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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 115 / 282
Ecabet DB05265
small molecule | CAS: 33159-27-2

Ecabet is a prescription eye drop for the treatment of dry eye syndrome. Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia. Mucin is a glycoprotein component…

Kategori:
Anti-Infective AgentsAnti-Ulcer AgentsAnticarcinogenic Agents +10
Target Protein:
Urease subunit alphaNADPH oxidase organizer 1
Waktu Paruh-
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Ecallantide Approved DB05311
biotech | CAS: 460738-38-9

Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in _Pichia pastoris_ yeast cells that contains three …

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAnalgesics, Non-Narcotic +10
Target Protein:
Plasma kallikrein
Waktu ParuhFollowing subcutane…
Vol. DistribusiThe volume of distr…
KlirensPlasma clearance wa…
Genetik -
Ecamsule Approved DB09534
small molecule | CAS: 92761-26-7

Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability. Ecamsule has been approved for use in the U.S. since 2006, but only a…

Kategori:
AcidsAcids, NoncarboxylicBicyclic Monoterpenes +12
Waktu ParuhEcamsule is not abs…
Vol. DistribusiEcamsule is intende…
KlirensEcamsule is used to…
Genetik -
Ecgonine DB01525
small molecule | CAS: 481-37-8

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnalgesicsAza Compounds +7
Waktu Paruh-
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Echinacea Approved DB14240
biotech

Deskripsi belum tersedia.

Kategori:
Cytochrome P-450 CYP3A InducersCytochrome P-450 CYP3A4 InducersCytochrome P-450 CYP3A4 Inducers (moderate) +2
Waktu Paruh-
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Genetik -
Echinacea angustifolia root Approved DB14237
biotech

Deskripsi belum tersedia.

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Echinacea purpurea Approved DB14239
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsAsteraceaeBiological Products +9
Waktu Paruh-
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Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsAsteraceaeBiological Products +8
Waktu Paruh-
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Echinacoside DB15488
small molecule | CAS: 82854-37-3

Echinacoside is a phenylethanoid glycoside isolated from _Echinacea angustifolia_ in 1950, and currently being investigated for the treatment of Parkinson's, Alzheimer's, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis.[A184577] E…

Kategori:
CarbohydratesCOMT SubstratesHerbs and Natural Products
Target Protein:
Growth hormone secretagogue receptor type 1Androgen receptor
Waktu Paruh-
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Echinomycin DB15582
small molecule | CAS: 512-64-1

Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from _Streptomyces echinatus_ that binds to DNA and inhibits RNA synthesis.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
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Echothiophate Approved DB01057
small molecule | CAS: 6736-03-4

A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.

Kategori:
Antiglaucoma Preparations and MioticsAutonomic AgentsCholinergic Agents +15
Target Protein:
CholinesteraseAcetylcholinesterase
Waktu Paruh-
Vol. Distribusi-
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Ecklonia cava DB19252
biotech

Deskripsi belum tersedia.

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Ecnoglutide DB19019
biotech | CAS: 2459531-73-6

Ecnoglutide is under investigation in clinical trial NCT05813795 (A Phase 3 Study to Evaluate the Efficacy of XW003 in Adults With Overweight or Obesity).

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Econazole Approved DB01127
small molecule | CAS: 27220-47-9

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +21
Target Protein:
Lanosterol 14-alpha demethylaseNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
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Ecopipam DB12273
small molecule | CAS: 112108-01-7

Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +7
Target Protein:
D(1A) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ecraprost DB16148
small molecule | CAS: 136892-64-3

Ecraprost is under investigation in clinical trial NCT00059657 (Efficacy/safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease).

Kategori:
AutacoidsBiological FactorsEicosanoids +5
Target Protein:
Prostaglandin E2 receptor EP1 subtype
Waktu Paruh-
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Ecromeximab DB12797
biotech | CAS: 292819-64-8

Ecromeximab has been used in trials studying the treatment of Cutaneous Melanoma and Metastatic Melanoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
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ECT204 DB18605
biotech

ECT204 is an autologous T-cell therapy whereby T cells are genetically modified to target tumor-specific antigens.

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Ectoine DB19171
small molecule | CAS: 96702-03-3

Ectoine is under investigation in clinical trial NCT03186755 (Clinical Evaluation of Hylo-dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis).

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
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Eculizumab Approved DB01257
biotech | CAS: 219685-50-4

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab w…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +14
Target Protein:
Complement C5
Waktu ParuhThe half life of ec…
Vol. DistribusiThe volume of distr…
KlirensPharmacokinetic pro…
Genetik -
Edaglitazone DB06519
small molecule | CAS: 213411-83-7

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Edaravone Approved DB12243
small molecule | CAS: 89-25-8

Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties.[A254257] It has three tautomers.[A19140] Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophi…

Kategori:
AntioxidantsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +14
Target Protein:
Apoptosis regulator Bcl-2
Waktu ParuhThe mean terminal e…
Vol. DistribusiAfter intravenous a…
KlirensFollowing intraveno…
Genetik -
Edasalonexent DB15010
small molecule | CAS: 1204317-86-1

Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).

Kategori:
AmidesEicosanoidsFatty Acids +3
Target Protein:
Nuclear factor NF-kappa-B p105 subunitTranscription factor RelBNuclear factor NF-kappa-B p100 subunit +2
Waktu Paruh-
Vol. Distribusi-
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Edecesertib DB18917
small molecule | CAS: 2408839-73-4

Edecesertib is under investigation in clinical trial NCT05629208 (Study of Edecesertib in Participants With Cutaneous Lupus Erythematosus (CLE)).

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small molecule | CAS: 62-33-9

Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body.[L12774] It is on the World Health Organization Model List of Essential Medicines.[A204173] Edetate calcium disodium was granted FDA…

Kategori:
AcetatesAcids, AcyclicAmines +26
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 14025-15-1

Deskripsi belum tersedia.

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Edetate disodium anhydrous Approved DB14600
small molecule | CAS: 139-33-3

Edetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.[A204275]

Kategori:
Calcium BinderCalcium Chelating ActivityCalcium Chelating Agents +8
Target Protein:
LeadIronManganese cation
Waktu Paruh-
Vol. DistribusiData regarding the …
KlirensThe mean clearance …
Genetik -
Edetate sodium DB13404
small molecule | CAS: 64-02-8

Deskripsi belum tersedia.

Kategori:
OphthalmologicalsSensory Organs
Waktu Paruh-
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Edetic acid Approved DB00974
small molecule | CAS: 60-00-4

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Kategori:
AcetatesAcids, AcyclicAmines +19
Target Protein:
LeadIronManganese cation
Waktu ParuhThe half life of ed…
Vol. Distribusi-
Klirens-
Genetik -
EDI-200 DB18188
biotech

EDI-200 is a fusion protein consisting of human immunoglobim G1 constant region Fc region fused to the human receptor binding domain of ectodysplasin-A1.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Proteins +17
Waktu Paruh-
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Edifoligide DB06556
biotech | CAS: 476273-48-0

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
Vol. Distribusi-
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EDIT-301 DB18645
biotech

EDIT-301 is an investigational cell therapy consisting of autologous CD34+ hematopoietic stem and progenitor cells edited by CRISPR/CAS12a at the gamma globin gene (HBG1 and HBG2).

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Edivoxetine DB09184
small molecule | CAS: 1194508-25-2

Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment. Edivoxetine failed to be approved for maj…

Kategori:
Adrenergic Uptake InhibitorsAlcoholsAntidepressive Agents +2
Waktu Paruh-
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Edobacomab DB17779
biotech | CAS: 141410-98-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
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Edodekin alfa DB15631
biotech | CAS: 187348-17-0

Edodekin alfa is under investigation in clinical trial NCT01468896 (Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery).

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAngiogenesis Inhibitors +12
Waktu Paruh-
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Edonerpic DB05938
small molecule | CAS: 519187-23-6

Edonerpic is a neurotrophic agent intended for the treatment of Alzheimer's disease which is under phase I clinical trial.

Kategori:
Acids, AcyclicDicarboxylic AcidsSulfur Compounds
Target Protein:
Amyloid-beta precursor protein
Waktu Paruh-
Vol. Distribusi-
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Edotecarin DB04882
small molecule | CAS: 174402-32-5

Edotecarin is a novel, non-camptothecin, DNA topoisomerase I inhibitor. It is member of the class of compounds called indolocarbazoles.

Kategori:
Heterocyclic Compounds, Fused-RingIndoles
Target Protein:
DNA topoisomerase 1
Waktu Paruh20 to 25 hours
Vol. Distribusi-
Klirens-
Genetik -
Edotreotide DB17969
small molecule | CAS: 204318-14-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCompounds used in a research, industrial, or household settingDiagnostic Uses of Chemicals +6
Waktu Paruh-
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Edotreotide gallium Ga-68 Approved DB15494
small molecule | CAS: 2101630-92-4

Edotreotide gallium Ga-68 is an 8 amino acid peptide bound to the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).[L8603] Edotreotide gallium Ga-68 is indicated for localizing somatostatin receptor positive neuroendocrine tumors by po…

Kategori:
Diagnostic RadiopharmaceuticalsGallium RadioisotopesRadiopharmaceuticals +1
Target Protein:
Somatostatin receptor type 2Somatostatin receptor type 5Somatostatin receptor type 3 +1
Waktu ParuhEdotreotide gallium…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
small molecule | CAS: 322407-70-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesPeptides, Cyclic +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Edoxudine Approved DB13421
small molecule | CAS: 15176-29-1

Edoxudine is a deoxythymidine analog with activity against herpes simplex virus. It is a potent and selective inhibitor of herpes simplex virus type 1 and 2. The obtained product is an antiviral ointment.[L2407] The activity of edoxudine against herpes simple…

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxyribonucleosides +5
Target Protein:
Thymidine kinase, cytosolicDNA polymerase
Waktu ParuhIn preclinical tria…
Vol. DistribusiThis pharmacokineti…
KlirensThe plasma clearanc…
Genetik -
EDP1815 DB16486
biotech

EDP1815, was investigated in several clinical trials (NCT05066373, NCT05439941, NCT05682222, NCT03733353, NCT04603027, NCT04488575, NCT05121480, NCT04393246) to evaluate its safety and efficacy in conditions such as gastrointestinal behavior, atopic dermatiti…

Kategori:
Experimental Unapproved Treatments for COVID-19
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Edralbrutinib DB18095
small molecule | CAS: 1858206-58-2

Edralbrutinib is an orally available small molecule inhibitor of Bruton's tyrosine kinase.

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Edratide DB15272
small molecule | CAS: 433922-67-9

Edratide is under investigation in clinical trial NCT00203151 (A Study to Evaluate the Tolerability, Safety and Effectiveness of Edratide in the Treatment of Lupus).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
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Edrophonium Approved DB01010
small molecule | CAS: 312-48-1

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Kategori:
AminesAntidotesCholinergic Agents +10
Target Protein:
CholinesteraseAcetylcholinesterase
Waktu ParuhDistribution half-l…
Vol. Distribusi* 1.6±0.4 L/kg [Adu…
Klirens* 6.8 +/- 2. mL/kg/…
Genetik -
EF-022 DB17768
biotech

EF-022 is a modified version of vitamin D binding protein macrophage activator, with potential antineoplastic and anti-angiogenic activities.

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Efalizumab Approved DB00095
biotech | CAS: 214745-43-4

Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the anti…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +15
Target Protein:
Integrin alpha-XIntegrin alpha-L
Waktu Paruh5 days
Vol. Distribusi-
Klirens-
Genetik -
Efanesoctocog alfa Approved DB16662
biotech | CAS: 2252477-42-0

Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A.[L45379] Th…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +6
Target Protein:
Coagulation factor IXCoagulation factor XLow-density lipoprotein receptor-related protein 2 +1
Waktu ParuhEfanesoctocog alfa …
Vol. DistribusiEfanesoctocog alfa …
KlirensEfanesoctocog alfa …
Genetik -
Efatutazone DB11894
small molecule | CAS: 223132-37-4

Efatutazone has been used in trials studying the treatment of Lymphoma, Liposarcoma, Solid Tumors, Multiple Myeloma, and Recurrent Thyroid Cancer, among others.

Kategori:
Antineoplastic AgentsPPAR gamma, antagonists & inhibitorsSulfur Compounds +1
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2049067-94-7

Efavaleukin alfa is a fusion protein consisting of interleukin mutein fused to the C-terminus of an immunoglobulin G Fc domain by way of a G4S linker. It is under investigation in clinical trial NCT03422627 (Safety and Efficacy of AMG 592 in Subjects With Ste…

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Menampilkan 5701–5750 dari 14063
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