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15718

Total database: 17430
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10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
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15718 (100.0%)

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Halaman 141 / 315
biotech

Forsythia suspensa fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +10
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Fosamprenavir Approved DB01319
small molecule | CAS: 226700-79-4

Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.

Kategori:
Acids, AcyclicAmidesAmprenavir and Prodrugs +22
Target Protein:
Pol polyproteinGag-Pol polyprotein
Waktu ParuhThe plasma eliminat…
Vol. Distribusi-
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Fosaprepitant Approved DB06717
small molecule | CAS: 172673-20-0

Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.

Kategori:
AntiemeticsAprepitant and ProdrugsAutonomic Agents +24
Target Protein:
Substance-P receptor
Waktu Paruh9-13 hours
Vol. Distribusi-
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Fosbretabulin DB12577
small molecule | CAS: 222030-63-9

Fosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer.

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicBenzene Derivatives +1
Waktu Paruh-
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Foscarbidopa Approved DB16171
small molecule | CAS: 1907685-81-7

Foscarbidopa is under investigation in clinical trial NCT04379050 (Extension Study to Evaluate Safety and Tolerability of 24-hour Daily Exposure of Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Parkinson's Disease).

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Fosciclopirox DB18772
small molecule | CAS: 1380539-06-9

Deskripsi belum tersedia.

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small molecule | CAS: 1951476-79-1

Fosclevudine alafenamide is under investigation in clinical trial NCT05238844 (A Study of Safety and Efficacy of ATI-2173 and Vebicorvir in Combination With Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B Virus Infection).

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Fosdagrocorat DB12198
small molecule | CAS: 1044535-58-1

Fosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Waktu Paruh-
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Fosdenopterin Approved DB16628
small molecule | CAS: 150829-29-1

Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a deficiency of three molybdenum-dependent enzymes: sulfite oxidase (SOX), xanthine dehydrogenase, and aldehyde oxidase.[A230088] Signs and symptoms begin…

Kategori:
Alimentary Tract and MetabolismBiological FactorsCyclic Pyranopterin Monophosphate +9
Target Protein:
Molybdenum cofactor biosynthesis protein 1Xanthine dehydrogenase/oxidase
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensTotal body clearanc…
Genetik -
Fosdevirine DB06166
small molecule | CAS: 1018450-26-4

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
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Fosfomycin Approved DB00828
small molecule | CAS: 23155-02-4

Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by _Streptomyces fradiae_.[A229338,A230348] It may also be produced synthetically and is commercially available as the disodium salt for intraven…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAnti-Infective Agents, Urinary +7
Target Protein:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Waktu ParuhThe mean eliminatio…
Vol. DistribusiIn healthy subjects…
KlirensIn one study, the r…
Genetik -
Fosfructose DB13863
small molecule | CAS: 488-69-7

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCarbohydratesCardiac Therapy +10
Waktu Paruh-
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small molecule | CAS: 1562406-27-2

NUC-1031 is under investigation in clinical trial NCT03610100 (Acelarin First Line Randomised Pancreatic Study).

Kategori:
Antineoplastic AgentsCytosine NucleotidesNucleic Acids, Nucleotides, and Nucleosides +4
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small molecule | CAS: 1332837-31-6

Fosifloxuridine nafalbenamide is under investigation in clinical trial NCT03428958 (A Safety Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment).

Target Protein:
Thymidylate synthase
Waktu Paruh-
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Fosigotifator DB19409
small molecule | CAS: 2415715-84-1

Fosigotifator is under investigation in clinical trial NCT05757141 (An Open-label Exploratory Study of ABBV-CLS-7262 Subjects With Vanishing White Matter Disease).

Waktu Paruh-
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Fosinoprilat DB14207
small molecule | CAS: 95399-71-6

Fosinoprilat is the active phosphinic acid metabolite of prodrug [fosinopril], which is activated by esterases in vivo. It binds zinc with phosphinic acid group.

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +13
Waktu Paruh-
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Foslevodopa Approved DB16683
small molecule | CAS: 97321-87-4

Foslevodopa is under investigation in clinical trial NCT04750226 (Study to Assess Adverse Events and Change in Disease Activity of 24-hour Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Advanced Parkinson's Disease).

Kategori:
Anti-Parkinson DrugsDopa and Dopa DerivativesDopamine Agents +1
Waktu Paruh-
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Foslinanib DB16172
small molecule | CAS: 1256037-60-1

Foslinanib is under investigation in clinical trial NCT03600233 (Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors).

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Fosmanogepix DB15183
small molecule | CAS: 2091769-17-2

Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia).

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Fosnetupitant Approved DB14019
small molecule | CAS: 1703748-89-3

In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment opti…

Kategori:
Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Inhibitors +6
Target Protein:
Substance-P receptor
Waktu ParuhNetupitant is elimi…
Vol. DistribusiThe mean SD volume …
KlirensNetupitant has a me…
Genetik -
Fosphenytoin Approved DB01320
small molecule | CAS: 93390-81-9

Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage…

Kategori:
Anti-epileptic AgentAnticonvulsantsCardiovascular Agents +38
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu ParuhFosphenytoin has a …
Vol. DistribusiThe volume of distr…
Klirens-
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Fospropofol Approved DB06716
small molecule | CAS: 258516-89-1

Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December…

Kategori:
Agents that reduce seizure thresholdAnestheticsAnesthetics, General +5
Target Protein:
Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit beta-3
Waktu ParuhWhen given to a pat…
Vol. DistribusiFospropofol = 0.33±…
KlirensTotal body clearanc…
Genetik -
Fosravuconazole DB15204
small molecule | CAS: 351227-64-0

Fosravuconazole is under investigation in clinical trial NCT03378661 (BENDITA BEnznidazole New Doses Improved Treatment and Associations).

Kategori:
Antifungals for Dermatological UseAntifungals for Systemic UseDermatologicals
Waktu Paruh-
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Fostamatinib Approved DB12010
small molecule | CAS: 901119-35-5

Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has als…

Kategori:
AminesBCRP/ABCG2 InhibitorsBlood and Blood Forming Organs +17
Target Protein:
Tyrosine-protein kinase SYKAdenosine receptor A3Synaptic vesicular amine transporter +297
Waktu ParuhR406 has a half-lif…
Vol. DistribusiR406 has an apparen…
KlirensR406 has an apparen…
Genetik -
Fostemsavir Approved DB11796
small molecule | CAS: 864953-29-7

Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor.[L14867] It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +18
Target Protein:
Envelope glycoprotein gp160
Waktu ParuhThe half-life of te…
Vol. DistribusiThe steady-state vo…
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 2129993-56-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fotemustine DB04106
small molecule | CAS: 92118-27-9

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAmidesAntineoplastic Agents +3
Target Protein:
Thioredoxin reductase 1, cytoplasmic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FOV 2501 DB17886
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Foxy-5 DB13034
small molecule | CAS: 881188-51-8

Foxy-5 has been used in trials studying the treatment of Prostate Cancer, Colorectal Cancer, Metastatic Colon Cancer, Metastatic Breast Cancer, and Metastatic Prostate Cancer.

Waktu Paruh-
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small molecule | CAS: 141790-23-0

Fozivudine Tidoxil has been used in trials studying the treatment of HIV Infections.

Kategori:
DeoxyribonucleosidesDideoxynucleosidesNucleic Acids, Nucleotides, and Nucleosides +3
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
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FP-1096 DB05310
small molecule

FP1096 reduced the painful symptoms of endometriosis in trial subjects with very minimal side effect.

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FP0011 DB05090
small molecule

FP0011 is a small molecule antiglutamatergic compound with symptomatic and disease modifying effects in a variety of neurological disorders (amyotrophic lateral sclerosis and Parkinson's disease). It acts on the presynaptic regulation of glutamate and shows s…

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FR-234938 DB03220
small molecule | CAS: 256461-79-7

Deskripsi belum tersedia.

Target Protein:
Adenosine deaminase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
FR117016 DB02616
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenosine deaminase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
FR221647 DB02096
small molecule | CAS: 256461-28-6

Deskripsi belum tersedia.

Target Protein:
Adenosine deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FR230513 DB03572
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenosine deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FR236913 DB02830
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenosine deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fradafiban DB06472
small molecule | CAS: 148396-36-5

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesPlatelet Glycoprotein GPIIb-IIIa Complex, antagonists & inhibitors
Target Protein:
Integrin alpha-IIbIntegrin beta-3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Framycetin Approved DB00452
small molecule | CAS: 119-04-0

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +10
Target Protein:
16S ribosomal RNA30S ribosomal protein S12C-X-C chemokine receptor type 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Frangula purshiana bark Approved DB15478
biotech | CAS: 8015-89-2

Deskripsi belum tersedia.

Kategori:
Biological ProductsCascaraLaxatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Frankincense DB16592
biotech

Deskripsi belum tersedia.

Kategori:
Biological ProductsBiopolymersComplex Mixtures +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fraxinus americana pollen Approved DB10348
biotech

Fraxinus americana pollen is the pollen of the Fraxinus americana plant. Fraxinus americana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Fraxinus latifolia pollen Approved DB10723
biotech

Fraxinus latifolia pollen is the pollen of the Fraxinus latifolia plant. Fraxinus latifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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biotech

Fraxinus pennsylvanica pollen is the pollen of the Fraxinus pennsylvanica plant. Fraxinus pennsylvanica pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Fraxinus velutina pollen Approved DB10455
biotech

Fraxinus velutina pollen is the pollen of the Fraxinus velutina plant. Fraxinus velutina pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Fremanezumab Approved DB14041
biotech | CAS: 1655501-53-3

Fremanezumab is a humanized monoclonal antibody targeted against human calcitonin gene-related peptide (CGRP) for the prevention of migraine headaches.[L11749] It was developed by Teva Pharmaceuticals USA and approved by the FDA in September 2018.[L11779] Alo…

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAntibodies +12
Target Protein:
Calcitonin gene-related peptide 1Calcitonin gene-related peptide 2
Waktu ParuhThe mean half-life …
Vol. DistribusiFremanezumab has an…
KlirensThe apparent cleara…
Genetik -
Freneslerbart DB19080
biotech | CAS: 2453195-94-1

Freneslerbart is under investigation in clinical trial NCT04981717 (A Study to Examine the Efficacy and Safety of Anti-fel D 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic Rhinitis Who Live With a Cat).

Waktu Paruh-
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Freselestat DB03925
small molecule | CAS: 208848-19-5

Deskripsi belum tersedia.

Kategori:
Leukocyte Elastase, antagonists & inhibitorsOxazolesPyrimidines
Target Protein:
Chymotrypsin-like elastase family member 1Neutrophil elastase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Fresolimumab DB12396
biotech | CAS: 948564-73-6

Fresolimumab has been used in trials studying the treatment of Primary Brain Tumors, Metastatic Breast Cancer, Diffuse Systemic Sclerosis, Pleural Malignant Mesothelioma, and Primary Focal Segmental Glomerulosclerosis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Frexalimab DB18926
biotech | CAS: 2515463-86-0

Frexalimab is under investigation in clinical trial NCT06141486 (Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis).

Waktu Paruh-
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