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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
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6694 (100.0%)

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Halaman 119 / 134
Sulfogaiacol DB15992
small molecule | CAS: 7134-11-4

Deskripsi belum tersedia.

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Sulfur hexafluoride Approved DB11104
small molecule | CAS: 2551-62-4

Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms …

Kategori:
AnionsElectrolytesFluorides +6
Waktu ParuhThe terminal half-l…
Vol. DistribusiIn a study of healt…
Klirens-
Genetik -
Sulfuric acid DB11309
small molecule | CAS: 7664-93-9

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicSulfur Acids +1
Waktu Paruh-
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Sulindac Approved DB00605
small molecule | CAS: 38194-50-2

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a pro…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +20
Target Protein:
Prostaglandin G/H synthase 2Aldo-keto reductase family 1 member B1Prostaglandin G/H synthase 1 +4
Waktu ParuhThe mean half-life …
Vol. Distribusi-
Klirens* Renal cl=68.12 +/…
Genetik -
Sulisobenzone DB11185
small molecule | CAS: 4065-45-6

Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations [F38]. It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage [L2153]. The UV-filter s…

Kategori:
Benzene DerivativesDrugs that are Mainly Renally ExcretedKetones +1
Target Protein:
Skin epithelial cells
Waktu Paruh-
Vol. Distribusi-
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Sulopenem DB15284
small molecule | CAS: 120788-07-0

Sulopenem is a penem antibacterial. It is marketed as the prodrug [sulopenem etzadroxil] in combination with [probenecid].[L51768]

Kategori:
Amides
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Sulopenem etzadroxil Approved DB16335
small molecule | CAS: 1000296-70-7

Sulopenem etzadroxil is a prodrug of the penem antibacterial [sulopenem]. Like other beta-lactam antibacterials, it is a time-dependent inhibitor of bacterial cell wall synthesis.[L51768] Sulopenem etzadroxil was approved by the FDA in October 2024 for the…

Kategori:
OAT3/SLC22A8 SubstratesPenem Antibacterial
Target Protein:
Penicillin-binding protein 2Penicillin-binding protein 1APenicillin-binding protein 1B +4
Waktu ParuhIn the fasted state…
Vol. DistribusiIn the fasted state…
KlirensIn the fasted state…
Genetik -
Sultamicillin Approved DB12127
small molecule | CAS: 76497-13-7

Sultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sunitinib Approved DB01268
small molecule | CAS: 557795-19-4

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stroma…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +31
Target Protein:
Platelet-derived growth factor receptor betaVascular endothelial growth factor receptor 1Mast/stem cell growth factor receptor Kit +6
Gen Terkait:
CYP3A4
Waktu ParuhFollowing administr…
Vol. Distribusi* 2230 L (apparent …
Klirens* 34 - 62 L/h [Tota…
Genetik 1 Varian
Sunobinop DB18955
small molecule | CAS: 1126793-40-5

Sunobinop is under investigation in clinical trial NCT04035200 (Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation).

Waktu Paruh-
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Suprofen Approved DB00870
small molecule | CAS: 40828-46-4

An ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAnalgesics +23
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
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Suptavumab DB12759
biotech | CAS: 1629615-23-1

Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial Virus Infections.

Waktu Paruh-
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Suratadenoturev DB18672
biotech | CAS: 1268642-13-2

Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.

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Surotomycin DB12076
small molecule | CAS: 1233389-51-9

Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection. It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.…

Kategori:
Amino Acids, Peptides, and ProteinsLipidsPeptides
Waktu Paruh-
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SurVaxM DB17397
biotech | CAS: 2416847-76-0

Deskripsi belum tersedia.

Waktu Paruh-
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biotech

Sus scrofa placenta is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

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biotech

Deskripsi belum tersedia.

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Susoctocog alfa Approved DB11606
biotech | CAS: 1339940-90-7

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare blee…

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
von Willebrand factor
Waktu ParuhThe terminal half-l…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
Sutilain Approved DB09379
biotech | CAS: 12211-28-8

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from _Bacillus subtilis_ and it is available as a cr…

Kategori:
EndopeptidasesEnzymesEnzymes and Coenzymes +4
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Suvorexant Approved DB09034
small molecule | CAS: 1030377-33-3

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +13
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhMean half life is a…
Vol. DistribusiMean volume of dist…
Klirens-
Genetik -
SVV-001 DB06129
biotech

SVV-001 is investigated for use/treatment in cancer/tumors and lung cancer. SVV-001 is a solid. SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neur…

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SX-682 DB19210
small molecule | CAS: 1648843-04-2

SX-682 is under investigation in clinical trial NCT04574583 (Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With Bintrafusp Alfa (M7824 or Tgf-beta "Trap"/pd-l1) With CV301 TRIC…

Target Protein:
C-X-C chemokine receptor type 2C-X-C chemokine receptor type 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 30344-00-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +1
Target Protein:
Haloalkane dehalogenase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SYN-101 DB05958
biotech

SYN-101 is an investigational antibody-drug conjugate developed for the treatment of cancer. SYN101 is comprised of an immune cell specific antibody linked to an ALK5 inhibitor payload to selectively block TGF-b signalling in immune cells.

Waktu Paruh-
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SynOV1.1 DB17539
biotech

SynOV1.1 is an investigational cancer immunotherapy developed by SyngenTech. It is a recombinant oncolytic adenovirus, controlled by synthetic gene circuit, encoding the human immunostimulating factor cytokine granulocyte-macrophage colony-stimulating factor …

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Genetik -
small molecule

Synthetic conjugated estrogens A are composed of a blend of the following nine synthetic estrogenic substances: estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihydroequilin sulfate, sodiu…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
small molecule | CAS: 746658-13-9

Synthetic conjugated estrogens, B tablets contain a blend of ten synthetic estrogenic substances. The estrogenic substances are: sodium estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihyd…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
Syrosingopine Approved DB19379
small molecule | CAS: 84-36-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntihypertensive AgentsHeterocyclic Compounds, Fused-Ring +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
T611 DB06391
small molecule | CAS: 350595-61-8

T611 is an investigational oral anti-cytomegalovirus (CMV) drug candidate.

Target Protein:
Transmembrane anterior posterior transformation protein 1 homolog
Waktu Paruh-
Vol. Distribusi-
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Genetik -
TA-CIN DB05809
biotech

TA-CIN is a subunit vaccine comprising L2/E6/E7 proteins from Human Papillomavirus (HPV16), designed to generate a strong cellular immune response against HPV-infected cells.

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TA-NIC DB05445
biotech

TA-NIC is a novel and proprietary vaccine in development as an aid to quitting smoking in motivated patients. It is designed to raise anti-nicotine antibodies which bind to nicotine molecules in the patient's blood stream, reducing the rate and quantity of ni…

Kategori:
Biological ProductsComplex Mixtures
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Tabelecleucel Approved DB17072
biotech

Tabelecleucel is an innovative therapy that uses Epstein-Barr virus (EBV)-specific allogeneic cytotoxic T cells (CTLs). It is produced by mixing T-cells with B-cells that have been infected with the Epstein-Barr virus (EBV). Both T-cells and B-cells are obtai…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAntineoplastic cell and gene therapy
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 943980-47-0

Taberminogene vadenovec (EG004) is a novel product consisting of a local delivery device and a gene-based medicine, being developed to prevent the blocking of veins and arteries that frequently occurs after vascular surgery. The initial target market is haemo…

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small molecule | CAS: 2412170-98-8

Tabirafusp tedromer is under investigation in clinical trial NCT06556368 (A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneratio…

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Tacalcitol DB13689
small molecule | CAS: 57333-96-7

Deskripsi belum tersedia.

Kategori:
Anti-Inflammatory AgentsAntipsoriaticsAntipsoriatics for Topical Use +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tacrolimus Approved DB00864
small molecule | CAS: 104987-11-3

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of …

Kategori:
Agents causing hyperkalemiaAgents Causing Muscle ToxicityAgents for Dermatitis, Excluding Corticosteroids +33
Target Protein:
Protein phosphatase 3 catalytic subunit alphaPeptidyl-prolyl cis-trans isomerase FKBP1A
Gen Terkait:
CYP3A5 ABCB1
Waktu ParuhThe elimination hal…
Vol. Distribusi* 2.6 ± 2.1 L/kg [p…
Klirens* 0.040 L/hr/kg [he…
Genetik 2 Varian
Tadekinig alfa DB14858
biotech | CAS: 220712-29-8

Tadekinig alfa is under investigation in clinical trial NCT03113760 (Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency).

Waktu Paruh-
Vol. Distribusi-
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TAFA-93 DB05887
small molecule

TAFA93 is a novel prodrug of the mTOR inhibitor rapamycin which has successfully completed Phase 1 clinical development. mTOR inhibitors are currently used in the prevention of organ rejection in transplantation, the treatment of autoimmune and oncological di…

Waktu Paruh-
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Tafasitamab Approved DB15044
biotech | CAS: 1422527-84-1

Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies.[L15302] It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which ha…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
B-lymphocyte antigen CD19
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe total volume of…
KlirensThe clearance of ta…
Genetik -
Tafenoquine Approved DB06608
small molecule | CAS: 106635-80-7

Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that wou…

Kategori:
AminoquinolinesAnti-Infective AgentsAntimalarials +11
Waktu ParuhTafenoquine present…
Vol. DistribusiTafenoquine present…
KlirensTafenoquine present…
Genetik -
Tafolecimab DB16336
biotech | CAS: 2225109-03-3

Tafolecimab is under investigation in clinical trial NCT04031742 (A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial Hypercholesterolemia).

Waktu Paruh-
Vol. Distribusi-
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Tagatose DB04936
small molecule | CAS: 87-81-0

Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food addit…

Kategori:
CarbohydratesChelating AgentsCompounds used in a research, industrial, or household setting +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Tagetitoxin DB04788
small molecule | CAS: 87913-21-1

Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.

Kategori:
Acids, AcyclicBacterial Toxins
Target Protein:
DNA-directed RNA polymerase subunit betaDNA-directed RNA polymerase subunit beta'
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
TAK-603 DB17892
small molecule | CAS: 158146-85-1

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Interferon gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TAK-733 DB12241
small molecule | CAS: 1035555-63-5

TAK-733 has been used in trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and Advanced Non-hematologic Malignancies.

Kategori:
PyridinesPyrimidines
Waktu Paruh-
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TAK-754 DB17850
biotech

TAK-754 is an adeno-associated virus serotype 8 vector (AAV8) expressing B domain deleted codon optimized factor VIII. Developed by Takeda, it is being investigated for the treatment of hemophilia A.[A259831]

Waktu Paruh-
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Genetik -
Talampicillin DB13814
small molecule | CAS: 47747-56-8

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Talbutal Approved DB00306
small molecule | CAS: 115-44-6

Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.

Kategori:
Anticholinergic AgentsBarbiturates, PlainCentral Nervous System Depressants +6
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-3 +9
Waktu Paruh-
Vol. Distribusi-
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Talc Approved DB09511
small molecule | CAS: 14807-96-6

Talc is a mineral composed primarily of magnesium, silicon and oxygen. It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders. Talc helps absorb moisture, freshen materials, and red…

Kategori:
AntiperspirantsCompounds used in a research, industrial, or household settingCosmetics +6
Waktu ParuhIntended for local …
Vol. DistribusiIntended for local …
KlirensIntended for local …
Genetik -
Menampilkan 5901–5950 dari 6694
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