vol. Distribusi-
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PF-00446687 DB12517
small molecule | CAS: 862281-92-3

PF-00446687 has been investigated for the treatment of Erectile Dysfunction.

Kategori:
Receptor, Melanocortin, Type 4, agonists
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PF-00489791 DB11736
small molecule | CAS: 853003-48-2

PF-00489791 has been used in trials studying the treatment of Hypertension, Raynaud's Disease, Diabetic Nephropathies, Hypertension, Pulmonary, and Peripheral Vascular Disease.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
Waktu Paruh-
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Genetik -
PF-00610355 DB11871
small molecule | CAS: 862541-45-5

PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others.

Kategori:
AcetamidesAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +7
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
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Genetik -
PF-03187207 DB05746
small molecule

PF-03187207 is a nitric oxide-donating prostaglandin F2-alpha analogs for the potential treatment of glaucoma. Based on the very promising preclinical results and on the well-known activities of nitric oxide, PF-03187207 is expected to have an increased capac…

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PF-03382792 DB12949
small molecule | CAS: 1400811-63-3

Pf 03382792 is under investigation in clinical trial NCT01045863 (To Evaluate Safety, Tolerability, Plasma Drug Levels And Other Biological Effects In Healthy Volunteers).

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PF-03463275 DB11993
small molecule | CAS: 1173239-39-8

PF-03463275 has been used in trials studying the treatment of Schizophrenia and Cognitive Impairments Associated With Schizophrenia.

Kategori:
Aza CompoundsGlycine Plasma Membrane Transport Proteins, antagonists & inhibitors
Target Protein:
Sodium- and chloride-dependent glycine transporter 1
Waktu Paruh-
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PF-03654746 DB12201
small molecule | CAS: 935840-31-6

PF-03654746 has been investigated for the treatment of Narcolepsy, Schizophrenia, Tourette's Syndrome, and Excessive Daytime Sleepiness.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
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PF-03654764 DB12360
small molecule | CAS: 935840-35-0

PF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
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PF-03715455 DB12138
small molecule | CAS: 1056164-52-3

PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesAnionsAza Compounds +7
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PF-03758309 DB11775
small molecule | CAS: 898044-15-0

PF-03758309 has been used in trials studying the treatment of Advanced Solid Tumors.

Kategori:
p21-Activated Kinases, antagonists & inhibitors
Target Protein:
Serine/threonine-protein kinase PAK 4
Waktu Paruh-
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PF-03814735 DB13059
small molecule | CAS: 942487-16-3

PF-03814735 has been used in trials studying the treatment of Solid Tumors.

Kategori:
Heterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
Aurora kinase AAurora kinase B
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Genetik -
PF-04217903 DB12848
small molecule | CAS: 956905-27-4

PF-04217903 has been used in trials studying the treatment of Neoplasms.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
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Genetik -
PF-04418948 DB12024
small molecule | CAS: 1078166-57-0

Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).

Kategori:
AzetinesReceptors, Prostaglandin E, EP2 Subtype
Target Protein:
Prostaglandin E2 receptor EP2 subtype
Waktu Paruh-
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Genetik -
PF-04447943 DB11953
small molecule | CAS: 1082744-20-4

PF-04447943 has been investigated for the treatment of Alzheimer's Disease.

Kategori:
Phosphodiesterase InhibitorsPyrimidines
Target Protein:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-04457845 DB12012
small molecule | CAS: 1020315-31-4

PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.

Kategori:
Amides
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Pf-04531083 DB12468
small molecule | CAS: 1079400-07-9

Pf-04531083 has been investigated for the treatment of Pain and Chronic Pain.

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PF-04620110 DB14887
small molecule | CAS: 1109276-89-2

PF-04620110 is under investigation in clinical trial NCT01146327 (A Multiple Dose Study Of PF-04620110 In Healthy Overweight Or Obese Subjects).

Kategori:
AzepinesDiacylglycerol O-Acyltransferase
Target Protein:
Diacylglycerol O-acyltransferase 1
Waktu Paruh-
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Genetik -
PF-04634817 DB14955
small molecule | CAS: 1228111-63-4

PF-04634817 is under investigation in clinical trial NCT01140672 (A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects).

Kategori:
Aza Compounds
Waktu Paruh-
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Genetik -
PF-04691502 DB11974
small molecule | CAS: 1013101-36-4

PF-04691502 has been used in trials studying the treatment of Cancer, Breast Neoplasms, Early Breast Cancer (Phase 2), and Advanced Breast Cancer (Phase 1b).

Kategori:
Phosphatidylinositol 3-Kinases, antagonists & inhibitorsPyridines
Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-04856884 DB17550
biotech

PF-04856884 or CVX-060 is a selective angiopoietin (Ang)-2 inhibitor.[A257291] It is under investigation in clinical trial NCT01441414 (PF-04856884 (CVX-060) in Combination With Axitinib in Patients With Previously Treated Metastatic Renal Cell Carcinoma).

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PF-04937319 DB15009
small molecule | CAS: 1245603-92-2

PF-04937319 is under investigation in clinical trial NCT01513928 (A Study To Compare The Pharmacokinetics Of Different Formulations Of PF-04937319 In Healthy Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Hexokinase-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04991532 DB11765
small molecule | CAS: 1215197-37-7

PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders.

Kategori:
Enzyme InhibitorsGlucokinase, antagonists & inhibitorsPyridines
Target Protein:
Hexokinase-4
Waktu Paruh-
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Genetik -
PF-04995274 DB12675
small molecule | CAS: 1331782-27-4

Pf 04995274 is under investigation in clinical trial NCT01193062 (Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274).

Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
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Genetik -
PF-05089771 DB14856
small molecule | CAS: 1235403-62-9

PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).

Kategori:
AmidesBenzene DerivativesEthers +4
Target Protein:
Sodium channel protein type 9 subunit alphaSolute carrier family 22 member 12
Waktu Paruh-
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Genetik -
PF-05105679 DB15450
small molecule | CAS: 1398583-31-7

PF-05105679 is under investigation in clinical trial NCT01393652 (Single Dose, Dose Escalation Healthy Volunteers Study Of PF-05105679).

Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
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Genetik -
PF-05175157 DB12096
small molecule | CAS: 1301214-47-0

PF-05175157 has been used in trials studying the basic science and treatment of Acne Vulgaris, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2, and Diabetes Mellitus, Type 2, among others.

Target Protein:
Acetyl-CoA carboxylase 2
Waktu Paruh-
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Genetik -
PF-05212377 DB16044
small molecule | CAS: 1226793-34-5

PF-05212377 is under investigation in clinical trial NCT01712074 (Study Evaluating Thesafety and Efficacy of PF-05212377 or Placebo in Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms on Donepezil).

Waktu Paruh-
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PF-05230907 DB18417
biotech

PF-05230907 is a recombinant activated Factor X variant.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-05241328 DB15124
small molecule | CAS: 1387633-03-5

PF-05241328 is under investigation in clinical trial NCT01165736 (To Calculate the Pharmacokinetics (Concentration of Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not Have Any Pharmacological Activity).

Target Protein:
Sodium channel protein type 9 subunit alpha
Waktu Paruh-
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Genetik -
PF-06260414 DB15221
small molecule | CAS: 1612755-71-1

PF-06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Androgen receptor
Waktu Paruh-
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PF-06273340 DB12269
small molecule | CAS: 1402438-74-7

Pf 06273340 is under investigation in clinical trial NCT01934738 (A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06273340 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56…

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PF-06282999 DB11683
small molecule | CAS: 1435467-37-0

Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects).

Kategori:
AcetatesAcids, AcyclicAmides +1
Waktu Paruh-
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Genetik -
PF-06291874 DB15065
small molecule | CAS: 1393124-08-7

PF-06291874 is under investigation in clinical trial NCT02175121 (Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of PF-06291874 as Oral Monotherapy To Treat Adults With Type 2 Diabetes Mellitus).

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Glucagon receptor
Waktu Paruh-
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Genetik -
PF-06305591 DB12106
small molecule | CAS: 1449473-97-5

Pf 06305591 is under investigation in clinical trial NCT01776619 (Safety and Tolerability Study of Multiple Doses of PF-06305591).

Waktu Paruh-
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PF-06459988 DB14768
small molecule | CAS: 1428774-45-1

PF-06459988 is under investigation in clinical trial NCT02297425 (A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer).

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PF-06650833 DB15143
small molecule | CAS: 1817626-54-2

PF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects).

Kategori:
AmidesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
PF-06700841 DB15003
small molecule | CAS: 1883299-62-4

PF-06700841 is under investigation in clinical trial NCT03236493 (Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers).

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Non-receptor tyrosine-protein kinase TYK2Tyrosine-protein kinase JAK1
Waktu Paruh-
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Genetik -
PF-06751979 DB15105
small molecule | CAS: 1818339-66-0

PF-06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults).

Kategori:
Sulfur Compounds
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PF-06821497 DB14799
small molecule | CAS: 1844849-10-0

PF-06821497 is under investigation in clinical trial NCT03460977 (PF-06821497 Treatment Of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma).

Target Protein:
Histone-lysine N-methyltransferase EZH2
Waktu Paruh-
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