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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
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15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 125 / 315
Elzovantinib DB18918
small molecule | CAS: 2271119-26-5

Elzovantinib is under investigation in clinical trial NCT03993873 (Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET).

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EM-1745 DB02323
small molecule

Deskripsi belum tersedia.

Kategori:
17-Hydroxysteroid Dehydrogenases, antagonists & inhibitorsEstradiol CongenersEstranes +7
Target Protein:
17-beta-hydroxysteroid dehydrogenase type 1
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Emactuzumab DB14905
biotech | CAS: 1448221-67-7

Emactuzumab is under investigation in clinical trial NCT01494688 (A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Emapalumab Approved DB14724
biotech | CAS: 1709815-23-5

Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapal…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +14
Target Protein:
Interferon gamma
Waktu ParuhEmapalumab eliminat…
Vol. DistribusiThe central and per…
KlirensEmapalumab clearanc…
Genetik -
Emapunil DB12666
small molecule | CAS: 226954-04-7

Emapunil has been used in trials studying the basic science and diagnostic of Baseline, Blocking Receptor Binding, and Neurodegenerative Disorders.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Translocator protein
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Emavusertib DB18060
small molecule | CAS: 1801344-14-8

Deskripsi belum tersedia.

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EMB-01 DB16091
biotech

EMB-01 is under investigation in clinical trial NCT03797391 (A Dose Escalation Study of EMB-01 in Participants With Advanced/metastatic Solid Tumors).

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Embutramide DB01487
small molecule | CAS: 15687-14-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAminesAminobenzoates +7
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EMD-1201081 DB06181
biotech | CAS: 847484-35-9

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
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Emedastine Approved DB01084
small molecule | CAS: 87233-61-2

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Kategori:
Anti-Allergic AgentsDecongestants and AntiallergicsHeterocyclic Compounds, Fused-Ring +9
Target Protein:
Histamine H1 receptor
Waktu ParuhThe elimination hal…
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Emepronium DB13505
small molecule | CAS: 27892-33-7

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAmines +19
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
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Emeramide DB12192
small molecule | CAS: 351994-94-0

Emeramide has been used in trials studying the treatment of Mercury Poisoning.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingSequestering Agents +1
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Emerfetamab DB18474
biotech | CAS: 2250261-27-7

Emerfetamab is a bispecific T cell engager antibody construct with a half-life extension Fc moiety capable of binding to the neonatal Fc receptor.

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Emetine DB13393
small molecule | CAS: 483-18-1

Deskripsi belum tersedia.

Kategori:
Agents Causing Muscle ToxicityAlkaloidsAmebicides +14
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small molecule | CAS: 5982-52-5

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
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Emfilermin DB06562
small molecule | CAS: 159075-60-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCytokines +3
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EMI-137 DB19174
biotech

EMI-137 is under investigation in clinical trial NCT03360461 (EMI-137 in Laparoscopic Colonic Resections).

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Emibetuzumab DB11849
biotech | CAS: 1365287-97-3

Emibetuzumab has been used in trials studying the treatment of Advanced Cancer, Renal Cell Carcinoma, Hepatocellular Cancer, Gastric Adenocarcinoma, and Non-Small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Emicerfont DB12910
small molecule | CAS: 786701-13-1

Emicerfont has been used in trials studying the diagnostic and treatment of Social Anxiety Disorder and Irritable Bowel Syndrome (IBS).

Kategori:
Corticotropin-Releasing Hormone, antagonists & inhibitors
Target Protein:
Corticotropin-releasing factor receptor 1
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Emicizumab Approved DB13923
biotech | CAS: 1610943-06-0

Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three differen…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Coagulation factor IXCoagulation factor X
Waktu ParuhEmcicizumab present…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Emivirine DB08188
small molecule | CAS: 149950-60-7

Emivirine has been used in trials studying the treatment of HIV Infections.

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +5
Target Protein:
Gag-Pol polyproteinGag-Pol polyprotein
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Emixustat DB12608
small molecule | CAS: 1141777-14-1

Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration.

Kategori:
AlcoholsAminesAmino Alcohols +4
Target Protein:
Retinoid isomerohydrolase
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Emlenoflast DB18304
small molecule | CAS: 1995067-59-8

Deskripsi belum tersedia.

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Emodepside DB11403
biotech | CAS: 155030-63-0

Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntiparasitic Agents +2
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Emodin DB07715
small molecule | CAS: 518-82-1

Emodin has been investigated for the treatment of Polycystic Kidney.

Kategori:
AnthracenesAnthraquinonesBiological Products +7
Target Protein:
Casein kinase II subunit alphaPutative ketoacyl reductase3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ +1
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Emopamil DB14064
small molecule | CAS: 78370-13-5

Prevents renal injury after warm & cold ischemia.

Kategori:
Agents causing hyperkalemiaAminesAntiarrhythmic agents +11
Target Protein:
ATP-dependent translocase ABCB1
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Emoxypine DB19172
small molecule | CAS: 2364-75-2

Emoxypine is under investigation in clinical trial NCT06221826 (MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure).

Kategori:
Antiarrhythmic agentsAntioxidantsAntiplatelet agents +13
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Empagliflozin Approved DB09038
small molecule | CAS: 864070-44-0

Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.[A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other …

Kategori:
Alimentary Tract and MetabolismBCRP/ABCG2 SubstratesBenzene Derivatives +16
Target Protein:
Sodium/glucose cotransporter 2
Waktu ParuhThe apparent termin…
Vol. DistribusiThe estimated appar…
KlirensApparent oral clear…
Genetik -
Empasiprubart DB16469
biotech | CAS: 2579031-19-7

Empasiprubart is a humanized sweeping antibody designed to bind to C2, a protein in the complement cascade that leads to cell destruction when activated.[L50783]

Kategori:
Experimental Unapproved Treatments for COVID-19
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Empegfilgrastim DB16155
biotech | CAS: 1192706-53-8

Empegfilgrastim is under investigation in clinical trial NCT01569087 (Dose-finding Study of Empegfilgrastim for Neutropenia Prophylaxis in Patients With Breast Cancer).

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsColony-Stimulating Factors
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Emprumapimod DB17603
small molecule | CAS: 765914-60-1

Emprumapimod is a potent, orally active and selective inhibitor of p38? mitogen-activated kinase inhibitor. It was investigated for dilated cardiomyopathy.

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Emraclidine DB18706
small molecule | CAS: 2170722-84-4

Deskripsi belum tersedia.

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Emricasan DB05408
small molecule | CAS: 254750-02-2

Emricasan is the first caspase inhibitor tested in human which has received orphan drug status by FDA. It is developed by Pfizer and made in such a way that it protects liver cells from excessive apoptosis.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Caspase-1Caspase-3Caspase-7
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Emrusolmin DB13927
small molecule | CAS: 882697-00-9

Emrusolmin restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. [A31409]

Kategori:
DioxolesHeterocyclic Compounds, Fused-Ring
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Emtricitabine Approved DB00879
small molecule | CAS: 143491-57-0

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults.[L9010] Emtri…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +23
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyprotein
Waktu ParuhThe half life of em…
Vol. DistribusiThe apparent centra…
KlirensEmtricitabine has a…
Genetik -
Emvododstat DB18010
small molecule | CAS: 1219951-09-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-RingIndoles
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Emylcamate DB13572
small molecule | CAS: 78-28-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAnti-Anxiety AgentsCarbamates +3
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EMZ702 DB05021
small molecule

EMZ702, a non-toxic agent that has strong anti-viral synergy with interferon, is an ideal candidate for combination with current standard hepatitis C treatments. EMZ702 has an excellent safety profile and the combination of EMZ702 with interferon and ribaviri…

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ENA-001 DB18153
small molecule | CAS: 1380341-99-0

Deskripsi belum tersedia.

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Enadenotucirev DB14873
biotech | CAS: 1402042-02-7

Enadenotucirev is under investigation in clinical trial NCT02636036 (Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors).

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Enadoline DB16967
small molecule | CAS: 124378-77-4

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCardiovascular AgentsCentral Nervous System Agents +4
Target Protein:
Kappa-type opioid receptor
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Enalapril Approved DB00584
small molecule | CAS: 75847-73-3

Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +21
Target Protein:
Angiotensin-converting enzyme
Waktu ParuhThe average termina…
Vol. DistribusiThe volume of distr…
KlirensFollowing oral admi…
Genetik -
Enalkiren DB03395
small molecule | CAS: 113082-98-7

Deskripsi belum tersedia.

Kategori:
Agents Acting on the Renin-Angiotensin SystemAmino Acids, Peptides, and ProteinsEnzyme Inhibitors +4
Target Protein:
Renin
Waktu Paruh-
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biotech | CAS: 1912424-97-5

Enapotamab vedotin is under investigation in clinical trial NCT02988817 (Enapotamab Vedotin (Humax-axl-adc) Safety Study in Patients With Solid Tumors).

Kategori:
Antibody-drug Conjugates
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Enarodustat DB14985
small molecule | CAS: 1262132-81-9

Enarodustat is under investigation in clinical trial NCT02581124 (Study to Evaluate Effect of Lapatinib on Pharmacokinetics of JTZ-951 in Subjects With End-stage Renal Disease).

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsPeptides +1
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Enasidenib Approved DB13874
small molecule | CAS: 1446502-11-9

Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +62
Target Protein:
Isocitrate dehydrogenase [NADP] cytoplasmicIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIsocitrate dehydrogenase [NAD] subunit beta, mitochondrial +2
Waktu ParuhEnasidenib has a te…
Vol. DistribusiThe mean volume of …
KlirensEnasidenib has a me…
Genetik -
Enavogliflozin DB18970
small molecule | CAS: 1415472-28-4

Enavogliflozin is under investigation in clinical trial NCT06399835 (Enavogliflozin vs. Pioglitazone on Glucose and Atherosclerosis).

Kategori:
Heterocyclic Compounds, Fused-Ring
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ENB-003 DB17340
small molecule

ENB-003 is a selective and potent inhibitor of the endothelin B receptor (ETBR) being investigated for cancer.

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Enbucrilate DB12358
small molecule | CAS: 6606-65-1

Enbucrilate is under investigation in clinical trial NCT02468206 (Secondary Prophylaxis of Gastric Variceal Bleed).

Kategori:
Acids, AcyclicAcrylatesCompounds used in a research, industrial, or household setting +5
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Encainide Approved DB01228
small molecule | CAS: 66778-36-7

All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufac…

Kategori:
AmidesAminesAnilides +13
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu Paruh1-2 hours
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