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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 168 / 272
Mavrilimumab DB12534
biotech | CAS: 1085337-57-0

Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MAX-40279 DB15191
small molecule | CAS: 2070931-57-4

MAX-40279 is under investigation in clinical trial NCT03412292 (MAX-40279 in Subjects With Acute Myelogenous Leukemia (AML)).

Waktu Paruh-
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Maxacalcitol DB06272
small molecule | CAS: 103909-75-7

Deskripsi belum tersedia.

Kategori:
Anticarcinogenic AgentsAntineoplastic AgentsCholestanes +13
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MaxAdFVIII DB17713
biotech

MaxAdFVIII is an adenoviral vector that expresses the full-length human Factor VIII (hFVIII) cDNA. First developed by GenStar, it is being investigated for the treatment of hemophilia.

Waktu Paruh-
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Maxy-G34 DB05718
biotech

MAXY-G34 is a pegylated variant of human granulocyte-colony stimulating factor (G-CSF). This variant contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as PEGylation sites, and from which mu…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mazaticol DB13448
small molecule | CAS: 42024-98-6

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAgents producing tachycardia +8
Waktu Paruh-
Vol. Distribusi-
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Mazdutide DB19099
biotech | CAS: 2259884-03-0

Mazdutide is under investigation in clinical trial NCT06143956 (A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-specific-appendices (Isas) in Adult Participants With Obesity or Overweight).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
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Mazindol Approved DB00579
small molecule | CAS: 22232-71-9

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only …

Kategori:
Adrenergic AgentsAdrenergic Uptake InhibitorsAlimentary Tract and Metabolism +19
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent dopamine transporterSodium-dependent serotonin transporter +1
Waktu Paruh10-13 hours
Vol. Distribusi-
Klirens-
Genetik -
Mazorelvimab DB17767
biotech | CAS: 2419087-89-9

Deskripsi belum tersedia.

Waktu Paruh-
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MB-07803 DB05053
small molecule | CAS: 882757-24-6

MB07803 is a second generation gluconeogenesis inhibitor for the treatment of type 2 diabetes. It is designed to block the metabolic pathway in the liver that is responsible for producing glucose.

Target Protein:
Fructose-1,6-bisphosphatase isozyme 2Fructose-1,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

MB-102 are autologous T cells genetically modified to express CD123-specific, hinge-optimized CD28-costimulatory chimeric receptor and a truncated human epidermal growth factor receptor.

Waktu Paruh-
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MB-107 DB18566
biotech

MB-107 consists of mobilized peripheral blood-derived autologous CD34+ hematopoietic stem cells that are genetically modified to express the IL2RG gene.

Waktu Paruh-
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MB07133 DB17139
small molecule | CAS: 685111-92-6

Deskripsi belum tersedia.

Kategori:
ArabinonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MBO7133 DB04999
small molecule

MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is used to treat leukemia but is ineffective against primary liver cancer. AraC's anti-cancer activity is associated with its ability to be converted to its bio…

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MBP134 DB18686
biotech

MBP134 is a pan-ebolavirus cocktail comprising two broadly neutralizing human antibodies. It is under investigation for the treatment of Sudan ebolavirus (SUDV).

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MBS-2320 DB18059
small molecule | CAS: 1642602-54-7

Deskripsi belum tersedia.

Waktu Paruh-
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MBT-0312 DB05880
small molecule

MediGene's newly acquired drug candidates MBT-0312 aim at a novel method of cancer therapy by "starving out" tumors.

Waktu Paruh-
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MBX-2109 DB18658
biotech

MBX-2109 is a long-acting parathyroid hormone peptide prodrug under investigation for the treatment of hyperparathyroidism.[L48365]

Waktu Paruh-
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MBX-2982 DB12345
small molecule | CAS: 1037792-44-1

MBX-2982 has been used in trials studying the treatment of Diabetes.

Kategori:
Sulfur Compounds
Target Protein:
Glucose-dependent insulinotropic receptor
Waktu Paruh-
Vol. Distribusi-
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MC-1 DB05315
small molecule

Medicure's MC-1 drug is a cardio-protectant, designed to reduce the damage to the heart when arteries are blocked and when they are subsequently reopened after bypass surgery.

Waktu Paruh-
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MC-16 DB18005
small molecule | CAS: 2036329-47-0

Deskripsi belum tersedia.

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MCMV3068A DB17764
biotech

MCMV3068A is an anticytomegalovirus monoclonal IgG1 antibody used in combination with [MCMV5322A] to form RG7667.[A259362]

Waktu Paruh-
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MCMV5322A DB17763
biotech

MCMV5322A is an anticytomegalovirus monoclonal IgG1 antibody used in combination with [MCMV3068A] to form RG7667.[A259362]

Waktu Paruh-
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MD05 DB06375
small molecule

MD05 is a beta-tricalcium phosphate (beta-TCP) coated with recombinant human growth/differentiation factor-5 (rhGDF-5).

Waktu Paruh-
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Mdl 101,146 DB02341
small molecule | CAS: 149859-17-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHydrocarbons, FluorinatedHydrocarbons, Halogenated +3
Target Protein:
Neutrophil elastaseChymotrypsin-like elastase family member 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mdl-29951 DB04175
small molecule | CAS: 101861-63-6

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Fructose-1,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MDL72527 DB04188
small molecule | CAS: 99207-33-7

Deskripsi belum tersedia.

Kategori:
AminesBiogenic AminesBiogenic Polyamines +3
Target Protein:
Spermine oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MDR-101 DB18513
biotech

MDR-101 is a CD34+ hematopoietic stem and progenitor cells with CD3+ T-cells

Waktu Paruh-
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MDX-1097 DB18383
biotech

MDX-1097 is a chimeric monoclonal antibody directed against the kappa myeloma antigen (KMA).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
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MDX-1303 DB05945
biotech | CAS: 915947-57-8

MDX-1303 is a fully human antibody against the inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium, and targets a protein component of these lethal toxins known as the anthrax protective antigen.

Target Protein:
Anthrax toxin receptor 2Anthrax toxin receptor 1
Waktu Paruh-
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MDX-1379 DB05329
biotech

MDX-1379 vaccine consists of two gp100 melanoma peptides. This drug is underinvestigation to treat malignant melanoma.

Waktu Paruh-
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ME-344 DB13062
small molecule | CAS: 1374524-68-1

ME-344 has been used in trials studying the treatment of Solid Tumors.

Kategori:
BenzopyransChromonesFlavonoids +2
Target Protein:
Target of rapamycin complex 2 subunit MAPKAP1Serine/threonine-protein kinase mTOR
Waktu Paruh-
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Genetik -
Me-4(18F)DG DB19207
small molecule | CAS: 915776-36-2

Me-4(18F)DG is under investigation in clinical trial NCT05558904 (An Investigational Scan (Me-4fdg PET/CT) for the Detection of Sodium-glucose Transport for Early Diagnosis of Lung Cancer).

Kategori:
CarbohydratesFluorine RadioisotopesGlycosides
Waktu Paruh-
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Genetik -
biotech | CAS: 153065-40-8

Meadowfoam seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesLipids +3
Waktu Paruh-
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Genetik -
biotech

Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strai…

Kategori:
Actively Acquired ImmunityLive Attenuated Measles Virus VaccineVaccines
Waktu Paruh-
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Mebendazole Approved DB00643
small molecule | CAS: 31431-39-7

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Kategori:
Acids, AcyclicAnthelminticsAnti-Infective Agents +11
Target Protein:
Tubulin alpha-1A chainTubulin beta-4B chain
Waktu Paruh2.5 to 5.5 hours (r…
Vol. Distribusi-
Klirens-
Genetik -
Mebenil DB14728
small molecule | CAS: 7055-03-0

An obsolete fungicide used to control various pathogens on cereals and seed potatoes.

Kategori:
AmidesAminesAniline Compounds
Waktu Paruh-
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Mebeverine Approved DB12554
small molecule | CAS: 3625-06-7

Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.

Kategori:
Agents Causing Muscle ToxicityAgents producing tachycardiaAlimentary Tract and Metabolism +10
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Mebhydrolin DB13808
small molecule | CAS: 524-81-2

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseHeterocyclic Compounds, Fused-RingIndole Alkaloids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mebicar DB13522
small molecule | CAS: 10095-06-4

Deskripsi belum tersedia.

Kategori:
AmidesAnalgesicsAnti-Anxiety Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mebutamate Approved DB06797
small molecule | CAS: 64-55-1

Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a sedative. Side effects include dizziness and headaches.

Kategori:
Anti-Anxiety AgentsCarbamatesCentral Nervous System Depressants +2
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mebutizide DB13430
small molecule | CAS: 3568-00-1

Deskripsi belum tersedia.

Kategori:
DiureticsHeterocyclic Compounds, Fused-RingHyperglycemia-Associated Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1570067-55-8

Mecapegfilgrastim is under investigation in clinical trial NCT05463601 (Mecapegfilgrastim for the Prevention of Dalpiciclib -Induced Neutropenia in Advanced Breast Cancer).

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +13
Waktu Paruh-
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Mecasermin rinfabate Approved DB14751
biotech | CAS: 478166-15-3

Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH)[A176020]. Mecasermin rinfabate is similar to [DB01277] in that both drugs…

Kategori:
Anterior Pituitary Lobe Hormones and AnaloguesPituitary and Hypothalamic Hormones and AnaloguesSomatropin and Somatropin Agonists +1
Target Protein:
Insulin-like growth factor 1 receptorInsulin receptorCation-independent mannose-6-phosphate receptor
Waktu ParuhHalf life ranges fr…
Vol. DistribusiApproximately 1000m…
KlirensClearance ranges fr…
Genetik -
biotech | CAS: 2460400-64-8

Mecbotamab vedotin is an anti-Axl humanized monoclonal antibody conjugated to monomethyl auristatin E using a cleavable linker (CAB-Axl-ADC).[A255212]

Waktu Paruh-
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Mechlorethamine Approved DB00888
small molecule | CAS: 51-75-2

A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal…

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +16
Target Protein:
DNA
Waktu Paruh15 minutes
Vol. Distribusi-
Klirens-
Genetik -
Meclinertant DB06455
small molecule | CAS: 146362-70-1

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, Neurotensin, antagonists & inhibitors
Target Protein:
Neurotensin receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Meclizine Approved DB00737
small molecule | CAS: 569-65-3

Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous …

Kategori:
Anti-Allergic AgentsAnticholinergic AgentsAntiemetics +19
Target Protein:
Histamine H1 receptorNuclear receptor subfamily 1 group I member 3
Waktu ParuhMeclizine has a pla…
Vol. DistribusiThe volume of distr…
KlirensThere is limited da…
Genetik -
Meclocycline DB13092
small molecule | CAS: 2013-58-3

Meclocycline is under investigation in clinical trial NCT00385515 (Efficacy of SNX-1012 in the Treatment of Oral Mucositis) [L797].

Kategori:
Anti-Acne PreparationsAnti-Acne Preparations for Topical UseAnti-Bacterial Agents +5
Target Protein:
30S ribosomal protein S7
Waktu ParuhHalf life estimated…
Vol. DistribusiEstimated Vd of 121…
Klirens-
Genetik -
Meclofenamic acid Approved DB00939
small molecule | CAS: 644-62-2

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +25
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2Polyunsaturated fatty acid 5-lipoxygenase +2
Waktu ParuhIn a study in 10 he…
Vol. Distribusi* 9.1 to 43.2 L
Klirens* Oral cl=206 mL/min
Genetik -
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