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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 115 / 349
Clorgiline DB04017
small molecule | CAS: 17780-72-2

An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

Kategori:
Agents that produce hypertensionAminesAntidepressive Agents +9
Target Protein:
Amine oxidase [flavin-containing] A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloricromen DB13367
small molecule | CAS: 68206-94-0

Deskripsi belum tersedia.

Kategori:
Antiplatelet agentsBenzopyransBlood and Blood Forming Organs +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloridarol DB13291
small molecule | CAS: 3611-72-1

Cloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s [A176222].

Kategori:
Cardiac TherapyHeterocyclic Compounds, Fused-RingVasodilators Used in Cardiac Diseases
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorindione DB13275
small molecule | CAS: 1146-99-2

Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansIndenes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorobiocin DB03966
small molecule | CAS: 39868-96-7

Clorobiocin is an aminocoumarin antibiotic, similar to [novobiocin] and coumermycin A1.

Kategori:
AminocoumarinsBenzopyransCarbohydrates +4
Target Protein:
DNA topoisomerase 2-betaDNA topoisomerase 2-alphaDNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorotepine DB15971
small molecule | CAS: 13448-22-1

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingSulfur CompoundsThiepins
Target Protein:
5-hydroxytryptamine receptor 2CHistamine H1 receptorAlpha-1B adrenergic receptor +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorsulon DB11389
small molecule | CAS: 60200-06-8

Deskripsi belum tersedia.

Kategori:
AmidesAminesAniline Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clortermine DB01527
small molecule | CAS: 10389-73-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clostebol DB01521
small molecule | CAS: 1093-58-9

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 855-19-6

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Clostridium tetani Approved DB09876
biotech

Deskripsi belum tersedia.

Kategori:
Inactivated Clostridium Tetani Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture …

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBacterial Vaccines +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clothiapine Approved DB13256
small molecule | CAS: 2058-52-8

Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clotiazepam Approved DB01559
small molecule | CAS: 33671-46-4

Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.

Kategori:
Anti-Anxiety AgentsBenzodiazepines and benzodiazepine derivativesCentral Nervous System Depressants +8
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
Clotrimazole Approved DB00257
small molecule | CAS: 23593-75-1

This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic a…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntifungal Agents +54
Target Protein:
C-X-C chemokine receptor type 2Lanosterol 14-alpha demethylaseIntermediate conductance calcium-activated potassium channel protein 4 +3
Waktu Paruh-
Vol. DistribusiThe topical form is…
Klirens-
Genetik -
Clove Approved DB10672
biotech | CAS: 84961-50-2

Clove allergenic extract is used in allergenic testing.

Kategori:
AngiospermsBiological ProductsCell-mediated Immunity +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clove oil Approved DB11338
biotech | CAS: 8000-34-8

Clove oil is obtained by extraction from the dried flower buds of the clove plant. Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. It is also found in topical analgesics. Clove oil has shown to exert some antimicrobial activ…

Kategori:
Biological ProductsComplex MixturesDrugs that are Mainly Renally Excreted +3
Target Protein:
Vascular cell adhesion protein 1C-X-C motif chemokine 10Collagen alpha-1(I) chain +1
Waktu ParuhIn a pharmacokineti…
Vol. Distribusi-
Klirens-
Genetik -
Cloxacillin Approved DB01147
small molecule | CAS: 61-72-3

A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin].

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +12
Target Protein:
D-alanyl-D-alanine carboxypeptidase DacAPenicillin-binding protein 2XPenicillin-binding protein 1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloxazolam DB01553
small molecule | CAS: 24166-13-0

Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects. It is marketed in the Argentina, Australia, Portugal, Belgium, Switzerland, Luxembourg, Germany, Taiwan and Japan -- mainly for anti-anxiety. The us…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +4
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh65 hours
Vol. Distribusi-
Klirens-
Genetik -
Cloxyquin DB15933
small molecule | CAS: 130-16-5

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingHydroxyquinolinesQuinolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clozapine Approved DB00363
small molecule | CAS: 5786-21-0

Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent.[A256708] Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation ant…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +65
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2AD(1A) dopamine receptor +30
Gen Terkait:
GNB3
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe median volume o…
KlirensThe median clearanc…
Genetik 1 Varian
CLX-0921 DB05854
small molecule

CLX-0921 is investigated for use/treatment in diabetes mellitus type 2. CLX-0921 is a solid. CLX-0921 has a spectrum of activity that differs from commercially available thiazolidinediones. This substance targets the protein peroxisome proliferator-activated …

Kategori:
Sulfur Compounds
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CLZ-2002 DB18638
biotech

CLZ-2002 consists of allogeneic mesenchymal stem cells derived neuronal regeneration-promoting cells.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CM-101 DB18293
biotech

Deskripsi belum tersedia.

Kategori:
AntigensAntigens, BacterialAntineoplastic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CM-4307 DB15414
small molecule | CAS: 1130115-44-4

CM-4307 is under investigation in clinical trial NCT03602495 (Donafenib in 131I-Refractory Differentiated Thyroid Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CM4620 DB16466
small molecule | CAS: 1713240-67-5

CM4620 (Zegocractin), is under investigation in multiple clinical trials, including NCT04195347 (pancreatitis due to asparaginase), NCT03709342 (PK/PD study in acute pancreatitis), NCT03401190 and NCT04681066 (pancreatitis and SIRS), and NCT04661540 (critical…

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CMC 001 DB05353
small molecule

CMC 001 is an orally administered MRI contrast agent in development for enhancement of the liver, bile ducts and gastrointestinal tract.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CMG901 DB18619
biotech

CMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CMLVAX100 DB05164
biotech

CMLVAX100 is a vaccine targeting the BCR-ABL-derived p210 fusion protein which reduces residual disease in some patients with chronic myeloid leukemia. It is developed by Breakthrough Therapeutics and has completed phase I of its clinical trial.

Target Protein:
BCR/ABL p210 fusion protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
3-deoxy-manno-octulosonate cytidylyltransferase3-deoxy-manno-octulosonate cytidylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CMX-2043 DB12795
small molecule | CAS: 910627-26-8

CMX-2043 has been used in trials studying the treatment and prevention of Non STEMI, Unstable Angina, Stable Coronary Artery Disease, and Percutaneous Coronary Intervention.

Kategori:
Amino Acids, Peptides, and ProteinsCoenzymesEnzymes and Coenzymes +6
Target Protein:
RAC-alpha serine/threonine-protein kinaseHepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CN-105 DB18345
small molecule | CAS: 1632243-07-2

CN-105 is a neuroprotective pentapeptide with the sequence Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CN-201 DB18726
biotech

CN-201 is a humanized anti-CD3/CD19 bispecific antibody.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CNDO-109 DB17290
biotech

CNDO-109 are CNDO-109-activated allogeneic natural killer cells.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CNM-Au8 DB17952
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CNS-5161 DB05824
small molecule

CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials as a novel compound for the treatment of neuropathic pain.

Target Protein:
Glutamate receptor ionotropic, NMDA 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CNV-2197944 DB15229
small molecule | CAS: 1204535-44-3

CNV-2197944 is under investigation in clinical trial NCT01893125 (Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Diabetic Peripheral Neuropathy).

Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serotonin N-acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serotonin N-acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serotonin N-acetyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 181054-95-5

Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and functional characterist…

Kategori:
Blood Coagulation FactorsHemostaticsIncreased Coagulation Activity
Target Protein:
Coagulation factor XCoagulation factor XICoagulation factor VII +4
Waktu Paruh18.8 ± 5.4 hours
Vol. Distribusi-
Klirens8.62 ± 1.7
Genetik -
Coagulation Factor IX Human Approved DB13152
biotech | CAS: 181054-95-5

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +9
Target Protein:
Coagulation factor XCoagulation factor XICoagulation factor VII +4
Waktu Paruh18.8 ± 5.4 hours.
Vol. Distribusi-
Klirens8.62 ± 1.7.
Genetik -
Coagulation factor VII human Approved DB13150
biotech

Coagulation factor VII is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +8
Target Protein:
Tissue factorCoagulation factor XCoagulation factor IX
Waktu Paruh5 h
Vol. Distribusi45 ml/kg
Klirens7.4 ml/kgh
Genetik -
biotech | CAS: 102786-61-8

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed i…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +15
Target Protein:
Coagulation factor XTissue factor
Waktu Paruh-
Vol. Distribusi* 121 ± 30 mL/kg [a…
Klirens* 33 - 37 mL/h x kg…
Genetik -
Coagulation factor X human Approved DB13148
biotech

Coagulation Factor X (Human), is a plasma-derived human blood coagulation factor is used by adults and children (aged 12 years and above) with hereditary Factor X deficiency. However its use is limited in the perioperative setting for the management of bleedi…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +11
Waktu ParuhFollowing a single …
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
biotech | CAS: 9013-55-2

Coagulation factor XIa is under investigation in clinical trial NCT01701947 (HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coagulin-B DB17703
biotech

Coagulin-B is an adeno-associated viral vector expressing human blood-coagulation Factor IX.[A259038, A259043] It was previously investigated for the treatment of hemophilia; however, the manufacturing company discontinued the Phase I trial in 2004, halting i…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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