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14361

Total database: 17430
Struktur (SMILES)
9916 (69.0%)
Target
7893 (55.0%)
Genomik
112 (0.8%)
Referensi
14361 (100.0%)

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Hasil Pencarian (14361)

Halaman 124 / 288
Exlinkibart DB17474
biotech | CAS: 2642171-64-8

Deskripsi belum tersedia.

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biotech

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biotech

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biotech

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EXT608 DB18453
biotech

EXT608 is a long-acting PTH derivative under investigation for the treatment of hyperparathyroidism.[L48270]

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Ezabenlimab DB17483
biotech | CAS: 2249882-54-8

Deskripsi belum tersedia.

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biotech | CAS: 2226647-27-2

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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Ezatiostat DB05460
small molecule | CAS: 168682-53-9

Ezatiostat is investigated in clinical trials for treating myelodysplastic syndrome. This compound belongs to the peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation o…

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Target Protein:
Glutathione S-transferase P
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Ezeprogind DB16954
small molecule | CAS: 615539-20-3

Deskripsi belum tersedia.

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Ezetimibe Approved DB00973
small molecule | CAS: 163222-33-1

Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it …

Kategori:
Anticholesteremic AgentsAzetinesBCRP/ABCG2 Substrates +20
Target Protein:
NPC1-like intracellular cholesterol transporter 1Sterol O-acyltransferase 1Aminopeptidase N
Waktu ParuhBoth ezetimibe and …
Vol. DistribusiThe relative volume…
KlirensThere are no pharma…
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Ezogabine Approved DB04953
small molecule | CAS: 150812-12-7

Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunct…

Kategori:
Acids, AcyclicAminesAniline Compounds +15
Target Protein:
Potassium voltage-gated channel subfamily KQT member 3Potassium voltage-gated channel subfamily KQT member 2Potassium voltage-gated channel subfamily KQT member 4 +1
Waktu ParuhTerminal half-life …
Vol. Distribusi8.7 L/kg
Klirens0.58 - 0.76 L/h·kg.…
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Ezurpimtrostat DB16458
small molecule | CAS: 1914148-72-3

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
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Ezutromid DB12888
small molecule | CAS: 945531-77-1

Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne.

Kategori:
Heterocyclic Compounds, Fused-RingMuscular Dystrophy, Duchenne
Target Protein:
Utrophin
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F-15599 DB16936
small molecule | CAS: 635323-95-4

Deskripsi belum tersedia.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +3
Target Protein:
5-hydroxytryptamine receptor 1A
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small molecule | CAS: 78-96-6

Deskripsi belum tersedia.

Target Protein:
Glutamate mutase sigma subunit
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F6-734 DB17444
biotech

F6-734 is a bispecific monoclonal antibody with affinity for anticarcinoembryonic antigen (CEA) and anti-diethylenetriamine pentaacetic acid (DTPA) (hMN-14 × m734).[A255217,A255222]

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Factor IX Complex (Human) Approved DB11330
biotech | CAS: 37224-63-8

Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (an…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +6
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Factor XIII (human) Approved DB12909
biotech | CAS: 9013-56-3

Factor XIII (human) is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade [FDA Label]. For people with congenital deficiency…

Kategori:
AcyltransferasesAmino Acids, Peptides, and ProteinsAminoacyltransferases +14
Waktu Paruh6.6 ±2.29 days [FDA…
Vol. DistribusiVss = 51.1 mL/kg (v…
Klirens0.25 ±0.09 mL/hr/kg…
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Fagus grandifolia pollen Approved DB10350
biotech

Fagus grandifolia pollen is the pollen of the Fagus grandifolia plant. Fagus grandifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Faldaprevir DB11808
small molecule | CAS: 801283-95-4

Faldaprevir has been investigated for the treatment of Chronic Hepatitis C.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Branched-Chain +16
Target Protein:
Gag-Pol polyprotein
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Fallypride DB15167
small molecule | CAS: 166173-78-0

Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +5
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Fallypride F-18 DB19254
small molecule | CAS: 166173-82-6

Fallypride F-18 is under investigation in clinical trial NCT00846040 (Reduced Carbohydrate Versus Fat in Obese Subjects).

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Falnidamol DB12966
small molecule | CAS: 196612-93-8

Falnidamol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

Target Protein:
Epidermal growth factor receptor
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Famciclovir Approved DB00426
small molecule | CAS: 104227-87-4

Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +12
Target Protein:
DNA polymerase catalytic subunit
Waktu Paruh10 hours
Vol. Distribusi* 1.08±0.17 L/kg [h…
Klirens* 36.6 +/- 6.3 L/hr…
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Famotidine Approved DB00927
small molecule | CAS: 76824-35-6

Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease …

Kategori:
Acid ReducersAlimentary Tract and MetabolismAnti-Ulcer Agents +20
Target Protein:
Histamine H2 receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe steady-state vo…
KlirensRenal clearance is …
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Famphur DB11408
small molecule | CAS: 52-85-7

Deskripsi belum tersedia.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsecticides +8
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Famprofazone DB16702
small molecule | CAS: 22881-35-2

Famprofazone is a nonsteroidal anti-inflammatory agent found in combination products such as ‘Gewodin’ which is marketed in Taiwan.[L34724] It is important to note that the drug is metabolized to [methamphetamine] and [amphetamine] in the body and can lead to…

Kategori:
AminesAmphetaminesAnalgesics +7
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Famtozinameran Approved DB17088
biotech

The Omicron variant of SARS-CoV-2 is a variant of concern that was first reported in November 2021.[L43922] It tends to cause less severe disease but is significantly more virulent than both the original virus and earlier variants (e.g. Delta).[L43917] As of …

Kategori:
Amino Acids, Peptides, and ProteinsAntigensBiological Factors +12
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Fanapanel DB12393
small molecule | CAS: 161605-73-8

Fanapanel has been investigated for the treatment of Visual Acuity.

Kategori:
Heterocyclic Compounds, Fused-RingOrganophosphorus Compounds
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FAPi-46 GA-68 DB18827
small molecule | CAS: 2374784-98-0

Deskripsi belum tersedia.

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Farampator DB15012
small molecule | CAS: 211735-76-1

Farampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression).

Kategori:
Oxazoles
Target Protein:
Glutamate receptor 1
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Farglitazar DB19311
small molecule | CAS: 274687-78-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Peroxisome proliferator-activated receptor gamma
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Faricimab Approved DB15303
biotech | CAS: 1607793-29-2

Retinal vascular diseases (RVDs) such as diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) are typically caused by retinal ischemia and subsequent neovascularization (NV).[A225985, A225990, A225995] Vascula…

Kategori:
Amino Acids, Peptides, and ProteinsAngiogenesis InhibitorsAngiogenesis Modulating Agents +15
Target Protein:
Vascular endothelial growth factor A, long formAngiopoietin-2
Waktu ParuhFaricimab has an es…
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Farletuzumab DB05595
biotech | CAS: 896723-44-7

Farletuzumab (MORAb-003) is a fully humanized monoclonal antibody against the folate receptor alpha, for the potential treatment of epithelial ovarian cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Target Protein:
Folate receptor alpha
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biotech | CAS: 2407465-18-1

Farletuzumab ecteribulin is under investigation in clinical trial NCT04300556 (A Study to Evaluate the Safety, Tolerability, and Efficacy of Morab-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (Fr?)-targeting Antibody-drug Conj…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Farnesol DB02509
small molecule | CAS: 4602-84-0

A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (Fr…

Kategori:
AlcoholsFatty AlcoholsLipids +2
Target Protein:
Amine oxidase [flavin-containing] BBile acid receptor
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small molecule | CAS: 13058-04-3

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPotential QTc-Prolonging Agents +2
Target Protein:
Squalene synthaseProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaProtein farnesyltransferase subunit beta +9
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small molecule

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPotential QTc-Prolonging Agents +2
Target Protein:
Geranylgeranyl pyrophosphate synthaseMevalonate kinaseDehydrosqualene synthase +1
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Faropenem DB12190
small molecule | CAS: 106560-14-9

Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia.

Kategori:
AmidesAntibacterials for Systemic UseAntiinfectives for Systemic Use +3
Target Protein:
Dihydropteroate synthase
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small molecule | CAS: 141702-36-5

Faropenem medoxomil is an ester prodrug derivative of the beta-lactam antibiotic [faropenem]. The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic concentrations of the drug. Faropenem medoxomil is a bro…

Kategori:
AmidesHeterocyclic Compounds, Fused-RingLactams +1
Target Protein:
Penicillin-binding protein 1APenicillin-binding protein 2BPeptidoglycan D,D-transpeptidase FtsI
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Farudodstat DB16049
small molecule | CAS: 1035688-66-4

Farudodstat (ASLAN003) is under investigation in clinical trial NCT03451084 (A Dose Optimisation Study of ASLAN003 in Acute Myeloid Leukemia).

Kategori:
AminesEnzyme InhibitorsPyridines
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Fasiglifam DB12491
small molecule | CAS: 1000413-72-8

Fasiglifam has been used in trials studying the treatment of Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Diabetes Mellitus, Type 2.

Kategori:
Heterocyclic Compounds, Fused-RingSulfur Compounds
Target Protein:
Free fatty acid receptor 1
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Fasinumab DB12157
biotech | CAS: 1190239-42-9

Fasinumab is a human IgG1k monoclonal antibody targeted against nerve growth factor (NGF). It is currently under investigation for the treatment osteoarthritic pain[A241045] and has demonstrated significantly greater pain relief and functional improvement as …

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +11
Target Protein:
Beta-nerve growth factor
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Fasitibant DB15646
small molecule | CAS: 869939-83-3

Fasitibant is under investigation in clinical trial NCT02205814 (Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee).

Kategori:
AmidesAmino AcidsAmino Acids, Basic +9
Target Protein:
B2 bradykinin receptor
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Fasoracetam DB16163
small molecule | CAS: 110958-19-5

Fasoracetam is under investigation in clinical trial NCT03609619 (PART B: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and Without Mglur Mutations).

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins +2
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FAV-201 DB06130
biotech

FAV-201 is a patient-specific immunotherapy for the treatment of T-cell lymphoma.

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Favezelimab DB16729
biotech | CAS: 2231068-83-8

Favezelimab is under investigation in clinical trial NCT04626479 (Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)).

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FavId DB05249
small molecule

FavId, is an active immunotherapy that is based upon unique genetic information extracted from a patient's tumor.

Target Protein:
Granulocyte colony-stimulating factor receptor
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Favipiravir Approved DB12466
small molecule | CAS: 259793-96-9

Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, wh…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +11
Target Protein:
DNA-directed RNA polymerase subunit betaDNA-directed RNA polymerase subunit beta'RNA-directed RNA polymerase catalytic subunit
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe recommended ora…
Genetik -
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