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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
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13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 112 / 272
Elimusertib DB19041
small molecule | CAS: 1876467-74-1

Elimusertib is under investigation in clinical trial NCT05071209 (Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors).

Target Protein:
Serine/threonine-protein kinase ATR
Waktu Paruh-
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Genetik -
Elinogrel DB06350
small molecule | CAS: 936500-94-6

A P2Y12 inhibitor and platelet aggregation inhibitor.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingQuinazolines +2
Target Protein:
P2Y purinoceptor 12
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Elinzanetant DB18968
small molecule | CAS: 929046-33-3

Elinzanetant is under investigation in clinical trial NCT05099159 (A Study to Learn More About How Well Elinzanetant Works and How Safe It Is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who …

Target Protein:
Neuromedin-K receptorSubstance-P receptor
Waktu Paruh-
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Genetik -
Eliprodil DB12869
small molecule | CAS: 119431-25-3

Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.

Kategori:
Central Nervous System AgentsCompounds used in a research, industrial, or household settingExcitatory Amino Acid Agents +5
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 1
Waktu Paruh-
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Genetik -
Elivaldogene autotemcel Approved DB16746
biotech

Elivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy,[L39491] an X-linked genetic disorder cha…

Kategori:
Alimentary Tract and MetabolismCellular and Gene TherapyVarious Alimentary Tract and Metabolism Products
Waktu ParuhAs elivaldogene aut…
Vol. DistribusiAs elivaldogene aut…
KlirensAs elivaldogene aut…
Genetik -
biotech | CAS: 1905397-73-0

Deskripsi belum tersedia.

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Ellagic acid DB08846
small molecule | CAS: 476-66-4

Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant. Ellagic acid is also present in vegetables. …

Kategori:
BenzopyransCytochrome P-450 CYP2E1 InhibitorsCytochrome P-450 CYP2E1 Inhibitors (strength unknown) +6
Target Protein:
Heat shock 70 kDa protein 1AHeat shock 70 kDa protein 1BGlycogen synthase kinase-3 beta +17
Waktu Paruh-
Vol. Distribusi-
KlirensEllagic acid is eli…
Genetik -
Ellipticine DB17026
small molecule | CAS: 519-23-3

Ellipticine is a potent antineoplastic agent.[A252992]

Kategori:
AlkaloidsAntineoplastic AgentsCarbazoles +8
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
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Elobixibat DB12486
small molecule | CAS: 439087-18-0

Elobixibat has been used in trials studying the treatment and basic science of Dyslipidemia, Constipation, Chronic Constipation, Functional Constipation, and Chronic Idiopathic Constipation.

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAzepines +5
Target Protein:
Ileal sodium/bile acid cotransporter
Waktu Paruh-
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Elosulfase alfa Approved DB09051
biotech | CAS: 9025-60-9

Elosulfase alfa is a synthetic version of the enzyme N-acetylgalactosamine-6-sulfatase. It was approved by the FDA in 2014 for the treatment of Morquio syndrome. Elosulfase alfa was developed by BioMarin Pharmaceutical Inc. and is marketed under the brand Vim…

Kategori:
Alimentary Tract and MetabolismCarbon-Oxygen LyasesChondroitinases and Chondroitin Lyases +9
Waktu Paruhweek 0: 7.52 min w…
Vol. Distribusi396 mL/kg, standard…
Klirens10.0 mL/min/kg. (…
Genetik -
Elotuzumab Approved DB06317
biotech | CAS: 915296-00-3

Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, a…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +15
Target Protein:
SLAM family member 7
Waktu Paruh-
Vol. Distribusi-
KlirensThe clearance of el…
Genetik -
Elraglusib DB16047
small molecule | CAS: 1034895-42-5

Elraglusib is under investigation in clinical trial NCT04218071 (Actuate 1901: 9-ING-41 in Myelofibrosis).

Target Protein:
Glycogen synthase kinase-3 beta
Waktu Paruh-
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Elranatamab Approved DB15395
biotech | CAS: 2408850-14-4

Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb,[A261060] each of which con…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalBispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager +5
Target Protein:
Tumor necrosis factor receptor superfamily member 17T-cell surface glycoprotein CD3
Waktu ParuhThe mean (CV%) half…
Vol. DistribusiThe mean (CV%) stea…
KlirensThe mean (CV%) clea…
Genetik -
Elsamitrucin DB05129
small molecule | CAS: 97068-30-9

The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. (PMID: 8150873)

Kategori:
Antibiotics, AntineoplasticAntineoplastic AgentsCarbohydrates +1
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-betaDNA +1
Waktu Paruh36–60 h
Vol. Distribusi-
Klirens-
Genetik -
Elsiglutide DB06336
small molecule | CAS: 914009-84-0

Deskripsi belum tersedia.

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Elsubrutinib DB18850
small molecule | CAS: 1643570-24-4

Elsubrutinib is under investigation in clinical trial NCT04451772 (A Study of the Safety of Oral Elsubrutinib Capsules and Oral Upadacitinib Tablets Given Alone or in Combination (ABBV-599) for Adult Participants With Moderately to Severely Active Systemic Lu…

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Elsulfavirine DB14929
small molecule | CAS: 868046-19-9

Elsulfavirine is under investigation in clinical trial NCT03706898 (Study to Evaluate the Safety and PK of Elpida® in Healthy Subjects and Patients With Hepatic Impairment and to Assess the Impact of Food Intake and Drug-Drug Interactions With Other Antiviral…

Kategori:
AmidesAminesAniline Compounds +11
Waktu Paruh-
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Eltanexor DB16153
small molecule | CAS: 1642300-52-4

Eltanexor is under investigation in clinical trial NCT02649790 (Study of the Safety, Tolerability and Efficacy of KPT-8602 in Patients With Relapsed/refractory Cancer Indications).

Target Protein:
Exportin-1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Eltanolone DB12308
small molecule | CAS: 128-20-1

Eltanolone is under investigation in clinical trial NCT02603926 (Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone).

Kategori:
AnestheticsCentral Nervous System AgentsCentral Nervous System Depressants +3
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
Waktu Paruh-
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Genetik -
Eltoprazine DB12883
small molecule | CAS: 98224-03-4

Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +6
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Eltrekibart DB19017
biotech | CAS: 2484883-56-7

Eltrekibart is under investigation in clinical trial NCT06046729 (A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa).

Waktu Paruh-
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Elubrixin DB12135
small molecule | CAS: 688763-64-6

Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesBenzene DerivativesReceptors, Interleukin-8B, antagonists & inhibitors +2
Target Protein:
C-X-C chemokine receptor type 2
Waktu Paruh-
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Genetik -
Eluforsen DB16154
biotech | CAS: 2101868-82-8

Eluforsen is under investigation in clinical trial NCT02532764 (Dose Escalation Study of QR-010 in Homozygous ?F508 Cystic Fibrosis Patients).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
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Genetik -
Eluvixtamab DB17252
biotech | CAS: 1679391-73-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
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Genetik -
Elvitegravir Approved DB09101
small molecule | CAS: 697761-98-1

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibitio…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +22
Target Protein:
IntegraseGag-Pol polyprotein
Waktu ParuhThe median terminal…
Vol. Distribusi-
Klirens-
Genetik -
Elvucitabine DB06236
small molecule | CAS: 181785-84-2

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +13
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ELX-02 DB15080
small molecule | CAS: 1375073-95-2

ELX-02 is under investigation in clinical trial NCT03309605 (Phase 1 Study of ELX-02 in Healthy Adult Subjects).

Waktu Paruh-
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Elzasonan DB18969
small molecule | CAS: 361343-19-3

Elzasonan is under investigation in clinical trial NCT00275197 (A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)).

Kategori:
Oxazines
Waktu Paruh-
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Elzovantinib DB18918
small molecule | CAS: 2271119-26-5

Elzovantinib is under investigation in clinical trial NCT03993873 (Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET).

Waktu Paruh-
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EM-1745 DB02323
small molecule

Deskripsi belum tersedia.

Kategori:
17-Hydroxysteroid Dehydrogenases, antagonists & inhibitorsEstradiol CongenersEstranes +7
Target Protein:
17-beta-hydroxysteroid dehydrogenase type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emapalumab Approved DB14724
biotech | CAS: 1709815-23-5

Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapal…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +14
Target Protein:
Interferon gamma
Waktu ParuhEmapalumab eliminat…
Vol. DistribusiThe central and per…
KlirensEmapalumab clearanc…
Genetik -
Emavusertib DB18060
small molecule | CAS: 1801344-14-8

Deskripsi belum tersedia.

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EMB-01 DB16091
biotech

EMB-01 is under investigation in clinical trial NCT03797391 (A Dose Escalation Study of EMB-01 in Participants With Advanced/metastatic Solid Tumors).

Waktu Paruh-
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EMD-1201081 DB06181
biotech | CAS: 847484-35-9

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emedastine Approved DB01084
small molecule | CAS: 87233-61-2

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Kategori:
Anti-Allergic AgentsDecongestants and AntiallergicsHeterocyclic Compounds, Fused-Ring +9
Target Protein:
Histamine H1 receptor
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Emepronium DB13505
small molecule | CAS: 27892-33-7

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAmines +19
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emeramide DB12192
small molecule | CAS: 351994-94-0

Emeramide has been used in trials studying the treatment of Mercury Poisoning.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingSequestering Agents +1
Waktu Paruh-
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Klirens-
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Emetine DB13393
small molecule | CAS: 483-18-1

Deskripsi belum tersedia.

Kategori:
Agents Causing Muscle ToxicityAlkaloidsAmebicides +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5982-52-5

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EMI-137 DB19174
biotech

EMI-137 is under investigation in clinical trial NCT03360461 (EMI-137 in Laparoscopic Colonic Resections).

Waktu Paruh-
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Emibetuzumab DB11849
biotech | CAS: 1365287-97-3

Emibetuzumab has been used in trials studying the treatment of Advanced Cancer, Renal Cell Carcinoma, Hepatocellular Cancer, Gastric Adenocarcinoma, and Non-Small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicerfont DB12910
small molecule | CAS: 786701-13-1

Emicerfont has been used in trials studying the diagnostic and treatment of Social Anxiety Disorder and Irritable Bowel Syndrome (IBS).

Kategori:
Corticotropin-Releasing Hormone, antagonists & inhibitors
Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emicizumab Approved DB13923
biotech | CAS: 1610943-06-0

Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three differen…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Coagulation factor IXCoagulation factor X
Waktu ParuhEmcicizumab present…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Emivirine DB08188
small molecule | CAS: 149950-60-7

Emivirine has been used in trials studying the treatment of HIV Infections.

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +5
Target Protein:
Gag-Pol polyproteinGag-Pol polyprotein
Waktu Paruh-
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Klirens-
Genetik -
Emlenoflast DB18304
small molecule | CAS: 1995067-59-8

Deskripsi belum tersedia.

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Emodepside DB11403
biotech | CAS: 155030-63-0

Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntiparasitic Agents +2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Emodin DB07715
small molecule | CAS: 518-82-1

Emodin has been investigated for the treatment of Polycystic Kidney.

Kategori:
AnthracenesAnthraquinonesBiological Products +7
Target Protein:
Casein kinase II subunit alphaPutative ketoacyl reductase3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Emopamil DB14064
small molecule | CAS: 78370-13-5

Prevents renal injury after warm & cold ischemia.

Kategori:
Agents causing hyperkalemiaAminesAntiarrhythmic agents +11
Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
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Emoxypine DB19172
small molecule | CAS: 2364-75-2

Emoxypine is under investigation in clinical trial NCT06221826 (MEXIDOL® in the Rehabilitation Treatment of Patients With Acute Cerebral Failure).

Kategori:
Antiarrhythmic agentsAntioxidantsAntiplatelet agents +13
Waktu Paruh-
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Menampilkan 5551–5600 dari 13591
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