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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 133 / 349
Dienogest Approved DB09123
small molecule | CAS: 65928-58-7

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17?-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with eth…

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsAntineoplastic Agents, Hormonal +29
Target Protein:
Progesterone receptorAndrogen receptor
Waktu ParuhElimination half-li…
Vol. DistribusiThe apparent volume…
KlirensThe metabolic clear…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptorNuclear receptor coactivator 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphotriesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3762-25-2

Deskripsi belum tersedia.

Kategori:
Organophosphorus Compounds
Target Protein:
Parathion hydrolaseParathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diethyl ether DB13598
small molecule | CAS: 60-29-7

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 762-04-9

Deskripsi belum tersedia.

Kategori:
Cholinesterase Inhibitors
Target Protein:
CholinesteraseDiacylglycerol acyltransferase/mycolyltransferase Ag85C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Shiga-like toxin 1 subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 302776-68-7

Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is …

Kategori:
AminesAniline CompoundsBenzene Derivatives +3
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Diethylcarbamazine Approved DB00711
small molecule | CAS: 90-89-1

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Kategori:
Acids, AcyclicAnthelminticsAnti-Infective Agents +11
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenaseProstaglandin G/H synthase 1
Waktu ParuhApproximately 8 hou…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 112-36-7

Deskripsi belum tersedia.

Target Protein:
AcetylcholinesteraseBeta-hexosaminidasePhosphoenolpyruvate-protein phosphotransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1002-67-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 119422-08-1

Diethylhomospermine has been used in trials studying the treatment of Diarrhea and HIV Infections.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 121749-39-1

Deskripsi belum tersedia.

Kategori:
AminesAntihypertensive AgentsAntineoplastic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diethylpropion Approved DB00937
small molecule | CAS: 90-84-6

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAlimentary Tract and Metabolism +14
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterSodium-dependent dopamine transporter
Waktu ParuhUsing a phosphoresc…
Vol. Distribusi-
Klirens-
Genetik -
Diethylstilbestrol Approved DB00255
small molecule | CAS: 56-53-1

A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been…

Kategori:
Adrenal Cortex HormonesAntineoplastic Agents, HormonalAntineoplastic and Immunomodulating Agents +42
Target Protein:
Estrogen receptor betaEstrogen receptorEstrogen-related receptor gamma +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 86-14-6

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diethyltoluamide Approved DB11282
small molecule | CAS: 134-62-3

Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-borne illnesses like W…

Kategori:
Acids, CarbocyclicAgrochemicalsAmides +11
Waktu ParuhThe elimination hal…
Vol. DistribusiAfter dermal applic…
KlirensReadily accessible …
Genetik -
small molecule | CAS: 61-51-8

Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine.

Kategori:
Acids, CarbocyclicAgrochemicalsAmides +12
Target Protein:
5-hydroxytryptamine receptor 6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difamilast DB14987
small molecule | CAS: 937782-05-3

Difamilast is under investigation in clinical trial NCT01702181 (A Safety Study to Evaluate the Use and Effectiveness of a Topical Ointment to Treat Adults With Atopic Dermatitis).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difelikefalin Approved DB11938
small molecule | CAS: 1024828-77-0

Difelikefalin (CR845) is an agonist of kappa opioid receptors (KORs) useful in the treatment of pruritus secondary to chronic kidney disease. KORs were first associated with itching in 1984.[A237610] Further investigations revealed that dynorphins, endogenous…

Kategori:
Kappa Opioid Receptor Agonist
Target Protein:
Kappa-type opioid receptor
Waktu ParuhThe half-life of di…
Vol. DistribusiThe mean volume of …
KlirensOne cycle of hemodi…
Genetik -
Difemerine DB13380
small molecule | CAS: 80387-96-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difenoxin Approved DB01501
small molecule | CAS: 28782-42-5

Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, w…

Kategori:
Alimentary Tract and MetabolismAntidiarrhealsAntidiarrheals, Intestinal Antiinflammatory/antiinfective Agents +4
Target Protein:
Mu-type opioid receptor
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Difenpiramide DB13371
small molecule | CAS: 51484-40-3

Deskripsi belum tersedia.

Kategori:
AcetatesAcetic Acid Derivatives and Related SubstancesAcids, Acyclic +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difetarsone DB13599
small molecule | CAS: 3639-19-8

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsAntiprotozoalsArsenicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diflomotecan DB16138
small molecule | CAS: 220997-97-7

Diflomotecan is under investigation in clinical trial NCT00080015 (Diflomotecan (BN80915) Administered Once Every 3 Weeks in Treating Patients With Sensitive Small Cell Lung Cancer (SCLC)).

Kategori:
Alkaloids
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diflorasone Approved DB00223
small molecule | CAS: 2557-49-5

Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +13
Target Protein:
Phospholipase A2Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difloxacin DB11511
small molecule | CAS: 98106-17-3

Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone ant…

Kategori:
4-QuinolonesAnti-Bacterial AgentsCytochrome P-450 CYP1A2 Inhibitors +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diflunisal Approved DB00861
small molecule | CAS: 22494-42-4

Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action …

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +23
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh8 to 12 hours
Vol. Distribusi-
Klirens-
Genetik -
Difluocortolone Approved DB09095
small molecule | CAS: 2607-06-9

Difluocortolone is a potent topical corticosteroid. It is commonly used in dermatology for the reduction of inflammation and itching. It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.[L1082]

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +24
Target Protein:
Annexin A3Glucocorticoid receptor
Waktu ParuhThe half-life of di…
Vol. DistribusiLess of 1% of the a…
KlirensDiflucortolone gets…
Genetik -
small molecule | CAS: 15845-96-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Methionine--tRNA ligase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Difluprednate Approved DB06781
small molecule | CAS: 23674-86-4

Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(?), 9(?)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyra…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +17
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Digitoxigenin DB04177
small molecule | CAS: 143-62-4

Digitoxigenin is a cardenolide which is the aglycon of digitoxin.

Kategori:
CardanolidesCardenolidesCardiac Glycosides +3
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Digitoxin Approved DB01396
small molecule | CAS: 71-63-6

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)

Kategori:
Antiarrhythmic agentsCarbohydratesCardanolides +21
Target Protein:
Sodium/potassium-transporting ATPase subunit beta-2Sodium/potassium-transporting ATPase subunit beta-3Sodium/potassium-transporting ATPase subunit alpha-1 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diglyme DB02935
small molecule | CAS: 111-96-6

Deskripsi belum tersedia.

Kategori:
AlcoholsEthersGlycols
Target Protein:
Endoplasmin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Digoxigenin DB03671
small molecule | CAS: 1672-46-4

Digoxigenin is a cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.

Kategori:
CardanolidesCardenolidesCardiac Glycosides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Digoxin Approved DB00390
small molecule | CAS: 20830-75-5

Digoxin is one of the oldest cardiovascular medications used today.[A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure.[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +28
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-2Sodium/potassium-transporting ATPase subunit alpha-3Sodium/potassium-transporting ATPase subunit beta-1 +4
Waktu ParuhDigoxin has a half-…
Vol. DistribusiThis drug is widely…
KlirensThe clearance of di…
Genetik -
Digoxin Immune Fab (Ovine) Approved DB00076
biotech

Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.

Kategori:
Amino Acids, Peptides, and ProteinsAntidotesBlood Proteins +6
Target Protein:
Digoxin
Waktu Paruh15-20 hrs
Vol. Distribusi* 0.3 L/kg [DigiFab…
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
mRNA-capping enzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 97067-70-4

Dihematoporphyrin ether is under investigation in clinical trial NCT00118222 (High Light and Low Light Dose PDT in Glioma).

Kategori:
Antineoplastic AgentsBiological FactorsDermatologicals +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dihexyverine DB13678
small molecule | CAS: 561-77-3

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1783-84-2

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.

Kategori:
Dietary SupplementsEicosanoidsFatty Acids +3
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dihydralazine Approved DB12945
small molecule | CAS: 484-23-1

Dihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).

Kategori:
Antihypertensive AgentsArteriolar Smooth Muscle, Agents Acting OnCardiovascular Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dihydrexidine DB12890
small molecule | CAS: 123039-93-0

Dihydrexidine has been used in trials studying the treatment of SPD, Cocaine-Related Disorders, and Schizotypal Personality Disorder.

Kategori:
Dopamine AgentsDopamine AgonistsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
D(1A) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 959343-20-5

Deskripsi belum tersedia.

Kategori:
Anticholinergic AgentsNicotinic Antagonists
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dihydro-alpha-ergocryptine Approved DB11274
small molecule | CAS: 25447-66-9

Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from …

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates
Target Protein:
5-hydroxytryptamine receptor 75-hydroxytryptamine receptor 2BD(2) dopamine receptor +2
Waktu ParuhAlpha-dihydroergocr…
Vol. DistribusiIn preclinical stud…
KlirensIn preclinical stud…
Genetik -
Menampilkan 6601–6650 dari 17430
Sebelumnya Halaman 133 / 349 Berikutnya