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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
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14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 119 / 282
Enoblituzumab DB15017
biotech | CAS: 1353485-38-7

Enoblituzumab is under investigation in clinical trial NCT02982941 (Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enobosarm DB12078
small molecule | CAS: 841205-47-8

Enobosarm has been used in trials studying the treatment of Stress Urinary Incontinence and Triple Negative Breast Cancer.

Kategori:
AmidesAminesAniline Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enokizumab DB05555
biotech | CAS: 909875-08-7

A humanized immunoglobulin G1k anti-interleukin-9 mAb.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enoxaparin Approved DB01225
small molecule | CAS: 9005-49-6

Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several …

Kategori:
Agents causing hyperkalemiaAnticoagulantsBlood and Blood Forming Organs +7
Target Protein:
Antithrombin-IIICoagulation factor XProthrombin
Waktu ParuhThe half-life of en…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
Enpatoran DB16501
small molecule | CAS: 2101938-42-3

Enpatoran (M5049) was under investigation in clinical trials for various conditions. It was investigated for systemic lupus erythematosus and cutaneous lupus erythematosus in completed trials (NCT04647708 and NCT05162586) and in a recruiting trial (NCT0554032…

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enprofylline Approved DB00824
small molecule | CAS: 41078-02-8

Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. L…

Kategori:
Adenosine A2 Receptor AntagonistsAlkaloidsAnti-Asthmatic Agents +11
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4B5'-nucleotidaseAdenosine receptor A2b +4
Waktu Paruh1.9 hours
Vol. Distribusi-
Klirens-
Genetik -
Enprostil DB13824
small molecule | CAS: 73121-56-9

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAnti-Ulcer AgentsAutacoids +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enrasentan DB06460
small molecule | CAS: 167256-08-8

Deskripsi belum tersedia.

Kategori:
Endothelin Receptor AntagonistsIndenes
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enrofloxacin DB11404
small molecule | CAS: 93106-60-6

Enrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant strains of _Campylobacter_, in September …

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensartinib DB14860
small molecule | CAS: 1370651-20-9

Ensartinib is under investigation in clinical trial NCT03420508 (Treating Patients With Melanoma and ALK Alterations With Ensartinib).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
ALK tyrosine kinase receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensifentrine Approved DB16157
small molecule | CAS: 1884461-72-6

Ensifentrine is a first-in-class, selective dual inhibitor of the phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) enzymes.[L50903] On June 26, 2024, the FDA announced the approval of an inhaled product of ensifentrine for the treatment of chronic o…

Kategori:
BCRP/ABCG2 SubstratesCytochrome P-450 CYP2C9 SubstratesCytochrome P-450 CYP2D6 Substrates +6
Target Protein:
Phosphodiesterase 3Phosphodiesterase 4
Waktu ParuhFollowing twice-dai…
Vol. DistribusiApparent central an…
Klirens-
Genetik -
Ensitrelvir DB18834
small molecule | CAS: 2647530-73-0

Ensitrelvir is under investigation in clinical trial NCT05605093 (Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)).

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensituximab DB12342
biotech | CAS: 1092658-06-4

Ensituximab has been used in trials studying the treatment of Pancreatic Cancer, Adult, Metastatic Colorectal Cancer, and Metastatic Pancreatic Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensovibep DB19078
biotech | CAS: 2451126-06-8

Ensovibep is under investigation in clinical trial NCT04501978 (ACTIV-3: Therapeutics for Inpatients With COVID-19).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensulizole Approved DB11115
small molecule | CAS: 27503-81-7

Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due t…

Kategori:
AcidsAcids, NoncarboxylicHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entacapone Approved DB00494
small molecule | CAS: 130929-57-6

Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., c…

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson DrugsBenzene Derivatives +11
Target Protein:
Catechol O-methyltransferase
Waktu Paruh0.4-0.7 hour
Vol. Distribusi* 20 L
Klirens* 850 mL/min
Genetik -
biotech | CAS: 2247971-01-1

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entecavir Approved DB00442
small molecule | CAS: 142217-69-4

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer cl…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +12
Target Protein:
DNA
Waktu ParuhAfter reaching peak…
Vol. Distribusi-
Klirens* renal cl=383.2 +/…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entinostat DB11841
small molecule | CAS: 209783-80-2

Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +8
Target Protein:
Histone deacetylaseHistone deacetylase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entolimod DB12304
biotech | CAS: 951628-22-1

Entolimod has been used in trials studying the treatment of Mucositis, Tongue Cancer, Colorectal Cancer, Stage IVA Verrucous Carcinoma of the Larynx, and Stage IVB Verrucous Carcinoma of the Larynx, among others.

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entospletinib DB12121
small molecule | CAS: 1229208-44-9

Entospletinib has been used in trials studying the treatment of Oncology, Follicular Lymphoma, B-cell Malignancies, Mantle Cell Lymphoma, and Non-Hodgkin Lymphoma, among others.

Kategori:
Heterocyclic Compounds, Fused-RingOxazinesPyrazoles
Target Protein:
Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entrectinib Approved DB11986
small molecule | CAS: 1108743-60-7

Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positi…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +17
Target Protein:
ALK tyrosine kinase receptorHigh affinity nerve growth factor receptorNT-3 growth factor receptor +4
Waktu ParuhEntrectinib has a h…
Vol. DistribusiEntrectinib has an …
KlirensThe apparent cleara…
Genetik -
Envafolimab DB15769
biotech | CAS: 2102192-68-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enviomycin DB08993
small molecule | CAS: 33103-22-9

Cyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enzacamene Approved DB11219
small molecule | CAS: 36861-47-9

Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reprodu…

Kategori:
Bicyclic MonoterpenesBornanesBridged-Ring Compounds +5
Target Protein:
Progesterone receptorAndrogen receptorEstrogen receptor beta +1
Waktu ParuhThe half life of en…
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Enzalutamide Approved DB08899
small molecule | CAS: 915087-33-1

Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic.[L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A2…

Kategori:
AmidesAndrogen Receptor AntagonistsAndrogen Receptor Inhibitors +35
Target Protein:
Androgen receptor
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe mean (%CV) volu…
KlirensThe mean apparent c…
Genetik -
Enzalutamide d3 DB19123
small molecule | CAS: 1443331-82-5

Enzalutamide d3 is under investigation in clinical trial NCT03850795 (HC-1119 Versus Enzalutamide in Metastatic Castration-resistant Prostate Cancer (Mcrpc)).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EO-3021 DB18358
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eosin DB13706
small molecule | CAS: 17372-87-1

Deskripsi belum tersedia.

Kategori:
Antiseptics and DisinfectantsColoring AgentsCompounds used in a research, industrial, or household setting +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-0042 DB18120
small molecule | CAS: 1402709-93-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-2104R DB05675
biotech

EP-2104R is an imaging pharmaceutical under development for the detection of blood clots. It is the first targeted high-resolution technique designed to visualize blood clots directly. It is being developed by EPIX Pharmaceuticals, Inc.

Kategori:
Amino Acids, Peptides, and ProteinsContrast MediaElements +3
Target Protein:
Fibrinogen alpha chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-217609 DB18393
small molecule | CAS: 894494-99-6

Deskripsi belum tersedia.

Kategori:
CarbohydratesCoenzymesEnzymes and Coenzymes +2
Target Protein:
Coagulation factor XProthrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epacadostat DB11717
small molecule | CAS: 1204669-58-8

Epacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others.

Kategori:
AmidesAminesAntineoplastic Agents +4
Target Protein:
Indoleamine 2,3-dioxygenase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epafipase DB16158
biotech | CAS: 208576-22-1

Epafipase is under investigation in clinical trial NCT00037687 (Safety and Efficacy of Recombinant Human Platelet-activating Factor Acetylhydrolase for the Treatment of Severe Sepsis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epalrestat DB15293
small molecule | CAS: 82159-09-9

Epalrestat is under investigation in clinical trial NCT03244358 (Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer).

Kategori:
Enzyme InhibitorsSulfur CompoundsThiazoles
Target Protein:
Aldo-keto reductase family 1 member B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epaminurad DB18973
small molecule | CAS: 1198153-15-9

Epaminurad is under investigation in clinical trial NCT05815901 (A Therapeutic Confirmatory Study of Epaminurad Versus Febuxostat in Gout Patients).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EPC2407 DB05189
small molecule

EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas. It is intended for the treatment of advanced cancer patients with solid tumors that are well vascularized…

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epcoritamab Approved DB16672
biotech | CAS: 2134641-34-0

Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +13
Target Protein:
B-lymphocyte antigen CD20T-cell surface glycoprotein CD3 epsilon chain
Waktu ParuhA full dose of epco…
Vol. DistribusiEpcoritamab has an …
KlirensA full dose of epco…
Genetik -
Epelsiban DB11934
small molecule | CAS: 872599-83-2

Epelsiban has been investigated for the treatment of Premature Ejaculation.

Kategori:
OxazinesPiperazines
Target Protein:
Oxytocin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eperisone DB08992
small molecule | CAS: 64840-90-0

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAutonomic Agents +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_. The sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for a…

Kategori:
Adrenergic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-Agonists +22
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterAlpha-2A adrenergic receptor +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ephedrine Approved DB01364
small molecule | CAS: 299-42-3

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic rece…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +39
Target Protein:
D(2) dopamine receptorAlpha-1A adrenergic receptorBeta-1 adrenergic receptor +2
Waktu ParuhOral ephedrine has …
Vol. DistribusiOral ephedrine has …
KlirensOral ephedrine has …
Genetik -
small molecule | CAS: 1082659-36-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EPI-589 DB16041
small molecule | CAS: 1147883-03-1

EPI-589 is under investigation in clinical trial NCT02460679 (Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epibatidine DB07720
small molecule | CAS: 140111-52-0

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticCentral Nervous System Agents +6
Target Protein:
CHRNA7-FAM7A fusion proteinNeuronal acetylcholine receptor subunit alpha-7Neuronal acetylcholine receptor subunit beta-2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicaptopril DB02032
small molecule | CAS: 63250-36-2

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAmino AcidsAmino Acids, Cyclic +6
Target Protein:
Metallo-beta-lactamase L1Beta-lactamaseOrganic hydroperoxide resistance protein, putative +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicatechin DB12039
small molecule | CAS: 490-46-0

Epicatechin has been used in trials studying the treatment of Pre-diabetes.

Kategori:
BenzopyransCatechinChromans +4
Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicept NP-1 DB05492
small molecule

EpiCept NP-1 is a prescription topical analgesic cream designed to provide effective, long-term relief from the pain of peripheral neuropathies. Peripheral neuropathies are medical conditions caused by damage to the nerves in the peripheral nervous system. Th…

Target Protein:
Mu-type opioid receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2B +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicillin DB13300
small molecule | CAS: 26774-90-3

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5901–5950 dari 14063
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