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Namodenoson DB12885

small molecule | CAS: 163042-96-4

Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma.

Kategori:

Heterocyclic Compounds, Fused-RingNeurotransmitter AgentsNucleic Acids, Nucleotides, and Nucleosides +7

Target Protein:

Adenosine receptor A3

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Nanatinostat DB15419

small molecule | CAS: 1256448-47-1

Nanatinostat is under investigation in clinical trial NCT00697879 (Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours).

Kategori:

Antineoplastic AgentsAza CompoundsHistone Deacetylase Inhibitors

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Nandrolone decanoate Approved DB08804

small molecule | CAS: 360-70-3

Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.[A233789,A233849,L3256…

Kategori:

Anabolic AgentsAndrogensBone Density Conservation Agents +16

Target Protein:

Androgen receptorProtein c-Fos5-hydroxytryptamine 2 receptor +3

Waktu ParuhNandrolone decanoat…

Vol. Distribusi-

Klirens50 mg, 100 mg, and …

Genetik -

Nandrolone hydrogen sulfate DB14624

small molecule | CAS: 98804-55-8

Deskripsi belum tersedia.

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Nangibotide DB16247

biotech | CAS: 2014384-91-7

Nangibotide is under investigation in clinical trial NCT04055909 (Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock).

Kategori:

Amino Acids, Peptides, and ProteinsAnti-Inflammatory AgentsFatty Acids +4

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Nanrilkefusp alfa DB17480

biotech

Nanrilkefusp alfa is a human fusion protein consisting of the cytokine interleukin (IL)-15 and the high-affinity binding sushi+ domain of IL-15 receptor alpha (IL-15Ra).

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Nanvuranlat DB18250

small molecule | CAS: 1037592-40-7

Deskripsi belum tersedia.

Kategori:

Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +2

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NAP-226-90 DB04556

small molecule | CAS: 139306-10-8

Deskripsi belum tersedia.

Kategori:

AminesBenzene DerivativesEthylamines

Target Protein:

Acetylcholinesterase

Waktu Paruh-

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Napabucasin DB12155

small molecule | CAS: 83280-65-3

Napabucasin has been investigated for the treatment of Colorectal Carcinoma.

Kategori:

Heterocyclic Compounds, Fused-RingNaphthalenesQuinones

Target Protein:

Signal transducer and activator of transcription 3

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Naphazoline Approved DB06711

small molecule | CAS: 835-31-4

Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles[L5804,L5807]. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations[L5804,L5807]. Naphazoline was…

Kategori:

Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +17

Target Protein:

D(2) dopamine receptorAlpha-2A adrenergic receptorAlpha-1A adrenergic receptor

Waktu ParuhHalf life has not b…

Vol. DistribusiDistribution data f…

KlirensClearance data for …

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naphthalene-1,2,4,5,7-pentol DB06915

small molecule

Deskripsi belum tersedia.

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Naphthalene-2,6-disulfonic acid DB04640

small molecule | CAS: 581-75-9

Deskripsi belum tersedia.

Kategori:

ArylsulfonatesArylsulfonic AcidsNaphthalenes +3

Target Protein:

Bacterioferritin comigratory proteinL-lactate dehydrogenase

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Naphthoquine DB16249

small molecule | CAS: 173531-57-2

Naphthoquine is under investigation in clinical trial NCT01930331 (Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO).

Kategori:

AminesAntimalarialsAntiparasitic Products, Insecticides and Repellents +4

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Naporafenib DB18865

small molecule | CAS: 1800398-38-2

Naporafenib is under investigation in clinical trial NCT06346067 (A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With Nras-mutant Melanoma (SEACRAFT-2)).

Kategori:

AminesAntineoplastic AgentsEnzyme Inhibitors +2

Target Protein:

RAF proto-oncogene serine/threonine-protein kinase

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Naproxcinod DB06682

small molecule | CAS: 163133-43-5

Deskripsi belum tersedia.

Kategori:

Antiinflammatory and Antirheumatic ProductsAntiinflammatory and Antirheumatic Products, Non-SteroidsCardiovascular Agents +5

Target Protein:

Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2

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Naproxen Approved DB00788

small molecule | CAS: 22204-53-1

Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975] It can effectively manage acute pain as well as pain related to rheumatic …

Kategori:

Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +41

Target Protein:

Pancreatic triacylglycerol lipaseProstaglandin G/H synthase 1Prostaglandin G/H synthase 2 +1

Waktu ParuhThe elimination hal…

Vol. DistribusiNaproxen has a volu…

KlirensNaproxen is cleared…

Genetik -

Naproxen etemesil DB12398

small molecule | CAS: 385800-16-8

Naproxen etemesil has been used in trials studying the treatment of Osteoarthritis.

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Naptumomab estafenatox DB12807

biotech | CAS: 676258-98-3

Naptumomab Estafenatox has been used in trials studying the treatment of Pancreatic Cancer, Renal Cell Carcinoma, and Non-Small-Cell Lung Carcinoma.

Kategori:

Amino Acids, Peptides, and ProteinsAntibodiesBiological Factors +8

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Narasin DB11432

small molecule | CAS: 55134-13-9

Narasin is an agent with coccidiostatic and antibacterial properties.

Kategori:

Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +3

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Naratriptan Approved DB00952

small molecule | CAS: 121679-13-8

Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.

Kategori:

Agents that produce hypertensionAminesAnalgesics +23

Target Protein:

5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B +1

Gen Terkait:

GNB3

Waktu Paruh5-8 hours

Vol. Distribusi* 170 L

Klirens* 6.6 mL/min/kg

Genetik 1 Varian

Naratuximab emtansine DB15453

biotech | CAS: 1607824-64-5

Naratuximab emtansine is under investigation in clinical trial NCT01534715 (IMGN529 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia).

Kategori:

Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7

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Narazaciclib DB19038

small molecule | CAS: 1357470-29-1

Narazaciclib is under investigation in clinical trial NCT06351644 (On 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed And/or Refractory Multiple Myeloma).

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Naringin DB16859

small molecule | CAS: 10236-47-2

Deskripsi belum tersedia.

Kategori:

BenzopyransChromonesFlavonoids +2

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Narlaprevir DB14760

small molecule | CAS: 865466-24-6

Deskripsi belum tersedia.

Kategori:

AmidesAmino AcidsAmino Acids, Branched-Chain +6

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Narlumosbart DB19002

biotech | CAS: 2646587-68-8

Narlumosbart is under investigation in clinical trial NCT06314698 (Narlumosbart Compared With Denosumab in Patients With Multiple Myeloma Bone Disease).

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Narmafotinib DB18463

small molecule | CAS: 1393653-34-3

Deskripsi belum tersedia.

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Narnatumab DB14964

biotech | CAS: 1188275-92-4

Narnatumab is under investigation in clinical trial NCT01119456 (A Study of IMC-RON8 in Advanced Solid Tumors).

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Naronapride DB05542

small molecule | CAS: 860174-12-5

Deskripsi belum tersedia.

Kategori:

Acids, CarbocyclicAmidesAntidepressive Agents +7

Target Protein:

5-hydroxytryptamine receptor 4

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Narsoplimab DB16418

biotech | CAS: 2108782-45-0

Thrombotic microangiopathies (TMA), including thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome, are associated with injury and dysregulation of microvascular endothelium and platelets.[A241030] Evidence increasingly points to a role …

Kategori:

Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6

Target Protein:

Mannan-binding lectin serine protease 2

Waktu Paruh-

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NasoVAX DB15859

biotech

NasoVAX contains replication-deficient adenovirus vectors in suspension. It is a vaccine administered through a nasal spray that expresses influenza hemagglutinin in nasal epithelial cells[L16313]. Created by Altimmune, Inc., NasoVAX is currently being devel…

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Nateglinide Approved DB00731

small molecule | CAS: 105816-04-4

Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to ? cells of the pancreas to stimulate i…

Kategori:

Alimentary Tract and MetabolismAmino AcidsAmino Acids, Aromatic +21

Target Protein:

ATP-binding cassette sub-family C member 8Peroxisome proliferator-activated receptor gamma

Waktu Paruh1.5 hours

Vol. Distribusi10 liters in health…

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Nattokinase DB15329

biotech | CAS: 133876-92-3

Nattokinase is under investigation in clinical trial NCT00749801 (Efficacy and Safety of Geneferm Nattokinase).

Kategori:

EndopeptidasesEnzymesEnzymes and Coenzymes +5

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Natural Killer Cell DB15721

biotech

Natural Killer (NK) cells originate and differentiate from hematopoietic stem cells through various signalling pathways involving cytokines and interleukins. These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human per…

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NAV 1800 DB05437

biotech

RIGScan CR49, a 125I-labelled CR monoclonal antibody directed against the tumour-associated antigen TAG-72, is undergoing development with Neoprobe for the intraoperative detection of metastatic colorectal cancer.

Kategori:

Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5

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Navafenterol DB19195

small molecule | CAS: 1435519-06-4

Navafenterol is under investigation in clinical trial NCT02971293 (Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871).

Kategori:

Heterocyclic Compounds, Fused-Ring

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Navitoclax DB12340

small molecule | CAS: 923564-51-6

Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is an orally bioavailable sma…

Kategori:

AmidesAminesAntineoplastic Agents +3

Target Protein:

Bcl-2-like protein 1G1/S-specific cyclin-D1Apoptosis regulator Bcl-2 +2

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Navocaftor DB19039

small molecule | CAS: 2159103-66-7

Navocaftor is under investigation in clinical trial NCT04853368 (Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/navocaftor/abbv-119 or Galicaftor/navocaftor/abbv-576 Combination Therapies in Adult Participants…

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Navoximod DB15439

small molecule | CAS: 1402837-78-8

Navoximod is under investigation in clinical trial NCT02048709 (Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Advanced Solid Tumors).

Kategori:

Heterocyclic Compounds, Fused-Ring

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Navtemadlin DB15299

small molecule | CAS: 1352066-68-2

Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia).

Kategori:

Acids, AcyclicAntineoplastic AgentsFatty Acids +3

Target Protein:

E3 ubiquitin-protein ligase Mdm2

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Navuridine DB17759

small molecule | CAS: 84472-85-5

Deskripsi belum tersedia.

Kategori:

DeoxyribonucleosidesDideoxynucleosidesNucleic Acids, Nucleotides, and Nucleosides +3

Target Protein:

Gag-Pol polyprotein

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Naxifylline DB06471

small molecule | CAS: 166374-49-8

Deskripsi belum tersedia.

Kategori:

Adenosine A1 Receptor AntagonistsAlkaloidsHeterocyclic Compounds, Fused-Ring +6

Target Protein:

Adenosine receptor A1

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Naxitamab Approved DB15965

biotech | CAS: 1879925-92-4

Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 …

Kategori:

Agents that produce hypertensionAmino Acids, Peptides, and ProteinsAntibodies +18

Target Protein:

GD2 disialoganglioside

Waktu ParuhThe mean terminal h…

Vol. Distribusi-

KlirensThe clearance of na…

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Nazartinib DB16250

small molecule | CAS: 1508250-71-2

Nazartinib is under investigation in clinical trial NCT03529084 (Phase III Study of Nazartinib (EGF816) Versus Erlotinib/gefitinib in First-line Locally Advanced / Metastatic NSCLC With EGFR Activating Mutations).

Kategori:

AlkaloidsAntineoplastic AgentsHeterocyclic Compounds, Fused-Ring +2

Target Protein:

Epidermal growth factor receptor

Waktu Paruh-

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NB-124 sulfate DB16951

small molecule | CAS: 1375073-96-3

Deskripsi belum tersedia.

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NBI-6024 DB05819

biotech

NBI-6024 is an altered peptide ligand that is designed to cause an immune response which result in preservation of beta-cell function and endogenous insulin production.

Kategori:

Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +3

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NBI-98782 Approved DB16905

small molecule | CAS: 85081-18-1

Deskripsi belum tersedia.

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NBL-015 DB18183

biotech

Deskripsi belum tersedia.

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Ncs-Chromophore DB04408

small molecule | CAS: 81604-85-5

Deskripsi belum tersedia.

Target Protein:

Neocarzinostatin

Waktu Paruh-

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NCX 1015 DB05825

small molecule

NCX 1015 is nitric oxide-releasing derivative of prednisolone developed for the treatment of inflammatory bowel disease (IBD) by NicOx SA.

Kategori:

Fused-Ring CompoundsPregnadienesPregnadienetriols +2

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NCX 1022 DB05410

small molecule | CAS: 571186-50-0

NCX is an NO-releasing derivative of hydrocortisone.

Kategori:

11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +8

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