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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 131 / 321
E-6005 DB12776
small molecule | CAS: 947620-48-6

E6005 has been used in trials studying the treatment of Atopic Dermatitis.

Kategori:
Acids, CarbocyclicAntipruriticsHeterocyclic Compounds, Fused-Ring +2
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E-6201 DB11687
small molecule | CAS: 603987-35-5

E6201 has been investigated for the treatment of Chronic Plaque Psoriasis.

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E-7820 DB12505
small molecule | CAS: 289483-69-8

E7820 has been investigated for the treatment of Colon Cancer and Rectal Cancer.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
Integrin alpha-2
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E1v1.11 DB18363
biotech

E1v1.11 is an antisense oligonucleotide targeting the _SMN2_ gene which is under investigation for the treatment of spinal muscular atrophy (SMA).[L48196]

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E5531 DB06447
small molecule | CAS: 162679-36-9

E5531 is an endotoxin antagonist.

Kategori:
AntigensAntigens, BacterialBacterial Toxins +8
Target Protein:
Toll-like receptor 4
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E7107 DB12508
small molecule | CAS: 630100-90-2

E7107 has been used in trials studying the treatment of Cancer.

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EA-230 DB19114
small molecule | CAS: 503844-09-5

EA-230 is under investigation in clinical trial NCT03145220 (Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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EA-2353 DB18506
small molecule

EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway.

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EB003 DB18362
biotech

EB003 is a CRISPR-based sequence-specific antimicrobial (SSAM) targeted against shiga toxin-producing _E. coli_.

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EB05 DB16477
biotech | CAS: 2641646-59-3

EB05, in combination with standard of care (SOC), is being investigated in clinical trial NCT04401475 to evaluate its safety and efficacy in adult hospitalized patients with COVID-19 and ARDS.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Ebastine Approved DB11742
small molecule | CAS: 90729-43-4

Ebastine is under investigation for the treatment of Irritable Bowel Syndrome (IBS). Ebastine has been investigated for the treatment of Urticaria.

Kategori:
Antihistamines for Systemic UseCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +9
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Eberconazole DB13656
small molecule | CAS: 128326-82-9

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseCycloparaffins +2
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biotech

Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by _Zaire ebolavirus_ in adults, prevent outbreaks, and reduce the extent of the virus spreading in case of outbreaks.[L10854] Ebola virus disease, formerly known as Ebola hemorrhagic…

Kategori:
ImmunizationImmunologic FactorsVaccines +1
Waktu ParuhThere is limited ph…
Vol. DistribusiThere is limited ph…
KlirensThere is limited ph…
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Ebopiprant DB16147
small molecule | CAS: 2005486-31-5

Ebopiprant is under investigation in clinical trial NCT03369262 (Poc Study of OBE022 in Threatened Preterm Labour).

Kategori:
Sulfur CompoundsThiazoles
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Ebselen DB12610
small molecule | CAS: 60940-34-3

Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus.

Kategori:
Agents that produce hypertensionAnalgesicsAnalgesics, Non-Narcotic +17
Target Protein:
AlbuminLysine-specific demethylase 4ABifunctional epoxide hydrolase 2
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Ebvaciclib DB18967
small molecule | CAS: 2185857-97-8

Ebvaciclib is under investigation in clinical trial NCT03519178 (A Study of PF-06873600 in People With Cancer).

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EC-0652 DB15340
small molecule | CAS: 1025066-50-5

EC-0652 is under investigation in clinical trial NCT02202447 (Phase 1 of EC1169 In Patients With Recurrent MCRPC).

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EC-17 DB12559
small molecule | CAS: 583037-91-6

Folate Fitc has been used in trials studying the diagnostic of Ovarian Cancer.

Target Protein:
Folate receptor alpha
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Ecabet DB05265
small molecule | CAS: 33159-27-2

Ecabet is a prescription eye drop for the treatment of dry eye syndrome. Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia. Mucin is a glycoprotein component…

Kategori:
Anti-Infective AgentsAnti-Ulcer AgentsAnticarcinogenic Agents +10
Target Protein:
Urease subunit alphaNADPH oxidase organizer 1
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Ecallantide Approved DB05311
biotech | CAS: 460738-38-9

Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in _Pichia pastoris_ yeast cells that contains three …

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +10
Target Protein:
Plasma kallikrein
Waktu ParuhFollowing subcutane…
Vol. DistribusiThe volume of distr…
KlirensPlasma clearance wa…
Genetik -
Ecamsule Approved DB09534
small molecule | CAS: 92761-26-7

Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability. Ecamsule has been approved for use in the U.S. since 2006, but only a…

Kategori:
AcidsAcids, NoncarboxylicBicyclic Monoterpenes +12
Waktu ParuhEcamsule is not abs…
Vol. DistribusiEcamsule is intende…
KlirensEcamsule is used to…
Genetik -
Ecgonine DB01525
small molecule | CAS: 481-37-8

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnalgesicsAza Compounds +7
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Echinacea angustifolia root Approved DB14237
biotech

Deskripsi belum tersedia.

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Echinacoside DB15488
small molecule | CAS: 82854-37-3

Echinacoside is a phenylethanoid glycoside isolated from _Echinacea angustifolia_ in 1950, and currently being investigated for the treatment of Parkinson's, Alzheimer's, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis.[A184577] E…

Kategori:
CarbohydratesCOMT SubstratesHerbs and Natural Products
Target Protein:
Growth hormone secretagogue receptor type 1Androgen receptor
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Echinomycin DB15582
small molecule | CAS: 512-64-1

Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from _Streptomyces echinatus_ that binds to DNA and inhibits RNA synthesis.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
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Echothiophate Approved DB01057
small molecule | CAS: 6736-03-4

A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.

Kategori:
Antiglaucoma Preparations and MioticsAutonomic AgentsCholinergic Agents +15
Target Protein:
CholinesteraseAcetylcholinesterase
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Ecklonia cava DB19252
biotech

Deskripsi belum tersedia.

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Ecnoglutide DB19019
biotech | CAS: 2459531-73-6

Ecnoglutide is under investigation in clinical trial NCT05813795 (A Phase 3 Study to Evaluate the Efficacy of XW003 in Adults With Overweight or Obesity).

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Econazole Approved DB01127
small molecule | CAS: 27220-47-9

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +21
Target Protein:
Lanosterol 14-alpha demethylaseNuclear receptor subfamily 1 group I member 2
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Ecopipam DB12273
small molecule | CAS: 112108-01-7

Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +7
Target Protein:
D(1A) dopamine receptor
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Ecraprost DB16148
small molecule | CAS: 136892-64-3

Ecraprost is under investigation in clinical trial NCT00059657 (Efficacy/safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease).

Kategori:
AutacoidsBiological FactorsEicosanoids +5
Target Protein:
Prostaglandin E2 receptor EP1 subtype
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Ecromeximab DB12797
biotech | CAS: 292819-64-8

Ecromeximab has been used in trials studying the treatment of Cutaneous Melanoma and Metastatic Melanoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
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ECT204 DB18605
biotech

ECT204 is an autologous T-cell therapy whereby T cells are genetically modified to target tumor-specific antigens.

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Ectoine DB19171
small molecule | CAS: 96702-03-3

Ectoine is under investigation in clinical trial NCT03186755 (Clinical Evaluation of Hylo-dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis).

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
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Eculizumab Approved DB01257
biotech | CAS: 219685-50-4

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab w…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +14
Target Protein:
Complement C5
Waktu ParuhThe half life of ec…
Vol. DistribusiThe volume of distr…
KlirensPharmacokinetic pro…
Genetik -
Edaglitazone DB06519
small molecule | CAS: 213411-83-7

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Target Protein:
Peroxisome proliferator-activated receptor gamma
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Edaravone Approved DB12243
small molecule | CAS: 89-25-8

Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers.[A19140] Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophi…

Kategori:
AntioxidantsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +14
Target Protein:
Apoptosis regulator Bcl-2
Waktu ParuhThe mean terminal e…
Vol. DistribusiAfter intravenous a…
KlirensFollowing intraveno…
Genetik -
Edasalonexent DB15010
small molecule | CAS: 1204317-86-1

Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).

Kategori:
AmidesEicosanoidsFatty Acids +3
Target Protein:
Nuclear factor NF-kappa-B p105 subunitTranscription factor RelBNuclear factor NF-kappa-B p100 subunit +2
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Edecesertib DB18917
small molecule | CAS: 2408839-73-4

Edecesertib is under investigation in clinical trial NCT05629208 (Study of Edecesertib in Participants With Cutaneous Lupus Erythematosus (CLE)).

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small molecule | CAS: 62-33-9

Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body.[L12774] It is on the World Health Organization Model List of Essential Medicines.[A204173] Edetate calcium disodium was granted FDA…

Kategori:
AcetatesAcids, AcyclicAmines +26
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 14025-15-1

Deskripsi belum tersedia.

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Edetate disodium anhydrous Approved DB14600
small molecule | CAS: 139-33-3

Edetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.[A204275]

Kategori:
Calcium BinderCalcium Chelating ActivityCalcium Chelating Agents +8
Target Protein:
LeadIronManganese cation
Waktu Paruh-
Vol. DistribusiData regarding the …
KlirensThe mean clearance …
Genetik -
Edetate sodium DB13404
small molecule | CAS: 64-02-8

Deskripsi belum tersedia.

Kategori:
OphthalmologicalsSensory Organs
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Edetic acid Approved DB00974
small molecule | CAS: 60-00-4

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Kategori:
AcetatesAcids, AcyclicAmines +19
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
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EDI-200 DB18188
biotech

EDI-200 is a fusion protein consisting of human immunoglobim G1 constant region Fc region fused to the human receptor binding domain of ectodysplasin-A1.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Proteins +17
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Edifoligide DB06556
biotech | CAS: 476273-48-0

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
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EDIT-101 DB18687
biotech

EDIT-101 is a recombinant adeno-associated virus pseudotyped with serotype 5 viral capsid encoding CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats associated protein 9) gene editing constructs.

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EDIT-301 DB18645
biotech

EDIT-301 is an investigational cell therapy consisting of autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the gamma globin gene (HBG1 and HBG2).

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Edivoxetine DB09184
small molecule | CAS: 1194508-25-2

Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment. Edivoxetine failed to be approved for maj…

Kategori:
Adrenergic Uptake InhibitorsAlcoholsAntidepressive Agents +2
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Edobacomab DB17779
biotech | CAS: 141410-98-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
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