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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 118 / 315
Dirithromycin DB00954
small molecule | CAS: 62013-04-1

Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
23S ribosomal RNA
Waktu ParuhThe mean plasma hal…
Vol. Distribusi-
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Genetik -
biotech | CAS: 2163074-23-3

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
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Dirlotapide DB11399
small molecule | CAS: 481658-94-0

Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, _Slentrol_, and is not intended for human use.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Microsomal triglyceride transfer protein large subunit
Waktu Paruh-
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Dirocaftor DB16143
small molecule | CAS: 2137932-23-9

Dirocaftor is under investigation in clinical trial NCT03251092 (Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis).

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Diroximel fumarate Approved DB14783
small molecule | CAS: 1577222-14-0

Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life.[A176474] It is the main cause of neurological disability not caused by trauma in the young a…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsDicarboxylic Acids +3
Target Protein:
Neuronal acetylcholine receptor subunit alpha-10
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensNo clearance inform…
Genetik -
Dirucotide DB04921
biotech | CAS: 152074-97-0

Dirucotide is a synthetically prepared peptide. In particular, the sequence prepared is a 17 amino acid chain that is identical to a section of myelin basic protein (MBP) that is found in humans. Dirucotide has been developed for the treatment of multiple scl…

Kategori:
Amino Acids, Peptides, and ProteinsMembrane ProteinsMyelin Proteins +3
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small molecule | CAS: 130114-83-9

Disaccharide tripeptide glycerol dipalmitoyl is under investigation in clinical trial NCT00003667 (Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma).

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biotech | CAS: 2136633-23-1

Disitamab vedotin is an antibody-drug conjugate drug targeting human epidermal growth factor receptor 2 (HER2). It is currently being investigated for cancers.[A254721]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibody-drug Conjugates +9
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Disitertide DB12953
biotech | CAS: 272105-42-7

Disitertide has been used in trials studying the treatment of Skin Fibrosis.

Target Protein:
Transforming growth factor beta-1 proprotein
Waktu Paruh-
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Disomotide DB17469
biotech | CAS: 181477-43-0

Disomotide is a synthetic peptide cancer vaccine.

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Disperse Blue 106 Approved DB14203
small molecule | CAS: 68516-81-4

Disperse Blue 106 is used in allergenic testing.

Kategori:
AllergensAntigensBiological Factors +3
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Distearyldimonium Approved DB14143
small molecule | CAS: 14357-21-2

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAminesAmmonium Compounds +6
Waktu Paruh-
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Distichlis spicata pollen Approved DB10494
biotech

Distichlis spicata pollen is the pollen of the Distichlis spicata plant. Distichlis spicata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
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Distigmine DB13694
small molecule | CAS: 17299-00-2

Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to [DB00545] and [DB01400]. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase inhibitor that binds directly and …

Kategori:
Cholinergic AgentsCholinesterase InhibitorsEnzyme Inhibitors +4
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Disufenton DB17298
small molecule | CAS: 168021-77-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsArylsulfonatesArylsulfonic Acids +9
Target Protein:
Extracellular sulfatase Sulf-2
Waktu Paruh-
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Disulfiram Approved DB00822
small molecule | CAS: 97-77-8

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde con…

Kategori:
Acetyl Aldehyde Dehydrogenase InhibitorsAcids, AcyclicAgents that reduce seizure threshold +26
Target Protein:
Dopamine beta-hydroxylaseAldehyde dehydrogenase family 3 member A2Aldehyde dehydrogenase, mitochondrial
Waktu Paruh-
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Ditazole DB08994
small molecule | CAS: 18471-20-0

Ditazole is a non-steroidal anti-inflammatory drug (NSAID). Ditazole's analgesic and antipyretic effects are similar to phenylbutazone. Additionally, ditazole is a platelet aggregation inhibitor marketed in Spain and Portugal with trade name Ageroplas.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansPlatelet Aggregation Inhibitors Excl. Heparin
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Dithiazanine DB11516
small molecule | CAS: 7187-55-5

Dithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was associated with eight fatal cases of severe acidosis and s…

Kategori:
AnthelminticsAnti-Infective AgentsAntinematodal Agents +11
Waktu Paruh-
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small molecule | CAS: 6892-68-8

A compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups. [PubChem]

Kategori:
AlcoholsCarbohydratesCompounds used in a research, industrial, or household setting +6
Target Protein:
Listeriolysin regulatory protein6,7-dimethyl-8-ribityllumazine synthaseThymidine kinase, cytosolic
Waktu Paruh-
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Dithiopyr DB15230
small molecule | CAS: 97886-45-8

Dithiopyr is under investigation in clinical trial NCT01236781 (Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates).

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Ditiocarb DB02520
small molecule | CAS: 147-84-2

A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.

Kategori:
Acids, AcyclicAdjuvants, ImmunologicAnti-Infective Agents +15
Waktu Paruh-
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Ditiocarb zinc Approved DB14193
small molecule | CAS: 14324-55-1

Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. Sensitivity to ditiocarb zinc may be identified with a clinical patch test.

Kategori:
Acids, AcyclicAdjuvants, ImmunologicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +18
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Divarasib DB17488
small molecule | CAS: 2417987-45-0

Deskripsi belum tersedia.

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Divozilimab DB18878
biotech | CAS: 2254061-60-2

Divozilimab is under investigation in clinical trial NCT05730699 (Efficacy and Safety of Divozilimab in Patients With Neuromyelitis Optica Spectrum Disorders (AQUARELLE)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic and Immunomodulating Agents +5
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Dixanthogen DB13712
small molecule | CAS: 502-55-6

Deskripsi belum tersedia.

Kategori:
AnionsAntiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. Scabicides +7
Waktu Paruh-
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Dixyrazine DB13784
small molecule | CAS: 2470-73-7

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAntiemetics +16
Waktu Paruh-
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DL-alpha tocopheryl acetate Approved DB14477
small molecule | CAS: 52225-20-4

Deskripsi belum tersedia.

Kategori:
Vitamin EVitaminsVitamins (Fat Soluble)
Waktu Paruh-
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DL-alpha-Tocopherol Approved DB14476
small molecule | CAS: 10191-41-0

Deskripsi belum tersedia.

Kategori:
Vitamin EVitaminsVitamins (Fat Soluble)
Waktu Paruh-
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small molecule | CAS: 18656-38-7

A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. It is used in commercial drug preparations to solubilize drugs for injection [A32711]

Kategori:
Compounds used in a research, industrial, or household settingGlycerophosphatesGlycerophospholipids +7
Waktu Paruh-
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small molecule | CAS: 61361-72-6

DL-dimyristoylphosphatidylglycerol is a phospholipid used in commercially available pharmaceutical preparations to solubilize drugs for injection.

Kategori:
GlycerophosphatesGlycerophospholipidsLipids +3
Waktu Paruh-
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DL-Methylephedrine Approved DB11278
small molecule | CAS: 1201-56-5

Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world [L2838], [L2839], [L2840]. The abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is n…

Kategori:
Adrenergic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-Agonists +10
Target Protein:
Beta-1 adrenergic receptorAlpha-2A adrenergic receptorAlpha adrenergic receptor +1
Waktu Paruh3-6 hours (Ephedrin…
Vol. DistribusiEphedrine: 2.5-3.0 …
Klirens-
Genetik -
DLO6001 DB05178
small molecule

DL6001 is developed by DanioLabs using proprietary zebrafish technology to treat Parkinson’s disease symptoms including sialorrhoea and hyperhidrosis.

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DLO6002 DB05179
small molecule

DLO6002 is developed by Summit Corporation and is in phase I of clinical trials for the treatment of Parkinson's disease.

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DM-1157 DB18600
small molecule | CAS: 1239953-66-2

Deskripsi belum tersedia.

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DMP-777 DB18488
small molecule | CAS: 157341-41-8

DMP-777 is a selective inhibitor of polymorphonuclear leukocyte (PMN) elastase.

Kategori:
AzetinesEnzyme InhibitorsPancreatic Elastase, antagonists & inhibitors
Target Protein:
Neutrophil elastase
Waktu Paruh-
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DNB-001 DB05757
small molecule

DNB-001 is a first-in-class oral therapy with dual mechanism of action, which is initially being developed for the treatment of glaucoma. In preclinical animal models, DNB-001 has demonstrated potent IOP- lowering effects as well as neuroprotective effects on…

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DNL343 DB18678
small molecule | CAS: 2278265-85-1

DNL343 is under investigation in clinical trial NCT05842941 (HEALEY ALS Platform Trial - Regimen G DNL343).

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biotech

Deskripsi belum tersedia.

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Dobesilic acid DB13529
small molecule | CAS: 88-46-0

Deskripsi belum tersedia.

Kategori:
Antivaricose TherapyArylsulfonatesArylsulfonic Acids +9
Waktu Paruh-
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Dobutamine Approved DB00841
small molecule | CAS: 34368-04-2

A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +28
Target Protein:
Alpha-1 adrenergic receptorsBeta-1 adrenergic receptorBeta-2 adrenergic receptor +1
Waktu Paruh2 minutes
Vol. Distribusi-
Klirens-
Genetik -
Docaravimab DB17802
biotech | CAS: 2247196-23-0

Deskripsi belum tersedia.

Waktu Paruh-
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Docarpamine DB18046
small molecule | CAS: 74639-40-0

Deskripsi belum tersedia.

Kategori:
AminesBenzene DerivativesBiogenic Amines +8
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
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Docetaxel Approved DB01248
small molecule | CAS: 114977-28-5

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic ana…

Kategori:
Agents Causing Muscle ToxicityAntimitotic AgentsAntineoplastic Agents +32
Target Protein:
Tubulin beta-1 chainApoptosis regulator Bcl-2Nuclear receptor subfamily 1 group I member 2
Gen Terkait:
ABCC2
Waktu ParuhWith plasma samplin…
Vol. DistribusiDocetaxel has a ste…
KlirensAfter the administr…
Genetik 1 Varian
small molecule | CAS: 177021-00-0

Deskripsi belum tersedia.

Kategori:
AnticoagulantsCarbohydratesExperimental Unapproved Treatments for COVID-19 +3
Waktu Paruh-
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Doconexent Approved DB03756
small molecule | CAS: 6217-54-5

A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic acid or commercially manu…

Kategori:
Cytochrome P-450 CYP2C9 InhibitorsCytochrome P-450 CYP2C9 Inhibitors (strength unknown)Cytochrome P-450 CYP2C9 Substrates +11
Target Protein:
Peroxisome proliferator-activated receptor alphaProstaglandin G/H synthase 1Prostaglandin G/H synthase 2 +6
Waktu ParuhApproximately 20 ho…
Vol. DistribusiDHA is the most abu…
Klirens-
Genetik -
Docosanol Approved DB00632
small molecule | CAS: 661-19-8

Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses inclu…

Kategori:
AlcoholsAnti-Infective AgentsAntiviral Agents +2
Target Protein:
Envelope glycoprotein GP350Envelope glycoprotein GP340
Waktu Paruh-
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Docusate Approved DB11089
small molecule | CAS: 10041-19-7

Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201]. Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass [L1801]. Docusate can be ora…

Kategori:
Alimentary Tract and MetabolismDrugs for ConstipationEnemas +5
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small molecule

Deskripsi belum tersedia.

Kategori:
Cholinesterase Inhibitors
Target Protein:
Cholinesterase
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small molecule | CAS: 1442645-21-7

Deskripsi belum tersedia.

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Dodecyl sulfate DB03967
small molecule | CAS: 151-41-7

Deskripsi belum tersedia.

Kategori:
AlcoholsAlkanesulfonatesAlkanesulfonic Acids +8
Target Protein:
Lysozyme CLipid A palmitoyltransferase PagP
Waktu Paruh-
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Genetik -
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