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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 125 / 272
small molecule | CAS: 303-40-2

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorescein Approved DB00693
small molecule | CAS: 2321-07-5

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA f…

Kategori:
BSEP/ABCB11 SubstratesColoring AgentsColouring Agents +21
Target Protein:
Organic anion transporter 3Immunoglobulin kappa variable 2-30DNA
Waktu Paruh-
Vol. Distribusi* 0.5 L/kg
Klirens* renal cl=1.75 mL/…
Genetik -
small molecule | CAS: 140616-46-2

Fluorescein lisicol has been used in trials studying the diagnostic of Pharmacokinetics, Hepatic Cirrhosis, Hepatitis, Viral, Human, Nonalcoholic Steatohepatitis, and Non-Alcoholic Fatty Liver Disease.

Kategori:
Heterocyclic Compounds, Fused-RingSpiro CompoundsXanthenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorescin DB07764
small molecule | CAS: 518-44-5

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoride ion F-18 Approved DB09398
small molecule | CAS: 67862-54-8

Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intra…

Kategori:
Diagnostic RadiopharmaceuticalsRadioactive Diagnostic AgentRadiopharmaceutical Activity +1
Waktu Paruh110 min.
Vol. Distribusi0.5-0.7 L/Kg
KlirensRenal clearance for…
Genetik -
Fluorine F-18 DB13134
small molecule | CAS: 13981-56-1

Fluorine-18 is under investigation in clinical trial NCT00870974 (A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions).

Kategori:
IsotopesRadioisotopes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7574-44-9

Fluoroacetic acid F-18 is under investigation in clinical trial NCT01320787 (18-F-Fluoroacetate as PET Imaging Agent).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 864084-85-5

Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).

Kategori:
Compounds used in a research, industrial, or household settingDiagnostic Uses of ChemicalsFluorine Radioisotopes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 407582-13-2

Deskripsi belum tersedia.

Kategori:
AlcoholsAminesAmino Alcohols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 865838-26-2

Fluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosidesPyrimidine Nucleosides +2
Target Protein:
DNA (cytosine-5)-methyltransferase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorodopa (18F) Approved DB13848
small molecule | CAS: 92812-82-3

Fluorodopa F 18 is a fluorinated analog of [levodopa] used as a diagnostic agent for positron emission tomography (PET) in the evaluation of Parkinsonian syndromes.[L12849] Fluorodopa F 18 PET is used adjunctly with other diagnostic investigations and serves …

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +8
Waktu ParuhThe plasma half-lif…
Vol. Distribusi-
KlirensThe agent is cleare…
Genetik -
Fluoroestradiol F-18 Approved DB15690
small molecule | CAS: 94153-53-4

Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions.[L14096] The ability to image ER-positive tumors _in vivo_ is advantageous in that, while helping to visualize tum…

Kategori:
Estradiol CongenersEstranesEstrogens +10
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. DistribusiAs fluoroestradiol …
KlirensFluoroestradiol F-1…
Genetik -
small molecule | CAS: 160388-43-2

Fluorofuranylnorprogesterone F-18 is under investigation in clinical trial NCT02455453 (Assessment of Functional Status of Estrogen Receptors in Breast Cancer by Positron Emission Tomography).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorometholone Approved DB00324
small molecule | CAS: 426-13-1

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Kategori:
Adrenal Cortex HormonesAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnti-Acne Preparations +32
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104613-87-8

Fluoromisonidazole F-18 is under investigation in clinical trial NCT01507428 (Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoxetine Approved DB00472
small molecule | CAS: 54910-89-3

Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).[A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to ma…

Kategori:
Agents that reduce seizure thresholdAminesAnticholinergic Agents +47
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2CNeuronal acetylcholine receptor subunit alpha-2 +4
Waktu ParuhThe half life of fl…
Vol. DistribusiThe volume of distr…
KlirensThe clearance value…
Genetik -
Fluoxymesterone Approved DB01185
small molecule | CAS: 76-43-7

An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.

Kategori:
3-Oxoandrosten (4) DerivativesAnabolic AgentsAndrogens +11
Target Protein:
Androgen receptorEstrogen receptorGlucocorticoid receptor +1
Waktu Paruh9.2 hours
Vol. Distribusi-
Klirens-
Genetik -
Flupentixol Approved DB00875
small molecule | CAS: 2709-56-0

Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is pro…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +35
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 2A +5
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensFollowing oral admi…
Genetik -
Fluperolone DB13491
small molecule | CAS: 3841-11-0

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids, Dermatological Preparations +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluphenazine Approved DB00623
small molecule | CAS: 69-23-8

A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.

Kategori:
Agents that reduce seizure thresholdAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +24
Target Protein:
5-hydroxytryptamine receptor 1BD(2) dopamine receptorD(1A) dopamine receptor +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flupirtine DB06623
small molecule | CAS: 56995-20-1

Flupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibro…

Kategori:
AminesAnalgesicsCentral Nervous System Agents +5
Target Protein:
Alpha-2A adrenergic receptor
Waktu Paruh6.5 hrs (average), …
Vol. Distribusi-
Klirens-
Genetik -
Fluprednidene DB08970
small molecule | CAS: 2193-87-5

Fluprednidene is a corticosteroid.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids, Dermatological Preparations +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1255-35-2

Fluprednidene acetate is a corticosteroid. It has anti-inflammatory and anti-allergic properties.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCytochrome P-450 CYP3A Inducers +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluprednisolone Approved DB09378
small molecule | CAS: 53-34-9

A synthetic glucocorticoid with anti-inflammatory properties.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 570-36-5

Deskripsi belum tersedia.

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluralaner DB11414
small molecule | CAS: 864731-61-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurandrenolide Approved DB00846
small molecule | CAS: 1524-88-5

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +16
Target Protein:
Steroid hormone receptor ERR1Steroid hormone receptor ERR2Estrogen-related receptor gamma +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2802-11-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurazepam Approved DB00690
small molecule | CAS: 17617-23-1

A benzodiazepine derivative used mainly as a hypnotic.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +22
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean apparent h…
Vol. Distribusi-
Klirens-
Genetik -
Flurbiprofen Approved DB00712
small molecule | CAS: 5104-49-4

Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and ankly…

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +37
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhR-flurbiprofen, 4.7…
Vol. Distribusi* 14 L [Normal Heal…
Klirens-
Genetik -
small molecule | CAS: 91503-79-6

Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients).

Kategori:
Acids, AcyclicAnalgesicsAnalgesics, Non-Narcotic +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurithromycin DB13338
small molecule | CAS: 82664-20-8

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurothyl DB08969
small molecule | CAS: 333-36-8

Flurothyl is a convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.

Kategori:
Central Nervous System AgentsCentral Nervous System StimulantsConvulsants +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 863887-89-2

Flurpiridaz F-18 is a radioactive diagnostic drug indicated for positron emission tomography (PET) myocardial perfusion imaging (MPI), which is an imaging process used in patients with known or suspected coronary artery disease (CAD).[A264519] Flurpiridaz F-1…

Kategori:
Fluorine RadioisotopesRadioactive Diagnostic Agent
Target Protein:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Waktu ParuhFluorine-18 has a h…
Vol. DistribusiFlurpiridaz F-18 di…
Klirens-
Genetik -
small molecule | CAS: 1211333-21-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flutamide Approved DB00499
small molecule | CAS: 13311-84-7

An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Kategori:
AmidesAminesAndrogen Receptor Antagonists +19
Target Protein:
Androgen receptorAryl hydrocarbon receptorNuclear receptor subfamily 1 group I member 2
Waktu ParuhThe plasma half-lif…
Vol. Distribusi-
Klirens-
Genetik -
Flutemetamol DB15058
small molecule | CAS: 637003-10-2

Flutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).

Kategori:
AminesCompounds used in a research, industrial, or household settingContrast Media +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flutemetamol (18F) Approved DB09151
small molecule | CAS: 765922-62-1

Flutemetamol (18F) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18. It is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate ? amyloid neuritic plaque density in adult patients with cognitive impair…

Kategori:
AminesCentral Nervous SystemCompounds used in a research, industrial, or household setting +11
Target Protein:
Amyloid-beta precursor protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluticasone Approved DB13867
small molecule | CAS: 90566-53-3

Fluticasone is a synthetic glucocorticoid available as 2 esters, [DB08906] and [DB00588][F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F…

Kategori:
Adrenal Cortex HormonesAndrostadienesAndrostanes +42
Target Protein:
Glucocorticoid receptorProgesterone receptorCytosolic phospholipase A2 +1
Waktu Paruh15.1 hours for intr…
Vol. Distribusi608L at steady stat…
Klirens57.8L/h for [DB0890…
Genetik -
Fluticasone furoate Approved DB08906
small molecule | CAS: 397864-44-7

Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label][F4364]. Fluticasone furoate was first approved in 2007[L5965].

Kategori:
Adrenal Cortex HormonesAgents to Treat Airway DiseaseAndrostanes +32
Target Protein:
Glucocorticoid receptorProgesterone receptorMineralocorticoid receptor
Waktu ParuhFollowing repeat-do…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
Fluticasone propionate Approved DB00588
small molecule | CAS: 80474-14-2

Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved …

Kategori:
Adrenal Cortex HormonesAdrenalsAgents to Treat Airway Disease +35
Target Protein:
Glucocorticoid receptorProgesterone receptorCytosolic phospholipase A2 +1
Waktu Paruh7.8 hours for intra…
Vol. DistribusiThe volume of distr…
Klirens1093mL/min for flut…
Genetik -
small molecule | CAS: 1274863-98-7

Flutriciclamide F-18 is under investigation in clinical trial NCT02350426 (A Study to Assess Inflammation in Rheumatoid Arthritis Using Molecular Imaging Techniques).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flutrimazole DB13425
small molecule | CAS: 119006-77-8

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluvastatin Approved DB01095
small molecule | CAS: 93957-54-1

Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belo…

Kategori:
Agents Causing Muscle ToxicityCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2B6 Inducers (strength unknown) +35
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHistone deacetylase 2
Waktu Paruh3 hours
Vol. Distribusi* 0.35 L/kg
Klirens* 0.8 L/h/kg * 107…
Genetik -
Fluvoxamine Approved DB00176
small molecule | CAS: 54739-18-3

Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in c…

Kategori:
AminesAnti-Anxiety AgentsAntidepressive Agents +44
Target Protein:
Sodium-dependent serotonin transporterVoltage-gated inwardly rectifying potassium channel KCNH2
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +3
Waktu Paruh15.6 hours [FDA Lab…
Vol. Distribusi* 25 L/kg [FDA Labe…
Klirens-
Genetik 6 Varian
Fluzoparib DB15637
small molecule | CAS: 1358715-18-0

Fluzoparib is under investigation in clinical trial NCT03863860 (A Trial of Maintenance Treatment With Fluzoparib Versus Placebo in Relapsed Ovarian Cancer Patients).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsPoly(ADP-ribose) Polymerase Inhibitors +1
Target Protein:
Poly [ADP-ribose] polymerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FN-1501 DB17383
small molecule | CAS: 1429515-59-2

Deskripsi belum tersedia.

Target Protein:
Cyclin-dependent kinase 2Receptor-type tyrosine-protein kinase FLT3Cyclin-dependent kinase 4 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fobrepodacin DB18409
small molecule | CAS: 1384984-31-9

Deskripsi belum tersedia.

Target Protein:
DNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Folic acid Approved DB00158
small molecule | CAS: 59-30-3

Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and m…

Kategori:
Antianemic PreparationsAutacoidsBCRP/ABCG2 Substrates +19
Target Protein:
Proton-coupled folate transporterReduced folate transporterFolate receptor gamma +2
Waktu Paruh-
Vol. DistribusiTetrahydrofolic aci…
Klirens-
Genetik -
Menampilkan 6201–6250 dari 13591
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