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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
Referensi
14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 144 / 290
Hydrocodone Approved DB00956
small molecule | CAS: 125-29-1

Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced b…

Kategori:
AlkaloidsAnalgesicsAntitussive Agents +23
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorSigma non-opioid intracellular receptor 1
Waktu ParuhThe half-life of el…
Vol. DistribusiThe apparent volume…
KlirensOfficial FDA labeli…
Genetik -
Hydrocortamate Approved DB00769
small molecule | CAS: 76-47-1

Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind …

Kategori:
Cytochrome P-450 CYP3A InducersCytochrome P-450 CYP3A4 InducersCytochrome P-450 CYP3A4 Inducers (strength unknown) +1
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone Approved DB00741
small molecule | CAS: 50-23-7

Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendal…

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +55
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu ParuhTotal hydrocortison…
Vol. DistribusiTotal hydrocortison…
KlirensTotal hydrocortison…
Genetik -
small molecule | CAS: 74050-20-7

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +25
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone acetate Approved DB14539
small molecule | CAS: 50-03-3

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +24
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone butyrate Approved DB14540
small molecule | CAS: 13609-67-1

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdministration, Topical +26
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone cypionate Approved DB14541
small molecule | CAS: 508-99-6

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +18
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone phosphate Approved DB14542
small molecule | CAS: 3863-59-0

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +18
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone probutate Approved DB14543
small molecule | CAS: 72590-77-3

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +26
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone succinate Approved DB14545
small molecule | CAS: 2203-97-6

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +22
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone valerate Approved DB14544
small molecule | CAS: 57524-89-7

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +23
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydroflumethiazide Approved DB00774
small molecule | CAS: 135-09-1

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)

Kategori:
AmidesAntihypertensive AgentsBenzothiadiazines +19
Target Protein:
Solute carrier family 12 member 1Carbonic anhydrase 7Carbonic anhydrase 9 +6
Waktu ParuhIt appears to have …
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen DB15127
small molecule | CAS: 1333-74-0

Hydrogen is under investigation in clinical trial NCT02830854 (Molecular Hydrogen for Cognitive Function and Performance in Elderly).

Kategori:
ElementsGases
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen fluoride Approved DB11072
small molecule | CAS: 7664-39-3

Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as [DB00472] (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also …

Kategori:
AcidsAcids, NoncarboxylicDental Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen iodide DB15778
small molecule | CAS: 10034-85-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen peroxide Approved DB11091
small molecule | CAS: 7722-84-1

Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it…

Kategori:
Alimentary Tract and MetabolismAnionsAnti-Infective Agents +19
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
Vol. DistribusiTarget organs affec…
Klirens-
Genetik -
biotech | CAS: 84836-98-6

Hydrogenated coconut oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 97281-48-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 8016-70-4

Extracted from the seeds of the soybean (Glycine soja), hydrogenated soybean oil is a major food fat used in the production of margarine, shortening, and salad and cooking oils. According to the FDA, hydrogenated soybean oil is generally recognized as safe (G…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 23599-55-5

Deskripsi belum tersedia.

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingPigments, Biological +1
Target Protein:
Precorrin-8X methylmutase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Nephrotoxic agents
Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 68607-88-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1236208-20-0

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydromorphone Approved DB00327
small molecule | CAS: 466-99-9

Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +22
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe volume of distr…
KlirensThe mean plasma cle…
Genetik -
Hydronidone DB06299
small molecule | CAS: 851518-71-3

Hydronidone has antifibrotic activity.

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinidine DB15300
small molecule | CAS: 1435-55-8

Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).

Kategori:
AlkaloidsAntiarrhythmic agentsAntiarrhythmics, Class I +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinone Approved DB09526
small molecule | CAS: 123-31-9

Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, b…

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +11
Target Protein:
TyrosinaseIntegrin beta-3Integrin alpha-IIb +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrotalcite Approved DB13322
small molecule | CAS: 12304-65-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkaliesAluminium Compounds +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxocobalamin Approved DB00200
small molecule | CAS: 13422-51-0

Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.

Kategori:
Antianemic PreparationsAntidotesBlood and Blood Forming Organs +10
Target Protein:
Methionine synthaseMethylmalonyl-CoA mutase, mitochondrialMethylmalonic aciduria type A protein, mitochondrial +4
Waktu ParuhApproximately 6 day…
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Liver carboxylesterase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyamphetamine Approved DB09352
small molecule | CAS: 103-86-6

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor side effe…

Kategori:
Adrenergic AgonistsAminesAmphetamines +7
Target Protein:
Trace amine-associated receptor 1
Waktu Paruh-
Vol. DistribusiIntended for local …
KlirensIntended for local …
Genetik -
small molecule | CAS: 821-33-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxychloroquine Approved DB01611
small molecule | CAS: 118-42-3

Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, ch…

Kategori:
AminoquinolinesAnti-Infective AgentsAntimalarials +22
Target Protein:
Toll-like receptor 7Toll-like receptor 9DNA +1
Waktu ParuhA half-life of 123.…
Vol. DistribusiHydroxychloroquine …
KlirensThe clearance of hy…
Genetik -
Hydroxycitronellal Approved DB14187
small molecule | CAS: 107-75-5

Hydroxycitronellal is a synthetic fragrance that is widely used in many cosmetics and hygiene products such as deodorants, soaps, antiseptics, and other household items. It has the smell of lilac, lily, and lily of the valley [A34269]. Hydroxycitronellal has …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleasePerfume +1
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhThe mean eliminatio…
Vol. DistribusiTmax was found to b…
Klirens-
Genetik -
Hydroxydione DB08956
small molecule | CAS: 303-01-5

Hydroxydione (Viadril) is a neuroactive steroid used as a general anesthetic.

Kategori:
Fused-Ring CompoundsNeurotransmitter AgentsPregnanes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl cellulose Approved DB11602
small molecule | CAS: 9004-62-0

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ion…

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl ethylcellulose Approved DB14139
small molecule | CAS: 9004-58-4

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl Starch Approved DB09106
small molecule | CAS: 9005-27-0

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average mol…

Kategori:
Blood and Blood Forming OrgansBlood and Related ProductsBlood Substitutes +14
Waktu ParuhTerminal half-life …
Vol. Distribusi5.9 L.
Klirens31.4 mL/min
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Gag-Pro-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyprogesterone caproate Approved DB06789
small molecule | CAS: 630-56-8

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17?-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was p…

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsCombination Contraceptives (with Estrogen and derivatives) +26
Target Protein:
Progesterone receptor
Waktu ParuhHalf-life = 16 days…
Vol. DistribusiHydroxyprogesterone…
KlirensClearance is highly…
Genetik -
Hydroxyproline DB08847
small molecule | CAS: 51-35-4

Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline i…

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 128446-35-5

Hydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).

Kategori:
beta-CyclodextrinsCarbohydratesCompounds used in a research, industrial, or household setting +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxypropyl cellulose Approved DB00840
small molecule | CAS: 9004-64-2

Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used t…

Kategori:
Artificial TearsBiopolymersCarbohydrates +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 439685-79-7

Hydroxypropyl tetrahydropyrantriol has been used in trials studying the basic science of Aging.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxystilbamidine Approved DB14753
small molecule | CAS: 495-99-8

Hydroxystilbamidine isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and pulmonary or systemic blastomycosis in children, with fewer side effects than amphotericin B. Hydroxystilbamidine isethionate is also us…

Kategori:
AmidinesBenzene DerivativesBenzylidene Compounds +1
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxytyrosol DB12771
small molecule | CAS: 10597-60-1

Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer.

Kategori:
AlcoholsAnti-Infective AgentsAntioxidants +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyurea Approved DB01005
small molecule | CAS: 127-07-1

Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928.[A262596] It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults.[A262601] Although c…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +11
Target Protein:
Ribonucleoside-diphosphate reductase large subunitRibonucleoside-diphosphate reductase subunit M2
Waktu ParuhIn adult cancer pat…
Vol. DistribusiHydroxyurea distrib…
KlirensThe total body clea…
Genetik -
Hydroxyzine Approved DB00557
small molecule | CAS: 68-88-2

Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since re…

Kategori:
Anti-Anxiety AgentsAntipruriticsCentral Nervous System Depressants +21
Target Protein:
Histamine H1 receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe mean volume of …
KlirensClearance of hydrox…
Genetik -
Hygromycin B DB11520
small molecule | CAS: 31282-04-9

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnthelmintics +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hymecromone DB07118
small molecule | CAS: 90-33-5

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismBenzopyransBile and Liver Therapy +8
Target Protein:
Arylsulfate sulfotransferase AssT
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 7151–7200 dari 14494
Sebelumnya Halaman 144 / 290 Berikutnya