Hasil Filter

15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (15718)

Halaman 145 / 315
GDC-0917 DB12336
small molecule | CAS: 1446182-94-0

CUDC-427 has been used in trials studying the treatment of LYMPHOMA and Solid Cancers.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-0927 DB14934
small molecule | CAS: 2100830-77-9

GDC-0927 is under investigation in clinical trial NCT02316509 (A Study of GDC-0927 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-1971 DB17487
small molecule | CAS: 2377352-49-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
GDP-mannose 6-dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDP-L-fucose DB18689
small molecule | CAS: 15839-70-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDX012 DB18448
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GE-2270A DB02975
small molecule | CAS: 134861-34-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +2
Target Protein:
Elongation factor Tu
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gebasaxturev DB17296
biotech | CAS: 2122169-83-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 921195-93-9

GED-0507-34-Levo is under investigation in clinical trial NCT02808390 (Efficacy and Safety Study of Ged-0507-34-levo for Treatment of UC).

Kategori:
Acids, CarbocyclicAmines
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gedatolisib DB11896
small molecule | CAS: 1197160-78-3

Gedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others.

Kategori:
Enzyme InhibitorsOxazinesProtein Kinase Inhibitors
Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gedivumab DB15277
biotech | CAS: 1807954-17-1

Gedivumab is under investigation in clinical trial NCT01877785 (A Study of MHAA4549A to Assess Safety And Pharmacokinetics in Healthy Volunteers).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gedocarnil DB13534
small molecule | CAS: 109623-97-4

Deskripsi belum tersedia.

Kategori:
Anti-Anxiety AgentsCentral Nervous System DepressantsHypnotics (Nonbenzodiazepine) +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gefapixant Approved DB15097
small molecule | CAS: 1015787-98-0

It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks.[L48601] A subset of these patients remain symptomatic despite thorough investigation and treatment, termed refractory c…

Kategori:
AmidesBCRP/ABCG2 SubstratesBenzene Derivatives +8
Target Protein:
P2X purinoceptor 3P2X purinoceptor 2
Waktu ParuhThe terminal half-l…
Vol. DistribusiBased on population…
KlirensPopulation pharmaco…
Genetik -
Gefarnate DB12079
small molecule | CAS: 51-77-4

Gefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease.

Kategori:
Alimentary Tract and MetabolismAnti-Ulcer AgentsDrugs for Acid Related Disorders +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gefitinib Approved DB00317
small molecule | CAS: 184475-35-2

Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +25
Target Protein:
Epidermal growth factor receptor
Gen Terkait:
EGFR EGFR EGFR +1
Waktu Paruh48 hours [IV admini…
Vol. Distribusi* 1400 L [IV admini…
Klirens* 595 mL/min [IV ad…
Genetik 4 Varian
Gefurulimab DB18928
biotech | CAS: 2456407-94-4

Gefurulimab is under investigation in clinical trial NCT05556096 (Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gelatin Approved DB11242
small molecule | CAS: 9000-70-8

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former.[A32432] As a thermoreversible hydrocolloid with a small gap bet…

Kategori:
Amino Acids, Peptides, and ProteinsBlood and Blood Forming OrgansBlood and Related Products +4
Waktu ParuhHalf-life is about …
Vol. Distribusi-
KlirensA large percentage …
Genetik -
GEM-231 DB05798
biotech | CAS: 255810-66-3

GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in …

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Target Protein:
cAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase type I-alpha regulatory subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemcabene DB05123
small molecule | CAS: 183293-82-5

Gemcabene is a new drug that lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemcitabine Approved DB00441
small molecule | CAS: 95058-81-4

Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers.[A233135] Gemcitabine is a cytidine analog with two fluorine atoms repla…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +23
Target Protein:
DNARibonucleoside-diphosphate reductase subunit M2Ribonucleoside-diphosphate reductase large subunit +2
Gen Terkait:
RRM1
Waktu ParuhFollowing intraveno…
Vol. DistribusiIn patients with va…
KlirensFollowing intraveno…
Genetik 1 Varian
small molecule | CAS: 210829-30-4

Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemeprost Approved DB08964
small molecule | CAS: 64318-79-2

Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for terminat…

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAutacoids +14
Target Protein:
Prostaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP2 subtype
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemfibrozil Approved DB01241
small molecule | CAS: 25812-30-0

Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exer…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +53
Target Protein:
Peroxisome proliferator-activated receptor alphaLipoprotein lipaseSolute carrier organic anion transporter family member 1B1 +3
Waktu ParuhGemfibrozil has a p…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ge…
Genetik -
Gemifloxacin Approved DB01155
small molecule | CAS: 175463-14-6

Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhib…

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +16
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +1
Waktu Paruh7 (± 2) hours
Vol. Distribusi* 1.66 to 12.12 L/kg
Klirens* renal cl=11.6+/- …
Genetik -
Gemigliptin DB12412
small molecule | CAS: 911637-19-9

Gemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.

Kategori:
Agents causing angioedemaAlimentary Tract and MetabolismBlood Glucose Lowering Agents +5
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemlapodect DB18769
small molecule | CAS: 1380329-87-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented autologous tumour cell vaccine. Furin is a convertase involved in the activation of TGF?-1 and TGF?-2.[A255163] Gemogenovatucel-T is being investigated in…

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemtuzumab ozogamicin Approved DB00056
biotech | CAS: 220578-59-6

Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has appro…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +28
Target Protein:
Myeloid cell surface antigen CD33Low affinity immunoglobulin gamma Fc region receptor III-BLow affinity immunoglobulin gamma Fc region receptor III-A +1
Waktu ParuhIn pediatric patien…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
GEN-001 DB17518
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Geneticin DB04263
small molecule | CAS: 49863-47-0

Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and…

Kategori:
Agents that produce neuromuscular block (indirect)AmebicidesAminoglycoside Antibacterials +8
Target Protein:
Ornithine decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Genipin DB19124
small molecule | CAS: 6902-77-8

Genipin is under investigation in clinical trial NCT05755750 (Intratendinous Genipin Injection in Horses With Tendon Injuries).

Kategori:
AdhesivesCholagogues and CholereticsCycloparaffins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Genistein DB01645
small molecule | CAS: 446-72-0

An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in hum…

Kategori:
Anticarcinogenic AgentsAntineoplastic AgentsBCRP/ABCG2 Inhibitors +31
Target Protein:
Estrogen receptor betaNuclear receptor coactivator 1Estrogen receptor +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gentamicin Approved DB00798
small molecule | CAS: 1403-66-3

Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.[A234349] It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234…

Kategori:
Agents that produce neuromuscular block (indirect)alpha-Galactosidase, antagonists & inhibitorsAminoglycoside Antibacterials +21
Target Protein:
30S ribosomal protein S1216S ribosomal RNA23S ribosomal RNA +4
Waktu ParuhOne study assessing…
Vol. Distribusi-
KlirensThe renal clearance…
Genetik -
Gentamicin C1a DB04729
small molecule | CAS: 26098-04-4

Deskripsi belum tersedia.

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +6
Target Protein:
30S ribosomal protein S1216S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gentamicin C2 DB17884
small molecule | CAS: 25876-11-3

Deskripsi belum tersedia.

Kategori:
Aminoglycoside AntibacterialsAnti-Bacterial AgentsCarbohydrates +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gentian violet cation Approved DB00406
small molecule | CAS: 7438-46-2

A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.

Kategori:
AminesAniline CompoundsAnti-Infective Agents +7
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gentulizumab DB18148
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Genz-10850 DB04289
small molecule

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Geotrichum candidum Approved DB10699
biotech

Geotrichum candidum is a fungus which can provoke allergic reactions. Geotrichum candidum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gepefrine DB13703
small molecule | CAS: 18840-47-6

Deskripsi belum tersedia.

Kategori:
Adrenergic and Dopaminergic AgentsAgents producing tachycardiaAgents that produce hypertension +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gepirone Approved DB12184
small molecule | CAS: 83928-76-1

Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release ta…

Kategori:
Anti-Anxiety AgentsAntidepressive AgentsCentral Nervous System Agents +12
Target Protein:
5-hydroxytryptamine receptor 1A
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensAfter the administr…
Genetik -
Gepotidacin DB12134
small molecule | CAS: 1075236-89-3

Gepotidacin has been used in trials studying the treatment of Gonorrhea, Infections, Bacterial, and Infections, Respiratory Tract.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Geptanolimab DB16417
biotech | CAS: 2348469-43-0

Geptanolimab is under investigation in clinical trial NCT03502629 (Clinical Trial in Chinese Patients of Relapsed and Refractory Peripheral T Cell Lymphoma (GB226)).

Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Geraniol Approved DB14183
small molecule | CAS: 106-24-1

Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from the flowers of many species of plant and is commonly used b…

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseMonoterpenes +2
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhIn vitro measuremen…
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPhosphate salts +3
Target Protein:
Farnesyl pyrophosphate synthaseProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaProtein farnesyltransferase subunit beta +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gestonorone DB13230
small molecule | CAS: 2137-18-0

Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.

Kategori:
Adrenal Cortex HormonesAntineoplastic and Immunomodulating AgentsEndocrine Therapy +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gestonorone caproate Approved DB14677
small molecule | CAS: 1253-28-7

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsNorpregnanesNorpregnenes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gestrinone Approved DB11619
small molecule | CAS: 16320-04-0

Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and is used primarily in the treatment of endometriosis. …

Kategori:
Adrenal Cortex HormonesAntigonadotropins and Similar AgentsContraceptive Agents, Female +19
Target Protein:
Progesterone receptorGlucocorticoid receptorAndrogen receptor +3
Waktu ParuhPlasma half-life is…
Vol. Distribusi67 L [L1700]
KlirensRenal Excretion acc…
Genetik -
GET-73 DB12928
small molecule | CAS: 202402-01-5

Get 73 has been investigated for the treatment of Alcohol Dependence.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 7201–7250 dari 15718
Sebelumnya Halaman 145 / 315 Berikutnya