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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Halaman 111 / 349
Choline C 11 Approved DB09277
small molecule | CAS: 87591-54-6

Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes.[A32041] It was developed by MCPRF and FDA first approved in September 2012.

Kategori:
Drugs that are Mainly Renally Excreted
Waktu ParuhThe isotope half-li…
Vol. Distribusi-
KlirensAfter intravenous i…
Genetik -
Choline C-11 Approved DB09563
small molecule | CAS: 94793-58-5

Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
Waktu Paruh-
Vol. Distribusi11C-choline distrib…
KlirensThe rate of 11C- ch…
Genetik -
small molecule | CAS: 64425-90-7

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +23
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choline salicylate Approved DB14006
small molecule | CAS: 2016-36-6

Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever [L2…

Kategori:
Acids, CarbocyclicAlcoholsAmines +20
Target Protein:
Choline-phosphate cytidylyltransferase BAcetylcholinesteraseCholine-phosphate cytidylyltransferase A +4
Waktu ParuhThe plasma half-lif…
Vol. Distribusi0.15 L/kg (salicyla…
Klirens-
Genetik -
Chondroitin sulfate Approved DB09301
small molecule | CAS: 24967-93-9

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).[A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a lon…

Kategori:
Antiinflammatory and Antirheumatic ProductsAntiinflammatory and Antirheumatic Products, Non-SteroidsCarbohydrates +5
Target Protein:
Neurotrophic factor BDNF precursor formGlial cell line-derived neurotrophic factorVascular endothelial growth factor A, long form +1
Waktu ParuhThe approximate hal…
Vol. DistribusiAfter intramuscular…
Klirens-
Genetik -
biotech

Chondrus crispus is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choriogonadotropin alfa Approved DB00097
biotech | CAS: 177073-44-8

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on bet…

Kategori:
Genito Urinary System and Sex HormonesGonadotropinsGonadotropins and Antigonadotropins +1
Target Protein:
Follicle-stimulating hormone receptorLutropin-choriogonadotropic hormone receptor
Waktu ParuhThe mean terminal h…
Vol. Distribusi* 5.9 ± 1.0 L
Klirens* 0.29 +/- 0.04 L/h…
Genetik -
biotech | CAS: 9002-61-3

Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows …

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsChorionic Gonadotropin +18
Target Protein:
Lutropin-choriogonadotropic hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromanol DB13111
small molecule | CAS: 950-99-2

Chromanol has been used in trials studying the treatment of Prostate Cancer.

Kategori:
AntioxidantsBenzopyransBiological Factors +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromic cation DB14525
small molecule | CAS: 16065-83-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromic chloride Approved DB09129
small molecule | CAS: 10025-73-7

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Kategori:
AnionsAntioxidantsBiological Factors +8
Target Protein:
Insulin receptor
Waktu Paruh31- 41 hours
Vol. DistribusiChromium is stored …
Klirens-
Genetik -
Chromic citrate DB14526
small molecule | CAS: 57072-40-9

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromic nitrate Approved DB14527
small molecule | CAS: 13548-38-4

Deskripsi belum tersedia.

Kategori:
AnionsDrugs that are Mainly Renally ExcretedElectrolytes +2
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium Approved DB11136
small molecule | CAS: 7440-47-3

Chromium is a transition element with the chemical symbol Cr and atomic number 24 that belongs to Group 6 of the periodic table. It is used in various chemical, industrial and manufacturing applications such as wood preservation and metallurgy. The uses of ch…

Kategori:
Cell-mediated ImmunityDiet, Food, and NutritionDrugs that are Mainly Renally Excreted +11
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium Cr-51 Approved DB11140
small molecule | CAS: 14392-02-0

Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and in hematology to determine red blo…

Kategori:
Chromium IsotopesElementsIsotopes +4
Waktu ParuhChromium Cr-51 has …
Vol. Distribusi-
Klirens-
Genetik -
Chromium gluconate Approved DB14528
small molecule | CAS: 33661-40-4

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
small molecule | CAS: 18984-90-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Essential +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromium nicotinate Approved DB14529
small molecule | CAS: 64452-96-6

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally ExcretedNicotinic Acids
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium picolinate Approved DB11255
small molecule | CAS: 14639-25-9

Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2…

Kategori:
Compounds used in a research, industrial, or household settingIron Chelating AgentsPyridines +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
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Genetik -
small molecule

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Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

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Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
Klirens-
Genetik -
Chromous sulfate Approved DB14530
small molecule | CAS: 13825-86-0

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chrysin DB15581
small molecule | CAS: 480-40-0

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Aldo-keto reductase family 1 member B1Cytochrome P450 1B1Aromatase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chrysoeriol DB17283
small molecule | CAS: 491-71-4

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesFlavonoids +2
Target Protein:
Xanthine dehydrogenase/oxidaseCytochrome P450 1B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chrysonilia sitophila Approved DB10935
biotech

Chrysonilia sitophila is a fungus which can provoke allergic reactions. Chrysonilia sitophila extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHS-828 DB12980
small molecule | CAS: 200484-11-3

CHS-828 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
AmidinesAnionsElectrolytes +2
Target Protein:
Nicotinamide phosphoribosyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration with the University of Pennsylvania in the US[L30673, L30678]. Pre-clinical studies in mice and monkeys showed evidence that the vaccine facilitates…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chymopapain Approved DB06752
biotech | CAS: 9001-09-6

Chymopapain was first isolated in 1941 from the crude latex derived from the fruit of Carica papaya by squeezing the green papaya while on the plant prior to harvest.[L2482]It is an extracellular plant cysteine proteinase similar to papain in specificity.[A32…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesEndopeptidases +5
Target Protein:
Bone marrow proteoglycan
Waktu ParuhFollowing intra-dis…
Vol. Distribusi-
Klirens-
Genetik -
Chymostatin DB01683
small molecule | CAS: 9076-44-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsChymotrypsin, antagonists & inhibitorsEnzyme Inhibitors +3
Target Protein:
ChymasePeptide amidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chymotrypsin Approved DB09375
small molecule | CAS: 9004-07-3

Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chy…

Kategori:
Blood and Blood Forming OrgansEndopeptidasesEnzymes +8
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
CI-1040 DB12429
small molecule | CAS: 212631-79-3

CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Mitogen-activated protein kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase 2Serine/threonine-protein kinase Sgk1 +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cianidanol Approved DB14086
small molecule | CAS: 154-23-4

An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

Kategori:
BenzopyransCatechinChromans +4
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 12Carbonic anhydrase 6 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cibacron Blue DB02633
small molecule | CAS: 84166-13-2

Deskripsi belum tersedia.

Target Protein:
Hematopoietic prostaglandin D synthaseNAD(P)H dehydrogenase [quinone] 1Glutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cibenzoline DB13358
small molecule | CAS: 53267-01-9

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsAntiarrhythmics, Class IAntiarrhythmics, Class Ia +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cibinetide DB13006
small molecule | CAS: 1208243-50-8

Cibinetide has been used in trials studying the basic science of Depression.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Erythropoietin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cibisatamab DB17349
biotech | CAS: 2101242-53-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ciclesonide Approved DB01410
small molecule | CAS: 126544-47-6

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.

Kategori:
Adrenal Cortex HormonesAdrenalsAgents to Treat Airway Disease +18
Target Protein:
Corticosteroid-binding globulinGlucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens* 152 L/hr [Followi…
Genetik -
Cicletanine DB12766
small molecule | CAS: 89943-82-8

Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension.

Kategori:
Antiarrhythmic agentsAntihypertensive AgentsCardiovascular Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ciclobendazole DB13465
small molecule | CAS: 31431-43-3

Deskripsi belum tersedia.

Kategori:
AnthelminticsAntinematodal AgentsAntiparasitic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ciclonicate DB13709
small molecule | CAS: 53449-58-4

Deskripsi belum tersedia.

Kategori:
Nicotinic Acid and DerivativesPeripheral VasodilatorsPyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 29546-59-6

Deskripsi belum tersedia.

Kategori:
Dioxoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ciclopirox Approved DB01188
small molecule | CAS: 29342-05-0

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea vers…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +14
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh1.7 hours for 1% to…
Vol. Distribusi-
Klirens-
Genetik -
Cidofovir Approved DB00369
small molecule | CAS: 113852-37-2

Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by …

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +16
Target Protein:
DNA polymerase catalytic subunitDNA polymerase catalytic subunit
Waktu Paruh2.4 to 3.2 hours
Vol. Distribusi* 537 ± 126 mL/kg […
Klirens* 179 +/- 23.1 mL/m…
Genetik -
Cidoxepin DB14750
small molecule | CAS: 3607-18-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ciforadenant DB16125
small molecule | CAS: 1202402-40-1

Ciforadenant is under investigation in clinical trial NCT02253745 (Safety, Tolerability, PK & Efficacy of V81444 in Volunteers With Attention Deficit/ Hyperactivity Disorder (ADHD)).

Target Protein:
Adenosine receptor A2a
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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