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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 139 / 272
Hydromorphone Approved DB00327
small molecule | CAS: 466-99-9

Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +22
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe volume of distr…
KlirensThe mean plasma cle…
Genetik -
Hydronidone DB06299
small molecule | CAS: 851518-71-3

Hydronidone has antifibrotic activity.

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinidine DB15300
small molecule | CAS: 1435-55-8

Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).

Kategori:
AlkaloidsAntiarrhythmic agentsAntiarrhythmics, Class I +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinine DB13718
small molecule | CAS: 522-66-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiarrhythmic agentsAutonomic Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinone Approved DB09526
small molecule | CAS: 123-31-9

Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, b…

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +11
Target Protein:
TyrosinaseIntegrin beta-3Integrin alpha-IIb +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrotalcite Approved DB13322
small molecule | CAS: 12304-65-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkaliesAluminium Compounds +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxide ion DB14522
small molecule | CAS: 14280-30-9

Deskripsi belum tersedia.

Kategori:
AlkaliesAnionsElectrolytes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxocobalamin Approved DB00200
small molecule | CAS: 13422-51-0

Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.

Kategori:
Antianemic PreparationsAntidotesBlood and Blood Forming Organs +10
Target Protein:
Methionine synthaseMethylmalonyl-CoA mutase, mitochondrialMethylmalonic aciduria type A protein, mitochondrial +4
Waktu ParuhApproximately 6 day…
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cyclin-A2Cyclin-dependent kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Liver carboxylesterase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyamphetamine Approved DB09352
small molecule | CAS: 103-86-6

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor side effe…

Kategori:
Adrenergic AgonistsAminesAmphetamines +7
Target Protein:
Trace amine-associated receptor 1
Waktu Paruh-
Vol. DistribusiIntended for local …
KlirensIntended for local …
Genetik -
small molecule | CAS: 821-33-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxychloroquine Approved DB01611
small molecule | CAS: 118-42-3

Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, ch…

Kategori:
AminoquinolinesAnti-Infective AgentsAntimalarials +22
Target Protein:
Toll-like receptor 7Toll-like receptor 9DNA +1
Waktu ParuhA half-life of 123.…
Vol. DistribusiHydroxychloroquine …
KlirensThe clearance of hy…
Genetik -
Hydroxycitronellal Approved DB14187
small molecule | CAS: 107-75-5

Hydroxycitronellal is a synthetic fragrance that is widely used in many cosmetics and hygiene products such as deodorants, soaps, antiseptics, and other household items. It has the smell of lilac, lily, and lily of the valley [A34269]. Hydroxycitronellal has …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleasePerfume +1
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhThe mean eliminatio…
Vol. DistribusiTmax was found to b…
Klirens-
Genetik -
Hydroxydione DB08956
small molecule | CAS: 303-01-5

Hydroxydione (Viadril) is a neuroactive steroid used as a general anesthetic.

Kategori:
Fused-Ring CompoundsNeurotransmitter AgentsPregnanes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl ethylcellulose Approved DB14139
small molecule | CAS: 9004-58-4

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Gag-Pro-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7647-63-4

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UsePhenothiazine Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68-96-2

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyprogesterone caproate Approved DB06789
small molecule | CAS: 630-56-8

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17?-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was p…

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsCombination Contraceptives (with Estrogen and derivatives) +26
Target Protein:
Progesterone receptor
Waktu ParuhHalf-life = 16 days…
Vol. DistribusiHydroxyprogesterone…
KlirensClearance is highly…
Genetik -
Hydroxyproline DB08847
small molecule | CAS: 51-35-4

Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline i…

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 128446-35-5

Hydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).

Kategori:
beta-CyclodextrinsCarbohydratesCompounds used in a research, industrial, or household setting +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxypropyl cellulose Approved DB00840
small molecule | CAS: 9004-64-2

Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used t…

Kategori:
Artificial TearsBiopolymersCarbohydrates +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 439685-79-7

Hydroxypropyl tetrahydropyrantriol has been used in trials studying the basic science of Aging.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxystilbamidine Approved DB14753
small molecule | CAS: 495-99-8

Hydroxystilbamidine isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and pulmonary or systemic blastomycosis in children, with fewer side effects than amphotericin B. Hydroxystilbamidine isethionate is also us…

Kategori:
AmidinesBenzene DerivativesBenzylidene Compounds +1
Target Protein:
DNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyzine Approved DB00557
small molecule | CAS: 68-88-2

Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since re…

Kategori:
Anti-Anxiety AgentsAntipruriticsCentral Nervous System Depressants +21
Target Protein:
Histamine H1 receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe mean volume of …
KlirensClearance of hydrox…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptide deformylasePeptide deformylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hygromycin B DB11520
small molecule | CAS: 31282-04-9

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnthelmintics +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hymecromone DB07118
small molecule | CAS: 90-33-5

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismBenzopyransBile and Liver Therapy +8
Target Protein:
Arylsulfate sulfotransferase AssT
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 83-49-8

Hyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.

Kategori:
Bile Acids and SaltsCholanesCholic Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hyoscyamine Approved DB00424
small molecule | CAS: 101-31-5

Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] …

Kategori:
Adjuvants, AnesthesiaAgents producing tachycardiaAlimentary Tract and Metabolism +26
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M2 +3
Waktu ParuhThe half life of hy…
Vol. Distribusi-
Klirens-
Genetik -
Hyperforin DB01892
small molecule | CAS: 11079-53-1

Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is _Hypericum perforatum_, also known as St John's wort.

Kategori:
Benzene DerivativesOATP1B1/SLCO1B1 InhibitorsPhenols
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenaseProstaglandin G/H synthase 1Nuclear receptor subfamily 1 group I member 2
Waktu Paruh9 hours
Vol. Distribusi-
Klirens-
Genetik -
Hypericin DB13014
small molecule | CAS: 548-04-9

Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.

Kategori:
AnthracenesAnti-Infective AgentsAntidepressive Agents +10
Target Protein:
Glutathione S-transferase A1Glutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypochlorite Approved DB11123
small molecule | CAS: 14380-61-1

Hypochlorite is an ion composed of chlorine and oxygen with the chemical formula ClO?. Being unstable in the pure form, hypochlorite is most commonly used for bleaching, disinfectation, and water treatment purposes in its salt form, sodium hypochlorite. Hypoc…

Kategori:
AcidsAcids, NoncarboxylicAnti-Infective Agents +14
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
small molecule | CAS: 7790-92-3

An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.

Kategori:
AcidsAcids, NoncarboxylicChlorine Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypophosphite DB04053
small molecule | CAS: 15460-68-1

Deskripsi belum tersedia.

Target Protein:
Thiosulfate sulfurtransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypothemycin DB07905
small molecule | CAS: 76958-67-3

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBiological FactorsLactones +4
Target Protein:
Mitogen-activated protein kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63296-34-4

Hypothiocyanite ion is under investigation in clinical trial NCT02598999 (Dose Escalation Study of ALX-009 in Healthy Men and Cystic Fibrosis (CF) and Non-CF Bronchiectasis Patients).

Kategori:
Anti-Infective AgentsCyanatesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hypromellose Approved DB11075
small molecule | CAS: 9004-65-3

Hypromellose, or hydroxypropyl methylcellulose (HPMC) [L1812], is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in soli…

Kategori:
Artificial TearsBiopolymersCarbohydrates +12
Target Protein:
Epithelial cell adhesion molecule
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
HZT-501 DB05369
small molecule

HZT-501 is under investigation by Horizon Therapeutics, Inc., a privately held biopharmaceutical company. It has entered Phase 3 clinical trials in March 2007 for reduction of the risk of development of ibuprofen-associated upper gastrointestinal (i.e., gastr…

Target Protein:
Histamine H2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ianalumab DB16666
biotech | CAS: 1929549-92-7

Ianalumab is under investigation in clinical trial NCT01930175 (Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibacitabine DB13776
small molecule | CAS: 611-53-0

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxycytidine +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibalizumab Approved DB12698
biotech | CAS: 680188-33-4

Ibalizumab (also known as _ibalizumab-uiyk_ and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-HIV AgentsAnti-Infective Agents +19
Target Protein:
C-C chemokine receptor type 5C-X-C chemokine receptor type 4T-cell surface glycoprotein CD4
Waktu ParuhThe half-life of ib…
Vol. Distribusi4.8 L [FDA label]
KlirensFollowing single-do…
Genetik -
Ibandronate Approved DB00710
small molecule | CAS: 114084-78-5

Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandron…

Kategori:
Agents Causing Muscle ToxicityBisphosphonatesBone Density Conservation Agents +7
Target Protein:
HydroxylapatiteGeranylgeranyl pyrophosphate synthaseFarnesyl pyrophosphate synthase
Waktu ParuhThe half life of ib…
Vol. DistribusiThe apparent termin…
KlirensThe total clearance…
Genetik -
Iberdomide DB12101
small molecule | CAS: 1323403-33-3

Iberdomide (CC-220) has been used in trials studying the treatment of Systemic Lupus Erythematosus.

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingImides +4
Target Protein:
Protein cereblon
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibezapolstat DB16189
small molecule | CAS: 1275582-97-2

Ibezapolstat is under investigation in clinical trial NCT04247542 (ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingNucleic Acid Synthesis Inhibitors +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
IBIO-100 DB18233
biotech

IBIO-100 is a high molecular weight multimer of E3-Fc, an endostatin C-terminus and IgG1-Fc fusion protein.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibipinabant DB12649
small molecule | CAS: 464213-10-3

Ibipinabant has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.

Kategori:
Agents producing tachycardiaAmidesCannabinoid Receptor Antagonists +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Iboctadekin DB14920
biotech | CAS: 479198-61-3

Iboctadekin is under investigation in clinical trial NCT00500058 (A Phase I, Dose-Escalation Study to Assess the Safety and Biological Activity of Recombinant Human Interleukin-18).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ibodutant DB12042
small molecule | CAS: 522664-63-7

Ibodutant has been used in trials studying the treatment of Irritable Bowel Syndrome and Irritable Bowel Syndrome With Diarrhea.

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides +2
Target Protein:
Substance-K receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 6901–6950 dari 13591
Sebelumnya Halaman 139 / 272 Berikutnya