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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 141 / 236
LY-2599506 DB05970
small molecule | CAS: 745051-65-4

LY2599506 was under investigation in clinical trials NCT01024244 and NCT01029795 for the treatment of patients with type 2 diabetes.

Target Protein:
Hexokinase-4
Waktu Paruh-
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LY-2608204 DB12284
small molecule | CAS: 1234703-40-2

LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

Kategori:
Enzyme ActivatorsSulfur Compounds
Target Protein:
Hexokinase-4Serine/threonine-protein kinase Chk1
Waktu Paruh-
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LY-2623091 DB15367
small molecule | CAS: 1162264-07-4

LY-2623091 is under investigation in clinical trial NCT02194465 (A Study of LY2623091 in Participants With High Blood Pressure).

Target Protein:
Mineralocorticoid receptor
Waktu Paruh-
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LY-2624803 DB15092
small molecule | CAS: 879409-35-5

LY-2624803 is under investigation in clinical trial NCT01236105 (Effect of Activated Charcoal and Time of Dose on the Pharmacokinetics of LY2624803 in Healthy Subject).

Target Protein:
Histamine H1 receptor
Waktu Paruh-
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LY-2811376 DB13065
small molecule | CAS: 1194044-20-6

LY2811376 has been used in trials studying the basic science of Alzheimer's Disease.

Kategori:
Sulfur Compounds
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LY-2874455 DB13022
small molecule | CAS: 1254473-64-7

LY2874455 has been used in trials studying the treatment of Advanced Cancer.

Kategori:
Heterocyclic Compounds, Fused-RingPyrazolesReceptors, Fibroblast Growth Factor, antagonists & inhibitors
Target Protein:
Fibroblast growth factor receptor 2
Waktu Paruh-
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LY-2886721 DB12547
small molecule | CAS: 1262036-50-9

LY2886721 has been used in trials studying the basic science of Alzheimer's Disease.

Kategori:
Heterocyclic Compounds, Fused-RingPyridines
Waktu Paruh-
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LY-294002 DB02656
small molecule | CAS: 154447-36-6

Specific inhibitor of phosphatidylinositol 3-kinase.

Kategori:
BenzopyransEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformSerine/threonine-protein kinase pim-1
Waktu Paruh-
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LY-295501 DB12574
small molecule | CAS: 150869-74-2

ILX-295501 has been used in trials studying the treatment of Ovarian Cancer, Metastatic Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cavity Cancer.

Kategori:
AmidesBenzene DerivativesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
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LY-3023414 DB12167
small molecule | CAS: 1386874-06-1

LY3023414 has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Waktu Paruh-
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LY-3039478 DB12050
small molecule | CAS: 1421438-81-4

LY3039478 has been used in trials studying the treatment and basic science of LYMPHOMA, Neoplasms, Solid Tumor, COLON CANCER, and BREAST CANCER, among others.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Neurogenic locus notch homolog protein 4Neurogenic locus notch homolog protein 1
Waktu Paruh-
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LY-3200882 DB16064
small molecule | CAS: 1898283-02-7

LY-3200882 is under investigation in clinical trial NCT04158700 (A Study of LY3200882 and Pembrolizumab in Participants With Advanced Cancer).

Target Protein:
TGF-beta receptor type-1
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LY-3499446 DB17486
small molecule | CAS: 2409131-50-4

Deskripsi belum tersedia.

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LY-377604 DB12858
small molecule | CAS: 204592-94-9

Ly377604 has been used in trials studying the treatment of Obesity.

Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
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LY-517717 DB05713
small molecule | CAS: 313489-71-3

LY517717 is an investigational oral direct inhibitor of activated Factor Xa. It is believed to be Lilly's PMD-3112 (licensed from Amgen).

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Coagulation factor X
Waktu Paruh-
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LY-518674 DB12988
small molecule | CAS: 425671-29-0

LY518674 has been used in trials studying the treatment of Metabolic Syndrome X.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Peroxisome proliferator-activated receptor alpha
Waktu Paruh-
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LY2275796 DB05165
small molecule

LY2275796 is a second-generation antisense anti-cancer drug candidate for clinical development. LY2275796 targets eukaryotic initiation factor- 4E (eIF-4E), a protein involved in the translation of key growth and survival factors that drive tumor progression,…

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Target Protein:
Eukaryotic translation initiation factor 4E
Waktu Paruh-
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LY2828360 DB16074
small molecule | CAS: 1231220-79-3

LY2828360 is under investigation in clinical trial NCT01319929 (A Study of LY2828360 in Patients With Osteoarthritic Knee Pain).

Kategori:
Cannabinoid Receptor AgonistsCannabinoids and similarsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
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LY341770 DB03038
small molecule

Deskripsi belum tersedia.

Target Protein:
Thymidylate synthaseThymidylate synthase
Waktu Paruh-
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LY374571 DB02358
small molecule

Deskripsi belum tersedia.

Target Protein:
C-1-tetrahydrofolate synthase, cytoplasmic
Waktu Paruh-
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LY3884961 DB17070
biotech

LY3884961 (previously PR001) is being developed by Prevail Therapeutics as a single-dose gene therapy for patients with Parkinson's disease and Gaucher disease.[L43468]

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Lycopene Approved DB11231
small molecule | CAS: 502-65-8

Lycopene is a naturally occurring red carotenoid pigment that is responsible for red to pink colors seen in tomatoes, pink grapefruit, and other foods [A27242]. Having a chemical formula of C40H56, lycopene is a tetraterpene assembled from eight isoprene unit…

Kategori:
AlkenesAnti-Inflammatory AgentsAnticarcinogenic Agents +13
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Lym-1-I-131 DB17445
biotech

Lym-1-I-131 is a monoclonal antibody labeled with iodine-131 (131I) that preferentially targets malignant lymphocytes.

Waktu Paruh-
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Genetik -
biotech

Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded …

Target Protein:
Toll-like receptor 2
Waktu Paruh1.2 hours (mammalia…
Vol. Distribusi-
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Lynestrenol Approved DB12474
small molecule | CAS: 52-76-6

Lynestrenol is a progestin and prodrug of [norethisterone].

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +25
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Lypressin Approved DB14642
small molecule | CAS: 50-57-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntidiuretic AgentsCardiovascular Agents +20
Target Protein:
Vasopressin V1a receptorVasopressin V2 receptorVasopressin V1b receptor
Waktu Paruh-
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small molecule

Lysergic acid 2,4-dimethylazetidide is under investigation in clinical trial NCT02765802 (A Study to Evaluate Pegylated Interferon Lambda Monotherapy in Patients With Chronic Hepatitis Delta Virus Infection).

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small molecule | CAS: 50-37-3

Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-trau…

Kategori:
Agents that produce hypertensionAlkaloidsAntidepressive Agents +18
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2B +1
Waktu Paruh3 hours
Vol. Distribusi-
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Lysine Approved DB00123
small molecule | CAS: 56-87-1

Lysine (abbreviated as Lys or K) is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and his…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +10
Target Protein:
High affinity cationic amino acid transporter 1Cationic amino acid transporter 4Cationic amino acid transporter 3 +2
Waktu Paruh-
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LYT-200 DB18179
biotech

LYT-200 is a fully human IgG4 monoclonal antibody directed against galectin-9.

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small molecule | CAS: 156021-12-4

Deskripsi belum tersedia.

Waktu Paruh-
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M-032 DB17258
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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M-2698 DB15431
small molecule | CAS: 1379545-95-5

M-2698 is under investigation in clinical trial NCT01971515 (First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies).

Target Protein:
RAC-alpha serine/threonine-protein kinaseRAC-gamma serine/threonine-protein kinaseRibosomal protein S6 kinase beta-1
Waktu Paruh-
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M-701 DB17504
biotech

M-701 is a recombinant anti-EpCAM/CD3 bispecific antibody.

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M-Cresol DB01776
small molecule | CAS: 108-39-4

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesPhenols
Target Protein:
Insulin
Waktu Paruh-
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small molecule | CAS: 1637-75-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzamides and benzamide derivatives +3
Target Protein:
Kynureninase
Waktu Paruh-
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M40403 DB04976
biotech

M40403 is a low molecular weight, synthetic manganese containing superoxide dismutase mimetic (SODm) that selectively removes superoxide anion.

Kategori:
ElementsMetalsMetals, Heavy +1
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Macelignan DB14129
small molecule | CAS: 107534-93-0

Macelignan is an NSAID with antioxidant, free radical scavenging, and neuroprotective activities.

Kategori:
Benzene DerivativesBenzyl Compounds
Waktu Paruh-
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Macimorelin Approved DB13074
small molecule | CAS: 381231-18-1

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH sec…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +11
Target Protein:
Growth hormone secretagogue receptor type 1
Waktu ParuhThe mean terminal h…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Macitentan Approved DB08932
small molecule | CAS: 441798-33-0

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] in part due to its lower risk of hepatotox…

Kategori:
AmidesAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +13
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhThe half-life of el…
Vol. DistribusiMacitentan has an a…
KlirensClearance data was …
Genetik -
Macozinone DB14821
small molecule | CAS: 1377239-83-2

Macozinone is under investigation in clinical trial NCT03036163 (Phase 1 Study of PBTZ169).

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsDrugs for Treatment of Tuberculosis +1
Waktu Paruh-
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Madecassic acid DB14037
small molecule | CAS: 18449-41-7

Deskripsi belum tersedia.

Kategori:
Terpenes
Waktu Paruh-
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Maduramicin DB11525
small molecule | CAS: 84878-61-5

Maduramicin is an antiprotozoal agent used in veterinary medicine as prophylaxis against coccidiosis. It is a naturally occurring compound which was first isolated from the actinomycete, Actinomadura rubra.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsIonophores
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Mafenide Approved DB06795
small molecule | CAS: 138-39-6

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.[L36773] In 1998, mafenide acetate was approved under the FDA’s accelerat…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +14
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 12Carbonic anhydrase 14 +2
Waktu Paruh-
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Maftivimab Approved DB15899
biotech | CAS: 2135632-36-7

Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.[A221825] Immune therapy using monoclonal antibodies (mAbs) is becoming …

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +10
Target Protein:
Envelope glycoprotein
Waktu ParuhMaftivimab administ…
Vol. DistribusiMaftivimab administ…
KlirensMaftivimab administ…
Genetik -
Magaldrate Approved DB08938
small molecule | CAS: 74978-16-8

Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.

Kategori:
Alimentary Tract and MetabolismAlkaliesAluminium Compounds +13
Waktu Paruh-
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Magnesium Approved DB14513
small molecule | CAS: 7439-95-4

Magnesium is classified as an alkaline earth metal and has 2 hydration shells.[A19349] The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.[A19349] Common dietary sources of magnesium incl…

Kategori:
ElementsLaxativesMagnesium Compounds +6
Waktu ParuhMagnesiums biologic…
Vol. DistribusiAccording to a phar…
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Magnesium acetate Approved DB13996
small molecule | CAS: 142-72-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents that produce neuromuscular block (indirect)Fatty Acids +3
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
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small molecule | CAS: 16674-78-5

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble …

Kategori:
Agents that produce neuromuscular block (indirect)Laxatives
Target Protein:
Glutamate (NMDA) receptor
Waktu ParuhElimination half-li…
Vol. DistribusiMagnesium ions disp…
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Magnesium Aluminum Silicate Approved DB11230
small molecule | CAS: 1327-43-1

Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group [A32782]. It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, …

Kategori:
Agents that produce neuromuscular block (indirect)MineralsPharmaceutic Aids +1
Waktu Paruh-
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Genetik -
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