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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
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12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 110 / 252
Fedratinib Approved DB12500
small molecule | CAS: 936091-26-8

Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative.[A183188] Fedratinib was granted FDA appro…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +25
Target Protein:
Tyrosine-protein kinase JAK2Receptor-type tyrosine-protein kinase FLT3Tyrosine-protein kinase JAK1
Waktu ParuhThe half life of fe…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of fe…
Genetik -
Fedrilate DB13825
small molecule | CAS: 23271-74-1

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Feladilimab DB16415
biotech

Feladilimab is under investigation in clinical trial NCT04128696 (Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Felbamate Approved DB00949
small molecule | CAS: 25451-15-4

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization). Alternatively, it is used to treat partial and generalized s…

Kategori:
Acids, AcyclicAlcoholsAnti-epileptic Agent +28
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 2A
Waktu Paruh20-23 hours
Vol. Distribusi* 756±82 mL/kg
Klirens* 26 +/- 3 mL/hr/kg…
Genetik -
Felbinac DB07477
small molecule | CAS: 5728-52-9

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +12
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2Procathepsin L
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Felcisetrag DB12725
small molecule | CAS: 916075-84-8

Felcisetrag (TD-8954) has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +4
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Felodipine Approved DB01023
small molecule | CAS: 72509-76-3

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smoot…

Kategori:
ACE Inhibitors and Calcium Channel BlockersAgents causing hyperkalemiaAntiarrhythmic agents +31
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent L-type calcium channel subunit beta-2 +10
Waktu Paruh17.5-31.5 hours in …
Vol. Distribusi* 10 L/kg
Klirens* 0.8 L/min [Young …
Genetik -
Felypressin DB00093
biotech | CAS: 56-59-7

A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less tha…

Kategori:
Amino Acids, Peptides, and ProteinsCardiovascular AgentsHormones +12
Target Protein:
Vasopressin V1a receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Felzartamab DB16375
biotech | CAS: 2197112-39-1

Felzartamab is under investigation in clinical trial NCT04145440 (Trial to Assess Safety and Efficacy of MOR202 in Anti-pla2r + Membranous Nephropathy (Amn)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenamole DB12506
small molecule | CAS: 5467-78-7

Fenamole has been investigated for the supportive care of Side Effects and Dental Plaque.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenbendazole DB11410
small molecule | CAS: 43210-67-9

Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms, pinworms, aelurostrongylus, parago…

Kategori:
Acids, AcyclicAnthelminticsAnti-Infective Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenbufen Approved DB08981
small molecule | CAS: 36330-85-5

Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet s…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +15
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenchone DB15918
small molecule | CAS: 1195-79-5

Deskripsi belum tersedia.

Kategori:
Bicyclic MonoterpenesBridged-Ring CompoundsMonoterpenes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenebrutinib DB14785
small molecule | CAS: 1434048-34-6

Fenebrutinib is under investigation in clinical trial NCT03174041 (A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin).

Kategori:
Pyridines
Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenfluramine Approved DB00574
small molecule | CAS: 458-24-2

Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with diseas…

Kategori:
Alimentary Tract and MetabolismAminesAnticonvulsants +27
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 2C +4
Waktu ParuhFenfluramine has an…
Vol. DistribusiFenfluramine has an…
KlirensFenfluramine has a …
Genetik -
Fennel Approved DB15615
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenobam DB12931
small molecule | CAS: 57653-26-6

Fenobam is under investigation in clinical trial NCT00637221 (Open Label Study Investigating Safety and Efficacy of Fenobam anhydrous 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance Tasks, Adults With Fragile X Syndrome).

Target Protein:
Metabotropic glutamate receptor 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenofibrate Approved DB01039
small molecule | CAS: 49562-28-9

Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil].[A185954] Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 Decemb…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +39
Target Protein:
Peroxisome proliferator-activated receptor alphaNuclear receptor subfamily 1 group I member 2Matrix metalloproteinase-25
Waktu ParuhFenofibric acid, th…
Vol. DistribusiThe volume of distr…
KlirensThe oral clearance …
Genetik -
Fenofibric acid Approved DB13873
small molecule | CAS: 42017-89-0

Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +17
Target Protein:
Peroxisome proliferator-activated receptor alphaFatty acid-binding protein, liverMatrix metalloproteinase-25 +3
Waktu ParuhFollowing once dail…
Vol. DistribusiThe volume of distr…
KlirensIn five elderly vol…
Genetik -
Fenoldopam Approved DB00800
small molecule | CAS: 67227-56-9

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.

Kategori:
Adrenergic and Dopaminergic AgentsAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +12
Target Protein:
D(1B) dopamine receptorD(1A) dopamine receptorAlpha-1B adrenergic receptor +5
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Fenoprofen Approved DB00573
small molecule | CAS: 29679-58-1

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +18
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1Peroxisome proliferator-activated receptor alpha +1
Waktu ParuhPlasma half-life is…
Vol. Distribusi-
Klirens-
Genetik -
Fenoterol Approved DB01288
small molecule | CAS: 13392-18-2

Fenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +28
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptorBeta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenoverine DB13042
small molecule | CAS: 37561-27-6

Fenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome.

Kategori:
Alimentary Tract and MetabolismAutonomic AgentsDrugs for Functional Gastrointestinal Disorders +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 66441-23-4

Fenoxaprop-ethyl (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance. Fenoxaprop-ethyl has been investigated to treat chronic a…

Kategori:
Acids, AcyclicAgrochemicalsCompounds used in a research, industrial, or household setting +6
Target Protein:
Nitric oxide synthase 3Nitric oxide synthase, inducible
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenozolone DB13341
small molecule | CAS: 15302-16-6

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAutonomic Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenpiprane DB13439
small molecule | CAS: 3540-95-2

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismBenzene DerivativesDrugs for Functional Gastrointestinal Disorders
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenpiverinium DB13759
small molecule | CAS: 258329-46-3

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenproporex DB01550
small molecule | CAS: 16397-28-7

Fenproporex is an orally active stimulant drug, which was developed in the 1960s. It is used as an appetite suppressant and a treatment for obesity. It is listed as an illicit substance in many countries due to addiction issues and listed as a prohibited subs…

Kategori:
AminesDrugs that are Mainly Renally ExcretedEthylamines +2
Waktu Paruh-
Vol. Distribusi-
KlirensThe amphetamine met…
Genetik -
Fenpyroximate DB16164
small molecule | CAS: 134098-61-6

Fenpyroximate is under investigation in clinical trial NCT02533336 (The Effectiveness of Non-pyrethroid Insecticide-treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania).

Kategori:
Acids, CarbocyclicBenzene DerivativesElectron Transport Complex I, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenretinide DB05076
small molecule | CAS: 65646-68-6

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.

Kategori:
AlkenesAnticarcinogenic AgentsAntineoplastic Agents +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenspiride DB08979
small molecule | CAS: 5053-06-5

Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopha…

Kategori:
Anti-Asthmatic AgentsAutonomic AgentsBronchodilator Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fentanyl Approved DB00813
small molecule | CAS: 437-38-7

Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia.[A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922…

Kategori:
AdjuvantsAdjuvants, AnesthesiaAgents that produce hypertension +32
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +1
Waktu ParuhThe half life of fe…
Vol. DistribusiThe intravenous vol…
KlirensTotal plasma cleara…
Genetik -
Fenthion DB11412
small molecule | CAS: 55-38-9

Fenthion is an _organothiophosphate_ drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is listed as a restricted use compound by the U…

Kategori:
AgrochemicalsCholinergic AgentsCholinesterase Inhibitors +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fentiazac DB13217
small molecule | CAS: 18046-21-4

Deskripsi belum tersedia.

Kategori:
Acetic Acid Derivatives and Related SubstancesAcids, AcyclicAgents causing hyperkalemia +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenvalerate DB18391
small molecule | CAS: 51630-58-1

Deskripsi belum tersedia.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingCyclopentane Monoterpenes +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenyramidol DB13414
small molecule | CAS: 553-69-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsMuscle RelaxantsMuscle Relaxants, Centrally Acting Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fepixnebart DB19079
biotech | CAS: 1799706-87-8

Fepixnebart is under investigation in clinical trial NCT04456686 (Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fepradinol DB15902
small molecule | CAS: 36981-91-6

Deskripsi belum tersedia.

Kategori:
AlcoholsAminesAmino Alcohols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 54063-42-2

Deskripsi belum tersedia.

Kategori:
Diagnostic RadiopharmaceuticalsVarious Diagnostic Radiopharmaceuticals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric ammonium citrate Approved DB09501
small molecule | CAS: 1185-57-5

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsContrast Media +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric carboxymaltose Approved DB08917
small molecule | CAS: 9007-72-1

Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.

Kategori:
CarbohydratesCompounds used in a research, industrial, or household settingDisaccharides +5
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe estimated volum…
Klirens-
Genetik -
Ferric cation Approved DB13949
small molecule | CAS: 20074-52-6

Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and ene…

Kategori:
Iron CompoundsParenteral Iron ReplacementPhosphate Binder +2
Target Protein:
Transferrin receptor protein 1Iron(3+)-hydroxamate-binding protein FhuD
Waktu ParuhThe pharmacokinetic…
Vol. DistribusiLess than 65% of ir…
KlirensThe rate of iron lo…
Genetik -
Ferric chloride Approved DB15536
small molecule | CAS: 7705-08-0

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric derisomaltose Approved DB15617
small molecule | CAS: 1345510-43-1

Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide. Iron deficiency results when iron intake, iron stores, and loss of iron from the body do not adequately support production of erythrocytes, also known as red …

Kategori:
Anemia, Iron-DeficiencyAntianemia DrugsAntianemic Preparations +6
Target Protein:
Hemoglobin subunit alphaTransferrin receptor
Waktu ParuhThe plasma-half liv…
Vol. DistribusiFerric derisomaltos…
KlirensIntravenous iron is…
Genetik -
Ferric glycerophosphate Approved DB15934
small molecule | CAS: 1301-70-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric maltol Approved DB15598
small molecule | CAS: 33725-54-1

Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate.[A189288] Ferric maltol has been described in literatu…

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansHematinics +8
Target Protein:
Integrin beta-3Natural resistance-associated macrophage protein 2
Waktu ParuhMaltol has a half l…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Ferric oxide DB11576
small molecule | CAS: 1309-37-1

Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite.

Kategori:
Contrast MediaIron CompoundsMagnetic Resonance Imaging Contrast Media +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20344-49-4

An antiferromagnetic material; constitutes the core of natural ferritin.

Kategori:
Iron CompoundsOrganometallic CompoundsPhosphate Binder +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10058-44-3

Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by py…

Kategori:
AcidsAcids, NoncarboxylicAnions +13
Target Protein:
Ferritin light chainHemoglobin subunit alphaHemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ferric pyrophosphate citrate Approved DB13995
small molecule | CAS: 1802359-96-1

Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly …

Kategori:
EnzymesEnzymes and CoenzymesHydrolases +3
Target Protein:
Ferritin light chainFerritin heavy chainHemoglobin subunit alpha +1
Waktu ParuhThe half-life of fe…
Vol. DistribusiThe apparent volume…
KlirensThe mean clearance …
Genetik -
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