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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

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Hasil Pencarian (6694)

Halaman 115 / 134
Sivopixant DB18816
small molecule | CAS: 2414285-40-6

Deskripsi belum tersedia.

Kategori:
Amines
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sizofiran DB13128
small molecule | CAS: 9050-67-3

A beta-D-glucan obtained from the Aphyllophoral fungus Schizophyllum commune. It is used as an immunoadjuvant in the treatment of neoplasms, especially tumors found in the stomach. Sizofiran has been used in trials studying the treatment of Cervical Cancer.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsAntineoplastic Agents, Phytogenic +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 162849-90-3

SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists.[A253132]

Kategori:
Antiarrhythmic agentsAntiplatelet agentsCalcium Channel Blockers +4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SLN500 DB18636
biotech

SLN500 is a synthetic double-strand small interfering ribonucleic acid (siRNA) oligonucleotide drug directed against C3 messenger RNA

Waktu Paruh-
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SM-1997 DB18670
biotech

SM-1997 is a protein-free solution derived from calf's blood comprising electrolytes, trace minerals, amino acids, peptides, nucleosides, and nucleotides.[A261816] It is under investigation for the treatment of cutaneous sulfur mustard-induced injury.

Waktu Paruh-
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biotech

The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations.[L12747] ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this s…

Kategori:
Actively Acquired ImmunityBiological ProductsComplex Mixtures +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Smilagenin DB05450
small molecule | CAS: 126-18-1

Smilagenin is a novel non-peptide, orally bioavailable neurotrophic factor inducer that readily reverses free radical neurotoxicity produced by 1-ethyl-4- phenylpyridium (MPP+) in dopaminergic neurones and reverses the decrease of neuronal growth factors and …

Kategori:
CholestanesDrugs, Chinese HerbalFused-Ring Compounds +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SN-38 DB05482
small molecule | CAS: 86639-52-3

7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of …

Kategori:
AlkaloidsAntineoplastic AgentsCytochrome P-450 CYP3A Inhibitors +9
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17989-41-2

Deskripsi belum tersedia.

Target Protein:
Fructose-bisphosphate aldolase BPyridoxine 5'-phosphate synthaseTriosephosphate isomerase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Snail, unspecified Approved DB14245
biotech

Snail, unspecified is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
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SNP-ACTH (1-39) DB18544
biotech

SNP-ACTH (1-39) is a synthetic porcine Corticotropin (ACTH)

Waktu Paruh-
Vol. Distribusi-
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SNS01-T DB17302
biotech

SNS01-T is a gene therapy nanoparticle. It is composed of three components: a B cell-specific plasmid expressing eIF5AK50R; an siRNA that targets the native eIF5A that promotes growth/anti-apoptosis of cancer cells; and polyethylenimine.[A254706]

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Soblidotin DB12677
small molecule | CAS: 149606-27-9

Soblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Amino Acids, Peptides, and ProteinsAntineoplastic AgentsPeptides
Waktu Paruh-
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Sodium acetate Approved DB09395
small molecule | CAS: 127-09-3

Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important compo…

Kategori:
AcetatesAcids, AcyclicBlood and Blood Forming Organs +5
Waktu Paruh-
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Sodium arsenite DB18508
small molecule | CAS: 7784-46-5

Deskripsi belum tersedia.

Kategori:
AnionsArsenicalsElectrolytes +3
Waktu Paruh-
Vol. Distribusi-
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Sodium ascorbate Approved DB14482
small molecule | CAS: 134-03-2

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAntioxidantsBiological Factors +13
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium bicarbonate Approved DB01390
small molecule | CAS: 144-55-8

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Kategori:
AntacidsAntacids and AdsorbentsBicarbonates +13
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1HA-type voltage-gated potassium channel KCND3Hydrogen ions
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium carbonate Approved DB09460
small molecule | CAS: 497-19-8

Sodium Carbonate is the disodium salt of carbonic acid with alkalinizing property. When dissolved in water, sodium carbonate forms carbonic acid and sodium hydroxide. As a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.

Kategori:
AlkaliesAnionsCarbon Compounds, Inorganic +3
Target Protein:
Carbonic anhydrase 1Carbonic anhydrase 2Carbonic anhydrase 4 +1
Waktu Paruh-
Vol. DistribusiDistribution occurs…
Klirens-
Genetik -
Sodium cellulose phosphate Approved DB06776
small molecule | CAS: 9038-41-9

Sodium cellulose phosphate is used to treat hypercalcemia and hypercalciuria. It has been used to prevent kidney stones. [A31694] This compound is an ion-exchange resin that can not be absorbed by the body. However, it can be used to restore normal intesti…

Kategori:
BiopolymersCalcium BinderCalcium Chelating Activity +8
Target Protein:
Calcium ions
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium chloride Approved DB09153
small molecule | CAS: 7647-14-5

Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid o…

Kategori:
Alimentary Tract and MetabolismBlood and Blood Forming OrgansBlood Substitutes and Perfusion Solutions +14
Waktu Paruh17 minutes
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Sodium chlorite DB13210
small molecule | CAS: 7758-19-2

Used as an agent for cleaning drinking water. It is also used as an additive in products like toothpaste and mouthwash. Acidified sodium chlorite was approved by the U.S. Food and Drug Administration as of 2004, as an anti-microbial agent which is non-toxic, …

Kategori:
AnionsChlorine CompoundsCicatrizants +4
Waktu Paruh-
Vol. Distribusi-
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Sodium citrate Approved DB09154
small molecule | CAS: 68-04-2

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the me…

Kategori:
Acids, AcyclicAntacids and AdsorbentsAnticoagulants +21
Target Protein:
Carbonic anhydrase 4
Waktu Paruh18-54 min [A19414]
Vol. Distribusi19-39L [A19414].
KlirensTotal clearance of …
Genetik -
small molecule

Sodium copper chlorophyllin (SCC) is a water-soluble and bright green mixture derived from natural chlorophyll that has potential antimutagenic and antioxidant properties[A227718]. This compound is used as a food colorant and supplement[A227718]. SCC of t…

Kategori:
Anti-Infective Agents, LocalAntimutagenic AgentsChlorophyll +4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 34089-81-1

Sodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography…

Kategori:
Iron PreparationsParenteral Iron Replacement
Target Protein:
Ferritin light chainHemoglobin subunit betaHemoglobin subunit alpha
Waktu ParuhThe terminal elimin…
Vol. DistribusiUsing single-dose p…
KlirensTotal clearance ran…
Genetik -
Sodium fluoride Approved DB09325
small molecule | CAS: 7681-49-4

Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18].[L4894] Sodium fluoride's benefits on dental health were first o…

Kategori:
Alimentary Tract and MetabolismAnionsCaries Prophylactic Agents +13
Target Protein:
Hydroxyapatite
Waktu ParuhThe terminal plasma…
Vol. DistribusiFluoride distribute…
KlirensSodium fluoride is …
Genetik -
Sodium fluorophosphate Approved DB09484
small molecule | CAS: 10163-15-2

Sodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.

Kategori:
AcidsAcids, NoncarboxylicAlimentary Tract and Metabolism +17
Waktu Paruh-
Vol. Distribusi-
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Sodium hydroxide Approved DB11151
small molecule | CAS: 1310-73-2

Sodium hydroxide is also known as _lye_ or _soda_ , or _caustic soda_ [L1971]. At room temperature, sodium hydroxide is a white crystalline odorless solid that absorbs moisture from the air. It is a synthetically manufactured substance. When dissolved in w…

Kategori:
AlkaliesAnionsCaustics +7
Waktu Paruh-
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Sodium iodide Approved DB11119
small molecule | CAS: 7681-82-5

Sodium iodide is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [L2065] but is more commonly used in veterinary medicine. Radiolabelled compound…

Kategori:
IodidesIodine CompoundsReplacement Preparations +2
Waktu Paruh-
Vol. DistribusiIodides are distrib…
Klirens-
Genetik -
small molecule | CAS: 151-21-3

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsi…

Kategori:
AlcoholsAlkanesulfonatesAlkanesulfonic Acids +9
Target Protein:
Albumin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium lauryl sulfoacetate Approved DB13157
small molecule | CAS: 1847-58-1

Sodium lauryl sulfoacetate is a wetting agent and surfactant used in enema-type laxative products.

Kategori:
Alimentary Tract and MetabolismDrugs for ConstipationEnemas
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 7681-57-4

Deskripsi belum tersedia.

Kategori:
AnionsAutonomic AgentsBronchoconstrictor Agents +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium metavanadate Approved DB14702
small molecule | CAS: 13718-26-8

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIons +2
Waktu Paruh-
Vol. Distribusi-
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Sodium oxybate Approved DB09072
small molecule | CAS: 502-85-2

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy.[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmit…

Kategori:
Acids, AcyclicAdjuvants, AnesthesiaAnesthetics +9
Target Protein:
GABA(B) ReceptorSolute carrier family 52, riboflavin transporter, member 2
Waktu ParuhGHB has an eliminat…
Vol. DistribusiThe apparent volume…
KlirensIn healthy GHB-naïv…
Genetik -
small molecule | CAS: 7601-89-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicChlorine Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10101-89-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium phosphate, dibasic Approved DB14502
small molecule | CAS: 7558-79-4

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +8
Target Protein:
Carbonic anhydrase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10140-65-5

Deskripsi belum tersedia.

Kategori:
LaxativesOsmotic Laxatives
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium phosphate, monobasic Approved DB09449
small molecule | CAS: 7558-80-7

Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.

Kategori:
AcidsAcids, NoncarboxylicAgents that reduce seizure threshold +19
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
LaxativesOsmotic Laxatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium stibogluconate Approved DB05630
small molecule | CAS: 16037-91-5

Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam (manufacture…

Kategori:
Acids, AcyclicAgents Against Leishmaniasis and TrypanosomiasisAnti-Infective Agents +10
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sodium sulfate Approved DB09472
small molecule | CAS: 7757-82-6

Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the …

Kategori:
Alimentary Tract and MetabolismAnionsDrugs for Constipation +11
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 1
Waktu ParuhSerum sulfate: 8.5 …
Vol. Distribusi-
Klirens-
Genetik -
Sodium tartrate Approved DB13707
small molecule | CAS: 868-18-8

Sodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals. It is obtained as a byproduct of wine manufacturing. Sodium tartrate is generally recognized as safe (GRAS) as a direct human food…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismCarbohydrates +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sodium tetradecyl sulfate Approved DB00464
small molecule | CAS: 139-88-8

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.

Kategori:
AcidsAlcoholsAlkanesulfonates +16
Target Protein:
Vitamin K-dependent protein SVitamin K-dependent protein C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sofosbuvir Approved DB08934
small molecule | CAS: 1190307-88-0

Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is c…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +18
Target Protein:
Genome polyproteinRNA-dependent RNA-polymerase
Waktu ParuhSofosbuvir has a te…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of so…
Genetik -
Sofpironium Approved DB19325
small molecule | CAS: 1628251-49-9

Sofpironium is a "soft" anticholinergic analog of [glycopyrronium] that has been modified with a readily hydrolyzable ester moiety.[L51109] Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabolic drug des…

Kategori:
Anticholinergic AgentsCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strength unknown) +13
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor
Waktu ParuhThe _in vitro_ half…
Vol. Distribusi-
Klirens-
Genetik -
Solenopsis richteri Approved DB11026
biotech

Solenopsis richteri allergenic extract is used in allergenic testing. It is extracted from the black imported fire ant which is native to South Amercia. The species has also been introduced in North Amercia. When stung, the bites are characterized by sterile …

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Solifenacin Approved DB01591
small molecule | CAS: 242478-37-1

Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency.[L7511] It has a long duration of action as it is usually taken once daily.[L7511] Solifenacin was grante…

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAnticholinergic Agents +19
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M4 +2
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of so…
Genetik -
Solithromycin DB09308
small molecule | CAS: 760981-83-7

Solithromycin is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Solriamfetol Approved DB14754
small molecule | CAS: 178429-62-4

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]…

Kategori:
Acids, AcyclicAdrenergic AgentsAdrenergic Uptake Inhibitors +22
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter
Waktu Paruh7.1 hours[FDA Label…
Vol. Distribusi199L[FDA Label]. Ot…
KlirensRenal clearance is …
Genetik -
Menampilkan 5701–5750 dari 6694
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