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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (11778)

Halaman 133 / 236
small molecule | CAS: 118313-25-0

L-deprenyl-D2 C-11 is under investigation in clinical trial NCT01701089 (A Study of RO4602522 in Patients With Alzheimer Disease and in Healthy Volunteers).

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small molecule | CAS: 998-06-1

Deskripsi belum tersedia.

Kategori:
GlycerophosphatesGlycerophospholipidsLipids +3
Target Protein:
Phosphatidylcholine transfer protein
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small molecule | CAS: 6779-87-9

7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde.

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Nitric oxide synthase, inducibleTyrosine 3-monooxygenasePhenylalanine-4-hydroxylase +3
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L-Gluconic Acid DB04304
small molecule | CAS: 526-97-6

Deskripsi belum tersedia.

Target Protein:
Beta-glucosidase A
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L-Glutamine Approved DB00130
small molecule | CAS: 56-85-9

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cel…

Kategori:
Alimentary Tract and MetabolismAmino AcidsAmino Acids and Derivatives +8
Target Protein:
CTP synthase 1AmidophosphoribosyltransferaseGlutamine synthetase
Waktu ParuhThe half life of el…
Vol. DistribusiVolume of distribut…
Klirens-
Genetik -
small molecule | CAS: 25679-93-0

Deskripsi belum tersedia.

Target Protein:
Histidinol-phosphate aminotransferaseHistidinol-phosphate aminotransferase
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L-homoarginine DB03974
small molecule | CAS: 156-86-5

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +2
Target Protein:
Nitric oxide synthase 3
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L-Homoserine DB04193
small molecule | CAS: 672-15-1

Deskripsi belum tersedia.

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L-Lactic acid Approved DB14475
small molecule | CAS: 79-33-4

Deskripsi belum tersedia.

Kategori:
Hydroxy AcidsLactates
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Genetik -
biotech | CAS: 120484-65-3

Deskripsi belum tersedia.

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small molecule | CAS: 29586-66-1

L-lysyl-l-arginine is under investigation in clinical trial NCT03972488 (Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET).

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small molecule | CAS: 62697-73-8

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +2
Target Protein:
Thymidylate synthaseAmyloid-beta precursor proteinCatalase +1
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Thymidylate synthasePossible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)Ras-related protein Rab-5A +3
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Genetik -
small molecule | CAS: 7314-32-1

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +2
Target Protein:
Catalase
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nitric oxide synthase 3Nitric oxide synthase 1
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Genetik -
small molecule | CAS: 80875-98-5

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Pyruvate kinase PKM
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small molecule | CAS: 471-87-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +1
Target Protein:
Glycine betaine-binding periplasmic protein
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L-Saccharopine DB04207
small molecule | CAS: 997-68-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +1
Target Protein:
Alpha-aminoadipic semialdehyde synthase, mitochondrial
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Genetik -
small molecule | CAS: 626-69-7

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins
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L-tartaric acid DB09459
small molecule | CAS: 87-69-4

Tartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes.Tartaric is an alpha-hydroxy-carboxylic acid, is diprotic and aldaric in acid characteristics, and is a dihydroxyl derivative of succinic acid.

Kategori:
Acids, AcyclicCarbohydratesChelating Agents +4
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L-thioproline DB02846
small molecule | CAS: 2756-91-4

Deskripsi belum tersedia.

Target Protein:
Annexin A5
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L-threonic acid DB11192
small molecule | CAS: 7306-96-9

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
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L-Threoninol DB01724
small molecule | CAS: 3228-51-1

Deskripsi belum tersedia.

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L523S DB06498
biotech

According to Nemunaitis J., et al, "L523S is an immunogenic lung cancer antigen that has demonstrated preclinical safety when the gene is injected intramuscularly as an expressive plasmid (pVAX/L523S) and when delivered following incorporation into an E1B-del…

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biotech

Deskripsi belum tersedia.

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Labetalol Approved DB00598
small molecule | CAS: 36894-69-6

Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture.[L7730] Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 …

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +35
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorAlpha-1 adrenergic receptors
Waktu ParuhLabetalol has a hal…
Vol. DistribusiIn normotensive pat…
KlirensLabetalol has a pla…
Genetik -
Labetuzumab DB05097
biotech | CAS: 219649-07-7

Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth. It is used in radioimmunotherapy.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Target Protein:
Cell adhesion molecule CEACAM5
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biotech | CAS: 1469876-18-3

Labetuzumab govitecan has been used in trials studying the treatment of Colon Cancer, Rectal Cancer, and Metastatic Colorectal Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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Labradimil DB06549
small molecule | CAS: 159768-75-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAutacoidsBiological Factors +8
Target Protein:
B2 bradykinin receptor
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Lacidipine Approved DB09236
small molecule | CAS: 103890-78-4

Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia [A31536]. It displays specificity in the vascular smooth muscle, whe…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +16
Target Protein:
Voltage-dependent L-type calcium channel
Waktu ParuhThe average termina…
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Lacosamide Approved DB06218
small molecule | CAS: 175481-36-4

Lacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. Lacosamide exhibits a stereoselective mode of interaction with sodium chan…

Kategori:
AcetamidesAcetatesAcids, Acyclic +21
Target Protein:
Dihydropyrimidinase-related protein 2Sodium channel protein type 11 subunit alphaSodium channel protein type 9 subunit alpha +2
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Lactaldehyde DB03776
small molecule | CAS: 598-35-6

Deskripsi belum tersedia.

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Lactide, L- DB19115
small molecule | CAS: 4511-42-6

Lactide, L- is under investigation in clinical trial NCT05450471 (Effectiveness of Endonasal Polymeric Implant for Chronic Rhinosinusitis).

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biotech

Lactobacillus is a common bacteria found in the gut with Lactobacillus coryniformis K8 being originally isolated from artisan goat cheese.

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biotech

*Lactobacillus plantarum* is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and me…

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Lactoferrin DB16555
biotech | CAS: 151186-19-5

Lactoferrin is under investigation in clinical trial NCT03748043 (The Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis).

Kategori:
Amino Acids, Peptides, and ProteinsAnimal Proteins, DietaryAnti-Infective Agents +22
Target Protein:
Tryptase alpha/beta-1
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Lactulose Approved DB00581
small molecule | CAS: 4618-18-2

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite be…

Kategori:
Acidifying ActivityAlimentary Tract and MetabolismAmmonia Detoxicants +8
Target Protein:
Evolved beta-galactosidase subunit alpha
Waktu ParuhThe data regarding …
Vol. DistribusiNegligible amounts …
KlirensNegligible amounts …
Genetik -
Lacutamab DB15322
biotech | CAS: 2187368-16-5

Lacutamab is under investigation in clinical trial NCT02593045 (Study of IPH4102 in Patients With Relapsed/Refractory Cutaneous T-cell Lymphomas (CTCL)).

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Ladarixin DB16212
small molecule | CAS: 849776-05-2

Ladarixin is under investigation in clinical trial NCT04628481 (A Study of Oral Ladarixin in New-onset Type 1 Diabetes and a Low Residual ?-Cell Function).

Kategori:
AmidesReceptors, Interleukin-8A, antagonists & inhibitorsSulfones +1
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Lademirsen DB17611
biotech | CAS: 1404019-95-9

Deskripsi belum tersedia.

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biotech | CAS: 1629760-29-7

Ladiratuzumab vedotin is under investigation in clinical trial NCT01969643 (A Safety Study of SGN-LIV1A in Breast Cancer Patients).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Ladostigil DB16213
small molecule | CAS: 209394-27-4

Ladostigil is under investigation in clinical trial NCT01429623 (A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment).

Kategori:
IndenesMonoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates
Target Protein:
Amine oxidase [flavin-containing] BAmine oxidase [flavin-containing] AAcetylcholinesterase
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Laevulinic Acid DB02239
small molecule | CAS: 123-76-2

Deskripsi belum tersedia.

Target Protein:
Delta-aminolevulinic acid dehydratase
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Lafutidine DB12770
small molecule | CAS: 118288-08-7

Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD).

Kategori:
AcetatesAcids, AcyclicAlimentary Tract and Metabolism +10
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Lamb Approved DB10537
biotech

Lamb allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Azurin
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Lamivudine Approved DB00709
small molecule | CAS: 134678-17-4

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +26
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseHDNA +1
Waktu Paruh5 to 7 hours (healt…
Vol. DistribusiApparent volume of …
Klirens* Renal clearance =…
Genetik -
Lamotrigine Approved DB00555
small molecule | CAS: 84057-84-1

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA)…

Kategori:
Agents causing hyperkalemiaAgents producing tachycardiaAnti-epileptic Agent +31
Target Protein:
Voltage-dependent R-type calcium channel subunit alpha-1ESodium channel protein type 11 subunit alphaVoltage-gated sodium channel alpha subunit +15
Waktu ParuhThe average elimina…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent p…
Genetik -
Lampalizumab DB11826
biotech | CAS: 1278466-20-8

Lampalizumab has been used in trials studying the treatment of Geographic Atrophy.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +9
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