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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Halaman 161 / 236
Nelotanserin DB12555
small molecule | CAS: 839713-36-9

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sl…

Kategori:
AmidesBenzene Derivatives
Target Protein:
5-hydroxytryptamine receptor 2A
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Nemiralisib DB16253
small molecule | CAS: 1254036-71-9

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors +1
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Nemolizumab Approved DB15252
biotech | CAS: 1476039-58-3

Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA),[L51159] which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders.[A264254…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAmino Acids, Peptides, and ProteinsAntibodies +10
Target Protein:
Interleukin-31 receptor subunit alpha
Waktu ParuhThe estimated termi…
Vol. DistribusiThe estimated volum…
KlirensThe estimated syste…
Genetik -
Nemonapride DB19314
small molecule | CAS: 75272-39-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +9
Target Protein:
D(2) dopamine receptor
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Nemonoxacin DB06600
small molecule | CAS: 378746-64-6

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
DNA gyrase subunit ADNA gyrase subunit B
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Nemtabrutinib DB18866
small molecule | CAS: 2095393-15-8

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-0…

Target Protein:
Tyrosine-protein kinase BTK
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biotech | CAS: 2315268-27-8

Deskripsi belum tersedia.

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biotech | CAS: 1853254-97-3

Nendratareotide uzatansine is a peptide-drug conjugate comprising a peptide analog of somatostatin conjugated to the cytotoxin mertansine.

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NEO-212 DB17100
small molecule | CAS: 1361198-79-9

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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Neoarsphenamine DB18729
small molecule | CAS: 457-60-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsArsenicalsHaptens
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Neocartilage DB05257
biotech

Neocartilage, a novel cartilage regeneration treatment. Neocartilage is generated from juvenile rather than adult chondrocytes. Neocartilage is the only scaffold-free living cartilage graft on the market.

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Neodymium DB15318
small molecule | CAS: 7440-00-8

Neodymium is under investigation in clinical trial NCT03525522 (Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus).

Kategori:
ElementsLanthanoid Series ElementsMetals +1
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Neomycin Approved DB00994
small molecule | CAS: 1404-04-2

Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_.[L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C.[A191529] Neomycin B, also known as [framyceti…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAminoglycoside Antibacterials +28
Target Protein:
30S ribosomal protein S1216S ribosomal RNAExtracellular calcium-sensing receptor
Waktu ParuhThere is limited in…
Vol. DistribusiThe small fraction …
KlirensThere is limited in…
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Neon Approved DB11589
small molecule | CAS: 7440-01-9

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a re…

Kategori:
ElementsGasesNoble Gases
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Neopterin DB15050
small molecule | CAS: 2009-64-5

Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
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Neosaxitoxin DB12989
small molecule | CAS: 64296-20-4

Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).

Kategori:
AgrochemicalsBacterial ToxinsBiological Factors +16
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Neovastat DB05387
small molecule

Neovastat is a naturally occurring anti-angiogenic compound, extracted from cartilage, with multiple anti-angiogenic mechanisms of action that provide broad therapeutic potential for a number of diseases. It is currently in international Phase III trials for …

Kategori:
CartilageComplex Mixtures
Target Protein:
72 kDa type IV collagenaseMatrix metalloproteinase-9Macrophage metalloelastase
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Nepadutant DB12538
small molecule | CAS: 183747-35-5

Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Asthmatic AgentsAutonomic Agents +5
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Nepafenac Approved DB06802
small molecule | CAS: 78281-72-8

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.

Kategori:
AcetamidesAcetatesAcids, Acyclic +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
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Nepicastat DB12979
small molecule | CAS: 173997-05-2

Nepicastat has been investigated for the treatment of Cocaine Dependence and Posttraumatic Stress Disorder.

Kategori:
Dopamine beta-Hydroxylase, antagonists & inhibitorsSulfur Compounds
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Nequinate DB11433
small molecule | CAS: 13997-19-8

Nequinate is an antiprotozoan used as a coccidiostat for poultry and rabbits. Nequinate belongs to the family of Hydroquinolones. These are compounds containing an hydrogenated quinoline bearing a ketone group.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
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Nerandomilast DB18237
small molecule | CAS: 1423719-30-5

Deskripsi belum tersedia.

Kategori:
Cycloparaffins
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Neratinib Approved DB11828
small molecule | CAS: 698387-09-6

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under inve…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A Substrates +11
Target Protein:
Vascular endothelial growth factor receptor 2Receptor tyrosine-protein kinase erbB-2Epidermal growth factor receptor
Waktu ParuhThe mean half life …
Vol. DistribusiThe apparent volume…
KlirensThe total clearance…
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Neridronic Acid DB11620
small molecule | CAS: 79778-41-9

Deskripsi belum tersedia.

Kategori:
OrganophosphonatesOrganophosphorus Compounds
Target Protein:
Farnesyl pyrophosphate synthase
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Nerinetide DB12595
biotech | CAS: 500992-11-0

Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
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Nerispirdine DB12714
small molecule | CAS: 119229-65-1

Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2Sodium channel protein type 11 subunit alpha
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Nerofe DB14786
small molecule | CAS: 1311294-45-7

Nerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).

Kategori:
Amino Acids, Peptides, and Proteins
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Nesbuvir DB07238
small molecule | CAS: 691852-58-1

Nesbuvir has been investigated for the treatment of Hepatitis C.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
Genome polyproteinGenome polyproteinGenome polyprotein
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Nesolicaftor DB15239
small molecule | CAS: 1953130-87-4

Nesolicaftor (PTI-428) is under investigation in clinical trial NCT03258424 (Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy).

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Nesuparib DB18110
small molecule | CAS: 2055357-64-5

Deskripsi belum tersedia.

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Nesvacumab DB15330
biotech | CAS: 1296818-77-3

Nesvacumab is under investigation in clinical trial NCT01997164 (Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular (Wet) Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME)).

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Nesvategrast DB19337
small molecule | CAS: 1621332-91-9

Nesvategrast is under investigation in clinical trial NCT05409235 (Nesvategrast (OTT166) in Diabetic Retinopathy (DR)).

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Netakimab DB18870
biotech | CAS: 1796570-08-5

Netakimab is under investigation in clinical trial NCT03447704 (International Multicenter Comparative Randomized Placebo-controlled Clinical Study of Efficacy and Safety of BCD-085 in Patients With Ankylosing Spondylitis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
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Netarsudil Approved DB13931
small molecule | CAS: 1254032-66-0

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elev…

Kategori:
Acids, CarbocyclicAlanineAmino Acids +8
Target Protein:
Rho-associated protein kinase 1Rho-associated protein kinase 2Sodium-dependent noradrenaline transporter
Waktu ParuhThe half-life of ne…
Vol. DistribusiAs netarsudil and i…
KlirensThe clearance of ne…
Genetik -
Netoglitazone DB09199
small molecule | CAS: 161600-01-7

Netoglitazone (MCC-555) is a hypoglycemic agent.

Kategori:
Blood Glucose Lowering AgentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (strength unknown) +8
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
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Netupitant Approved DB09048
small molecule | CAS: 290297-26-6

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant …

Kategori:
AcetamidesAmidesBCRP/ABCG2 Inhibitors +15
Target Protein:
Substance-P receptor
Waktu Paruh96 hours with CV% o…
Vol. DistribusiIn cancer patients,…
KlirensEstimated systemic …
Genetik -
NeuroCell-HD DB17915
biotech

Deskripsi belum tersedia.

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NeuroCell-PD DB17941
biotech

Deskripsi belum tersedia.

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Neuropeptide Y Approved DB11788
biotech | CAS: 82785-45-3

Neuropeptide Y is under investigation for the basic science of Type 2 Diabetes Mellitus.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsNeuropeptide Y, drug effects +3
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NeuroVax DB16941
biotech | CAS: 1007558-71-5

Deskripsi belum tersedia.

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Nevanimibe DB16254
small molecule | CAS: 133825-80-6

Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome).

Kategori:
AmidesBenzene Derivatives
Target Protein:
Sterol O-acyltransferase 1Sterol O-acyltransferase 2
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Nezastomig DB19061
biotech | CAS: 2657613-60-8

Nezastomig is under investigation in clinical trial NCT06085664 (A Pilot Presurgical Trial of REGN5678 (Anti-psma X CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy).

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NGD-4715 DB06027
small molecule | CAS: 476322-70-0

NGD-4715 is an investigational compound developed for the treatment of Obesity. NGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.

Target Protein:
Melanin-concentrating hormone receptor 1
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NGGT-002 DB17881
biotech

NGGT-002 is a recombinant adeno-associated virus serotype 8 vector encoding human phenylalanine hydroxylase (PAH).

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NGX267 DB05152
small molecule | CAS: 503431-81-0

NGX267 is a muscarinic agonist. It is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression.

Kategori:
Cholinergic AgentsCholinergic AgonistsMuscarinic Agonists +2
Target Protein:
Muscarinic acetylcholine receptor M1
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Niacin Approved DB00627
small molecule | CAS: 59-67-6

Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565]

Kategori:
Agents Causing Muscle ToxicityCardiovascular AgentsCytochrome P-450 CYP2D6 Inhibitors +31
Target Protein:
Hydroxycarboxylic acid receptor 3Diacylglycerol O-acyltransferase 2Hydroxycarboxylic acid receptor 2 +2
Waktu ParuhThe half life of ni…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Niacinamide ascorbate Approved DB14486
small molecule | CAS: 1987-71-9

Deskripsi belum tersedia.

Kategori:
Urinary Acidifying AgentsVitamin B ComplexVitamin C and analogues +1
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Nialamide Approved DB04820
small molecule | CAS: 51-12-7

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +11
Target Protein:
Amine oxidase [flavin-containing] BAmine oxidase [flavin-containing] ACatechol O-methyltransferase
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Niaprazine DB13687
small molecule | CAS: 27367-90-4

Niaprazine is a selective brain catecholamine depletor.

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +3
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