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13591

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10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
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13591 (100.0%)

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Halaman 114 / 272
Enrofloxacin DB11404
small molecule | CAS: 93106-60-6

Enrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant strains of _Campylobacter_, in September …

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensartinib DB14860
small molecule | CAS: 1370651-20-9

Ensartinib is under investigation in clinical trial NCT03420508 (Treating Patients With Melanoma and ALK Alterations With Ensartinib).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
ALK tyrosine kinase receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensifentrine Approved DB16157
small molecule | CAS: 1884461-72-6

Ensifentrine is a first-in-class, selective dual inhibitor of the phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) enzymes.[L50903] On June 26, 2024, the FDA announced the approval of an inhaled product of ensifentrine for the treatment of chronic o…

Kategori:
BCRP/ABCG2 SubstratesCytochrome P-450 CYP2C9 SubstratesCytochrome P-450 CYP2D6 Substrates +6
Target Protein:
Phosphodiesterase 3Phosphodiesterase 4
Waktu ParuhFollowing twice-dai…
Vol. DistribusiApparent central an…
Klirens-
Genetik -
Ensitrelvir DB18834
small molecule | CAS: 2647530-73-0

Ensitrelvir is under investigation in clinical trial NCT05605093 (Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)).

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensituximab DB12342
biotech | CAS: 1092658-06-4

Ensituximab has been used in trials studying the treatment of Pancreatic Cancer, Adult, Metastatic Colorectal Cancer, and Metastatic Pancreatic Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensovibep DB19078
biotech | CAS: 2451126-06-8

Ensovibep is under investigation in clinical trial NCT04501978 (ACTIV-3: Therapeutics for Inpatients With COVID-19).

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ensulizole Approved DB11115
small molecule | CAS: 27503-81-7

Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due t…

Kategori:
AcidsAcids, NoncarboxylicHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entacapone Approved DB00494
small molecule | CAS: 130929-57-6

Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., c…

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson DrugsBenzene Derivatives +11
Target Protein:
Catechol O-methyltransferase
Waktu Paruh0.4-0.7 hour
Vol. Distribusi* 20 L
Klirens* 850 mL/min
Genetik -
Entinostat DB11841
small molecule | CAS: 209783-80-2

Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +8
Target Protein:
Histone deacetylaseHistone deacetylase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entolimod DB12304
biotech | CAS: 951628-22-1

Entolimod has been used in trials studying the treatment of Mucositis, Tongue Cancer, Colorectal Cancer, Stage IVA Verrucous Carcinoma of the Larynx, and Stage IVB Verrucous Carcinoma of the Larynx, among others.

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ENTR-601-44 DB17836
biotech

ENTR-601-44 is an exon 44 skipping phosphorodiamidate morpholino oligonucleotide (PMO). Developed by Entrada Therapeutics, it was investigated for the treatment of Duchenne muscular dystrophy.[L46641]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Entrectinib Approved DB11986
small molecule | CAS: 1108743-60-7

Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positi…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +17
Target Protein:
ALK tyrosine kinase receptorHigh affinity nerve growth factor receptorNT-3 growth factor receptor +4
Waktu ParuhEntrectinib has a h…
Vol. DistribusiEntrectinib has an …
KlirensThe apparent cleara…
Genetik -
Enviomycin DB08993
small molecule | CAS: 33103-22-9

Cyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enzacamene Approved DB11219
small molecule | CAS: 36861-47-9

Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reprodu…

Kategori:
Bicyclic MonoterpenesBornanesBridged-Ring Compounds +5
Target Protein:
Progesterone receptorAndrogen receptorEstrogen receptor beta +1
Waktu ParuhThe half life of en…
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Enzalutamide Approved DB08899
small molecule | CAS: 915087-33-1

Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic.[L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A2…

Kategori:
AmidesAndrogen Receptor AntagonistsAndrogen Receptor Inhibitors +35
Target Protein:
Androgen receptor
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe mean (%CV) volu…
KlirensThe mean apparent c…
Genetik -
Enzalutamide d3 DB19123
small molecule | CAS: 1443331-82-5

Enzalutamide d3 is under investigation in clinical trial NCT03850795 (HC-1119 Versus Enzalutamide in Metastatic Castration-resistant Prostate Cancer (Mcrpc)).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Enzastaurin DB06486
small molecule | CAS: 170364-57-5

Enzastaurin, an investigational, targeted, oral agent, will be evaluated at more than 100 sites worldwide for the treatment of relapsed glioblastoma multiforme (GBM), an aggressive and malignant form of brain cancer.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Protein kinase C beta typePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformRAC-alpha serine/threonine-protein kinase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EO-3021 DB18358
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eosin DB13706
small molecule | CAS: 17372-87-1

Deskripsi belum tersedia.

Kategori:
Antiseptics and DisinfectantsColoring AgentsCompounds used in a research, industrial, or household setting +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-0042 DB18120
small molecule | CAS: 1402709-93-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-1043 DB06118
biotech

EP-1043 is an epitope-based recombinant protein vaccine designed to induce HIV-1 specific helper T-lymphocyte (HTL) responses. The vaccine consists of a string of 18 HIV-derived major histocompatibility complex (MHC) Class II restricted epitopes, each separat…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EP-217609 DB18393
small molecule | CAS: 894494-99-6

Deskripsi belum tersedia.

Kategori:
CarbohydratesCoenzymesEnzymes and Coenzymes +2
Target Protein:
Coagulation factor XProthrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epafipase DB16158
biotech | CAS: 208576-22-1

Epafipase is under investigation in clinical trial NCT00037687 (Safety and Efficacy of Recombinant Human Platelet-activating Factor Acetylhydrolase for the Treatment of Severe Sepsis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epalrestat DB15293
small molecule | CAS: 82159-09-9

Epalrestat is under investigation in clinical trial NCT03244358 (Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer).

Kategori:
Enzyme InhibitorsSulfur CompoundsThiazoles
Target Protein:
Aldo-keto reductase family 1 member B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epaminurad DB18973
small molecule | CAS: 1198153-15-9

Epaminurad is under investigation in clinical trial NCT05815901 (A Therapeutic Confirmatory Study of Epaminurad Versus Febuxostat in Gout Patients).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epanolol DB13757
small molecule | CAS: 86880-51-5

Epanolol is an beta blocker.

Kategori:
AcetamidesAdrenergic AgentsAdrenergic Antagonists +18
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epcoritamab Approved DB16672
biotech | CAS: 2134641-34-0

Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +13
Target Protein:
B-lymphocyte antigen CD20T-cell surface glycoprotein CD3 epsilon chain
Waktu ParuhA full dose of epco…
Vol. DistribusiEpcoritamab has an …
KlirensA full dose of epco…
Genetik -
Epeleuton DB18100
small molecule | CAS: 1667760-39-5

Deskripsi belum tersedia.

Kategori:
Dietary FatsDietary Fats, UnsaturatedEicosanoids +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epelsiban DB11934
small molecule | CAS: 872599-83-2

Epelsiban has been investigated for the treatment of Premature Ejaculation.

Kategori:
OxazinesPiperazines
Target Protein:
Oxytocin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eperisone DB08992
small molecule | CAS: 64840-90-0

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAutonomic Agents +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epetraborole DB11744
small molecule | CAS: 1093643-37-8

Epetraborole has been used in trials studying the treatment of Infections, Bacterial, Infections, Intestinal, Infections, Urinary Tract, and Community-acquired Infection.

Kategori:
Anti-Bacterial AgentsLeucine-tRNA Ligase, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Ephedra is an alkaloid chemical compound traditionally obtained from the plant _Ephedra sinica_. The sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for a…

Kategori:
Adrenergic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-Agonists +22
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterAlpha-2A adrenergic receptor +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ephedrine Approved DB01364
small molecule | CAS: 299-42-3

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic rece…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +39
Target Protein:
D(2) dopamine receptorAlpha-1A adrenergic receptorBeta-1 adrenergic receptor +2
Waktu ParuhOral ephedrine has …
Vol. DistribusiOral ephedrine has …
KlirensOral ephedrine has …
Genetik -
small molecule | CAS: 1082659-36-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EPI-589 DB16041
small molecule | CAS: 1147883-03-1

EPI-589 is under investigation in clinical trial NCT02460679 (Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicaptopril DB02032
small molecule | CAS: 63250-36-2

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAmino AcidsAmino Acids, Cyclic +6
Target Protein:
Metallo-beta-lactamase L1Beta-lactamaseOrganic hydroperoxide resistance protein, putative +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicatechin DB12039
small molecule | CAS: 490-46-0

Epicatechin has been used in trials studying the treatment of Pre-diabetes.

Kategori:
BenzopyransCatechinChromans +4
Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicillin DB13300
small molecule | CAS: 26774-90-3

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicoccum nigrum Approved DB10434
biotech

Epicoccum nigrum is a fungus which can provoke allergic reactions. Epicoccum nigrum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epicriptine Approved DB11275
small molecule | CAS: 88660-47-3

Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dihydroergocryptine, it represents one-third of the ergoloid mesylate mixture. Epicriptine differs from th…

Kategori:
AlkaloidsDopamine Agonists
Target Protein:
Dopamine receptor
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
small molecule | CAS: 25615-05-8

Epigallo Catechin Gallate is under investigation in clinical trial NCT00799890 (Sunphenon in Progressive Forms of Multiple Sclerosis).

Kategori:
BenzopyransChromansChromones +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 970-74-1

Deskripsi belum tersedia.

Kategori:
BenzopyransChromansChromones +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 989-51-5

Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy.

Kategori:
Anticarcinogenic AgentsAntimutagenic AgentsAntineoplastic Agents +13
Target Protein:
Fatty acid synthaseSignal transducer and activator of transcription 3Gag-Pol polyprotein +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Epimedium grandiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epimestrol DB13386
small molecule | CAS: 7004-98-0

Deskripsi belum tersedia.

Kategori:
EstranesEstrenesEstrogens +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epinastine Approved DB00751
small molecule | CAS: 80012-43-7

Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic respon…

Kategori:
Acid ReducersAntidepressive AgentsCentral Nervous System Depressants +27
Target Protein:
Histamine H1 receptorHistamine H2 receptorAlpha-1A adrenergic receptor +3
Waktu Paruh12 hours
Vol. Distribusi-
Klirens* 56 L/hr [patients…
Genetik -
Epinephrine Approved DB00668
small molecule | CAS: 51-43-4

Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, …

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +52
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorBeta-1 adrenergic receptor +5
Waktu ParuhThe plasma half-lif…
Vol. Distribusi-
KlirensIntravenous injecti…
Genetik -
Epirizole DB08991
small molecule | CAS: 18694-40-1

Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Epirubicin Approved DB00445
small molecule | CAS: 56420-45-2

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

Kategori:
Anthracycline Topoisomerase InhibitorAnthracyclinesAnthracyclines and Related Substances +17
Target Protein:
DNA topoisomerase 2-betaDNADNA topoisomerase 2-alpha
Waktu ParuhHalf-lives for the …
Vol. Distribusi* 21 ± 2 L/kg [60 m…
Klirens* 65 +/- 8 L/hour […
Genetik -
Epitalon DB17882
small molecule | CAS: 307297-39-8

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Telomerase reverse transcriptase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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