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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
Referensi
14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 140 / 290
Halofantrine Approved DB01218
small molecule | CAS: 69756-53-2

Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poiso…

Kategori:
Agents that reduce seizure thresholdAnti-Infective AgentsAntimalarials +13
Target Protein:
Fe(II)-protoporphyrin IXCalmodulin-1Calmodulin-3 +3
Waktu Paruh6-10 days
Vol. Distribusi-
Klirens-
Genetik -
Halofuginone DB04866
small molecule | CAS: 55837-20-2

Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice. Collgard Bio…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAnti-Infective Agents +10
Target Protein:
Collagen alpha-1(I) chain72 kDa type IV collagenase
Waktu Paruh23.8 to 72.1 hours
Vol. Distribusi-
Klirens-
Genetik -
Haloperidol Approved DB00502
small molecule | CAS: 52-86-8

Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide.[A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain,[A274…

Kategori:
Agents that reduce seizure thresholdAnti-Dyskinesia AgentsAntidepressive Agents +50
Target Protein:
5-hydroxytryptamine receptor 2CD(2) dopamine receptor5-hydroxytryptamine receptor 2A +15
Waktu ParuhFollowing oral admi…
Vol. DistribusiThe apparent volume…
KlirensFollowing intraveno…
Genetik -
Haloprogin Approved DB00793
small molecule | CAS: 777-11-7

Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Com…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Halothane Approved DB01159
small molecule | CAS: 151-67-7

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxatio…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +14
Target Protein:
Potassium channel subfamily K member 3Potassium channel subfamily K member 9GABA(A) Receptor +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Haloxyfop-P DB07870
small molecule | CAS: 95977-29-0

Deskripsi belum tersedia.

Target Protein:
Acetyl-CoA carboxylase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hard fat Approved DB11578
small molecule

Deskripsi belum tersedia.

Kategori:
Pharmaceutical Vehicles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Harmine DB07919
small molecule | CAS: 442-51-3

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntidepressive AgentsCarbolines +13
Target Protein:
Dual specificity tyrosine-phosphorylation-regulated kinase 2Dual specificity tyrosine-phosphorylation-regulated kinase 3Dual specificity tyrosine-phosphorylation-regulated kinase 1A +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hazelnut Approved DB10654
biotech

Hazelnut allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HCV-086 DB05884
small molecule

HCV-086 is a small molecule antiviral designed to block an enzyme required for the replication of the hepatitis C virus.

Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Heat stable ricin vaccine is an alum-adjuvanted, heat stable recombinant subunit vaccine.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Hedera helix leaf extract allergenic extract is used in allergenic testing.

Kategori:
Cough and Cold PreparationsExpectorants
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Helianthus annuus pollen Approved DB10910
biotech

Helianthus annuus pollen is the pollen of the Helianthus annuus plant. Helianthus annuus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Helium Approved DB09155
small molecule | CAS: 7440-59-7

Helium is a second most abundant chemical element in the universe with symbol He and atomic number 2. It is a colorless, odorless, tasteless, non-toxic, inert, monatomic gas located at the top of the noble gases on the periodic table. Its boiling and melting …

Kategori:
ElementsGasesMedical Gases +3
Waktu Paruh0.8 seconds
Vol. Distribusi-
Klirens-
Genetik -
Helium He-3 DB12940
small molecule | CAS: 14762-55-1

Helium He-3 is under investigation in clinical trial NCT00846014 (Asthma Exacerbation and Helium-3 MRI).

Kategori:
ElementsGasesNoble Gases
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Helminthosporium solani Approved DB10436
biotech

Helminthosporium solani is a fungus which can provoke allergic reactions. Helminthosporium solani extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemicellulase DB15820
biotech | CAS: 9025-56-3

Deskripsi belum tersedia.

Kategori:
EnzymesEnzymes and CoenzymesHydrolases
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemin Approved DB03404
biotech | CAS: 16009-13-5

Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.

Kategori:
Biological FactorsBlood and Blood Forming OrgansHeme +5
Target Protein:
5-aminolevulinate synthase, non-specific, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemoglobin Approved DB04945
biotech | CAS: 9008-02-0

The respiratory protein of the red blood cells. It consists primarily of globin and heme.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 142261-03-8

Hemoglobin in which the alpha-subunit are cross-linked intramolecularly.

Kategori:
Amino Acids, Peptides, and ProteinsBenzene DerivativesBlood and Blood Forming Organs +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 192230-36-7

Hemoglobin glutamer-250 (bovine) is under investigation in clinical trial NCT00300040 (Safety/feasibility Study of HBOC-201 in Amputation At/below Knee From Critical Lower Limb Ischemia).

Kategori:
Amino Acids, Peptides, and ProteinsBiomimetic MaterialsBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 679404-95-6

Hemoglobin glutamer-256 (human) is under investigation in clinical trial NCT00076648 (Safety and Efficacy of Polyheme(r) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-hospital Setting).

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsBlood Substitutes +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemopexin DB18229
biotech

Deskripsi belum tersedia.

Kategori:
Acute-Phase ProteinsAmino Acids, Peptides, and ProteinsBeta-Globulins +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemoporfin DB16183
small molecule | CAS: 14459-29-1

Hemoporfin is under investigation in clinical trial NCT03125057 (A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain).

Kategori:
Biological FactorsDermatologicalsHeterocyclic Compounds, Fused-Ring +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hemoximer DB17600
biotech

Hemoximer is a modified version of hemoglobin that undergoes pyridoxylation, for the purpose of lowering the oxygen affinity, and coupling with polyoxyethylene (POE), to increase its molecular weight.[A258528]

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBlood Proteins +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Henatinib DB13019
small molecule | CAS: 1239269-51-2

Henatinib has been used in trials studying the treatment of Advanced Solid Cancer.

Kategori:
Heterocyclic Compounds, Fused-RingVascular Endothelial Growth Factors, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Recombinant human heparan-N-sulfatase (rhHNS) is under investigation for the treatment mucopolysaccharidosis type IIIA.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Heparin Approved DB01109
small molecule | CAS: 9005-49-6

Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III …

Kategori:
Agents causing hyperkalemiaAnticoagulantsAntivaricose Therapy +16
Target Protein:
Antithrombin-IIICoagulation factor XP-selectin +9
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe volume of distr…
KlirensThe clearance in ad…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
C-C motif chemokine 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
C-C motif chemokine 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Heparin, bovine DB15404
small molecule | CAS: 9005-49-6

Heparin, bovine is under investigation in clinical trial NCT01072747 (Efficacy And Safety Of Unfractionated Heparin In Patients With Cardiovascular Surgery Using Cardiopulmonary Bypass).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hepatitis A Vaccine Approved DB10989
biotech

Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure.[A199182] Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has bee…

Kategori:
Actively Acquired ImmunityBiological ProductsComplex Mixtures +4
Target Protein:
B-lymphocytes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hepatitis B immune globulin Approved DB05276
biotech

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatit…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseBlood Proteins +12
Target Protein:
HBsAg
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. …

Kategori:
Actively Acquired ImmunityAmino Acids, Peptides, and ProteinsAntigens +19
Waktu ParuhEvaluation of pharm…
Vol. DistribusiEvaluation of pharm…
KlirensEvaluation of pharm…
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hepcidin-25 DB19226
biotech | CAS: 1356390-47-0

Hepcidin-25 is under investigation in clinical trial NCT03381833 (A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Patients With Transfusion-dependent Beta Thalassemia).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HEPES DB16872
small molecule | CAS: 7365-45-9

Deskripsi belum tersedia.

Kategori:
AlkanesAlkanesulfonic AcidsBuffers +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5617-32-3

Deskripsi belum tersedia.

Kategori:
Pegylated agents
Target Protein:
Carbonyl reductase [NADPH] 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Heptanoic acid DB02938
small molecule | CAS: 111-14-8

Deskripsi belum tersedia.

Target Protein:
Phospholipase A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78617-12-6

Deskripsi belum tersedia.

Target Protein:
Peptidyl-prolyl cis-trans isomerase FKBP1APeroxisome proliferator-activated receptor delta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HER-902 DB17948
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Herring Approved DB10617
biotech

Herring allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hesperetin DB01094
small molecule | CAS: 520-33-2

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside [hesperidin], is the predominant flavonoid in lemons and oranges.

Kategori:
BCRP/ABCG2 InhibitorsBenzopyransCarbohydrates +8
Target Protein:
Diacylglycerol O-acyltransferase 1Microsomal triglyceride transfer protein large subunitSterol O-acyltransferase 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hesperidin Approved DB04703
small molecule | CAS: 520-26-3

Hesperidin is a flavan-on glycoside found in citrus fruits.

Kategori:
BenzopyransCarbohydratesChromones +5
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1BAurora kinase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24292-52-2

Deskripsi belum tersedia.

Kategori:
BenzopyransCarbohydratesChromones +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hetacillin Approved DB00739
small molecule | CAS: 3511-16-8

Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of ant…

Kategori:
AmidesAnti-Bacterial AgentsAntibacterials for Systemic Use +8
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 1bPenicillin-binding protein 3 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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