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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
Referensi
11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 117 / 236
Hycanthone DB14061
small molecule | CAS: 3105-97-3

Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.

Kategori:
AnthelminticsAnti-Infective AgentsAntiparasitic Agents +7
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylosuccinate synthetaseAdenylosuccinate synthetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydracarbazine DB09243
small molecule | CAS: 3614-47-9

Hydracarbazine is a pyridazine that has found use as an antihypertensive agent [A19790] It was once marketed in France under the tradename Normatensyl.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 503-66-2

Deskripsi belum tersedia.

Kategori:
Hydroxy AcidsIsomerismLactates
Target Protein:
Pimeloyl-[acyl-carrier protein] methyl ester esterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydralazine Approved DB01275
small molecule | CAS: 86-54-4

Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed.[A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and onl…

Kategori:
Antihypertensive AgentsAntihypertensive Agents Indicated for HypertensionArteriolar Smooth Muscle, Agents Acting On +15
Target Protein:
Amine oxidase [copper-containing] 3Hypoxia-inducible factor 1-alphaProlyl 4-hydroxylase subunit alpha-1
Waktu ParuhHydralazine has a h…
Vol. DistribusiThe volume of distr…
KlirensThe majority of hyd…
Genetik -
Hydrastine DB19354
small molecule | CAS: 118-08-1

Deskripsi belum tersedia.

Kategori:
AlkaloidsHeterocyclic Compounds, Fused-RingHydrastis +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrastinine DB19359
small molecule | CAS: 6592-85-4

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingIsoquinolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7647-01-0

Deskripsi belum tersedia.

Kategori:
Acid PreparationsAcidsAcids, Noncarboxylic +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrochlorothiazide Approved DB00999
small molecule | CAS: 58-93-5

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A18513…

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +25
Target Protein:
Solute carrier family 12 member 3Angiotensin-converting enzymeCalcium-activated potassium channel subunit alpha-1
Waktu ParuhThe plasma half lif…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
Hydrocodone Approved DB00956
small molecule | CAS: 125-29-1

Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced b…

Kategori:
AlkaloidsAnalgesicsAntitussive Agents +23
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorSigma non-opioid intracellular receptor 1
Waktu ParuhThe half-life of el…
Vol. DistribusiThe apparent volume…
KlirensOfficial FDA labeli…
Genetik -
Hydrocortamate Approved DB00769
small molecule | CAS: 76-47-1

Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind …

Kategori:
Cytochrome P-450 CYP3A InducersCytochrome P-450 CYP3A4 InducersCytochrome P-450 CYP3A4 Inducers (strength unknown) +1
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone butyrate Approved DB14540
small molecule | CAS: 13609-67-1

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdministration, Topical +26
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone cypionate Approved DB14541
small molecule | CAS: 508-99-6

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +18
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone phosphate Approved DB14542
small molecule | CAS: 3863-59-0

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +18
Target Protein:
Annexin A1Glucocorticoid receptor11-beta-hydroxysteroid dehydrogenase type 2 +1
Waktu Paruh6-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Hydrocortisone succinate Approved DB14545
small molecule | CAS: 2203-97-6

Deskripsi belum tersedia.

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +22
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen fluoride Approved DB11072
small molecule | CAS: 7664-39-3

Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as [DB00472] (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also …

Kategori:
AcidsAcids, NoncarboxylicDental Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrogen peroxide Approved DB11091
small molecule | CAS: 7722-84-1

Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it…

Kategori:
Alimentary Tract and MetabolismAnionsAnti-Infective Agents +19
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1
Waktu Paruh-
Vol. DistribusiTarget organs affec…
Klirens-
Genetik -
biotech | CAS: 84836-98-6

Hydrogenated coconut oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
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Genetik -
biotech | CAS: 68990-82-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 97281-48-6

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
biotech | CAS: 8016-70-4

Extracted from the seeds of the soybean (Glycine soja), hydrogenated soybean oil is a major food fat used in the production of margarine, shortening, and salad and cooking oils. According to the FDA, hydrogenated soybean oil is generally recognized as safe (G…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 23599-55-5

Deskripsi belum tersedia.

Kategori:
Biological FactorsHeterocyclic Compounds, Fused-RingPigments, Biological +1
Target Protein:
Precorrin-8X methylmutase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 68607-88-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 1236208-20-0

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydromorphinol DB01512
small molecule | CAS: 2183-56-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydromorphone Approved DB00327
small molecule | CAS: 466-99-9

Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +22
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe volume of distr…
KlirensThe mean plasma cle…
Genetik -
Hydronidone DB06299
small molecule | CAS: 851518-71-3

Hydronidone has antifibrotic activity.

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinine DB13718
small molecule | CAS: 522-66-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiarrhythmic agentsAutonomic Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinone Approved DB09526
small molecule | CAS: 123-31-9

Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, b…

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +11
Target Protein:
TyrosinaseIntegrin beta-3Integrin alpha-IIb +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydrotalcite Approved DB13322
small molecule | CAS: 12304-65-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAlkaliesAluminium Compounds +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Liver carboxylesterase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Collagenase 3Stromelysin-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyamphetamine Approved DB09352
small molecule | CAS: 103-86-6

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor side effe…

Kategori:
Adrenergic AgonistsAminesAmphetamines +7
Target Protein:
Trace amine-associated receptor 1
Waktu Paruh-
Vol. DistribusiIntended for local …
KlirensIntended for local …
Genetik -
Hydroxychloroquine Approved DB01611
small molecule | CAS: 118-42-3

Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, ch…

Kategori:
AminoquinolinesAnti-Infective AgentsAntimalarials +22
Target Protein:
Toll-like receptor 7Toll-like receptor 9DNA +1
Waktu ParuhA half-life of 123.…
Vol. DistribusiHydroxychloroquine …
KlirensThe clearance of hy…
Genetik -
Hydroxycitronellal Approved DB14187
small molecule | CAS: 107-75-5

Hydroxycitronellal is a synthetic fragrance that is widely used in many cosmetics and hygiene products such as deodorants, soaps, antiseptics, and other household items. It has the smell of lilac, lily, and lily of the valley [A34269]. Hydroxycitronellal has …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleasePerfume +1
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhThe mean eliminatio…
Vol. DistribusiTmax was found to b…
Klirens-
Genetik -
Hydroxydione DB08956
small molecule | CAS: 303-01-5

Hydroxydione (Viadril) is a neuroactive steroid used as a general anesthetic.

Kategori:
Fused-Ring CompoundsNeurotransmitter AgentsPregnanes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl cellulose Approved DB11602
small molecule | CAS: 9004-62-0

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ion…

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyethyl Starch Approved DB09106
small molecule | CAS: 9005-27-0

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average mol…

Kategori:
Blood and Blood Forming OrgansBlood and Related ProductsBlood Substitutes +14
Waktu ParuhTerminal half-life …
Vol. Distribusi5.9 L.
Klirens31.4 mL/min
Genetik -
small molecule | CAS: 7647-63-4

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UsePhenothiazine Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyfasudil DB04707
small molecule | CAS: 105628-72-6

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingIsoquinolinesPiperazines +3
Target Protein:
Chloride channel protein 2Rho-associated protein kinase 1cAMP-dependent protein kinase catalytic subunit alpha +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68-96-2

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyprogesterone caproate Approved DB06789
small molecule | CAS: 630-56-8

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17?-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was p…

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsCombination Contraceptives (with Estrogen and derivatives) +26
Target Protein:
Progesterone receptor
Waktu ParuhHalf-life = 16 days…
Vol. DistribusiHydroxyprogesterone…
KlirensClearance is highly…
Genetik -
small molecule | CAS: 128446-35-5

Hydroxypropyl betadex is under investigation in clinical trial NCT03471143 (Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C).

Kategori:
beta-CyclodextrinsCarbohydratesCompounds used in a research, industrial, or household setting +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxypropyl cellulose Approved DB00840
small molecule | CAS: 9004-64-2

Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used t…

Kategori:
Artificial TearsBiopolymersCarbohydrates +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 439685-79-7

Hydroxypropyl tetrahydropyrantriol has been used in trials studying the basic science of Aging.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxytyrosol DB12771
small molecule | CAS: 10597-60-1

Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer.

Kategori:
AlcoholsAnti-Infective AgentsAntioxidants +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hydroxyurea Approved DB01005
small molecule | CAS: 127-07-1

Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928.[A262596] It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults.[A262601] Although c…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +11
Target Protein:
Ribonucleoside-diphosphate reductase large subunitRibonucleoside-diphosphate reductase subunit M2
Waktu ParuhIn adult cancer pat…
Vol. DistribusiHydroxyurea distrib…
KlirensThe total body clea…
Genetik -
Hydroxyzine Approved DB00557
small molecule | CAS: 68-88-2

Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since re…

Kategori:
Anti-Anxiety AgentsAntipruriticsCentral Nervous System Depressants +21
Target Protein:
Histamine H1 receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhThe half-life of hy…
Vol. DistribusiThe mean volume of …
KlirensClearance of hydrox…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptide deformylasePeptide deformylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Hyoscyamine Approved DB00424
small molecule | CAS: 101-31-5

Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] …

Kategori:
Adjuvants, AnesthesiaAgents producing tachycardiaAlimentary Tract and Metabolism +26
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M2 +3
Waktu ParuhThe half life of hy…
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5801–5850 dari 11793
Sebelumnya Halaman 117 / 236 Berikutnya