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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 117 / 349
Colesevelam Approved DB00930
small molecule | CAS: 182815-43-6

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intesti…

Kategori:
AlkenesAllyl CompoundsAllylamine +11
Target Protein:
Bile acids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colestilan chloride Approved DB11634
small molecule | CAS: 95522-45-5

Colestilan is an ingredient in the EMA-withdrawn product BindRen.

Kategori:
Drugs for Treatment of Hyperkalemia and HyperphosphatemiaFused-Ring CompoundsSteroids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colestipol Approved DB00375
small molecule | CAS: 26658-42-4

Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease…

Kategori:
AminesAnion Exchange ResinsBile Acid Sequestrants +12
Target Protein:
Bile acids
Waktu ParuhColestipol is not a…
Vol. DistribusiColestipol is not a…
KlirensColestipol is not a…
Genetik -
Colforsin DB02587
small molecule | CAS: 66575-29-9

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pr…

Kategori:
Adjuvants, ImmunologicAnti-Asthmatic AgentsAutonomic Agents +12
Target Protein:
Adenylate cyclaseAdenylate cyclase type 2Guanine nucleotide-binding protein G(s) subunit alpha isoforms short +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colfosceril palmitate Approved DB09114
small molecule | CAS: 63-89-8

Colfosceril palmitate is a synthetic pulmonary surfactant administered in infants with respiratory distress syndrome.[A31510] It was part of the first generation of commercially available artificial surfactants.[T70] It was developed by Burroughs Wellcome and…

Kategori:
GlycerophosphatesGlycerophospholipidsLipids +6
Waktu ParuhThe half-life of co…
Vol. DistribusiColfosceril palmita…
KlirensAfter 5 days of dru…
Genetik -
Colistimethate Approved DB01111
small molecule | CAS: 12705-41-8

Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.

Kategori:
Agents that produce neuromuscular block (indirect)Amino Acids, Peptides, and ProteinsAntimicrobial Cationic Peptides +11
Target Protein:
Dihydropteroate synthaseBacterial outer membrane
Waktu Paruh2-3 hours following…
Vol. Distribusi-
Klirens-
Genetik -
Colistin Approved DB00803
biotech | CAS: 1066-17-7

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used o…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAmino Acids, Peptides, and Proteins +21
Target Protein:
Dihydropteroate synthaseBacterial outer membrane
Waktu Paruh5 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Collagen-polyvinylpyrrolidone is a copolymer generated from a mixture of type I collagen and low-molecular-weight PVP that has undergone ? irradiation[A227733]. It is characterized by antifibrotic, fibrolytic, and immunomodulatory properties[A227733].

Kategori:
AlkenesAmino Acids, Peptides, and ProteinsBiopolymers +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9001-12-1

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease.[L14882] The topical formulation is…

Kategori:
Collagen-specific EnzymeCollagenasesDermatologicals +11
Target Protein:
Collagen alpha-1(I) chainCollagen alpha-1(II) chainCollagen alpha-1(III) chain
Waktu Paruh-
Vol. DistribusiThere is no current…
KlirensClearance informati…
Genetik -
Colletotrichum coccodes Approved DB10824
biotech

Colletotrichum coccodes is a fungus which can provoke allergic reactions. Colletotrichum coccodes extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colloidal oatmeal Approved DB11286
biotech

Colloidal oatmeal is produced by grinding fine granules of oatmeal and boiling it to extract the colloidal material. It contains high concentrations of starches and beta-glucan that exhibits water-absorbing properties. Phenols are also contained in colloidal …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1269764-99-9

Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic leukemia (ALL).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAntibodies +16
Target Protein:
B-lymphocyte antigen CD19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Combretastatin DB12596
small molecule | CAS: 82855-09-2

Combretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.

Kategori:
Antimitotic AgentsAntineoplastic AgentsAntineoplastic Agents, Phytogenic +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 117048-59-6

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Common carp Approved DB10614
biotech

Common carp allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Comosain DB18354
biotech

Deskripsi belum tersedia.

Kategori:
Cysteine ProteasesEndopeptidasesEnzymes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Compound 18 DB02715
small molecule | CAS: 31112-66-0

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +1
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Compound 19 DB02615
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptorTyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Compound 4-D DB03742
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Tyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Conatumumab DB11646
biotech | CAS: 896731-82-1

Conatumumab has been used in trials studying the treatment of Sarcoma, Lymphoma, Oncology, Colon Cancer, and Rectal Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntineoplastic Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Conbercept DB12460
biotech | CAS: 1227158-72-6

Conbercept has been investigated for the basic science of Age-related Macular Degeneration.

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Concanamycin A DB14062
small molecule | CAS: 80890-47-7

Concanamycin A is an H+-ATPase (vacuolar) inhibitor.

Kategori:
Anti-Infective AgentsEnzyme InhibitorsLactones +3
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Concizumab DB12820
biotech | CAS: 1312299-39-0

Concizumab has been used in trials studying the treatment of Haemophilia A and Congenital Bleeding Disorder.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Concord grape Approved DB10875
biotech

Concord grape allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Condoliase DB12793
biotech | CAS: 9024-13-9

Condoliase has been used in trials studying the treatment of Lumbar Disc Disease, Lumbar Vertebra Hernia, and Intervertebral Disc Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Conestat alfa Approved DB09228
biotech | CAS: 80295-38-1

C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the comple…

Kategori:
Amino Acids, Peptides, and ProteinsAngioedemas, Hereditary, drug therapyBlood and Blood Forming Organs +16
Target Protein:
Complement C1r subcomponentComplement C1s subcomponentPlasma kallikrein +4
Waktu Paruh-
Vol. Distribusi-
KlirensClearance was found…
Genetik -
Conivaptan Approved DB00872
small molecule | CAS: 210101-16-9

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopres…

Kategori:
Antidiuretic Hormone Receptor AntagonistsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Substrates +12
Target Protein:
Vasopressin V1a receptorVasopressin V2 receptor
Waktu Paruh5 hours
Vol. Distribusi-
Klirens-
Genetik -
Conjugated estrogens Approved DB00286
small molecule | CAS: 12126-59-9

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sul…

Kategori:
Agents causing angioedemaBCRP/ABCG2 SubstratesCOMT Substrates +26
Target Protein:
Estrogen receptor betaEstrogen receptor
Waktu ParuhThe median half-lif…
Vol. DistribusiThe physiological d…
KlirensThe reported normal…
Genetik -
Contulakin-G DB05950
small molecule | CAS: 229180-41-0

Contulakin-G is a broad spectrum non-opioid analgesic. It is the synthetic form of a natural peptide extracted from the venom of the Conus Geographus sea snail.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsPeptides +1
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copanlisib Approved DB12483
small molecule | CAS: 1032568-63-0

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exi…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +17
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform +1
Waktu ParuhThe geometric mean …
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
Copper Approved DB09130
small molecule | CAS: 7440-50-8

Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. Copper is commonly used in contraceptive intrauterine devices…

Kategori:
Copper-containing Intrauterine DeviceDecreased Embryonic ImplantationDecreased Sperm Motility +12
Target Protein:
Amyloid-beta precursor proteinAdenosylhomocysteinaseHistone H2B type 1-C/E/F/G/I +143
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper Cu-64 Approved DB13980
small molecule | CAS: 13981-25-4

Copper-64 is a radiopharmaceutical usually found in the +2 oxidation state as the complexes including the +1 state tend to be more unstable.[T604] It is used in molecular radiotherapy and positron emission tomography.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper gluconate Approved DB11246
small molecule | CAS: 527-09-3

Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practi…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper oxodotreotide Cu-64 Approved DB15873
small molecule | CAS: 1426155-87-4

Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over <sup>68</sup>Ga-labeled somatostatin analogs for positron emission tomography (PET).[A220348] Copper Cu 64 dotatate has a longer half-life and can be prod…

Kategori:
Amino Acids, Peptides, and ProteinsCopper RadioisotopesPeptides +4
Target Protein:
Somatostatin receptor type 2
Waktu ParuhThe half-life of Co…
Vol. Distribusi-
Klirens-
Genetik -
Copper usnate DB13830
small molecule

Deskripsi belum tersedia.

Kategori:
Genito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68341-09-3

Deskripsi belum tersedia.

Kategori:
SemicarbazidesSemicarbazonesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coprelotamab DB16380
biotech | CAS: 2348469-84-9

Coprelotamab is under investigation in clinical trial NCT04170595 (Clinical Study of Recombinant Anti-her2 Humanized Monoclonal Antibody for Injection).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coprogen DB01747
small molecule | CAS: 31418-71-0

Deskripsi belum tersedia.

Kategori:
AminesHydroxy AcidsHydroxylamines +1
Target Protein:
Iron(3+)-hydroxamate-binding protein FhuD
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingPigments, Biological +1
Target Protein:
Uroporphyrinogen decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2624-63-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingPorphyrinogensPorphyrins
Target Protein:
Uroporphyrinogen decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coptisine DB19308
small molecule | CAS: 3486-66-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsBenzylisoquinolinesBerberine Alkaloids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake veno…

Kategori:
Antivenins
Waktu ParuhThe formal prescrib…
Vol. DistribusiThe formal prescrib…
KlirensThe formal prescrib…
Genetik -
Coramitug DB19411
biotech | CAS: 2626841-92-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corcorus capsularis fiber Approved DB10711
biotech

Corcorus capsularis fiber is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cordycepin DB12156
small molecule | CAS: 73-03-0

Cordycepin has been used in trials studying the treatment of Leukemia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 73-04-1

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesDeoxyribonucleotidesHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Poly(A) polymerase alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corifollitropin alfa Approved DB09066
biotech | CAS: 195962-23-3

Corifollitropin alfa, also known as _Elonva_ is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with _a gonadotropin-releasing hormone (GnRH) anta…

Kategori:
Drugs that are Mainly Renally ExcretedFollicle Stimulating HormoneGenito Urinary System and Sex Hormones +9
Target Protein:
Follicle-stimulating hormone receptor
Waktu ParuhCorifollitropin alf…
Vol. DistribusiDistribution, metab…
Klirens0.13 L/h (0.10-0.18…
Genetik -
Corn Approved DB10572
biotech

Corn allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5801–5850 dari 17430
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