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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 164 / 282
Lafutidine DB12770
small molecule | CAS: 118288-08-7

Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD).

Kategori:
AcetatesAcids, AcyclicAlimentary Tract and Metabolism +10
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biotech

Lagerstroemia indica whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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small molecule

Deskripsi belum tersedia.

Target Protein:
Camphor 5-monooxygenase
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Azurin
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Azurin
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Lamivudine Approved DB00709
small molecule | CAS: 134678-17-4

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +26
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseHDNA +1
Waktu Paruh5 to 7 hours (healt…
Vol. DistribusiApparent volume of …
Klirens* Renal clearance =…
Genetik -
Lamotrigine Approved DB00555
small molecule | CAS: 84057-84-1

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA)…

Kategori:
Agents causing hyperkalemiaAgents producing tachycardiaAnti-epileptic Agent +31
Target Protein:
Voltage-dependent R-type calcium channel subunit alpha-1ESodium channel protein type 11 subunit alphaVoltage-gated sodium channel alpha subunit +15
Waktu ParuhThe average elimina…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent p…
Genetik -
Lampalizumab DB11826
biotech | CAS: 1278466-20-8

Lampalizumab has been used in trials studying the treatment of Geographic Atrophy.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +9
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Lanabecestat DB14814
small molecule | CAS: 1383982-64-6

Lanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants With Liver Impairment).

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biotech | CAS: 1939139-26-0

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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Lanadelumab Approved DB14597
biotech | CAS: 1426055-14-2

Lanadelumab, also known as DX-2930, is a human IgG1 monoclonal antibody designed for subcutaneous self-injection.[L4538] It is a fully human immunoglobulin, k-light-chain made in recombinant Chinese Hamster Ovary cells.[L4537] It has been granted priority rev…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Plasma kallikrein
Waktu ParuhLanadelumab has a h…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Lanatoside C DB13467
small molecule | CAS: 17575-22-3

Deskripsi belum tersedia.

Kategori:
CarbohydratesCardanolidesCardenolides +6
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Lancovutide DB05029
small molecule | CAS: 1391-36-2

Lancovutide, a peptide antibiotic, is in clinical development for the treatment of cystic fibrosis. Lancovutide is a 19-amino-acid tetracyclic peptide produced by Streptoverticillium cinnamoneus and is closely related to cinnamycin (Ro09-0198). It belongs to …

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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Landiolol Approved DB12212
small molecule | CAS: 133242-30-5

Landiolol is a rapid-acting beta-blocker used for rapid ventricular rate control.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +11
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Landipirdine DB16214
small molecule | CAS: 1000308-25-7

Landipirdine is under investigation in clinical trial NCT02258152 (SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)).

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsSerotonin 5-HT2 Receptor Antagonists +3
Target Protein:
5-hydroxytryptamine receptor 65-hydroxytryptamine receptor 2A
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Landogrozumab DB11862
biotech | CAS: 1391726-30-9

Landogrozumab has been used in trials studying the treatment of Advanced Cancer, Muscular Atrophy, and Pancreatic Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Lanicemine DB11889
small molecule | CAS: 153322-05-5

Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder.

Kategori:
AminesAntidepressive AgentsCentral Nervous System Depressants +2
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Lanifibranor DB14801
small molecule | CAS: 927961-18-0

Lanifibranor is under investigation in clinical trial NCT03008070 (Phase 2b Study in NASH to Assess IVA337).

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +2
Target Protein:
Peroxisome proliferator-activated receptor alphaPeroxisome proliferator-activated receptor deltaPeroxisome proliferator-activated receptor gamma
Waktu Paruh-
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Lanimostim DB06559
small molecule | CAS: 117276-75-2

Deskripsi belum tersedia.

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Laninamivir DB12791
small molecule | CAS: 203120-17-6

Laninamivir has been used in trials studying the treatment of Influenza.

Kategori:
Acids, AcyclicAmidinesAmino Sugars +11
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small molecule | CAS: 203120-46-1

Laninamivir octanoate has been used in trials studying the treatment of Asthma.

Kategori:
Acids, AcyclicAmidinesAmino Sugars +10
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Laniquidar DB12799
small molecule | CAS: 197509-46-9

Laniquidar has been used in trials studying the treatment of Breast Cancer.

Kategori:
Carbon RadioisotopesDrug Resistance, MultipleHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Phosphatidylcholine translocator ABCB4
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Lanolin Approved DB11112
small molecule | CAS: 8006-54-0

Lanolin is a yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid [L2580]. The US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointme…

Kategori:
Basic Ointments and ProtectantsCompounds used in a research, industrial, or household settingCosmetics +3
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Lanolin alcohols Approved DB14181
small molecule | CAS: 8027-33-6

Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin. It is administered as an ointment base with topical insulin and has shown to be antagonistic to wound healing. It is commonly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseStandardized Chemical Allergen
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Lanopepden DB11912
small molecule | CAS: 1152107-25-9

Lanopepden has been used in trials studying the treatment of Pneumonia, Infections, Bacterial, Skin Diseases, Infectious, and Skin Infections, Bacterial.

Kategori:
AminesAnti-Bacterial AgentsEnzyme Inhibitors +2
Target Protein:
Peptide deformylase
Waktu Paruh-
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Lanoteplase DB06245
biotech | CAS: 171870-23-8

Deskripsi belum tersedia.

Kategori:
Agents causing angioedemaAmino Acids, Peptides, and ProteinsBiological Factors +10
Target Protein:
Urokinase plasminogen activator surface receptorFibrinogen alpha chainKallikrein-1 +14
Waktu Paruh-
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Lanraplenib DB14770
small molecule | CAS: 1800046-95-0

Lanraplenib is under investigation in clinical trial NCT03285711 (Safety and Efficacy of Filgotinib and Lanraplenib in Adults With Lupus Membranous Nephropathy (LMN)).

Target Protein:
Tyrosine-protein kinase SYK
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Lanreotide Approved DB06791
small molecule | CAS: 108736-35-2

Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatost…

Kategori:
AcromegalyAmino Acids, Peptides, and ProteinsAntineoplastic Agents +22
Target Protein:
Somatostatin receptor type 2Somatostatin receptor type 5
Waktu ParuhHalf-life is approx…
Vol. DistribusiEstimated Volume of…
KlirensEstimated Clearance…
Genetik -
small molecule | CAS: 131926-99-3

Deskripsi belum tersedia.

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesBenzimidazolesHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
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Lanthanum carbonate Approved DB06792
small molecule | CAS: 587-26-8

Lanthanum carbonate is a phosphate binder marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate …

Kategori:
Drugs for Treatment of Hyperkalemia and HyperphosphatemiaElementsKidney Failure, Chronic +6
Target Protein:
Phosphate
Waktu ParuhThe elimination hal…
Vol. Distribusi-
KlirensIn healthy voluntee…
Genetik -
small molecule | CAS: 16096-89-2

Deskripsi belum tersedia.

Kategori:
Metal cationsPhosphate BinderPhosphate Chelating Activity
Waktu Paruh-
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Lapachone DB11948
small molecule | CAS: 4707-32-8

Lapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +6
Target Protein:
DNA topoisomerase 1Retinol-binding protein 3
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Lapaquistat DB16215
small molecule | CAS: 189059-71-0

Lapaquistat is under investigation in clinical trial NCT00256178 (Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.).

Kategori:
AzepinesFarnesyl-Diphosphate Farnesyltransferase, antagonists & inhibitors
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Lapatinib Approved DB01259
small molecule | CAS: 231277-92-2

Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with t…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates +22
Target Protein:
Epidermal growth factor receptorEukaryotic elongation factor 2 kinaseReceptor tyrosine-protein kinase erbB-2
Gen Terkait:
HLA-DQA1 HLA-DRB1 HLA-DQB1 +1
Waktu ParuhSingle-dose termina…
Vol. Distribusi-
Klirens-
Genetik 4 Varian
Lapyrium Approved DB09376
small molecule | CAS: 109260-82-4

Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products [A19426]. It is commonly found formulated as lapyrium chloride.

Kategori:
Pyridines
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Laquinimod DB06685
small molecule | CAS: 248281-84-7

Laquinimod is an immunomodulator developed by Active Biotech and produced by Teva Pharmaceutical Industries. It is currently under development in phase III trials for treatment of multiple sclerosis as an oral therapy, like fingolimod. It has been shown to re…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +3
Target Protein:
Transcription factor RelBNuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit +3
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Larazotide DB05645
small molecule | CAS: 258818-34-7

An octapeptide inhibitor of paracellular permeability whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Haptoglobin
Waktu Paruh-
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Larcaviximab DB17775
biotech | CAS: 1792982-56-9

Deskripsi belum tersedia.

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Larix sibirica wood Approved DB14289
biotech

Larix sibirica wood is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Laromustine DB05817
small molecule | CAS: 173424-77-6

VNP40101M is a novel alkylating agent that has been used in trials studying the treatment of Leukemia, Lymphoma, Lung Cancer, Small Intestine Cancer, and Myelodysplastic Syndromes, among others.

Kategori:
AmidesSulfonesSulfur Compounds
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Laronidase Approved DB00090
biotech | CAS: 210589-09-6

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of th…

Kategori:
Alimentary Tract and MetabolismEnzymesEnzymes and Coenzymes +4
Target Protein:
Iduronic acid
Waktu Paruh1.5-3.6 hrs
Vol. Distribusi-
Klirens-
Genetik -
Laropiprant Approved DB11629
small molecule | CAS: 571170-77-9

Laropiprant is an ingredient in the EMA-withdrawn product Pelzont.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Prostaglandin E2 receptor EP2 subtype3-hydroxy-3-methylglutaryl-coenzyme A reductaseThromboxane A2 receptor +4
Waktu Paruh-
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Larotaxel DB12984
small molecule | CAS: 156294-36-9

Larotaxel has been used in trials studying the treatment of Cancer, Metastases, Breast Cancer, Breast Neoplasms, and Pancreatic Neoplasms, among others.

Kategori:
CyclodecanesCycloparaffinsDiterpenes +1
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Larotrectinib Approved DB14723
small molecule | CAS: 1223403-58-4

Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.[L49…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +8
Target Protein:
High affinity nerve growth factor receptorBDNF/NT-3 growth factors receptorNT-3 growth factor receptor
Waktu ParuhIn healthy subjects…
Vol. DistribusiFollowing intraveno…
KlirensThe mean clearance …
Genetik -
Larsucosterol DB18079
small molecule | CAS: 884905-07-1

Deskripsi belum tersedia.

Kategori:
CholestanesCholestenesFused-Ring Compounds +5
Waktu Paruh-
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Lartesertib DB19045
small molecule | CAS: 2495096-26-7

Lartesertib is under investigation in clinical trial NCT06433219 (Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (Ddriver EOC 302)).

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biotech | CAS: 2425817-08-7

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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LAS-191954 DB17816
small molecule | CAS: 1403947-26-1

Deskripsi belum tersedia.

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Lasalocid DB11423
small molecule | CAS: 25999-31-9

Lasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of _Streptomyces lasaliensis_.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +11
Waktu Paruh-
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Lasmiditan Approved DB11732
small molecule | CAS: 439239-90-4

Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022.[L43997] Traditionally, the…

Kategori:
AmidesAnalgesicsAntidepressive Agents +17
Target Protein:
5-hydroxytryptamine receptor 1F
Waktu ParuhThe mean eliminatio…
Vol. DistribusiLasmiditan has been…
Klirens-
Genetik -
Menampilkan 8151–8200 dari 14063
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