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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 132 / 315
Etilefrine Approved DB08985
small molecule | CAS: 709-55-7

Etilefrine is an adrenergic agonist that appears to interact with beta-1 and some alpha-adrenergic receptors. It has been used as a vasoconstrictor agent.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etilevodopa DB06535
small molecule | CAS: 37178-37-3

Deskripsi belum tersedia.

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1229-12-5

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 2Immunoglobulin heavy constant gamma 1Immunoglobulin kappa constant +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 199331-40-3

Etiprednol dicloacetate (BNP-166) is a soft corticosteroid with anti-inflammatory properties that has been indicated in the treatment of asthma and Chron's disease. Anti-asthmatic effects were associated with decreased cytokine production in lipopolysaccharid…

Kategori:
HormonesHormones, Hormone Substitutes, and Hormone Antagonists
Target Protein:
Glucocorticoid receptorInterleukin-1 beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etiracetam DB11868
small molecule | CAS: 33996-58-6

Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)).

Kategori:
AcetamidesAcetatesAcids, Acyclic +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 848779-32-8

Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma).

Kategori:
AlcoholsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etizolam DB09166
small molecule | CAS: 40054-69-1

Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant,…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +17
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding SitePlatelet-activating factor receptor
Waktu ParuhThe average elimina…
Vol. DistribusiApparent distributi…
Klirens-
Genetik -
Etodolac Approved DB00749
small molecule | CAS: 41340-25-4

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rhe…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +29
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1Retinoic acid receptor RXR-alpha
Waktu ParuhTerminal t<sub>1/2<…
Vol. Distribusi* 390 mL/kg
Klirens* Oral cl=49.1 mL/h…
Genetik -
Etofamide Approved DB13258
small molecule | CAS: 25287-60-9

Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued [L5617].

Kategori:
AcetatesAcids, AcyclicAmebicides +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etofibrate DB08983
small molecule | CAS: 31637-97-5

Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 13425-39-3

Etofylline nicotinate, a theophylline derivative, is a drug that causes vasodilation and relaxation of smooth muscle.

Kategori:
Peripheral VasodilatorsPurine Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etoglucid DB13339
small molecule | CAS: 1954-28-5

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etohexadiol DB13826
small molecule | CAS: 94-96-2

Deskripsi belum tersedia.

Kategori:
AlcoholsAntiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. Scabicides, Insecticides and Repellents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etokimab DB16661
biotech | CAS: 2022981-44-6

Etokimab is under investigation in clinical trial NCT03614923 (Etokimab in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps (Crswnp)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etomidate Approved DB00292
small molecule | CAS: 33125-97-2

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

Kategori:
Adrenergic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-Agonists +11
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-1Alpha-2B adrenergic receptor +1
Waktu Paruh75 minutes.
Vol. Distribusi-
Klirens-
Genetik -
Etonitazene DB01462
small molecule | CAS: 911-65-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Kappa-type opioid receptorDelta-type opioid receptorMu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etonogestrel Approved DB00294
small molecule | CAS: 54048-10-1

Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel.[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in…

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +18
Target Protein:
Progesterone receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe clearance rate …
Genetik -
Etoperidone DB09194
small molecule | CAS: 52942-31-1

Etoperidone is an atypical antidepressant introduced in Europe in 1977. It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profile.[T45] Etoperidone w…

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsCombined Inhibitors of Serotonin/Norepinephrine Reuptake +12
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2CAlpha-1 adrenergic receptors +3
Waktu ParuhAfter oral administ…
Vol. DistribusiThe high protein bi…
KlirensThe apparent cleara…
Genetik -
Etoposide Approved DB00773
small molecule | CAS: 33419-42-0

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II bin…

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicAntineoplastic and Immunomodulating Agents +38
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh4-11 hours
Vol. DistribusiThe disposition of …
Klirens* Total body cleara…
Genetik -
small molecule | CAS: 433304-61-1

Deskripsi belum tersedia.

Kategori:
Topoisomerase Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etoricoxib Approved DB01628
small molecule | CAS: 202409-33-4

Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib sel…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +34
Target Protein:
Prostaglandin G/H synthase 2
Waktu Paruh22 hours
Vol. Distribusi-
Klirens-
Genetik -
Etorphine DB01497
small molecule | CAS: 14521-96-1

A narcotic analgesic morphinan used as a sedative in veterinary practice. In certain countries, etorphine is classified as a Schedule 1 drug and hence, in these countries, it can be used legally only by health professionals and for research purposes. Etorphin…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +10
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etoxeridine DB01505
small molecule | CAS: 469-82-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etranacogene dezaparvovec Approved DB16791
biotech | CAS: 2156583-26-3

Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX.[L44176] Clotting factors, including factor IX, are necessary components of the signaling cascad…

Kategori:
Adeno-associated Viral Vector TherapiesBlood and Blood Forming OrgansBlood Coagulation Factors +2
Target Protein:
Coagulation factor IX
Waktu Paruh-
Vol. DistribusiIn a study to evalu…
KlirensIn a clinical study…
Genetik -
Etrasimod Approved DB14766
small molecule | CAS: 1206123-37-6

Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub> receptors. S1P receptors are membrane-derived lysophosp…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates +11
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 4Sphingosine 1-phosphate receptor 5
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe mean apparent v…
KlirensThe apparent steady…
Genetik -
Etravirine Approved DB06414
small molecule | CAS: 269055-15-4

Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the …

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiinfectives for Systemic Use +24
Target Protein:
Gag-Pol polyproteinGag-Pol polyproteinReverse transcriptase/RNaseH
Waktu ParuhHalf life of 9.05-4…
Vol. DistribusiDistribution of etr…
KlirensRenal clearance of …
Genetik -
Etretinate DB00926
small molecule | CAS: 54350-48-0

Etretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid. The mechanism of action of etretinate is still incompletely understood although, like retinoic acid, it is thought to interfere with the terminal differentiation o…

Kategori:
AlkenesAntipsoriaticsAntipsoriatics for Systemic Use +12
Target Protein:
Retinoic acid receptor alphaRetinoic acid receptor RXR-alphaRetinoic acid receptor beta +3
Waktu ParuhIn one study, the a…
Vol. Distribusi-
Klirens-
Genetik -
Etrinabdione DB18008
small molecule | CAS: 1818428-24-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etripamil DB12605
small molecule | CAS: 1593673-23-4

Etripamil has been used in trials studying the treatment of Paroxysmal Supraventricular Tachycardia (PSVT).

Kategori:
Acids, CarbocyclicAntiarrhythmic agentsBenzene Derivatives +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etrolizumab DB12189
biotech | CAS: 1044758-60-2

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and retention of intestinal-homing lymphocytes.[A244564, …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Integrin beta-7
Waktu ParuhEtrolizumab adminis…
Vol. DistribusiModelling of etroli…
KlirensEtrolizumab has a m…
Genetik -
Etrumadenant DB17506
small molecule | CAS: 2239273-34-6

Deskripsi belum tersedia.

Target Protein:
Adenosine receptor A2aAdenosine receptor A2b
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etryptamine DB01546
small molecule | CAS: 2235-90-7

In the 1960's, alpha-ethyltryptamine (?ET), a non hydrazine reversible monoamine oxidase inhibitor, was developed in the United States by the Upjohn chemical company for use as an antidepressant. ?ET was an FDA approved antidepressant under the name Monase. H…

Kategori:
AminesBiogenic AminesBiogenic Monoamines +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ETX101 DB18579
biotech

ETX101 is a non-replicating recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of SCN1A gene.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etybenzatropine DB13468
small molecule | CAS: 524-83-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlkaloidsAnti-Parkinson Drugs +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etymemazine DB11517
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etynodiol DB13866
small molecule | CAS: 1231-93-2

Etynodiol (INN), or ethynodiol (BAN) is a steroidal progestin related to norethisterone which was never marketed. While etynodiol is sometimes used as a synonym for etynodiol diacetate, it usually refers to etynodiol diacetate (see [DB00823]), not etynodiol.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EU204 DB17438
biotech

EU204 (EBViNT) is an Epstein-Barr virus (EBV)-positive T-cell therapy currently undergoing phase 1 and 2a clinical trials in Korea for patients with EBV-positive lymphoma and solid cancer.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptol DB03852
small molecule | CAS: 470-82-6

Eucalyptol is naturally produced cyclic ether and monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effe…

Kategori:
AgrochemicalsAlcoholsAnti-Infective Agents +29
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptus globulus leaf Approved DB14320
biotech

Eucalyptus globulus leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptus globulus pollen Approved DB10470
biotech

Eucalyptus globulus pollen is the pollen of the Eucalyptus globulus plant. Eucalyptus globulus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptus gum Approved DB15537
biotech | CAS: 9000-20-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptus oil Approved DB11114
biotech | CAS: 8000-48-4

Eucalyptus oil is a distilled oil derived from the leaves of the tree Eucalyptus. It is shown to be effective in reducing pain, swelling, and inflammation via its modulatory effect on the immune response. It is also shown to exhibit antibacterial activity aga…

Kategori:
Biological ProductsComplex MixturesDrugs that are Mainly Renally Excreted +6
Waktu ParuhStudies have determ…
Vol. DistribusiStudies have determ…
KlirensStudies have determ…
Genetik -
biotech

Eucommia ulmoides bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesPharmaceutical Preparations +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Euflavine DB13326
small molecule | CAS: 86-40-8

Deskripsi belum tersedia.

Kategori:
Acridine DerivativesAcridinesAntiseptics and Disinfectants +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eupatilin DB16885
small molecule | CAS: 22368-21-4

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesDrugs, Chinese Herbal +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Eupatorium capillifolium pollen is the pollen of the Eupatorium capillifolium plant. Eupatorium capillifolium pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
European pilchard Approved DB10622
biotech

European pilchard allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eurotium amstelodami Approved DB15526
biotech

Eurotium amstelodami allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eurotium herbariorum Approved DB10695
biotech

Eurotium herbariorum is a fungus which can provoke allergic reactions. Eurotium herbariorum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Eutrema japonicum whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 6551–6600 dari 15718
Sebelumnya Halaman 132 / 315 Berikutnya