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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 111 / 315
Demeclocycline Approved DB00618
small molecule | CAS: 127-33-3

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +8
Target Protein:
30S ribosomal proteinVasopressin V2 receptor
Waktu Paruh10-17 hours
Vol. Distribusi-
Klirens* Renal cl=35 mL/mi…
Genetik -
Demecolcine DB13318
small molecule | CAS: 477-30-5

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntimitotic AgentsAntineoplastic Agents +5
Target Protein:
Microtubule-associated protein 1BMicrotubule-associated protein 1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demegestone DB13857
small molecule | CAS: 10116-22-0

Demegestone is a progesterone receptor agonist that was previously used to treat luteal insufficiency. It was previously marketed in France as Lutionex, but has since been discontinued.

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptives, Oral +15
Target Protein:
Progesterone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demexiptiline DB08998
small molecule | CAS: 24701-51-7

Demexiptiline is marketed under the names Deparon or Tinoran. It is a tricyclic antidepressant which acts primarily as a norepinephrine reuptake inhibitor.

Kategori:
Benzocycloheptenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demoxytocin DB13798
small molecule | CAS: 113-78-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1009838-50-9

Demplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer).

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denagliptin DB16134
small molecule | CAS: 483369-58-0

Denagliptin is under investigation in clinical trial NCT00387972 (Study of Denagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM)).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denatonium DB18588
small molecule | CAS: 47324-98-1

Deskripsi belum tersedia.

Kategori:
Abuse-Deterrent FormulationsAminesAmmonium Compounds +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

The recombinant chimeric DC vaccine is a subunit-based vaccine candidate investigated for safety and effectiveness against SARS-CoV-2-induced pneumonia. With a better safety profile than inactivated and live-attenuated virus and virus-vector vaccines, the rec…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dendryphiella vinosa Approved DB11025
biotech

Dendryphiella vinosa is a fungus which can provoke allergic reactions. Dendryphiella vinosa extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denecimig DB18426
biotech | CAS: 2488745-86-2

Delpacibart is a humanized, bispecific, bivalent monoclonal antibody against coagulation factor 9.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denenicokin DB12908
biotech | CAS: 716840-32-3

Denenicokin is under investigation in clinical trial NCT01152788 (Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denfivontinib DB17159
small molecule | CAS: 1457983-28-6

Deskripsi belum tersedia.

Target Protein:
Tyrosine-protein kinase MerReceptor-type tyrosine-protein kinase FLT3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
DengueCide DB18546
biotech

DengueCide is a nonjugate of a dengue virus specific small chemical ligand and an amphiphilic PEG based polymer

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denibulin DB05932
small molecule | CAS: 284019-34-7

Denibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vascular endothelial growth factor A, long formVascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denifanstat DB17576
small molecule | CAS: 1399177-37-7

Denifanstat is an orally bioavailable fatty acid synthase (FASN) inhibitor. Due to its antineoplastic activities, it is being investigated for various cancers.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denileukin diftitox Approved DB00004
biotech | CAS: 173146-27-5

Denileukin diftitox is an IL2-receptor-directed cytotoxin, is a recombinant DNA-derived fusion protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met<sub>1</sub>-Thr<sub>387</sub>)-His and the sequence for human interleukin-2…

Kategori:
ADP Ribose TransferasesAmino Acids, Peptides, and ProteinsAntineoplastic Agents +15
Target Protein:
Interleukin-2 receptor subunit alphaInterleukin-2 receptor subunit beta
Waktu ParuhThe arithmetic mean…
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
Denosumab Approved DB06643
biotech | CAS: 615258-40-7

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +16
Target Protein:
Tumor necrosis factor ligand superfamily member 11
Waktu ParuhAfter C<sub>max</su…
Vol. DistribusiThe central volume …
KlirensNo information is a…
Genetik -
biotech

Dental pulp is a soft, connective tissue present in the dental crown of both third molar and first premolar teeth. Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. They are harvested through surgical extraction of wi…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denufosol DB04983
small molecule | CAS: 211448-85-0

Denufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial. A new drug application (NDA) was filed with the FDA in 2011, however, the second phase III clinical…

Kategori:
Cytosine NucleotidesDeoxyribonucleotidesNucleic Acids, Nucleotides, and Nucleosides +6
Target Protein:
P2Y purinoceptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Endoglucanase 5A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deoxycholic acid Approved DB03619
small molecule | CAS: 83-44-3

Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by…

Kategori:
Bile Acids and SaltsBSEP/ABCB11 inducersCholagogues and Choleretics +9
Target Protein:
Proliferating cell nuclear antigenSteroid Delta-isomeraseCytochrome C +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 501-15-5

Sympathomimetic, vasoconstrictor agent.

Kategori:
Agents that produce hypertensionAminesBenzene Derivatives +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723]. It is normally found in saliva, urine, pancreatic secretions, and blood[A227723]. Because of the hypothesis that increased concentrations of high-mol…

Kategori:
Deoxyribonuclease I, antagonists & inhibitorsDeoxyribonucleasesEndodeoxyribonucleases +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deoxyspergualin DB12991
small molecule | CAS: 89149-10-0

Deoxyspergualin has been used in trials studying the treatment of Lupus Nephritis, Chronic Rejection, and Diabetes Mellitus, Type 1.

Kategori:
AmidinesAntibiotics, AntineoplasticAntineoplastic Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 964-26-1

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Thymidylate synthaseDeoxyuridine 5'-triphosphate nucleotidohydrolaseThymidylate synthase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialDeoxyuridine 5'-triphosphate nucleotidohydrolaseDeoxyuridine 5'-triphosphate nucleotidohydrolase +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depatuxizumab DB12826
biotech | CAS: 1471999-69-5

Depatuxizumab has been used in trials studying the treatment and diagnostic of Adenocarcinoma and Advanced Solid Tumors.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1585973-65-4

Depatuxizumab/Denintuzumab mafodotin has been used in trials studying the treatment of Lymphoma, Gliosarcoma, Glioblastoma, Malignant Glioma, Squamous Cell Tumors, and Glioblastoma Multiforme.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Target Protein:
Tubulin beta chainEpidermal growth factor receptorB-lymphocyte antigen CD19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depelestat DB17873
biotech | CAS: 506433-25-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsLeukocyte Elastase, antagonists & inhibitors
Target Protein:
Neutrophil elastase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depemokimab DB18846
biotech | CAS: 2243274-14-6

Depemokimab is under investigation in clinical trial NCT05274750 (Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphopantetheine adenylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depreotide DB11628
small molecule | CAS: 161982-62-3

Depreotide is an ingredient in the EMA-withdrawn product NeoSpect.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deptropine DB13466
small molecule | CAS: 604-51-3

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntihistamines for Systemic UseAza Compounds +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depulfavirine DB18890
small molecule | CAS: 867365-76-2

Depulfavirine is under investigation in clinical trial NCT05204394 (Study to Evaluate Efficacy and Safety of Switching to VM-1500A-LAI + 2nrtis From the 1st Line Standard of Care Therapy).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dequalinium Approved DB04209
small molecule | CAS: 6707-58-0

Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties.[A249255] It is a quaternary ammonium compound,[L42190] as it consists of an amphipathic cati…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAnti-Infective Agents, Local +10
Target Protein:
Small conductance calcium-activated potassium channel protein 1Cyclic nucleotide-gated channel alpha-2Small conductance calcium-activated potassium channel protein 2 +10
Waktu ParuhThere is no informa…
Vol. DistribusiThere is no informa…
KlirensThere is no informa…
Genetik -
Deracoxib DB11395
small molecule | CAS: 169590-41-4

Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to increase palatability. Deramaxx received FDA approval in August 2002 …

Kategori:
AmidesAnalgesicsAnalgesics, Non-Narcotic +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deramciclane DB06512
small molecule | CAS: 120444-71-5

Deramciclane (EGIS-3886) is used for the treatment of a number of anxiety disorders. Deramciclane differs from other anti anxiety medications in that it is not a benzodiazepine and so has a different structure and target. It antagonizes 5-HT2A receptors, agon…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsAntidepressive Agents +17
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Derazantinib DB14889
small molecule | CAS: 1234356-69-4

Derazantinib is under investigation in clinical trial NCT03230318 (Derazantinib in Subjects With FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma).

Kategori:
AminesHeterocyclic Compounds, Fused-Ring
Target Protein:
Fibroblast growth factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Derenofylline DB12446
small molecule | CAS: 251945-92-3

Derenofylline has been used in trials studying the treatment of Congestive Heart Failure and Acute Decompensated Heart Failure; Renal Dysfunction.

Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24967-94-0

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCarbohydrates +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dermatophagoides farinae Approved DB10400
biotech

Dermatophagoides farinae extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy. This combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatment for dust mite allergies.

Kategori:
Allergenic ExtractsAllergensAntigens +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Dermatophagoides pteronyssinus extracts are sterile solutions used for intradermal testing or subcutaneous immunotherapy. This combination is approved for as a year-round, once-a-day tablet that's dissolved under the tongue as a treatment for dust mite allerg…

Kategori:
Allergenic ExtractsAllergensAntigens +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dersalazine DB06251
small molecule | CAS: 188913-58-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +5
Target Protein:
Platelet-activating factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dersimelagon DB18007
small molecule | CAS: 1835256-48-8

Deskripsi belum tersedia.

Target Protein:
Melanocyte-stimulating hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 130525-62-1

Deskripsi belum tersedia.

Target Protein:
Neuraminidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desaspidin DB13567
small molecule | CAS: 114-43-2

Deskripsi belum tersedia.

Kategori:
AnthelminticsAnticestodalsAntiparasitic Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Arginase-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5501–5550 dari 15718
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