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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 154 / 252
Mavodelpar DB17662
small molecule | CAS: 942594-93-6

Deskripsi belum tersedia.

Waktu Paruh-
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Mavoglurant DB13004
small molecule | CAS: 543906-09-8

Mavoglurant has been used in trials studying the treatment of Patient Diagnosed With OCD and and Resistant to SSRI Treatment (Failed SSRI Over 12 Weeks at Appropriate Doses).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Metabotropic glutamate receptor 5
Waktu Paruh-
Vol. Distribusi-
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Mavorixafor Approved DB05501
small molecule | CAS: 558447-26-0

Mavorixafor is a CXC chemokine receptor 4 (CXCR4) antagonist.[L50642] It was first approved by the FDA on April 30, 2024, for the treatment of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a genetic immunodeficiency disorder cha…

Kategori:
AlkanesAminesButanes +38
Target Protein:
C-X-C chemokine receptor type 4
Waktu ParuhThe mean (CV%) term…
Vol. DistribusiMavorixafor volume …
KlirensThe mean (CV%) appa…
Genetik -
Mavrilimumab DB12534
biotech | CAS: 1085337-57-0

Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
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MAX-40279 DB15191
small molecule | CAS: 2070931-57-4

MAX-40279 is under investigation in clinical trial NCT03412292 (MAX-40279 in Subjects With Acute Myelogenous Leukemia (AML)).

Waktu Paruh-
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Maxacalcitol DB06272
small molecule | CAS: 103909-75-7

Deskripsi belum tersedia.

Kategori:
Anticarcinogenic AgentsAntineoplastic AgentsCholestanes +13
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Maxy-G34 DB05718
biotech

MAXY-G34 is a pegylated variant of human granulocyte-colony stimulating factor (G-CSF). This variant contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as PEGylation sites, and from which mu…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Mazdutide DB19099
biotech | CAS: 2259884-03-0

Mazdutide is under investigation in clinical trial NCT06143956 (A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-specific-appendices (Isas) in Adult Participants With Obesity or Overweight).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
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Mazindol Approved DB00579
small molecule | CAS: 22232-71-9

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only …

Kategori:
Adrenergic AgentsAdrenergic Uptake InhibitorsAlimentary Tract and Metabolism +19
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent dopamine transporterSodium-dependent serotonin transporter +1
Waktu Paruh10-13 hours
Vol. Distribusi-
Klirens-
Genetik -
MB-07803 DB05053
small molecule | CAS: 882757-24-6

MB07803 is a second generation gluconeogenesis inhibitor for the treatment of type 2 diabetes. It is designed to block the metabolic pathway in the liver that is responsible for producing glucose.

Target Protein:
Fructose-1,6-bisphosphatase isozyme 2Fructose-1,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MB-107 DB18566
biotech

MB-107 consists of mobilized peripheral blood-derived autologous CD34+ hematopoietic stem cells that are genetically modified to express the IL2RG gene.

Waktu Paruh-
Vol. Distribusi-
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MB07133 DB17139
small molecule | CAS: 685111-92-6

Deskripsi belum tersedia.

Kategori:
ArabinonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MB07811 DB05192
small molecule

MB07811 is the first of a novel class of product candidates discovered by Metabasis designed to lower serum cholesterol and triglycerides. MB07811, a small molecule that is administered orally, has been extensively studied preclinically and is currently under…

Kategori:
Organophosphorus Compounds
Target Protein:
Thyroid hormone receptor beta
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MBS-2320 DB18059
small molecule | CAS: 1642602-54-7

Deskripsi belum tersedia.

Waktu Paruh-
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MBT-0312 DB05880
small molecule

MediGene's newly acquired drug candidates MBT-0312 aim at a novel method of cancer therapy by "starving out" tumors.

Waktu Paruh-
Vol. Distribusi-
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MBX-2044 DB05598
small molecule

MBX-2044 was under investigation in clinical trial NCT00422487 (Safety and Tolerability Study of MBX-2044 in Patients With Type 2 Diabetes).

Waktu Paruh-
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MBX-2109 DB18658
biotech

MBX-2109 is a long-acting parathyroid hormone peptide prodrug under investigation for the treatment of hyperparathyroidism.[L48365]

Waktu Paruh-
Vol. Distribusi-
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MBX-2982 DB12345
small molecule | CAS: 1037792-44-1

MBX-2982 has been used in trials studying the treatment of Diabetes.

Kategori:
Sulfur Compounds
Target Protein:
Glucose-dependent insulinotropic receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MC-1 DB05315
small molecule

Medicure's MC-1 drug is a cardio-protectant, designed to reduce the damage to the heart when arteries are blocked and when they are subsequently reopened after bypass surgery.

Waktu Paruh-
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MC-16 DB18005
small molecule | CAS: 2036329-47-0

Deskripsi belum tersedia.

Waktu Paruh-
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MCC DB05282
small molecule

Mycobacterial Cell Wall-DNA Complex (MCC) is formulated from Mycobacterium phlei, a non-pathogenic strain of mycobacteria. MCC has been shown to have immune stimulatory and apoptosis (programmed cell death) activity against cancer cells. The product is a ster…

Target Protein:
Apoptosis-inducing factor 1, mitochondrial
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MCMV3068A DB17764
biotech

MCMV3068A is an anticytomegalovirus monoclonal IgG1 antibody used in combination with [MCMV5322A] to form RG7667.[A259362]

Waktu Paruh-
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MCMV5322A DB17763
biotech

MCMV5322A is an anticytomegalovirus monoclonal IgG1 antibody used in combination with [MCMV3068A] to form RG7667.[A259362]

Waktu Paruh-
Vol. Distribusi-
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MD-0727 DB05948
small molecule

MD-0727 is a novel, potent cholesterol absorption inhibitor (CAI) under investigation for the treatment of hypercholesterolemia (high cholesterol.

Waktu Paruh-
Vol. Distribusi-
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MD05 DB06375
small molecule

MD05 is a beta-tricalcium phosphate (beta-TCP) coated with recombinant human growth/differentiation factor-5 (rhGDF-5).

Waktu Paruh-
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Mdl 101,146 DB02341
small molecule | CAS: 149859-17-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHydrocarbons, FluorinatedHydrocarbons, Halogenated +3
Target Protein:
Neutrophil elastaseChymotrypsin-like elastase family member 1
Waktu Paruh-
Vol. Distribusi-
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Mdl-29951 DB04175
small molecule | CAS: 101861-63-6

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Fructose-1,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
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MDL72527 DB04188
small molecule | CAS: 99207-33-7

Deskripsi belum tersedia.

Kategori:
AminesBiogenic AminesBiogenic Polyamines +3
Target Protein:
Spermine oxidase
Waktu Paruh-
Vol. Distribusi-
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MDR-101 DB18513
biotech

MDR-101 is a CD34+ hematopoietic stem and progenitor cells with CD3+ T-cells

Waktu Paruh-
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MDX-018 DB05484
small molecule

MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nerv…

Target Protein:
Interleukin-8
Waktu Paruh-
Vol. Distribusi-
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MDX-1303 DB05945
biotech | CAS: 915947-57-8

MDX-1303 is a fully human antibody against the inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium, and targets a protein component of these lethal toxins known as the anthrax protective antigen.

Target Protein:
Anthrax toxin receptor 2Anthrax toxin receptor 1
Waktu Paruh-
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MDX-1379 DB05329
biotech

MDX-1379 vaccine consists of two gp100 melanoma peptides. This drug is underinvestigation to treat malignant melanoma.

Waktu Paruh-
Vol. Distribusi-
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MDX-210 DB17250
biotech

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ME-344 DB13062
small molecule | CAS: 1374524-68-1

ME-344 has been used in trials studying the treatment of Solid Tumors.

Kategori:
BenzopyransChromonesFlavonoids +2
Target Protein:
Target of rapamycin complex 2 subunit MAPKAP1Serine/threonine-protein kinase mTOR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Me-4(18F)DG DB19207
small molecule | CAS: 915776-36-2

Me-4(18F)DG is under investigation in clinical trial NCT05558904 (An Investigational Scan (Me-4fdg PET/CT) for the Detection of Sodium-glucose Transport for Early Diagnosis of Lung Cancer).

Kategori:
CarbohydratesFluorine RadioisotopesGlycosides
Waktu Paruh-
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biotech | CAS: 153065-40-8

Meadowfoam seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesLipids +3
Waktu Paruh-
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Genetik -
biotech

Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strai…

Kategori:
Actively Acquired ImmunityLive Attenuated Measles Virus VaccineVaccines
Waktu Paruh-
Vol. Distribusi-
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Mebanazine DB09248
small molecule | CAS: 65-64-5

Mebanazine, also known as _Actomol_, is a monoamine oxidase inhibitor (MAOI) belonging to the _hydrazine_ class of chemicals. It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of its hepatotoxic potential.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +3
Waktu Paruh-
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Mebendazole Approved DB00643
small molecule | CAS: 31431-39-7

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Kategori:
Acids, AcyclicAnthelminticsAnti-Infective Agents +11
Target Protein:
Tubulin alpha-1A chainTubulin beta-4B chain
Waktu Paruh2.5 to 5.5 hours (r…
Vol. Distribusi-
Klirens-
Genetik -
Mebenil DB14728
small molecule | CAS: 7055-03-0

An obsolete fungicide used to control various pathogens on cereals and seed potatoes.

Kategori:
AmidesAminesAniline Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Mebeverine Approved DB12554
small molecule | CAS: 3625-06-7

Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.

Kategori:
Agents Causing Muscle ToxicityAgents producing tachycardiaAlimentary Tract and Metabolism +10
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Mebhydrolin DB13808
small molecule | CAS: 524-81-2

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseHeterocyclic Compounds, Fused-RingIndole Alkaloids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mebicar DB13522
small molecule | CAS: 10095-06-4

Deskripsi belum tersedia.

Kategori:
AmidesAnalgesicsAnti-Anxiety Agents +8
Waktu Paruh-
Vol. Distribusi-
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Mebrofenin Approved DB15779
small molecule | CAS: 78266-06-5

Deskripsi belum tersedia.

Kategori:
AminesAmino AcidsAmino Acids, Peptides, and Proteins
Waktu Paruh-
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Klirens-
Genetik -
Mebutamate Approved DB06797
small molecule | CAS: 64-55-1

Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a sedative. Side effects include dizziness and headaches.

Kategori:
Anti-Anxiety AgentsCarbamatesCentral Nervous System Depressants +2
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3
Waktu Paruh-
Vol. Distribusi-
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Mebutizide DB13430
small molecule | CAS: 3568-00-1

Deskripsi belum tersedia.

Kategori:
DiureticsHeterocyclic Compounds, Fused-RingHyperglycemia-Associated Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mecamylamine Approved DB00657
small molecule | CAS: 60-40-2

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a rese…

Kategori:
Agents that produce neuromuscular block (indirect)Antiadrenergic Agents, Ganglion-BlockingAnticholinergic Agents +15
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit alpha-7Neuronal acetylcholine receptor subunit alpha-4 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1570067-55-8

Mecapegfilgrastim is under investigation in clinical trial NCT05463601 (Mecapegfilgrastim for the Prevention of Dalpiciclib -Induced Neutropenia in Advanced Breast Cancer).

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mecasermin Approved DB01277
biotech | CAS: 68562-41-4

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid seque…

Kategori:
Amino Acids, Peptides, and ProteinsAnterior Pituitary Lobe Hormones and AnaloguesBiological Factors +15
Target Protein:
Insulin-like growth factor 1 receptorInsulin-like growth factor-binding protein 3Insulin receptor +1
Waktu ParuhMean half life of 5…
Vol. Distribusi* 0.257 ± 0.073 L/k…
KlirensClearance of Mecase…
Genetik -
Mecasermin rinfabate Approved DB14751
biotech | CAS: 478166-15-3

Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH)[A176020]. Mecasermin rinfabate is similar to [DB01277] in that both drugs…

Kategori:
Anterior Pituitary Lobe Hormones and AnaloguesPituitary and Hypothalamic Hormones and AnaloguesSomatropin and Somatropin Agonists +1
Target Protein:
Insulin-like growth factor 1 receptorInsulin receptorCation-independent mannose-6-phosphate receptor
Waktu ParuhHalf life ranges fr…
Vol. DistribusiApproximately 1000m…
KlirensClearance ranges fr…
Genetik -
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