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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 153 / 252
Malachite Green DB03895
small molecule | CAS: 10309-95-2

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAminesAniline Compounds +7
Target Protein:
HTH-type transcriptional regulator QacR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malacidin A DB14051
biotech

Malacidin A, along with [DB14052], is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria [A33312]. Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. Wh…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +3
Target Protein:
NAM/NAG peptide subunits of peptidoglycan
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malacidin B DB14052
small molecule

Malacidin B, along with [DB14051], is a member of a class of chemicals made by bacteria found in soil that can kill Gram-positive bacteria [A33312]. Malacidins are 10-member macrocycle lipopeptides discovered via gene sequencing and bioinformatic analysis. Wh…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +3
Target Protein:
NAM/NAG peptide subunits of peptidoglycan
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malathion Approved DB00772
small molecule | CAS: 121-75-5

Malathion is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. Malathion is an irreversible cholinesterase inhibitor and has low human toxicity.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsCholinergic Agents +19
Target Protein:
CholinesteraseAcetylcholinesterase
Waktu Paruh8-24 hours
Vol. Distribusi-
Klirens-
Genetik -
Malic acid DB12751
small molecule | CAS: 6915-15-7

Malic acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.

Kategori:
Acids, AcyclicDicarboxylic AcidsHydroxy Acids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malonaldehyde DB03057
small molecule | CAS: 542-78-9

Malonaldehyde is the dialdehyde of [malonic acid].

Kategori:
Aldehydes
Target Protein:
Beta-lactamase SHV-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malonic acid DB02175
small molecule | CAS: 141-82-2

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicDicarboxylic AcidsThallium
Target Protein:
Aspartate 1-decarboxylaseProto-oncogene tyrosine-protein kinase SrcSigma factor SigB regulation protein RsbQ +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malonyl-CoA DB04524
small molecule | CAS: 524-14-1

A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.

Kategori:
Adenine NucleotidesCoenzymesEnzymes and Coenzymes +7
Target Protein:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MALP-2 DB18482
small molecule | CAS: 250718-44-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsLipidsMacrophage Activation +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Malpighia emarginata extract Approved DB16545
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Maltitol DB16867
small molecule | CAS: 585-88-6

Deskripsi belum tersedia.

Kategori:
AlcoholsCarbohydratesDisaccharides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Maltodextrin DB12583
small molecule | CAS: 9050-36-6

Deskripsi belum tersedia.

Kategori:
Carbohydrates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Maltose DB03323
small molecule | CAS: 69-79-4

A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing (Grant & Hackh's Chemical Dictionary, 5th ed).

Kategori:
CarbohydratesCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +11
Target Protein:
Cyclomaltodextrin glucanotransferaseAlpha-amylase 2BBeta-amylase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Pancreatic alpha-amylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 280782-97-0

CS-917 is a novel inhibitor of fructose 1,6-bisphphosphatase (FBPase) which is one of the rate-limiting enzymes of gluconeogenesis.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsFructose-Bisphosphatase, antagonists & inhibitors +1
Target Protein:
Fructose-1,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mandelic acid Approved DB13218
small molecule | CAS: 90-64-2

Mandelic acid is an approved aromatic, alpha hydroxy acid [L5458]. Mandelic acid is used as an ingredient in cosmetics and drug products applied topically.

Kategori:
Acids, CarbocyclicAnti-Infective AgentsAntibacterials for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MANF DB17885
biotech

MANF is a human recombinant mesencephalic, astrocyte-derived neurotrophic factor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mangafodipir Approved DB06796
small molecule | CAS: 155319-91-8

Mangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas. This drug is made up of paramagnetic manganese (II) ions combined with the chelating agent…

Kategori:
AcetatesAcids, AcyclicAmines +15
Waktu ParuhThe mean initial pl…
Vol. DistribusiThe volume of distr…
KlirensThe approximate tot…
Genetik -
Manganese cation Approved DB06757
small molecule | CAS: 16397-91-4

Manganese is a transition metal that was first described in the 19th and 20th centuries.[A263657] It is environmentally abundant, being the fifth most abundant metal and the twelfth most abundant element overall on Earth.[A263657, A263667] Manganese intake p…

Kategori:
Diet, Food, and NutritionElectrolytesElements +12
Target Protein:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialTGF-beta-activated kinase 1 and MAP3K7-binding protein 1 +5
Waktu Paruh-
Vol. DistribusiMn can cross the bl…
Klirens-
Genetik -
Manganese citrate Approved DB14495
small molecule | CAS: 10060-26-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Manganese gluconate Approved DB11141
small molecule | CAS: 6485-39-8

Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink pow…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mango Approved DB10657
biotech

Mango allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Manidipine Approved DB09238
small molecule | CAS: 89226-50-6

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

Kategori:
ACE Inhibitors and Calcium Channel BlockersAgents causing hyperkalemiaAntiarrhythmic agents +28
Target Protein:
Voltage-dependent L-type calcium channelVoltage-dependent L-type calcium channel subunit alpha-1CCruzipain +5
Waktu ParuhThe half life of el…
Vol. Distribusi-
Klirens-
Genetik -
Manitimus DB06481
small molecule | CAS: 202057-76-9

FK778, a novel compound with multiple mechanisms of action, is efficacious, well tolerated and safe in kidney transplant patients, potentially offering a breakthrough in immunosuppressive therapy.

Kategori:
Hydrocarbons, Acyclic
Target Protein:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mannitol Approved DB00742
small molecule | CAS: 69-65-8

Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain…

Kategori:
Agents causing hyperkalemiaAlcoholsAlimentary Tract and Metabolism +31
Waktu ParuhMannitol has an eli…
Vol. DistribusiMannitol administer…
KlirensIntravenous adminis…
Genetik -
Mannose DB12907
small molecule | CAS: 3458-28-4

Mannose is under investigation for the basic science of IUGR and Pregnancy.

Kategori:
CarbohydratesHexosesMonosaccharides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3672-15-9

Mannose 6-phosphate has been used in trials studying the treatment of Wound, Cicatrix, Wound-healing, and Re-epithelialisation.

Target Protein:
Cation-independent mannose-6-phosphate receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mannosulfan DB13334
small molecule | CAS: 7518-35-6

Deskripsi belum tersedia.

Kategori:
AlkanesAlkanesulfonatesAlkanesulfonic Acids +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mapatumumab DB18945
biotech | CAS: 658052-09-6

Mapatumumab is under investigation in clinical trial NCT00094848 (Study of TRM-1 (TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-hodgkin's Lymphoma (NHL)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mapracorat DB12041
small molecule | CAS: 887375-26-0

Mapracorat has been investigated for the treatment of Eczema and Atopic Dermatitis.

Kategori:
AlcoholsFatty AlcoholsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Maralixibat Approved DB16226
small molecule | CAS: 716313-53-0

Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat].[A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome.[L38834] …

Kategori:
Alimentary Tract and MetabolismBile and Liver TherapyBile Therapy +9
Target Protein:
Ileal sodium/bile acid cotransporterHepatic sodium/bile acid cotransporter
Waktu ParuhThe mean half life …
Vol. Distribusi-
Klirens-
Genetik -
Maraviroc Approved DB04835
small molecule | CAS: 376348-65-1

Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally label…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +15
Target Protein:
C-C chemokine receptor type 5
Waktu Paruh14-18 hours
Vol. Distribusi* 194 L
Klirens-
Genetik -
Marbofloxacin DB11426
small molecule | CAS: 115550-35-1

Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary medicine. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mardepodect DB08387
small molecule | CAS: 898562-94-2

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Margetuximab Approved DB14967
biotech | CAS: 1350624-75-7

The HER2 oncoprotein, the product of the human _ERBB2_/mouse _neu_ genes, is a member of the HER family of receptor tyrosine kinases that includes the epidermal growth factor receptor (EGFR). Of the various subtypes of breast cancer, HER2-positive breast canc…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhMargetuximab has a …
Vol. DistribusiMargetuximab has a …
KlirensMargetuximab has a …
Genetik -
Maribavir Approved DB06234
small molecule | CAS: 176161-24-3

Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation.[L39322] Most standard CMV therapies, such as [ganciclovir] or [foscarnet], target CMV DNA polymerase - while gene…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +14
Target Protein:
Serine/threonine protein kinase UL97
Waktu ParuhIn post-transplant …
Vol. DistribusiThe mean apparent s…
KlirensIn post-transplant …
Genetik -
biotech | CAS: 2760218-55-9

Maridebart Cafraglutide is under investigation in clinical trial NCT05669599 (Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Marimastat DB00786
small molecule | CAS: 154039-60-8

Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement mem…

Kategori:
AminesEnzyme InhibitorsHydroxy Acids +2
Target Protein:
Interstitial collagenase72 kDa type IV collagenaseStromelysin-1 +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9007-34-5

Marine collagen, soluble is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntioxidantsAntiplatelet agents +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Marstacimab Approved DB17725
biotech | CAS: 1985638-39-8

Marstacimab is a human monoclonal immunoglobulin G Type 1 (IgG1) antibody produced by Chinese hamster ovary (CHO) cells by recombinant DNA technology.[L51803] It is a tissue factor pathway inhibitor (TFPI) antagonist, which is an endogenous anticoagulant.[A26…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Tissue factor pathway inhibitor
Waktu ParuhIn a study consisti…
Vol. DistribusiIn patients with he…
KlirensIn a study consisti…
Genetik -
Martinostat DB14979
small molecule | CAS: 1629052-58-9

Martinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).

Kategori:
AminesBridged-Ring CompoundsCarbon Radioisotopes +3
Target Protein:
Histone deacetylase 7Histone deacetylase 9Histone deacetylase 8 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1600492-21-4

Marzeptacog alfa (activated) is under investigation in clinical trial NCT01439971 (Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MAS825 DB16452
small molecule

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Masilukast DB16227
small molecule | CAS: 136564-68-6

Masilukast is under investigation in clinical trial NCT01740986 (Safety and Efficacy of SA09012 in Asthma).

Target Protein:
Cysteinyl leukotriene receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Masitinib DB11526
small molecule | CAS: 790299-79-5

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the USA it is distributed under the name Kinavet and has been available for veterinaries s…

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +5
Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Matairesinol DB04200
small molecule | CAS: 580-72-3

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzyl CompoundsPlants
Target Protein:
Dehydrogenase/reductase SDR family member 4-like 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Matuzumab DB05101
biotech | CAS: 339186-68-4

Matuzumab (formerly known as the experimental drug, EMD 72000) is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR (epithelial growth factor receptor), frequently associated with the growth of blood vessels in malignan…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Epidermal growth factor receptor
Waktu Paruh196 hours
Vol. Distribusi-
Klirens-
Genetik -
Mavatrep DB12875
small molecule | CAS: 956274-94-5

Mavatrep has been used in trials studying the treatment of Osteoarthritis, Knee.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Transient receptor potential cation channel subfamily V member 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mavelertinib DB16228
small molecule | CAS: 1776112-90-3

Mavelertinib is under investigation in clinical trial NCT02349633 (Study for Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 7601–7650 dari 12560
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