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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 134 / 321
Eltanexor DB16153
small molecule | CAS: 1642300-52-4

Eltanexor is under investigation in clinical trial NCT02649790 (Study of the Safety, Tolerability and Efficacy of KPT-8602 in Patients With Relapsed/refractory Cancer Indications).

Target Protein:
Exportin-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eltanolone DB12308
small molecule | CAS: 128-20-1

Eltanolone is under investigation in clinical trial NCT02603926 (Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone).

Kategori:
AnestheticsCentral Nervous System AgentsCentral Nervous System Depressants +3
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eltoprazine DB12883
small molecule | CAS: 98224-03-4

Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +6
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Eltrekibart DB19017
biotech | CAS: 2484883-56-7

Eltrekibart is under investigation in clinical trial NCT06046729 (A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa).

Waktu Paruh-
Vol. Distribusi-
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Eltrombopag Approved DB06210
small molecule | CAS: 496775-61-2

Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bru…

Kategori:
Acids, CarbocyclicBCRP/ABCG2 InhibitorsBenzene Derivatives +25
Target Protein:
Thrombopoietin receptor
Gen Terkait:
F5 SERPINC1
Waktu ParuhAbout 21-32 hours i…
Vol. DistribusiBased on a radiolab…
Klirens-
Genetik 2 Varian
Elubrixin DB12135
small molecule | CAS: 688763-64-6

Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesBenzene DerivativesReceptors, Interleukin-8B, antagonists & inhibitors +2
Target Protein:
C-X-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eluforsen DB16154
biotech | CAS: 2101868-82-8

Eluforsen is under investigation in clinical trial NCT02532764 (Dose Escalation Study of QR-010 in Homozygous ?F508 Cystic Fibrosis Patients).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eluvixtamab DB17252
biotech | CAS: 1679391-73-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eluxadoline Approved DB09272
small molecule | CAS: 864821-90-9

Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous…

Kategori:
Alimentary Tract and MetabolismAmino AcidsAmino Acids, Aromatic +15
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu ParuhThe mean plasma eli…
Vol. Distribusi-
Klirens-
Genetik -
Elvitegravir Approved DB09101
small molecule | CAS: 697761-98-1

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibitio…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +22
Target Protein:
IntegraseGag-Pol polyprotein
Waktu ParuhThe median terminal…
Vol. Distribusi-
Klirens-
Genetik -
Elvucitabine DB06236
small molecule | CAS: 181785-84-2

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +13
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ELX-02 DB15080
small molecule | CAS: 1375073-95-2

ELX-02 is under investigation in clinical trial NCT03309605 (Phase 1 Study of ELX-02 in Healthy Adult Subjects).

Waktu Paruh-
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Elzasonan DB18969
small molecule | CAS: 361343-19-3

Elzasonan is under investigation in clinical trial NCT00275197 (A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)).

Kategori:
Oxazines
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Elzovantinib DB18918
small molecule | CAS: 2271119-26-5

Elzovantinib is under investigation in clinical trial NCT03993873 (Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET).

Waktu Paruh-
Vol. Distribusi-
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EM-1745 DB02323
small molecule

Deskripsi belum tersedia.

Kategori:
17-Hydroxysteroid Dehydrogenases, antagonists & inhibitorsEstradiol CongenersEstranes +7
Target Protein:
17-beta-hydroxysteroid dehydrogenase type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emactuzumab DB14905
biotech | CAS: 1448221-67-7

Emactuzumab is under investigation in clinical trial NCT01494688 (A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emapalumab Approved DB14724
biotech | CAS: 1709815-23-5

Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapal…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +14
Target Protein:
Interferon gamma
Waktu ParuhEmapalumab eliminat…
Vol. DistribusiThe central and per…
KlirensEmapalumab clearanc…
Genetik -
Emapunil DB12666
small molecule | CAS: 226954-04-7

Emapunil has been used in trials studying the basic science and diagnostic of Baseline, Blocking Receptor Binding, and Neurodegenerative Disorders.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Translocator protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emavusertib DB18060
small molecule | CAS: 1801344-14-8

Deskripsi belum tersedia.

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EMB-01 DB16091
biotech

EMB-01 is under investigation in clinical trial NCT03797391 (A Dose Escalation Study of EMB-01 in Participants With Advanced/metastatic Solid Tumors).

Waktu Paruh-
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Embutramide DB01487
small molecule | CAS: 15687-14-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAminesAminobenzoates +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EMD-1201081 DB06181
biotech | CAS: 847484-35-9

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emedastine Approved DB01084
small molecule | CAS: 87233-61-2

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Kategori:
Anti-Allergic AgentsDecongestants and AntiallergicsHeterocyclic Compounds, Fused-Ring +9
Target Protein:
Histamine H1 receptor
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Emepronium DB13505
small molecule | CAS: 27892-33-7

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAmines +19
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emeramide DB12192
small molecule | CAS: 351994-94-0

Emeramide has been used in trials studying the treatment of Mercury Poisoning.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingSequestering Agents +1
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Emerfetamab DB18474
biotech | CAS: 2250261-27-7

Emerfetamab is a bispecific T cell engager antibody construct with a half-life extension Fc moiety capable of binding to the neonatal Fc receptor.

Waktu Paruh-
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Emetine DB13393
small molecule | CAS: 483-18-1

Deskripsi belum tersedia.

Kategori:
Agents Causing Muscle ToxicityAlkaloidsAmebicides +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5982-52-5

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emfilermin DB06562
small molecule | CAS: 159075-60-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCytokines +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EMI-137 DB19174
biotech

EMI-137 is under investigation in clinical trial NCT03360461 (EMI-137 in Laparoscopic Colonic Resections).

Waktu Paruh-
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Emibetuzumab DB11849
biotech | CAS: 1365287-97-3

Emibetuzumab has been used in trials studying the treatment of Advanced Cancer, Renal Cell Carcinoma, Hepatocellular Cancer, Gastric Adenocarcinoma, and Non-Small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicerfont DB12910
small molecule | CAS: 786701-13-1

Emicerfont has been used in trials studying the diagnostic and treatment of Social Anxiety Disorder and Irritable Bowel Syndrome (IBS).

Kategori:
Corticotropin-Releasing Hormone, antagonists & inhibitors
Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicizumab Approved DB13923
biotech | CAS: 1610943-06-0

Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three differen…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Coagulation factor IXCoagulation factor X
Waktu ParuhEmcicizumab present…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Emivirine DB08188
small molecule | CAS: 149950-60-7

Emivirine has been used in trials studying the treatment of HIV Infections.

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +5
Target Protein:
Gag-Pol polyproteinGag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emixustat DB12608
small molecule | CAS: 1141777-14-1

Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration.

Kategori:
AlcoholsAminesAmino Alcohols +4
Target Protein:
Retinoid isomerohydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emlenoflast DB18304
small molecule | CAS: 1995067-59-8

Deskripsi belum tersedia.

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Emodepside DB11403
biotech | CAS: 155030-63-0

Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntiparasitic Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emodin DB07715
small molecule | CAS: 518-82-1

Emodin has been investigated for the treatment of Polycystic Kidney.

Kategori:
AnthracenesAnthraquinonesBiological Products +7
Target Protein:
Casein kinase II subunit alphaPutative ketoacyl reductase3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emopamil DB14064
small molecule | CAS: 78370-13-5

Prevents renal injury after warm & cold ischemia.

Kategori:
Agents causing hyperkalemiaAminesAntiarrhythmic agents +11
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emoxypine DB19172
small molecule | CAS: 2364-75-2

Emoxypine is under investigation in clinical trial NCT06221826 (MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure).

Kategori:
Antiarrhythmic agentsAntioxidantsAntiplatelet agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Empagliflozin Approved DB09038
small molecule | CAS: 864070-44-0

Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.[A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other …

Kategori:
Alimentary Tract and MetabolismBCRP/ABCG2 SubstratesBenzene Derivatives +16
Target Protein:
Sodium/glucose cotransporter 2
Waktu ParuhThe apparent termin…
Vol. DistribusiThe estimated appar…
KlirensApparent oral clear…
Genetik -
Empasiprubart DB16469
biotech | CAS: 2579031-19-7

Empasiprubart is a humanized sweeping antibody designed to bind to C2, a protein in the complement cascade that leads to cell destruction when activated.[L50783]

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
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Empegfilgrastim DB16155
biotech | CAS: 1192706-53-8

Empegfilgrastim is under investigation in clinical trial NCT01569087 (Dose-finding Study of Empegfilgrastim for Neutropenia Prophylaxis in Patients With Breast Cancer).

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsColony-Stimulating Factors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emprumapimod DB17603
small molecule | CAS: 765914-60-1

Emprumapimod is a potent, orally active and selective inhibitor of p38? mitogen-activated kinase inhibitor. It was investigated for dilated cardiomyopathy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emraclidine DB18706
small molecule | CAS: 2170722-84-4

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
Emricasan DB05408
small molecule | CAS: 254750-02-2

Emricasan is the first caspase inhibitor tested in human which has received orphan drug status by FDA. It is developed by Pfizer and made in such a way that it protects liver cells from excessive apoptosis.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Caspase-1Caspase-3Caspase-7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emrusolmin DB13927
small molecule | CAS: 882697-00-9

Emrusolmin restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. [A31409]

Kategori:
DioxolesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
Emtricitabine Approved DB00879
small molecule | CAS: 143491-57-0

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults.[L9010] Emtri…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +23
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyprotein
Waktu ParuhThe half life of em…
Vol. DistribusiThe apparent centra…
KlirensEmtricitabine has a…
Genetik -
Emvododstat DB18010
small molecule | CAS: 1219951-09-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-RingIndoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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