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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 117 / 315
Dimethyl sulfoxide Approved DB01093
small molecule | CAS: 67-68-5

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. …

Kategori:
AntioxidantsCompounds used in a research, industrial, or household settingCryoprotective Agents +20
Target Protein:
Interleukin-5 receptor subunit alphaMucin-16Myc proto-oncogene protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Dual specificity tyrosine-phosphorylation-regulated kinase 1ADual specificity tyrosine-phosphorylation-regulated kinase 2Casein kinase II subunit alpha
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 358-72-5

Deskripsi belum tersedia.

Kategori:
Terpenes
Target Protein:
Farnesyl pyrophosphate synthaseIsopentenyl-diphosphate Delta-isomerase 14-hydroxy-3-methylbut-2-enyl diphosphate reductase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 1403357-81-2

Deskripsi belum tersedia.

Kategori:
CycloheptanesCycloparaffinsPolycyclic Sesquiterpenes +4
Waktu Paruh-
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Genetik -
small molecule | CAS: 63834-04-8

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal DisordersSynthetic Antispasmodics, Amides With Tertiary Amines
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Genetik -
small molecule | CAS: 52328-98-0

Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin. It is a novel anti-androgen that enhances androgen receptor degradation.

Kategori:
AlkanesBenzene DerivativesCatechols +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 131-11-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgrochemicalsAntiparasitic Products, Insecticides and Repellents +9
Waktu Paruh-
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Genetik -
small molecule | CAS: 524-84-5

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse po…

Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 61-50-7

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an an…

Kategori:
AminesAntidepressive AgentsBiogenic Amines +13
Target Protein:
5-hydroxytryptamine receptor 6Sigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetindene Approved DB08801
small molecule | CAS: 5636-83-9

Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +13
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetofrine DB13494
small molecule | CAS: 22950-29-4

Deskripsi belum tersedia.

Kategori:
Adrenergic and Dopaminergic AgentsAlcoholsAmines +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Diminazene DB03608
small molecule | CAS: 536-71-0

Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Az…

Kategori:
AmidinesAnti-Infective AgentsAntiparasitic Agents +4
Target Protein:
HTH-type transcriptional regulator QacRSerine protease 1Diamine oxidase [copper-containing] +1
Waktu Paruh-
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Dimiracetam DB13018
small molecule | CAS: 126100-97-8

Dimiracetam has been used in trials studying the treatment of AIDS, Neuropathy, and Acquired Immunodeficiency Syndrome.

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Dinaciclib DB12021
small molecule | CAS: 779353-01-4

Dinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others.

Kategori:
Cyclin-Dependent Kinases, antagonists & inhibitorsHeterocyclic Compounds, Fused-RingPyridines
Target Protein:
Cyclin-dependent kinase 9Cyclin-dependent kinase 2Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 311768-81-7

Dinalbuphine sebacate is under investigation in clinical trial NCT02468128 (A Study of Intramuscular Sebacoyl Dinalbuphine Ester for Post-Hemorrhoidectomy Pain Management).

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small molecule | CAS: 97-00-7

Dinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.

Kategori:
AntigensBenzene DerivativesBiological Factors +14
Target Protein:
Methylated-DNA--protein-cysteine methyltransferaseGlutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinoprost Approved DB12789
small molecule | CAS: 551-11-1

Dinoprost has been investigated in Headache.

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAutacoids +11
Target Protein:
Prostaglandin F2-alpha receptorThromboxane A2 receptorProstaglandin E2 receptor EP1 subtype +5
Waktu Paruh-
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Genetik -
Dinoprost tromethamine Approved DB01160
small molecule | CAS: 38562-01-5

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or …

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAngiography +11
Target Protein:
Prostaglandin F2-alpha receptorProstacyclin receptor
Waktu ParuhThe half-life of di…
Vol. Distribusi-
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Dinoprostone Approved DB00917
small molecule | CAS: 363-24-6

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, t…

Kategori:
AutacoidsBiological FactorsDinoprostone, antagonists & inhibitors +19
Target Protein:
Prostaglandin F2-alpha receptorProstaglandin E2 receptor EP2 subtypeProstaglandin E2 receptor EP1 subtype +3
Waktu ParuhLess than 5 minutes.
Vol. Distribusi-
Klirens-
Genetik -
Dinutuximab Approved DB09077
biotech | CAS: 1363687-32-4

Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
GD2 disialoganglioside
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe mean volume of …
KlirensThe clearance is 0.…
Genetik -
Dioctyldimonium Approved DB13970
small molecule | CAS: 20256-55-7

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Diodone DB13568
small molecule | CAS: 300-37-8

Deskripsi belum tersedia.

Kategori:
Compounds used in a research, industrial, or household settingContrast MediaDiagnostic Uses of Chemicals +5
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Diosmetin DB11259
small molecule | CAS: 520-34-3

Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits [A27231]. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic and anti-in…

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Cytochrome P450 1B1Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 467-86-7

Deskripsi belum tersedia.

Waktu Paruh-
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Dioxybenzone Approved DB11221
small molecule | CAS: 131-53-3

Dioxybenzone, or benzophenone-8, is an organic compound derived from [DB01878] that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525].

Kategori:
Benzene DerivativesKetonesSunscreen Agents
Target Protein:
Sex hormone-binding globulin
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 94-37-1

Deskripsi belum tersedia.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseStandardized Chemical Allergen
Target Protein:
Aldehyde dehydrogenase family 3 member A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diperodon DB11513
small molecule | CAS: 101-08-6

Deskripsi belum tersedia.

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Diphemanil Approved DB13720
small molecule | CAS: 15394-62-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnti-Asthmatic Agents +9
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphenadione DB13347
small molecule | CAS: 82-66-6

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCytochrome P-450 CYP3A Substrates +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphencyprone DB12173
small molecule | CAS: 886-38-4

Diphencyprone has been used in trials studying the treatment and basic science of Melanoma, Ultraviolet Rays, Immunosuppression, Neoplasm Metastasis, and Hypersensitivity, Delayed, among others.

Kategori:
Cycloparaffins
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Diphenhydramine Approved DB01075
small molecule | CAS: 58-73-1

Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, …

Kategori:
Agents producing tachycardiaAminesAminoalkyl Ethers +41
Target Protein:
Histamine N-methyltransferaseHistamine H1 receptorMuscarinic acetylcholine receptor M2
Waktu ParuhThe elimination hal…
Vol. DistribusiDiphenhydramine is …
KlirensValues for plasma c…
Genetik -
Diphenidol Approved DB01231
small molecule | CAS: 972-02-1

Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntiemetics +6
Target Protein:
Muscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1 +1
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
Diphenoxylate Approved DB01081
small molecule | CAS: 915-30-0

A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medica…

Kategori:
Alimentary Tract and MetabolismAnalgesicsAntidiarrheals +11
Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh12-14 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 117-34-0

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicPhenylacetates
Target Protein:
Cathepsin B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 244-54-2

An NADPH oxidase 2 (NOX2) inhibitor.[A252987]

Kategori:
Blood Glucose Lowering AgentsEnzyme InhibitorsNitric Oxide Synthase, antagonists & inhibitors
Waktu Paruh-
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Diphenylguanidine Approved DB14191
small molecule | CAS: 102-06-7

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen. Sensitivity to di…

Kategori:
AmidinesCell-mediated ImmunityIncreased Histamine Release +1
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Genetik -
Diphenylpyraline Approved DB01146
small molecule | CAS: 147-20-6

Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines a…

Kategori:
Aminoalkyl EthersAntihistamines for Systemic UseHistamine Antagonists +1
Target Protein:
Histamine H1 receptorSodium-dependent dopamine transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipipanone DB01491
small molecule | CAS: 467-83-4

Deskripsi belum tersedia.

Kategori:
Ketones
Waktu Paruh-
Vol. Distribusi-
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Dipivefrin Approved DB00449
small molecule | CAS: 52365-63-6

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +24
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-2A adrenergic receptor +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Dipotassium phosphate Approved DB09414
small molecule | CAS: 7758-11-4

Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.

Kategori:
AcidsAcids, NoncarboxylicAnions +14
Waktu ParuhIn healthy children…
Vol. DistribusiDistribution is lar…
KlirensPhosphates are rapi…
Genetik -
Dipraglurant DB12733
small molecule | CAS: 872363-17-2

Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).

Target Protein:
Metabotropic glutamate receptor 5
Waktu Paruh-
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Diprenorphine DB01548
small molecule | CAS: 14357-78-9

A narcotic antagonist similar in action to naloxone. It is used to remobilize animals after etorphine neuroleptanalgesia and is considered a specific antagonist to etorphine. [PubChem]

Kategori:
AlkaloidsCentral Nervous System AgentsHeterocyclic Compounds, Fused-Ring +6
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63065-88-3

Dipropyl-4-hydroxytryptamine is the 4-hydroxyl analog of dipropyltryptamine (DPT). Dipropyl-4-hydroxytryptamine was first synthesized by Alexander Shulgin. This agent and its properties haven't been fully elucidated.

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Genetik -
small molecule | CAS: 25265-71-8

Deskripsi belum tersedia.

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Dipyridamole Approved DB00975
small molecule | CAS: 58-32-2

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Kategori:
AnticoagulantsAntiplatelet agentsBlood and Blood Forming Organs +17
Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AcGMP-specific 3',5'-cyclic phosphodiesterase3',5'-cyclic-AMP phosphodiesterase 4A +3
Waktu Paruh40 minutes
Vol. Distribusi* 1 to 2.5 L/kg
Klirens* 2.3-3.5 mL/min/kg
Genetik -
Dipyrithione Approved DB11327
small molecule | CAS: 3696-28-4

Dipyrithione, a bactericidal and fungicidal pyrithione derivate, was formulated as Crimanex anti-dandruff shampoo, but is no longer available.[L2611] It is currently used as a pesticide, and not used in any FDA approved drug products.[A32829] Interestingl…

Target Protein:
Nitric oxide synthase, inducibleProstaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipyrocetyl DB13839
small molecule | CAS: 486-79-3

Deskripsi belum tersedia.

Kategori:
AnalgesicsAntiinflammatory and Antirheumatic ProductsMusculo-Skeletal System +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
CoenzymesEnzymes and Coenzymes
Target Protein:
Porphobilinogen deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diquafosol DB15919
small molecule | CAS: 59985-21-6

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +12
Target Protein:
P2Y purinoceptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diridavumab DB12607
biotech | CAS: 1393659-46-5

Cr6261 is under investigation in clinical trial NCT02016066 (A Study to Assess the Safety, Pharmacokinetics and Immunogenicity of Diridavumab in Japanese Healthy Participants).

Waktu Paruh-
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Genetik -
Menampilkan 5801–5850 dari 15718
Sebelumnya Halaman 117 / 315 Berikutnya