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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
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14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 145 / 290
Hymenoclea salsola pollen Approved DB10758
biotech

Hymenoclea salsola pollen is the pollen of the Hymenoclea salsola plant. Hymenoclea salsola pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 83-49-8

Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.

Kategori:
Bile Acids and SaltsCholanesCholic Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hyoscyamine Approved DB00424
small molecule | CAS: 101-31-5

Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] …

Kategori:
Adjuvants, AnesthesiaAgents producing tachycardiaAlimentary Tract and Metabolism +26
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M2 +3
Waktu ParuhThe half life of hy…
Vol. Distribusi-
Klirens-
Genetik -
Hyperforin DB01892
small molecule | CAS: 11079-53-1

Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is _Hypericum perforatum_, also known as St John's wort.

Kategori:
Benzene DerivativesOATP1B1/SLCO1B1 InhibitorsPhenols
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenaseProstaglandin G/H synthase 1Nuclear receptor subfamily 1 group I member 2
Waktu Paruh9 hours
Vol. Distribusi-
Klirens-
Genetik -
Hypericin DB13014
small molecule | CAS: 548-04-9

Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.

Kategori:
AnthracenesAnti-Infective AgentsAntidepressive Agents +10
Target Protein:
Glutathione S-transferase A1Glutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypochlorite Approved DB11123
small molecule | CAS: 14380-61-1

Hypochlorite is an ion composed of chlorine and oxygen with the chemical formula ClO?. Being unstable in the pure form, hypochlorite is most commonly used for bleaching, disinfectation, and water treatment purposes in its salt form, sodium hypochlorite. Hypoc…

Kategori:
AcidsAcids, NoncarboxylicAnti-Infective Agents +14
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
small molecule | CAS: 7790-92-3

An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.

Kategori:
AcidsAcids, NoncarboxylicChlorine Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypomyces perniciosus Approved DB10820
biotech

Hypomyces perniciosus is a fungus which can provoke allergic reactions. Hypomyces perniciosus extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypothemycin DB07905
small molecule | CAS: 76958-67-3

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBiological FactorsLactones +4
Target Protein:
Mitogen-activated protein kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63296-34-4

Hypothiocyanite ion is under investigation in clinical trial NCT02598999 (Dose Escalation Study of ALX-009 in Healthy Men and Cystic Fibrosis (CF) and Non-CF Bronchiectasis Patients).

Kategori:
Anti-Infective AgentsCyanatesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypoxanthine DB04076
small molecule | CAS: 68-94-0

Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 SubstratesHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Purine nucleoside phosphorylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypromellose Approved DB11075
small molecule | CAS: 9004-65-3

Hypromellose, or hydroxypropyl methylcellulose (HPMC) [L1812], is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in soli…

Kategori:
Artificial TearsBiopolymersCarbohydrates +12
Target Protein:
Epithelial cell adhesion molecule
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HZT-501 DB05369
small molecule

HZT-501 is under investigation by Horizon Therapeutics, Inc., a privately held biopharmaceutical company. It has entered Phase 3 clinical trials in March 2007 for reduction of the risk of development of ibuprofen-associated upper gastrointestinal (i.e., gastr…

Target Protein:
Histamine H2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ianalumab DB16666
biotech | CAS: 1929549-92-7

Ianalumab is under investigation in clinical trial NCT01930175 (Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibacitabine DB13776
small molecule | CAS: 611-53-0

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxycytidine +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibalizumab Approved DB12698
biotech | CAS: 680188-33-4

Ibalizumab (also known as _ibalizumab-uiyk_ and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-HIV AgentsAnti-Infective Agents +19
Target Protein:
C-C chemokine receptor type 5C-X-C chemokine receptor type 4T-cell surface glycoprotein CD4
Waktu ParuhThe half-life of ib…
Vol. Distribusi4.8 L [FDA label]
KlirensFollowing single-do…
Genetik -
Ibandronate Approved DB00710
small molecule | CAS: 114084-78-5

Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandron…

Kategori:
Agents Causing Muscle ToxicityBisphosphonatesBone Density Conservation Agents +7
Target Protein:
HydroxylapatiteGeranylgeranyl pyrophosphate synthaseFarnesyl pyrophosphate synthase
Waktu ParuhThe half life of ib…
Vol. DistribusiThe apparent termin…
KlirensThe total clearance…
Genetik -
Iberdomide DB12101
small molecule | CAS: 1323403-33-3

Iberdomide (CC-220) has been used in trials studying the treatment of Systemic Lupus Erythematosus.

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingImides +4
Target Protein:
Protein cereblon
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibezapolstat DB16189
small molecule | CAS: 1275582-97-2

Ibezapolstat is under investigation in clinical trial NCT04247542 (ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingNucleic Acid Synthesis Inhibitors +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
IBIO-100 DB18233
biotech

IBIO-100 is a high molecular weight multimer of E3-Fc, an endostatin C-terminus and IgG1-Fc fusion protein.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Iboctadekin DB14920
biotech | CAS: 479198-61-3

Iboctadekin is under investigation in clinical trial NCT00500058 (A Phase I, Dose-Escalation Study to Assess the Safety and Biological Activity of Recombinant Human Interleukin-18).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibrexafungerp Approved DB12471
small molecule | CAS: 1207753-03-4

Ibrexafungerp, also known as SCY-078 or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal approved for the treatment of vulvovaginal candidiasis (VVC), also known as a vaginal yeast infection.[A235384,L34349] It was developed out of a nee…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiinfectives for Systemic Use +17
Target Protein:
1,3-beta-glucan synthase component GSC2GTP-binding protein RHO1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensClearance values of…
Genetik -
Ibritumomab tiuxetan Approved DB00078
biotech | CAS: 206181-63-7

Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gam…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +18
Target Protein:
B-lymphocyte antigen CD20
Waktu Paruh0.8 hours (mammalia…
Vol. DistribusiBinding observed on…
KlirensApproximately 7.2% …
Genetik -
Ibrutinib Approved DB09053
small molecule | CAS: 936563-96-1

Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials.[A32299] Ibrutinib was develo…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBruton's tyrosine kinase (BTK) inhibitors +15
Target Protein:
Tyrosine-protein kinase BTK
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensIn patients with no…
Genetik -
Ibudilast DB05266
small molecule | CAS: 50847-11-5

Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) an…

Kategori:
Anti-Asthmatic AgentsAntiplatelet agentsAutonomic Agents +12
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4C +2
Waktu Paruh19 hours
Vol. Distribusi-
Klirens-
Genetik -
Ibuprofen Approved DB01050
small molecule | CAS: 15687-27-1

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while res…

Kategori:
Acids, CarbocyclicAgents causing angioedemaAgents causing hyperkalemia +47
Target Protein:
Prostaglandin G/H synthase 2C-X-C chemokine receptor type 2Interleukin-8 +10
Waktu ParuhThe serum half-life…
Vol. DistribusiThe apparent volume…
KlirensThe clearance rate …
Genetik -
small molecule | CAS: 64622-45-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicPhenylpropionates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibuproxam DB08955
small molecule | CAS: 53648-05-8

Ibuproxam is a non steroidal anti-inflammatory drug (NSAID).

Kategori:
AcetamidesAgents causing hyperkalemiaAgents that produce hypertension +18
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibutamoren DB18214
small molecule | CAS: 159634-47-6

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Growth hormone secretagogue receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibutilide Approved DB00308
small molecule | CAS: 122647-31-8

Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).

Kategori:
AmidesAntiarrhythmic agentsAntiarrhythmics, Class III +7
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent L-type calcium channel subunit beta-1Voltage-gated inwardly rectifying potassium channel KCNH2 +7
Waktu Paruh6 hours (ranges fro…
Vol. Distribusi* 11 L/kg
Klirens* 29 mL/min/kg
Genetik -
Ibuzatrelvir DB19451
small molecule | CAS: 2755812-39-4

Ibuzatrelvir is under investigation in clinical trial NCT06679140 (A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized but Are at Risk for Severe Disease).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
IC261 DB03083
small molecule

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesHeterocyclic Compounds, Fused-RingPhenols
Target Protein:
Casein kinase I isoform alphaCasein kinase I isoform epsilonCasein kinase I isoform gamma-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
IC41 DB05776
biotech

IC41 is a therapeutic peptide vaccine. It is being devloped by Intercell AG for the treatment of hepatitis C. The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell epitopes and the synthetic adjuvant poly-L…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ICA-105665 DB06089
small molecule

ICA-105665 is a novel small molecule compound for the treatment of epilepsy. It is a novel opener of the KCNQ ion channel which in preclinical studies has demonstrated a broad spectrum of activity in models of epilepsy. In addition, ICA-105665 has also demon…

Target Protein:
Potassium voltage-gated channel subfamily KQT member 1Potassium voltage-gated channel subfamily KQT member 3Potassium voltage-gated channel subfamily KQT member 4 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Icapamespib DB18106
small molecule | CAS: 1000999-96-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Icaridin DB14074
small molecule | CAS: 119515-38-7

Icaridin, also known as Picaridin or hydroxy-ethyl isobutyl piperidine carboxylate, is a cyclic amine and a member of the piperidine chemical family. Piperidines are structural components of [piperine], which is a plant extract from the genus _Piper _, or pep…

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsect Repellents +4
Target Protein:
Odorant binding protein
Waktu ParuhThe first eliminati…
Vol. DistribusiIn a rat study, der…
KlirensThere is no availab…
Genetik -
Icariin DB12052
small molecule | CAS: 489-32-7

Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans.

Kategori:
BenzopyransChromonesDrugs, Chinese Herbal +3
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Icaritin DB12672
small molecule | CAS: 118525-40-9

Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Icatibant Approved DB06196
biotech | CAS: 130308-48-4

Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B<sub>2</sub> receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher tha…

Kategori:
Agents causing angioedemaAmino Acids, Peptides, and ProteinsAnalgesics +21
Target Protein:
B2 bradykinin receptorAminopeptidase N
Waktu ParuhFollowing subcutane…
Vol. DistribusiFollowing subcutane…
KlirensFollowing subcutane…
Genetik -
Icerguastat DB16932
small molecule | CAS: 951441-04-6

Deskripsi belum tersedia.

Kategori:
AmidinesGuanidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ICG-001 DB18024
small molecule | CAS: 780757-88-2

Deskripsi belum tersedia.

Kategori:
Pyrimidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ICG-136 DB17343
biotech

ICG-136 is a compound chimeric antigen receptor (cCAR) T-cell therapy developed by iCell Gene Therapeutics. It was investigated for the treatment of acute myeloid leukemia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ICG-140 DB17344
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ichorcumab DB18930
biotech | CAS: 2589583-20-8

Ichorcumab is under investigation in clinical trial NCT03251482 (A Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Participants Undergoing Elective Total Knee Replacement Surgery).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ichthammol Approved DB11341
small molecule | CAS: 8029-68-3

Ichthammol is also referred to as ammonium bituminosulfonate or ammonium bituminosulphonate. It is an ammonium salt of dark sulfonated shale oil (bituminous schists) produced via distillation of the oil followed by sulfonation and neutralization. It is availa…

Kategori:
AminesAmmonium CompoundsDermatologicals +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ICI-164384 DB03860
small molecule | CAS: 98007-99-9

Deskripsi belum tersedia.

Kategori:
AlkenesAlkynesAmides +12
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Iclaprim DB06358
small molecule | CAS: 192314-93-5

Deskripsi belum tersedia.

Kategori:
Antibacterials for Systemic UseAntiinfectives for Systemic UseEnzyme Inhibitors +3
Target Protein:
Dihydrofolate reductaseDihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Iclepertin DB19058
small molecule | CAS: 1421936-85-7

Iclepertin is under investigation in clinical trial NCT05211947 (A Study to Test Long-term Safety of Iclepertin in People With Schizophrenia Who Took Part in a Previous CONNEX Study).

Target Protein:
Sodium- and chloride-dependent glycine transporter 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
iCo-007 DB05268
small molecule

iCo-007 (formerly known as ISIS 13650) is a second generation antisense compound being developed by iCo for the treatment of various eye diseases caused by the formation of new blood vessels (angiogenesis) such as age-related macular degeneration (AMD) and di…

Target Protein:
RAF proto-oncogene serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 7201–7250 dari 14494
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