Hasil Filter

11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (11778)

Halaman 113 / 236
Golvatinib DB11977
small molecule | CAS: 928037-13-2

Golvatinib has been investigated for the treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck.

Kategori:
AminesPyridinesVascular Endothelial Growth Factor Receptor-2, antagonists & inhibitors
Target Protein:
Vascular endothelial growth factor receptor 2Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gondoic acid DB14073
small molecule | CAS: 5561-99-9

Deskripsi belum tersedia.

Kategori:
Fatty AcidsFatty Acids, UnsaturatedLipids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gontivimab DB16179
biotech | CAS: 1257358-38-5

Gontivimab is under investigation in clinical trial NCT03468829 (Efficacy and Safety of ALX-0171 in Adult Hematopoietic Stem Cell Transplant (HSCT) Recipients Who Present With Respiratory Syncytial Virus (RSV) Infection).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntiviral Agents +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gonyautoxin II DB19186
small molecule | CAS: 60508-89-6

Gonyautoxin II is under investigation in clinical trial NCT04799041 (Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study).

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ToxinsBiological Factors +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gonyautoxin III DB19187
small molecule | CAS: 60537-65-7

Gonyautoxin III is currently under investigation in clinical trial (Gonyautoxin 2/?3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study) for the treatment of Acute Back Pain.

Kategori:
Bacterial ToxinsBiological FactorsComplex Mixtures +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Goose Approved DB10874
biotech

Goose allergenic extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Goserelin Approved DB00014
small molecule | CAS: 65807-02-5

Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cell…

Kategori:
Adrenal Cortex HormonesAmino Acids, Peptides, and ProteinsAntineoplastic Agents +22
Target Protein:
Lutropin-choriogonadotropic hormone receptorProgonadoliberin-1Gonadotropin-releasing hormone receptor
Waktu Paruh4-5 hours
Vol. Distribusi* 44.1 ± 13.6 L [su…
Klirens* 121 +/- 42.4 mL/m…
Genetik -
Gossypol DB13044
small molecule | CAS: 303-45-7

Gossypol has been used in trials studying the treatment of Non-small Cell Lung Cancer.

Kategori:
Adrenal Cortex HormonesContraceptive Agents, MaleHormonal Contraceptives for Systemic Use +3
Target Protein:
Apoptosis regulator Bcl-2Bcl-2-like protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gosuranemab DB15376
biotech | CAS: 1788032-39-2

Gosuranemab is under investigation in clinical trial NCT02460094 (Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Supranuclear Palsy).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gotistobart DB19100
biotech | CAS: 2226344-78-9

Gotistobart is under investigation in clinical trial NCT05671510 (ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GP-100 antigen DB14800
biotech

GP-100 antigen is under investigation in clinical trial NCT00006385 (Vaccine Therapy With or Without Biological Therapy in Treating Patients With Metastatic Melanoma).

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Neoplasm +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GP2 peptide DB16180
biotech | CAS: 160790-21-6

GP2 peptide is under investigation in clinical trial NCT00524277 (Vaccine Therapy in Treating Patients With Breast Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

The gp209-2M antigen is derived from gp209, and has potential immunomodulatory and antineoplastic activities.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GPI-1485 DB05814
small molecule | CAS: 186268-78-0

GPI 1485 is a product candidate that belongs to a class of small molecule compounds called neuroimmunophilin ligands. In preclinical experiments, neuroimmunophilin ligands have been shown to repair and regenerate damaged nerves without affecting normal, heal…

Kategori:
Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (strength unknown) +2
Target Protein:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GR270773 DB06427
small molecule

GR270773, was investigated in two clinical trials for its potential to treat sepsis: NCT00158769 (completed, comparing the effects of infusion between healthy adults and those with damaged livers) and NCT00089986 (completed with results, treatment of suspecte…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gramicidin D Approved DB00027
small molecule | CAS: 1405-97-6

Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins ar…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Granaticin B DB17273
small molecule | CAS: 19879-03-9

Deskripsi belum tersedia.

Kategori:
BenzopyransBenzoquinonesChromans +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Graphite Approved DB18717
small molecule | CAS: 7782-42-5

Deskripsi belum tersedia.

Kategori:
CarbonElementsGraphite +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Grapiprant DB12836
small molecule | CAS: 415903-37-6

Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists.[A…

Kategori:
AmidesBenzene DerivativesP-glycoprotein substrates +3
Target Protein:
Prostaglandin E2 receptor EP4 subtype
Waktu ParuhThe reported elimin…
Vol. DistribusiThe reported volume…
KlirensThe reported cleara…
Genetik -
Grazoprevir Approved DB11575
small molecule | CAS: 1350514-68-9

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nin…

Kategori:
Acids, AcyclicAmidesAnti-Infective Agents +24
Target Protein:
Genome polyprotein
Waktu ParuhThe geometric mean …
Vol. DistribusiGrazoprevir has an …
KlirensThe clearance of Gr…
Genetik -
Green tea leaf DB14307
biotech

Green tea leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BeveragesBiological ProductsComplex Mixtures +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gremubamab DB15014
biotech | CAS: 1800381-36-5

Gremubamab is under investigation in clinical trial NCT02255760 (Phase 1 Randomized Double-blind Placebo Controlled Study to Evaluate Safety and PK of MEDI3902 in Healthy Adults).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gresonitamab DB18210
biotech | CAS: 2413817-97-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Griseofulvin Approved DB00400
small molecule | CAS: 126-07-8

An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +14
Target Protein:
Tubulin beta chainKeratin, type I cytoskeletal 12
Waktu Paruh9-21 hours
Vol. Distribusi-
Klirens-
Genetik -
GS 0573 DB08843
small molecule | CAS: 113852-41-8

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsHeterocyclic Compounds, Fused-RingImmunologic Factors +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-100 DB18337
biotech

GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human NGLY1 gene coding sequence

Kategori:
CyclohexanesCycloparaffinsLipids +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-441524 DB15686
small molecule | CAS: 1191237-69-0

GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir].[A203057,L13239] This molecule was patented in 2009.[L13775] _In vitro_ studies of GS-441524 have determined it has a higher EC<sub>50</sub> than remdesivir against a number of vir…

Kategori:
Adenine NucleotidesAnti-Infective AgentsAntiviral Agents +10
Target Protein:
Replicase polyprotein 1abRNA-directed RNA polymerase L
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-5745 DB12296
biotech | CAS: 1518996-49-0

GS-5745 has been used in trials studying the treatment of Tumors, Breast Cancer, Crohn's Disease, Colorectal Cancer, and Pancreatic Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-6620 DB15222
small molecule | CAS: 1350735-70-4

GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection).

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsHeterocyclic Compounds, Fused-Ring +5
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-9191 DB15084
small molecule | CAS: 859209-84-0

GS-9191 is under investigation in clinical trial NCT00499967 (Safety and Effectiveness Study of an Experimental Topical Ointment (GS-9191) for the Treatment of Genital Warts).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-9256 DB12876
small molecule | CAS: 1001094-46-7

GS-9256 has been used in trials studying the treatment of HCV Infection and Chronic Hepatitis C Infection.

Kategori:
AcidsAcids, NoncarboxylicAmino Acids, Peptides, and Proteins +4
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS030-DP DB17847
biotech

GS030-DP is an optogenetic gene therapy being investigated for the treatment of retinitis pigmentosa. It targets retinal ganglion cells that encodes a light-sensitive channelrhodopsin, ChrimsonR-tdTomato (ChR-tdT), delivered by an AAV2.7m8 vector. It is a com…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1004723 DB12806
small molecule | CAS: 955359-72-5

Gsk1004723 has been investigated for the treatment of Allergic Rhinitis and Rhinitis, Allergic, Seasonal.

Kategori:
Histamine AntagonistsHistamine H1 AntagonistsPyridazines
Target Protein:
Histamine H3 receptorHistamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1292263 DB12627
small molecule | CAS: 1032823-75-8

GSK1292263 has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.

Target Protein:
Glucose-dependent insulinotropic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1521498 DB12886
small molecule | CAS: 1007573-18-3

GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.

Kategori:
IndenesReceptors, Opioid, mu
Target Protein:
Mu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2018682 DB11987
small molecule | CAS: 1034688-30-6

GSK2018682 has been investigated for the treatment of Multiple Sclerosis, Relapsing-Remitting.

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Sphingosine 1-phosphate receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-239512 DB15120
small molecule | CAS: 720691-69-0

GSK-239512 is under investigation in clinical trial NCT00474513 (An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.).

Kategori:
Heterocyclic Compounds, Fused-RingHistamine Antagonists
Target Protein:
Histamine H3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-256066 DB12137
small molecule | CAS: 801312-28-7

Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPhosphodiesterase 4 Inhibitors +3
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2636771 DB11795
small molecule | CAS: 1372540-25-4

GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsOxazines +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-269962A DB17030
small molecule | CAS: 850664-21-0

GSK-269962A is a Rho kinase (ROCK) inhibitor with both ROCK1 and ROCK2 affinity.[A253012]

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2879552 DB16895
small molecule | CAS: 1401966-69-5

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesCycloparaffins
Target Protein:
Lysine-specific histone demethylase 1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2881078 DB16888
small molecule | CAS: 1539314-06-1

Deskripsi belum tersedia.

Kategori:
Anabolic AgentsHeterocyclic Compounds, Fused-RingHormones +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2981278 DB16319
small molecule | CAS: 1474110-21-8

GSK-2981278 is under investigation in clinical trial NCT03004846 (A Study of GSK2981278 Ointment in Subjects With Plaque Psoriasis).

Kategori:
AmidesBenzene DerivativesSulfonamides +2
Target Protein:
Nuclear receptor ROR-gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2982772 DB16875
small molecule | CAS: 1622848-92-3

Deskripsi belum tersedia.

Target Protein:
Receptor-interacting serine/threonine-protein kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-3117391 DB15440
small molecule | CAS: 1018673-42-1

GSK-3117391 is under investigation in clinical trial NCT02965599 (Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3117391 in Subjects With Rheumatoid Arthritis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-356278 DB12542
small molecule | CAS: 720704-34-7

Gsk356278 has been used in trials studying the treatment and basic science of Anxiety Disorders, Huntington Disease, Depressive Disorder, Huntingtons Disease, and Depressive Disorder, Major, among others.

Kategori:
OxazolesSulfur Compounds
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4D3',5'-cyclic-AMP phosphodiesterase 4B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-364735 DB13119
small molecule | CAS: 863434-13-3

GSK-364735 (Naphthyridinone) has been used in trials studying the treatment of HIV-1 Infection and Infection, Human Immunodeficiency Virus.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-376501 DB12654
small molecule | CAS: 1010412-80-2

GSK376501 has been used in trials studying the treatment and diagnostic of Type 2 Diabetes Mellitus.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-424887 DB12219
small molecule

Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder.

Kategori:
AcetatesAcids, AcyclicAmides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-690693 DB12745
small molecule | CAS: 937174-76-0

GSK690693 has been used in trials studying the treatment of Tumor, CANCER, and Lymphoma.

Kategori:
Oxazoles
Target Protein:
RAC-gamma serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5601–5650 dari 11778
Sebelumnya Halaman 113 / 236 Berikutnya