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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Halaman 17 / 66
Coagulation factor X human Approved DB13148
biotech

Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for the management of bleedi…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +11
Waktu ParuhFollowing a single …
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Cobalt Approved DB14574
small molecule | CAS: 7440-48-4

A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocyt…

Kategori:
Cell-mediated ImmunityDiet, Food, and NutritionElements +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10124-43-3

Deskripsi belum tersedia.

Kategori:
ElementsMetalsMetals, Heavy +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cobamamide DB11191
small molecule | CAS: 13870-90-1

Cobamamide is one of the active forms of vitamin B12 that is also known as _adenosylcobalamin_ or _dibencozide_. This drug is available as a nutritional supplement to prevent vitamin B12 deficiency. Vitamin B12 is a collective term for these variously subs…

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansCoenzymes +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cobitolimod DB14819
biotech | CAS: 1226822-98-5

Cobitolimod is under investigation in clinical trial NCT03178669 (The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coblopasvir DB15315
small molecule | CAS: 1312608-46-0

Coblopasvir is under investigation in clinical trial NCT03416491 (Safety and Efficacy of KW-136 and Sofosbuvir for Treatment of Chronic Hepatitis C).

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cocaine Approved DB00907
small molecule | CAS: 50-36-2

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects sim…

Kategori:
Agents producing tachycardiaAgents that reduce seizure thresholdAlkaloids +36
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterSodium channel protein +5
Waktu Paruh1 hour
Vol. Distribusi-
Klirens-
Genetik -
biotech

Coccidioides immitis spherule is a skin test antigen indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis.

Kategori:
Cell-mediated ImmunitySkin Test Antigen
Target Protein:
HLA-DRHLA class I histocompatibility antigen, A-3 alpha chainHLA class I histocompatibility antigen, B-27 alpha chain
Waktu Paruh-
Vol. DistribusiNot absorbed system…
Klirens-
Genetik -
Codeine Approved DB00318
small molecule | CAS: 76-57-3

The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug…

Kategori:
AlkaloidsAnalgesicsAntitussive Agents +26
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhPlasma half-lives o…
Vol. DistribusiApparent volume of …
KlirensRenal clearance of …
Genetik 9 Varian
small molecule | CAS: 125-27-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colistimethate Approved DB01111
small molecule | CAS: 12705-41-8

Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.

Kategori:
Agents that produce neuromuscular block (indirect)Amino Acids, Peptides, and ProteinsAntimicrobial Cationic Peptides +11
Target Protein:
Dihydropteroate synthaseBacterial outer membrane
Waktu Paruh2-3 hours following…
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9001-12-1

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease.[L14882] The topical formulation is…

Kategori:
Collagen-specific EnzymeCollagenasesDermatologicals +11
Target Protein:
Collagen alpha-1(I) chainCollagen alpha-1(II) chainCollagen alpha-1(III) chain
Waktu Paruh-
Vol. DistribusiThere is no current…
KlirensClearance informati…
Genetik -
Colloidal oatmeal Approved DB11286
biotech

Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal material. It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. Phenols are also contained in colloidal …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1269764-99-9

Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic leukemia (ALL).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAntibodies +16
Target Protein:
B-lymphocyte antigen CD19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Combretastatin DB12596
small molecule | CAS: 82855-09-2

Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.

Kategori:
Antimitotic AgentsAntineoplastic AgentsAntineoplastic Agents, Phytogenic +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Compound 18 DB02715
small molecule | CAS: 31112-66-0

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +1
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Conbercept DB12460
biotech | CAS: 1227158-72-6

Conbercept has been investigated for the basic science of Age-related Macular Degeneration.

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Concizumab DB12820
biotech | CAS: 1312299-39-0

Concizumab has been used in trials studying the treatment of Haemophilia A and Congenital Bleeding Disorder.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Condoliase DB12793
biotech | CAS: 9024-13-9

Condoliase has been used in trials studying the treatment of Lumbar Disc Disease, Lumbar Vertebra Hernia, and Intervertebral Disc Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Conjugated estrogens Approved DB00286
small molecule | CAS: 12126-59-9

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sul…

Kategori:
Agents causing angioedemaBCRP/ABCG2 SubstratesCOMT Substrates +26
Target Protein:
Estrogen receptor betaEstrogen receptor
Waktu ParuhThe median half-lif…
Vol. DistribusiThe physiological d…
KlirensThe reported normal…
Genetik -
Copanlisib Approved DB12483
small molecule | CAS: 1032568-63-0

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exi…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +17
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform +1
Waktu ParuhThe geometric mean …
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
Copper gluconate Approved DB11246
small molecule | CAS: 527-09-3

Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practi…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2624-63-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingPorphyrinogensPorphyrins
Target Protein:
Uroporphyrinogen decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cordycepin DB12156
small molecule | CAS: 73-03-0

Cordycepin has been used in trials studying the treatment of Leukemia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1312542-61-2

Corticorelin acetate has been investigated for the treatment of Brain Edema and Brain Tumor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 121249-14-7

Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pit…

Kategori:
Amino Acids, Peptides, and ProteinsDiagnostic AgentsHormones +9
Target Protein:
Corticotropin-releasing factor receptor 1Corticotropin-releasing factor receptor 2
Waktu ParuhPlasma half-lives f…
Vol. DistribusiThe mean volume of …
Klirens95 ± 11 L/m2/day
Genetik -
Corticotropin Approved DB01285
biotech | CAS: 12427-33-7

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Kategori:
Adrenal Cortex HormonesAdrenocorticotropic HormoneAmino Acids, Peptides, and Proteins +27
Target Protein:
Adrenocorticotropic hormone receptorCorticoliberin
Waktu ParuhAbout 15 minutes fo…
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1272033-67-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsDiphtheria ToxinInactivated Pneumococcal Vaccine +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2246424-95-1

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector TherapiesAmino Acids, Peptides, and ProteinsGenetic Phenomena +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumarin 120 DB08168
small molecule | CAS: 26093-31-2

Deskripsi belum tersedia.

Kategori:
BenzopyransCompounds used in a research, industrial, or household settingHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Peptidyl-prolyl cis-trans isomerase APeptidyl-prolyl cis-trans isomerase APeptidyl-prolyl cis-trans isomerase F, mitochondrial +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumermycin A1 DB13912
small molecule | CAS: 4434-05-3

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsBenzopyransCoumarins +5
Target Protein:
DNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

COVID-19 convalescent plasma is plasma collected from patients who have acquired and subsequently recovered from COVID-19 and which contains antibodies against the causative agent SARS-CoV-2.[L14333] This investigational COVID-19 treatment is currently availa…

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-12 DB18169
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-122721 DB05421
small molecule | CAS: 145742-28-5

CP-122721, neurokinin 1 (NK1) antagonist is developed by Pfizer to treat depression, emesis, and inflammatory diseases including asthma and irritable bowel syndrome.

Target Protein:
Substance-P receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-547632 DB12962
small molecule | CAS: 252003-65-9

CP-547632 has been used in trials studying the treatment of Ovarian Cancer, Lung Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms, and Fallopian Tube Cancer, among others.

Kategori:
AmidesSulfur Compounds
Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-601927 DB12244
small molecule | CAS: 357425-02-6

CP-601,927 has been used in trials studying the basic science and treatment of Major Depressive Disorder.

Target Protein:
Neuronal acetylcholine receptor subunit alpha-4Neuronal acetylcholine receptor subunit beta-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-609754 DB12640
small molecule | CAS: 1190094-64-4

LNK 754 has been investigated in Mild Alzheimer's Disease.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-724714 DB12302
small molecule | CAS: 537705-08-1

CP-724,714 has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasm Metastasis.

Kategori:
Heterocyclic Compounds, Fused-RingReceptor, ErbB-2, antagonists & inhibitors
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP-866087 DB12196
small molecule | CAS: 519052-02-9

CP-866,087 has been used in trials studying the treatment of Obesity, Alcoholism, and Sexual Dysfunction, Physiological.

Kategori:
Aza Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CP1-1189 DB12311
small molecule | CAS: 183619-38-7

CPI-1189 has been used in trials studying the treatment of HIV Infections and AIDS Dementia Complex.

Kategori:
AlkanesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CPG-52852 DB12476
small molecule | CAS: 532959-63-0

852A has been used in trials studying the treatment of Melanoma, Neoplasms, Breast Cancer, Ovarian Cancer, and Cervical Cancer, among others.

Target Protein:
Toll-like receptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CPI-1205 DB14581
small molecule | CAS: 1621862-70-1

Potent and selective histone methyltransferase EZH2 inhibitor.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-Ring
Target Protein:
Histone-lysine N-methyltransferase EZH2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CRA-028129 DB05951
small molecule

CRA-028129 is cathepsin S inhibitor which is under investigation for the treatment of psoriasis.

Target Protein:
Cathepsin S
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CRA_17312 DB02084
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crolibulin DB12925
small molecule | CAS: 1000852-17-4

Crolibulin has been used in trials studying the treatment of Solid Tumor and Anaplastic Thyroid Cancer.

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crotedumab DB12815
biotech | CAS: 1452387-69-7

Crotedumab has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crotonaldehyde DB04381
small molecule | CAS: 123-73-9

Deskripsi belum tersedia.

Target Protein:
Transient receptor potential cation channel subfamily A member 1Aldehyde dehydrogenase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crovalimab Approved DB16128
biotech | CAS: 1917321-26-6

Crovalimab is a humanized monoclonal antibody and complement C5 inhibitor.[L50908] It consists of two heavy chains (451 amino acid residues each) and two light chains (217 amino acid residues each).[L50908] First developed by Chugai Pharmaceutical, in collabo…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic and Immunomodulating Agents +7
Target Protein:
Complement C5
Waktu ParuhThe mean estimated …
Vol. DistribusiThe mean central an…
KlirensIn PNH treatment-na…
Genetik -
Crozbaciclib DB18081
small molecule | CAS: 2099128-41-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CRS-3123 DB12262
small molecule | CAS: 1013915-71-3

CRS3123 has been used in trials studying the treatment of Clostridial Infection and Clostridium Difficile Colitis.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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