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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 145 / 321
Ferric cation Approved DB13949
small molecule | CAS: 20074-52-6

Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and ene…

Kategori:
Iron CompoundsParenteral Iron ReplacementPhosphate Binder +2
Target Protein:
Transferrin receptor protein 1Iron(3+)-hydroxamate-binding protein FhuD
Waktu ParuhThe pharmacokinetic…
Vol. DistribusiLess than 65% of ir…
KlirensThe rate of iron lo…
Genetik -
Ferric chloride Approved DB15536
small molecule | CAS: 7705-08-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric derisomaltose Approved DB15617
small molecule | CAS: 1345510-43-1

Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red …

Kategori:
Anemia, Iron-DeficiencyAntianemia DrugsAntianemic Preparations +6
Target Protein:
Hemoglobin subunit alphaTransferrin receptor
Waktu ParuhThe plasma-half liv…
Vol. DistribusiFerric derisomaltos…
KlirensIntravenous iron is…
Genetik -
Ferric glycerophosphate Approved DB15934
small molecule | CAS: 1301-70-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1309-33-7

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Compounds +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric maltol Approved DB15598
small molecule | CAS: 33725-54-1

Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate.[A189288] Ferric maltol has been described in literatu…

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansHematinics +8
Target Protein:
Integrin beta-3Natural resistance-associated macrophage protein 2
Waktu ParuhMaltol has a half l…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Ferric oxide DB11576
small molecule | CAS: 1309-37-1

Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite.

Kategori:
Contrast MediaIron CompoundsMagnetic Resonance Imaging Contrast Media +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20344-49-4

An antiferromagnetic material; constitutes the core of natural ferritin.

Kategori:
Iron CompoundsOrganometallic CompoundsPhosphate Binder +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10058-44-3

Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by py…

Kategori:
AcidsAcids, NoncarboxylicAnions +13
Target Protein:
Ferritin light chainHemoglobin subunit alphaHemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric pyrophosphate citrate Approved DB13995
small molecule | CAS: 1802359-96-1

Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly …

Kategori:
EnzymesEnzymes and CoenzymesHydrolases +3
Target Protein:
Ferritin light chainFerritin heavy chainHemoglobin subunit alpha +1
Waktu ParuhThe half-life of fe…
Vol. DistribusiThe apparent volume…
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 52031-09-1

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Preparations +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric subsulfate Approved DB13885
small molecule | CAS: 1310-45-8

Ferric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin biopsies.

Kategori:
AnionsCoagulantsElectrolytes +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric sulfate Approved DB11171
small molecule | CAS: 10028-22-5

Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with acidic properties. It is produced by the reaction of sulfuric acid and an oxidizing agent. It is used in different fields such as dermatology, dentistry a…

Kategori:
HematinicsIron Compounds
Waktu ParuhPharmacokinetic stu…
Vol. DistribusiPharmacokinetic stu…
KlirensPharmacokinetic stu…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Ferrichrome-iron receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Ferrimannitol-ovalbumin (FMOA) is an adduct between ovalbumin and the complex Fe(III)-mannitol.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferroheme DB18267
small molecule | CAS: 14875-96-8

Deskripsi belum tersedia.

Kategori:
Biological FactorsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 Inhibitors +7
Target Protein:
Heme oxygenase 1Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferroheme C DB03317
small molecule | CAS: 26598-29-8

Deskripsi belum tersedia.

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingMetalloporphyrins +2
Target Protein:
Nitrite reductaseHigh-molecular-weight cytochrome cCytochrome c'' +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous ascorbate Approved DB14490
small molecule | CAS: 24808-52-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAntianemic PreparationsAntioxidants +15
Target Protein:
Transferrin receptor protein 1Egl nine homolog 1Histone deacetylase 8 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 75802-64-1

The use of ferrous acetate over ferrous sulfate is currently undergoing an investigation by a clinical trial [L5464]. It is also used for dying of fabric or leather and as a wood preservative.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Bivalent, Oral Preparations +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous asparto glycinate Approved DB11169
small molecule

Ferrous asparto glycinate is an iron-amino acid chelate. It is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency anemia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous bisglycinate Approved DB11210
small molecule | CAS: 20150-34-9

Ferrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and a nutritionally functional [A27250]. It is found in foods for food enrichment or i…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsIron Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 563-71-3

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Bivalent, Oral Preparations +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous cation DB14510
small molecule | CAS: 15438-31-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7758-94-3

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Bivalent, Oral Preparations +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous fumarate Approved DB14491
small molecule | CAS: 141-01-5

Used in treatment of iron deficiency anemia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansDiet, Food, and Nutrition +9
Target Protein:
Transferrin receptor protein 1Egl nine homolog 1Histone deacetylase 8 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous gluconate Approved DB14488
small molecule | CAS: 299-29-6

Deskripsi belum tersedia.

Kategori:
Anemia, Iron-DeficiencyAntianemia DrugsAntianemic Preparations +8
Target Protein:
Transferrin receptor protein 1Egl nine homolog 1Histone deacetylase 8 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous glycine sulfate Approved DB14501
small molecule | CAS: 14729-84-1

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Bivalent, Oral Preparations +1
Target Protein:
Transferrin receptor protein 1Egl nine homolog 1Histone deacetylase 8 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous succinate Approved DB14489
small molecule | CAS: 10030-90-7

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansHematinics +4
Target Protein:
Transferrin receptor protein 1Egl nine homolog 1Histone deacetylase 8 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferrous sulfate anhydrous Approved DB13257
small molecule | CAS: 7720-78-7

Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age.[A190804] This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation o…

Kategori:
Anemia, Iron-DeficiencyDelayed-Action PreparationsHematinics +6
Target Protein:
Hemoglobin subunit alphaTransferrin receptor
Waktu ParuhThe half-life of or…
Vol. DistribusiAbout 60% of iron i…
Klirens-
Genetik -
small molecule | CAS: 2944-65-2

Deskripsi belum tersedia.

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansIron Bivalent, Oral Preparations +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferulic acid DB07767
small molecule | CAS: 1135-24-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAnalgesicsAnalgesics, Non-Narcotic +17
Target Protein:
Carbonic anhydrase 12Carbonic anhydrase 2Carbonic anhydrase 14 +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferumoxsil Approved DB09507
small molecule | CAS: 171544-35-7

Deskripsi belum tersedia.

Kategori:
ColloidsComplex MixturesCompounds used in a research, industrial, or household setting +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferumoxytol Approved DB06215
small molecule | CAS: 722492-56-0

Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [A32478]. It is comprised of superparamagnetic iron oxide nanoparti…

Kategori:
Compounds used in a research, industrial, or household settingFerric CompoundsFerrous Compounds +11
Waktu ParuhThe pharmacokinetic…
Vol. DistribusiThe population mean…
KlirensSince there is no r…
Genetik -
Fesoterodine Approved DB06702
small molecule | CAS: 286930-02-7

Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsBenzene Derivatives +14
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M1 +2
Waktu Paruh7-8 hours for the a…
Vol. DistribusiIV, 5-HMT: 169 L
Klirens5-HMT, healthy subj…
Genetik -
FET F-18 DB15405
small molecule | CAS: 178433-03-9

FET F-18 is under investigation in clinical trial NCT01756352 (FET-PET for Evaluation of Response of Recurrent GBM to Avastin).

Kategori:
Diagnostic RadiopharmaceuticalsTumour Detection
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fevipiprant DB12011
small molecule | CAS: 872365-14-5

Fevipiprant has been used in trials studying the treatment of Asthma, Atopic Dermatitis, and Allergic Rhinitis.

Kategori:
Heterocyclic Compounds, Fused-RingIndoles
Target Protein:
Prostaglandin D2 receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fexaramine DB02545
small molecule | CAS: 574013-66-4

Deskripsi belum tersedia.

Target Protein:
Bile acid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fexinidazole Approved DB12265
small molecule | CAS: 59729-37-2

Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per year in endemic areas) despite focussed control efforts. T…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAntiparasitic Products, Insecticides and RepellentsAntiprotozoals +43
Waktu ParuhFexinidazole, M1, a…
Vol. DistribusiFexinidazole has an…
KlirensFexinidazole has a …
Genetik -
Fexofenadine Approved DB00950
small molecule | CAS: 83799-24-0

Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms.[L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain bar…

Kategori:
Anti-Allergic AgentsAntihistamines for Systemic UseBenzene Derivatives +12
Target Protein:
Histamine H1 receptor
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensThe oral clearance …
Genetik -
Fezakinumab DB12344
biotech | CAS: 1007106-86-6

Fezakinumab has been used in trials studying the treatment of Atopic Dermatitis and Rheumatoid Arthritis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fezolinetant Approved DB15669
small molecule | CAS: 1629229-37-3

Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopau…

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C19 SubstratesCytochrome P-450 CYP2C9 Substrates +6
Target Protein:
Neuromedin-K receptor
Waktu ParuhThe effective half-…
Vol. DistribusiThe mean apparent v…
KlirensThe apparent cleara…
Genetik -
FF-10101-01 DB16050
small molecule | CAS: 1472797-69-5

FF-10101-01 is under investigation in clinical trial NCT03194685 (Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Receptor-type tyrosine-protein kinase FLT3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FF-10501-01 DB17554
small molecule

FF-10501-01 is a novel, selective inosine monophosphate dehydrogenase (IMPDH) inhibitor with anticancer activity.[A257306] FF-10501-01 is under investigation in clinical trial NCT03486353 (A Study of FF-10501-01 in Combination With Azacitidine in Patients Wit…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FG-2216 DB08687
small molecule | CAS: 223387-75-5

A orally active prolyl-hydroxylase inhibitor which can stabilize hypoxia-inducible transcription factor independent of oxygen availability. [A14422]

Target Protein:
Egl nine homolog 1Hypoxia-inducible factor 1-alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FG-9041 DB03759
small molecule | CAS: 2379-57-9

Deskripsi belum tersedia.

Kategori:
Excitatory Amino Acid AgentsExcitatory Amino Acid AntagonistsHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Glutamate receptor 1Glutamate receptor ionotropic, kainate 1Glutamate receptor ionotropic, NMDA 2B +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fiacitabine DB12901
small molecule | CAS: 69123-90-6

Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.

Kategori:
Anti-Infective AgentsAntineoplastic AgentsAntiviral Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fialuridine DB15427
small molecule | CAS: 69123-98-4

Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU).

Kategori:
Anti-Infective AgentsAntiviral AgentsArabinonucleosides +7
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fianlimab DB18858
biotech | CAS: 2126132-98-5

Fianlimab is under investigation in clinical trial NCT06190951 (A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-pd1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fiboflapon DB06346
small molecule | CAS: 936350-00-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAsthma, drug therapyFatty Acids +4
Target Protein:
Arachidonate 5-lipoxygenase-activating protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fibrin DB16604
biotech | CAS: 9001-31-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsFibrin +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 7201–7250 dari 16004
Sebelumnya Halaman 145 / 321 Berikutnya