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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
Referensi
14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 141 / 290
biotech

Deskripsi belum tersedia.

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Genetik -
Heterotheca inuloides flower Approved DB14331
biotech

Heterotheca inuloides flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
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Hetrombopag DB16184
small molecule | CAS: 1257792-41-8

Hetrombopag is under investigation in clinical trial NCT03976882 (Hetrombopag for the Treatment of Chemotherapy-induced Thrombocytopenia in Subjects With Malignancy.).

Kategori:
HydrazinesPyrazoles
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Hexachlorophene Approved DB00756
small molecule | CAS: 70-30-4

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorder…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiseptics and Disinfectants +8
Target Protein:
D-lactate dehydrogenaseSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialGlutamate dehydrogenase 1, mitochondrial +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexadecanal DB03381
small molecule | CAS: 629-80-1

Deskripsi belum tersedia.

Target Protein:
RhodopsinAcyl-CoA-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 86855-26-7

Deskripsi belum tersedia.

Kategori:
Fatty AcidsLipidsPalmitic Acids +1
Target Protein:
Palmitoyl-protein thioesterase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 29710-31-4

Deskripsi belum tersedia.

Target Protein:
HTH-type transcriptional regulator EthR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, HalogenatedKetones
Waktu Paruh-
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Genetik -
Hexafluronium Approved DB00941
small molecule | CAS: 4844-10-4

Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block the activity of plasma cholinesterases.

Kategori:
AminesAnticholinergic AgentsBis-Trimethylammonium Compounds +10
Target Protein:
Cholinesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexamethonium DB08960
small molecule | CAS: 60-26-4

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hyp…

Kategori:
AminesAnticholinergic AgentsAntihypertensive Agents +14
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Dihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexaminolevulinate Approved DB06261
small molecule | CAS: 140898-97-1

Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approv…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsCarbon Radioisotopes +5
Waktu ParuhBiphasic eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Hexanoyl-CoA DB02563
small molecule | CAS: 5060-32-2

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesCoenzymesEnzymes and Coenzymes +7
Target Protein:
Enoyl-CoA hydratase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 34367-89-0

Deskripsi belum tersedia.

Kategori:
AlcoholsCarbohydratesInositol Phosphates +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Calcium/calmodulin-dependent protein kinase type II subunit alphaUbiquitin-like modifier-activating enzyme 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexestrol DB07931
small molecule | CAS: 84-16-2

A synthetic estrogen that has been used as a hormonal antineoplastic agent.

Kategori:
Antineoplastic AgentsAntineoplastic Agents, HormonalBenzene Derivatives +11
Target Protein:
Aldo-keto reductase family 1 member C1Estrogen receptorNuclear receptor subfamily 1 group I member 2 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexetidine Approved DB08958
small molecule | CAS: 141-94-6

A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.

Kategori:
Alimentary Tract and MetabolismAnti-Infective AgentsAnti-Infective Agents, Local +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexobarbital DB01355
small molecule | CAS: 56-29-1

A barbiturate that is effective as a hypnotic and sedative.

Kategori:
AdjuvantsAnestheticsAnesthetics, General +18
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hexobendine Approved DB13265
small molecule | CAS: 54-03-5

Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has been used widely in Austria and Germany [T478].

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +9
Waktu Paruh-
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Hexocyclium Approved DB06787
small molecule | CAS: 6004-98-4

Hexocyclium is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea. It was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. Proton pump inhibitors lik…

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +1
Waktu Paruh-
Vol. Distribusi-
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Hexoprenaline DB08957
small molecule | CAS: 3215-70-1

Hexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +18
Waktu Paruh-
Vol. Distribusi-
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Hexylcaine Approved DB00473
small molecule | CAS: 532-77-4

Hexylcaine hydrochloride is also known as cyclaine and osmocaine. It is a short acting local anesthetic that acts through inhibition of sodium channels. Patients experience an overdose may present with headache, tinnitus, numbness and tingling around the mout…

Kategori:
AminesCyclohexanesCycloparaffins
Target Protein:
Sodium channel protein type 5 subunit alphaSodium channel protein type 10 subunit alpha
Waktu Paruh<10 minutes
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lipase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lipase
Waktu Paruh-
Vol. Distribusi-
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Hexylresorcinol Approved DB11254
small molecule | CAS: 136-77-6

Hexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic, and local anesthetic properties. It can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain relief and first aid …

Kategori:
AnthelminticsAnti-Infective AgentsAnti-Infective Agents, Local +6
Target Protein:
TyrosinaseDNA topoisomerase 1Protein-glutamine gamma-glutamyltransferase 2
Waktu ParuhReadily accessible …
Vol. DistribusiReadily accessible …
KlirensReadily accessible …
Genetik -
HG004 DB18666
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
HGS-TR2J DB05895
biotech

HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies. It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial.

Target Protein:
Tumor necrosis factor receptor superfamily member 10B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
HGTV-43 DB05807
biotech

HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection. HGTV43 is one of a number of so-called 'gene transfer vectors' developed by the biotechnology company Enzo Biochem, Inc.

Waktu Paruh-
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HH-009 DB18727
biotech

HH-009 is a recombinant human IgG4 monoclonal antibody against FGF19 being studied for the treatment of hepatocellular carcinoma.

Waktu Paruh-
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Higenamine DB12779
small molecule | CAS: 5843-65-2

Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects).

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +17
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Hiltonol DB17293
biotech | CAS: 59789-29-6

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAmino AcidsAmino Acids, Basic +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hippuric acid DB16842
small molecule | CAS: 495-69-2

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzamides and benzamide derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hispidulin DB14008
small molecule | CAS: 1447-88-7

Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties [A32513].

Kategori:
BenzopyransChromonesFlavonoids +2
Waktu Paruh-
Vol. Distribusi-
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Histamine Approved DB05381
small molecule | CAS: 51-45-6

A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Kategori:
Adjuvants, ImmunologicAminesAntineoplastic and Immunomodulating Agents +19
Target Protein:
Histamine H1 receptorHistamine H2 receptorHistamine H3 receptor +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1464897-15-1

Histamine glutarimide is under investigation in clinical trial NCT03450434 (XC8 in the Treatment of Patients With Bronchial Asthma).

Kategori:
AminesAnti-Asthmatic AgentsAutacoids +6
Waktu Paruh-
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Histidine DB00117
small molecule | CAS: 71-00-1

An essential amino acid that is required for the production of histamine.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Essential +4
Target Protein:
Histidine decarboxylaseHistidine--tRNA ligase, cytoplasmicSodium-coupled neutral amino acid transporter 3 +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Histrelin Approved DB06788
small molecule | CAS: 76712-82-8

Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher pot…

Kategori:
Adrenal Cortex HormonesAmino Acids, Peptides, and ProteinsAntineoplastic and Immunomodulating Agents +17
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu ParuhIn healthy voluntee…
Vol. DistribusiThe apparent volume…
KlirensIn prostate cancer …
Genetik -
small molecule | CAS: 729607-74-3

HIV Integrase Inhibitor is under investigation in clinical trial NCT00397566 (A Multiple Ascending Dose Study of BMS-707035 in HIV-1 Infected Subjects).

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HKI-357 DB13002
small molecule | CAS: 848133-17-5

Hki 357 is under investigation in clinical trial NCT00550381 (Study Evaluating the Safety, Tolerability, and Pharmacokinetics (PK) of HKI-357 Administered Orally to Healthy Subjects).

Waktu Paruh-
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HLX-58 DB18699
biotech

HLX-58 is an investigational monoclonal antibody targeted against claudin 18.2.

Waktu Paruh-
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HLX70 DB16509
biotech

HLX70, a recombinant humanized anti-S protein monoclonal antibody intended for intravenous infusion, was under investigation in clinical trials NCT05429385 and NCT04561076 to evaluate its safety and pharmacokinetics in healthy adult volunteers. The condition …

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
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Genetik -
HM15912 DB18266
biotech

HM15912 is a human glucagon-like peptide-2 analogue linked to a human immunoglobulin Fc fragment.

Waktu Paruh-
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Genetik -
HMI-103 DB17684
biotech

HMI-102 is an investigational gene therapy designed to encode the phenylalanine-4-hydroxylase (PAH) gene, mutated in people with phenylketonuria.

Waktu Paruh-
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HMI-203 DB18520
biotech

HMI-203 is an investigational gene therapy developed by Homology Medicines, Inc. It consists of a recombinant adeno-associated virus (AAV) serotype HSC15 (rAAVHSC15) encoding human iduronate-2-sulfatase (hIDS).

Waktu Paruh-
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HMI-204 DB18338
biotech

HMI-204 is an adeno-associated virus serotype HSC15 expressing human arylsulfatase A

Waktu Paruh-
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HMR4011 DB06225
small molecule

HMR4011 (IPL 576,092) is a novel steroidal anti-inflammatory compound with a mechanism of action distinct from that of glucocorticoid. IPL 576,092 has previously been investigated as a treatment for asthma.

Waktu Paruh-
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HNM01 DB06531
biotech

The drug hNM01, a humanized monoclonal antibody developed by SRD Pharmaceuticals, Inc., targets the V(3) region of the HIV-1 envelope protein gp120, functioning as an HIV replication inhibitor. It entered Phase 1 clinical trials for the treatment of HIV infec…

Waktu Paruh-
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Genetik -
Holcus lanatus pollen Approved DB10395
biotech

Holcus lanatus pollen is the pollen of the Holcus lanatus plant. Holcus lanatus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
Waktu Paruh-
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Genetik -
Homatropine Approved DB11181
small molecule | CAS: 87-00-3

Homatropine is an anticholinergic drug that acts as an antagonist at muscarinic acetylcholine receptors. It is present in antitussives, under the trade name Hycodan, in combination with hydrocodone (dihydrocodeinone) bitartrate indicated for the symptomatic r…

Kategori:
AlkaloidsAnticholinergic AgentsAutonomic Agents +8
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Homatropine methylbromide Approved DB00725
small molecule | CAS: 80-49-9

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together…

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAlkaloids +7
Target Protein:
Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M4 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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