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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 150 / 236
Mitoxantrone Approved DB01204
small molecule | CAS: 65271-80-9

An anthracenedione-derived antineoplastic agent.

Kategori:
AnalgesicsAnthracenesAnthracyclines and Related Substances +30
Target Protein:
DNA topoisomerase 2-betaDNADNA topoisomerase 2-alpha
Waktu Paruh75 hours
Vol. Distribusi* 1000 L/m2
Klirens* 21.3 L/hr/m2 [Eld…
Genetik -
MIV-701 DB05736
small molecule

MIV-701 is a selective, potent inhibitor of the protease Cathepsin K. It is developed for the treatment of osteoporosis.

Target Protein:
Cathepsin K
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MIV-711 DB15599
small molecule

Deskripsi belum tersedia.

Kategori:
Anti-Inflammatory AgentsAntineoplastic AgentsAntirheumatic Agents
Target Protein:
Cathepsin K
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mivavotinib DB16849
small molecule | CAS: 1312691-33-0

Deskripsi belum tersedia.

Target Protein:
Receptor-type tyrosine-protein kinase FLT3Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mivelsiran DB19003
biotech | CAS: 2572991-83-2

Mivelsiran is under investigation in clinical trial NCT06393712 (A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
ATP-dependent dethiobiotin synthetase BioD 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizagliflozin DB19036
small molecule | CAS: 666843-10-3

Mizagliflozin is under investigation in clinical trial NCT05721729 (Effect of Mizagliflozin Repeat Dosing on Adverse Events and Postprandial Glucose Excursions).

Kategori:
CarbohydratesGlycosides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizoribine DB12617
small molecule | CAS: 50924-49-7

Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Infective Agents +15
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0249 DB11910
small molecule | CAS: 1167574-41-5

MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia, Sleep Apnea, Obstructive, and Excessive Daytime Sleepiness, among others.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Target Protein:
Histamine H3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0354 DB05939
small molecule | CAS: 851776-28-8

MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis and related disorders. It targets G protein-coupled receptor, or GPCR, that have the potential to regulate plasma lipid profiles, including HDL, …

Target Protein:
Hydroxycarboxylic acid receptor 2G-protein coupled estrogen receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0482 DB17453
biotech

MK-0482 is a novel humanized IgG4 monoclonal antibody targeting the immunoglobulin-like transcript (ILT) 3.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0557 DB12168
small molecule | CAS: 328232-95-7

MK0557 has been investigated for the treatment of Schizophrenia and Paranoid Schizophrenia.

Kategori:
Cycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0668 DB15791
small molecule | CAS: 865110-07-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Integrin beta-1Integrin alpha-4VLA-4 (very late antigen-4)
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0686 DB12563
small molecule | CAS: 578727-68-1

MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic.

Kategori:
AcetatesAcids, AcyclicAcids, Carbocyclic +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0731 DB08037
small molecule | CAS: 845256-65-7

MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.

Target Protein:
Kinesin-like protein KIF11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0736 DB15209
small molecule | CAS: 719272-79-4

MK-0736 is under investigation in clinical trial NCT00679055 (A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)).

Waktu Paruh-
Vol. Distribusi-
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MK-0752 DB12852
small molecule | CAS: 471905-41-6

Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).

Kategori:
Acids, AcyclicAmyloid Precursor Protein Secretases, antagonists & inhibitorsEnzyme Inhibitors +5
Target Protein:
Gamma-secretase subunit PEN-2NicastrinGamma-secretase subunit APH-1B +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0767 DB12055
small molecule | CAS: 934017-32-0

MK0767 has been used in trials studying the treatment of Dyslipidemia, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Diabetes Mellitus, Type II, among others.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0773 DB16244
small molecule | CAS: 606101-58-0

MK-0773 is under investigation in clinical trial NCT00529659 (A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(mk-0773-005)).

Kategori:
Fused-Ring CompoundsSteroids
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0777 DB12238
small molecule | CAS: 252977-51-8

MK-0777 has been used in trials studying the treatment of Schizophrenia, Anxiety Disorder, and Generalized Anxiety Disorder.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0812 DB11990
small molecule | CAS: 624733-88-6

MK0812 has been used in trials studying the treatment of Relapsing-Remitting Multiple Sclerosis.

Target Protein:
C-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0873 DB13029
small molecule | CAS: 500355-52-2

MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPhosphodiesterase 4 Inhibitors +1
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4D
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1064 DB15028
small molecule | CAS: 1207253-08-4

MK-1064 is under investigation in clinical trial NCT02549014 (A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
MK-1454 DB14721
small molecule

A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes protein (STING), with potential immunoactivating and antineoplastic activities. Upon intratumoral (IT) administration, STING agonist MK-1454 binds to STING and activates the S…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1496 DB12763
small molecule | CAS: 1037254-47-9

MK-1496 has been used in trials studying the treatment of Neoplasms and Malignant.

Target Protein:
Serine/threonine-protein kinase PLK1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-212 DB12111
small molecule | CAS: 64022-27-1

MK-212 has been used in trials studying the treatment of Alcoholism.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +3
Target Protein:
5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-2748 DB15371
small molecule | CAS: 1193902-95-2

MK-2748 is under investigation in clinical trial NCT01593735 (A Multiple Dose Study to Evaluate the Safety and Efficacy of MK-2748 in Hepatitis C-Infected Participants (MK-2748-002 AM1)).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3207 DB12424
small molecule | CAS: 957118-49-9

Mk3207 has been used in trials studying the treatment of Migraine and Migraine Disorders.

Kategori:
Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3577 DB14957
small molecule | CAS: 1019112-29-8

MK-3577 is under investigation in clinical trial NCT00868790 (A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4541 DB17016
small molecule | CAS: 796885-38-6

MK-4541 is a 4-azasteroid and a selective androgen receptor modulator (SARM). MK-4541 acts as a dual selective SARM and is both a potent androgen receptor antagonist and a 5?-reductase inhibitor.[A252687]

Kategori:
Acids, AcyclicFused-Ring CompoundsSteroids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4721 DB05933
biotech

MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Prostate stem cell antigen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4830 DB17454
biotech

MK-4830 is a monoclonal antibody that targets the myeloid-specific immunoglobulin-like transcript (ILT) 4 receptor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-4965 DB08460
small molecule | CAS: 920035-77-4

MK-4965 is an HIV-1 reverse transcriptase inhibitor.

Kategori:
HIV Reverse Transcriptase, antagonists & inhibitors
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-6186 DB12999
small molecule | CAS: 1034474-19-5

MK6186 has been used in trials studying the treatment of HIV-1 Infection.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-7145 DB11968
small molecule | CAS: 1255204-84-2

MK-7145 has been used in trials studying the treatment of Hypertension and Renal Insufficiency.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-7288 DB17094
small molecule | CAS: 936626-07-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-7622 DB12897
small molecule | CAS: 1227923-29-6

MK-7622 has been used in trials studying the treatment of Alzheimer's Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-8189 DB19153
small molecule | CAS: 1424371-93-6

MK-8189 is under investigation in clinical trial NCT04624243 (Efficacy and Safety of MK-8189 in Participants With an Acute Episode of Schizophrenia (MK-8189-008)).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
MK-8666 DB14937
small molecule | CAS: 1544739-75-4

MK-8666 is under investigation in clinical trial NCT01971554 (Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of MK-8666 in Participants With Type 2 Diabetes Mellitus (MK-8666-003)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-8719 DB16989
small molecule | CAS: 1382799-40-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-8776 DB11899
small molecule | CAS: 891494-63-6

Sch 900776 has been used in trials studying the treatment of Neoplasms, Hodgkin Disease, Adult Erythroleukemia, Lymphoma, Non-Hodgkin, and Myelogenous Leukemia, Acute, among others.

Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-8777 DB18904
small molecule | CAS: 1026791-61-6

MK-8777 is under investigation in clinical trial NCT00610649 (Trial to Determine the Maximum Tolerated Dose (MTD) Based on Safety and Tolerability, of Org 26576 in Participants With Major Depressive Disorder (174001/P05704/MK-8777-001)).

Kategori:
Isoxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-886 DB16739
small molecule | CAS: 118414-82-7

MK-886 is an experimental inhibitor of leukotriene synthesis.

Kategori:
Benzene DerivativesEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenaseArachidonate 5-lipoxygenase-activating protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MLN-977 DB05431
small molecule | CAS: 175212-04-1

MLN-977 is a small molecule compound that inhibits the production of leukotrienes, especially 5-lipoxygenase. It is developed by PharmaEngine to treat asthma and chronic obstructive pulmonary disease.

Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MLN2704 DB06513
biotech

A Phase 1/2 trial (NCT00070837) evaluated the safety, dosage, and pharmacokinetics of MLN2704 in patients with metastatic androgen-independent prostate cancer.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MLN3897 DB06505
small molecule | CAS: 849105-26-6

MLN3897, a novel CCR1 inhibitor, disrupts osteoclast formation and blocks the interaction between multiple myeloma cells and osteoclasts.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
C-C chemokine receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MLN576 DB06517
small molecule | CAS: 346689-77-8

XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both topoisomerase (Topo) I and II.[A234609]

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MM-111 DB17983
biotech | CAS: 1361108-53-3

MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
MM3122 DB16737
small molecule

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsExperimental Unapproved Treatments for COVID-19Heterocyclic Compounds, Fused-Ring +2
Target Protein:
Transmembrane protease serine 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MMDA DB01442
small molecule | CAS: 13674-05-0

MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a member of the amphetamine drug class with stimulant and psychedelic properties. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils …

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAmines +11
Target Protein:
5-hydroxytryptamine receptor 2ASodium-dependent dopamine transporterSodium-dependent serotonin transporter +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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