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14494

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Halaman 143 / 290
Human interferon beta Approved DB14999
biotech | CAS: 74899-71-1

Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992.[L12081] Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and s…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsBiological Factors +7
Target Protein:
Interferon alpha/beta receptor 1
Waktu ParuhThe mean terminal e…
Vol. DistribusiThe average state v…
KlirensAverage serum clear…
Genetik -
biotech

Human interferon omega 1 (IFN-omega 1 = IFN-alpha II1) is a recently discovered protein structurally related to IFN-alpha and -beta. It occurs naturally in the human body and is currently being manufactured by Intarcia through genetic engineering. There are m…

Kategori:
Immunosuppressive AgentsMyelosuppressive Agents
Target Protein:
Interferon alpha/beta receptor 1Interferon alpha/beta receptor 2
Waktu Paruh-
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biotech

Interleukin-8 is under investigation in clinical trial NCT05148234 (BMS-986253 in Myelodysplastic Syndromes).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
Interleukin-8
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biotech

Human interleukin-2 is under investigation in clinical trial NCT03475134 (TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in mMEL).

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +12
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biotech

Human interleukin-6 is under investigation in clinical trial NCT03170245 (Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCytokines +4
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biotech | CAS: 183623-03-2

Human Lactoferrin Peptide hLF1-11 is under investigation in clinical trial NCT00509834 (A Study on the Tolerability and Early Efficacy of Hlf1-11 in Patients With Proven Candidaemia).

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biotech

Stem cells are self-renewing and proliferate without differentiation, with the two major groups being embryonic stem cells (ESCs) and adult stem cells (ASC). Differentiation occurs under different conditions into different cell types. ESCs are from the inner …

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biotech

Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
Waktu Paruh-
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biotech

Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityAmino Acids, Peptides, and ProteinsCancer immunotherapy +9
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biotech

Deskripsi belum tersedia.

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biotech

Human papillomavirus type 18 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age …

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
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biotech

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biotech

Human papillomavirus type 31 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 45 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 52L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 5…

Kategori:
Cancer immunotherapyImmunotherapy
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biotech

Human papillomavirus type 58 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type …

Kategori:
Cancer immunotherapyImmunotherapy
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Genetik -
biotech

Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age f…

Kategori:
Actively Acquired ImmunityCancer immunotherapyImmunotherapy +1
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biotech

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Human Rho(D) immune globulin Approved DB11597
biotech

Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilize…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseBlood Proteins +9
Target Protein:
Rhesus blood group D antigen
Waktu ParuhThe half life is 16…
Vol. DistribusiA single dose of 30…
KlirensMean systemic clear…
Genetik -
Human thrombin Approved DB11571
biotech | CAS: 9002-04-4

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This tra…

Kategori:
Blood Coagulation FactorsIncreased Coagulation Factor Activity
Target Protein:
Coagulation factor VCoagulation factor VIIICoagulation factor XI +5
Waktu ParuhDue to the nature o…
Vol. DistribusiDue to the nature o…
KlirensDue to the nature o…
Genetik -
biotech

Transplantation with human umbilical cord blood mononuclear cells (HUCBC) has demonstrated promising results in various disease states. While some of the positive results are credited to HUCBCs’ differentiation potential, the growth factors and cytokines thes…

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biotech

Stem cells obtained from amniotic fluid, the umbilical cord (UC), and placenta are gaining in popularity. Stem cells from the umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marro…

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biotech

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Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +10
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensReadily accessible …
Genetik -
biotech

Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). It is prepared from pools of healthy human donors' plasma vi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBiological Products +13
Waktu ParuhHuman Varicella-Zos…
Vol. DistribusiFollowing intraveno…
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Genetik -
biotech

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biotech

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The humanized anti-IL-12 antibody is an important addition to PDL's already strong pipeline of humanized antibodies being developed for the treatment of autoimmune diseases. SMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that…

Target Protein:
Interleukin-12 subunit beta
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Humicola grisea Approved DB10841
biotech

Humicola grisea allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Huperzine A Approved DB04864
small molecule | CAS: 102518-79-6

Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss _Huperzia serrata_. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in C…

Kategori:
Central Nervous System AgentsCholinergic AgentsCholinesterase Inhibitors +6
Target Protein:
Acetylcholinesterase
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Huperzine B DB03348
small molecule | CAS: 103548-82-9

Huperzine B is a novel acetylcholinesterase inhibitor.

Kategori:
Drugs, Chinese HerbalPlant Extracts
Target Protein:
Acetylcholinesterase
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HX-1171 DB12162
small molecule | CAS: 148081-72-5

Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects).

Kategori:
Benzene DerivativesPhenols
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HY-111996 DB16964
small molecule | CAS: 1380696-64-9

Deskripsi belum tersedia.

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HY10275 DB05079
small molecule

HY10275 is a novel compound specifically designed to modulate two key neurobiological mechanisms that interfere with the sleeping process. HY10275 is highly selective for histamine H1 and serotonin 5HT2a, two chemical receptors that are known to impact the ab…

Target Protein:
Histamine H1 receptor5-hydroxytryptamine receptor 2A
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Hyaluronic acid Approved DB08818
small molecule | CAS: 9004-61-9

Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluron…

Kategori:
Adjuvants, ImmunologicBiocompatible MaterialsCarbohydrates +16
Target Protein:
CD44 antigenIntercellular adhesion molecule 1Hyaluronan mediated motility receptor +12
Waktu ParuhWhen injected by th…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
small molecule | CAS: 9004-61-9

Hyaluronic acid (non-animal stabilized) is under investigation in clinical trial NCT03460158 (Prospective Evaluation of Facial Cosmetic Procedures).

Kategori:
CarbohydratesGlycosaminoglycansPolysaccharides
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Hyaluronidase Approved DB14740
biotech | CAS: 9001-54-1

Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.[L13338] The action of hyaluronidase was first described in 1936, and named in 1939.[A199026] Early research into hyaluron…

Kategori:
Blood and Blood Forming OrgansCarbon-Oxygen LyasesEnzymes +6
Target Protein:
Hyaluronic acidTransforming growth factor beta-1 proprotein
Waktu ParuhHyaluronidase has a…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
biotech | CAS: 757971-58-7

A purified preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragmen…

Kategori:
Blood and Blood Forming OrgansCarbon-Oxygen LyasesEnzymes +6
Target Protein:
Hyaluronic acidTransforming growth factor beta-1 proprotein
Waktu ParuhHyaluronidase has a…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Hyaluronidase (ovine) Approved DB00070
biotech | CAS: 488712-31-8

Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.

Kategori:
EnzymesEnzymes and CoenzymesGlycoside Hydrolases
Target Protein:
Transforming growth factor beta-1 proprotein
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Soluble cytochrome b562
Waktu Paruh-
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Hycanthone DB14061
small molecule | CAS: 3105-97-3

Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.

Kategori:
AnthelminticsAnti-Infective AgentsAntiparasitic Agents +7
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylosuccinate synthetaseAdenylosuccinate synthetase
Waktu Paruh-
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Genetik -
Hydracarbazine DB09243
small molecule | CAS: 3614-47-9

Hydracarbazine is a pyridazine that has found use as an antihypertensive agent [A19790] It was once marketed in France under the tradename Normatensyl.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +3
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small molecule | CAS: 503-66-2

Deskripsi belum tersedia.

Kategori:
Hydroxy AcidsIsomerismLactates
Target Protein:
Pimeloyl-[acyl-carrier protein] methyl ester esterase
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Hydralazine Approved DB01275
small molecule | CAS: 86-54-4

Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed.[A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and onl…

Kategori:
Antihypertensive AgentsAntihypertensive Agents Indicated for HypertensionArteriolar Smooth Muscle, Agents Acting On +15
Target Protein:
Amine oxidase [copper-containing] 3Hypoxia-inducible factor 1-alphaProlyl 4-hydroxylase subunit alpha-1
Waktu ParuhHydralazine has a h…
Vol. DistribusiThe volume of distr…
KlirensThe majority of hyd…
Genetik -
Hydrastine DB19354
small molecule | CAS: 118-08-1

Deskripsi belum tersedia.

Kategori:
AlkaloidsHeterocyclic Compounds, Fused-RingHydrastis +1
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small molecule | CAS: 7647-01-0

Deskripsi belum tersedia.

Kategori:
Acid PreparationsAcidsAcids, Noncarboxylic +7
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Hydrochlorothiazide Approved DB00999
small molecule | CAS: 58-93-5

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A18513…

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +25
Target Protein:
Solute carrier family 12 member 3Angiotensin-converting enzymeCalcium-activated potassium channel subunit alpha-1
Waktu ParuhThe plasma half lif…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
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