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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 110 / 282
small molecule | CAS: 19309-14-9

Cardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits to human health. Cardamonin's name comes from the …

Kategori:
BenzopyransChromonesFlavonoids +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 162870-29-3

Deskripsi belum tersedia.

Kategori:
AlcoholsEthylene GlycolsGlycols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1445-75-6

Deskripsi belum tersedia.

Target Protein:
Parathion hydrolaseParathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dilanubicel DB18722
biotech

Dilanubicel consists of ex vivo expanded hematopoietic stem and progenitor cells.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dilmapimod DB12140
small molecule | CAS: 444606-18-2

Dilmapimod has been used in trials studying the treatment and diagnostic of Nerve Trauma, Inflammation, Pain, Neuropathic, Arthritis, Rheumatoid, and Coronary Heart Disease, among others. Dilmapimod (SB-681323) is a p38 MAP-kinase inhibitor that has potential…

Kategori:
p38 Mitogen-Activated Protein Kinases, antagonists & inhibitorsPyridines
Target Protein:
Mitogen-activated protein kinase 14Tumor necrosis factorInterleukin-1 beta +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diloxanide DB08792
small molecule | CAS: 579-38-4

Diloxanide (as [Diloxanide furoate]) is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections. Although it is not currently approved for use in the United States, it was approved by a CDC study in the treatm…

Kategori:
AmebicidesAnti-Infective AgentsAntiparasitic Agents +4
Waktu Paruh3 hours
Vol. Distribusi-
Klirens-
Genetik -
Diloxanide furoate Approved DB14638
small molecule | CAS: 3736-81-0

Deskripsi belum tersedia.

Kategori:
AmebicidesAnti-Infective AgentsAntiparasitic Agents +1
Waktu Paruh3 hours
Vol. Distribusi-
Klirens-
Genetik -
Dilpacimab DB16140
biotech | CAS: 1791420-09-1

Dilpacimab is under investigation in clinical trial NCT03368859 (A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab).

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diltiazem Approved DB00343
small molecule | CAS: 42399-41-7

Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it prim…

Kategori:
Agents causing hyperkalemiaAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAntiarrhythmic agents +44
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent calcium channel gamma-1 subunit
Gen Terkait:
ADRB1
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe apparent volume…
KlirensFollowing a single …
Genetik 1 Varian
Dimazole Approved DB13858
small molecule | CAS: 95-27-2

Dimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimefline DB13482
small molecule | CAS: 1165-48-6

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimenhydrinate Approved DB00985
small molecule | CAS: 523-87-5

Dimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950.[L32995] Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery.[A233130…

Kategori:
AlkaloidsAminesAminoalkyl Ethers +21
Target Protein:
Histamine H1 receptor
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Dimepheptanol DB19094
small molecule | CAS: 545-90-4

Dimepheptanol is under investigation in clinical trial NCT00218127 (Treatment of Opioid/heroin Dependence: Comparison of Three Medication Dosing Regimens).

Kategori:
AnalgesicsCentral Nervous System AgentsCentral Nervous System Depressants +5
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimercaprol Approved DB06782
small molecule | CAS: 59-52-9

Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsen…

Kategori:
AntidotesChelating AgentsCompounds used in a research, industrial, or household setting +7
Target Protein:
ArsenicCadmiumMercury +1
Waktu ParuhThe drug has a shor…
Vol. Distribusi-
Klirens-
Genetik -
Dimercaptosuccinic acid Approved DB14089
small molecule | CAS: 2418-14-6

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAntidotesChelating Agents +8
Target Protein:
MercuryArsenic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 366472-45-9

Dimethandrolone Undecanoate is under investigation in clinical trial NCT03455075 (Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimethicone Approved DB11074
small molecule | CAS: 63148-62-9

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It…

Kategori:
Antifoaming AgentsAntiparasitic Products, Insecticides and RepellentsBasic Ointments and Protectants +11
Waktu Paruh-
Vol. DistribusiFollowing injection…
Klirens-
Genetik -
Dimethicone 410 Approved DB14005
small molecule | CAS: 9006-65-9

Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products.[A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit.[L1769] It is currently recognized by the FDA as a skin protect…

Waktu ParuhAs dimethicone is p…
Vol. DistribusiAs dimethicone is p…
KlirensA very minimal amou…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptorNuclear receptor coactivator 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 39589-98-5

Dimethyl carbate is used as an insect repellant.

Kategori:
Antiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. Scabicides, Insecticides and RepellentsInsecticides and Repellents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimethyl fumarate Approved DB08908
small molecule | CAS: 624-49-7

Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradati…

Kategori:
Acids, AcyclicAnti-Inflammatory AgentsAntineoplastic and Immunomodulating Agents +9
Target Protein:
Kelch-like ECH-associated protein 1Transcription factor p65
Waktu ParuhThe dimethyl fumara…
Vol. DistribusiIn healthy people, …
KlirensMonomethyl fumarate…
Genetik -
Dimethyl sulfoxide Approved DB01093
small molecule | CAS: 67-68-5

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. …

Kategori:
AntioxidantsCompounds used in a research, industrial, or household settingCryoprotective Agents +20
Target Protein:
Interleukin-5 receptor subunit alphaMucin-16Myc proto-oncogene protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Dual specificity tyrosine-phosphorylation-regulated kinase 1ADual specificity tyrosine-phosphorylation-regulated kinase 2Casein kinase II subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 358-72-5

Deskripsi belum tersedia.

Kategori:
Terpenes
Target Protein:
Farnesyl pyrophosphate synthaseIsopentenyl-diphosphate Delta-isomerase 14-hydroxy-3-methylbut-2-enyl diphosphate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylate dimethylallyltransferasetRNA dimethylallyltransferaseFarnesyl diphosphate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1403357-81-2

Deskripsi belum tersedia.

Kategori:
CycloheptanesCycloparaffinsPolycyclic Sesquiterpenes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63834-04-8

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal DisordersSynthetic Antispasmodics, Amides With Tertiary Amines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 52328-98-0

Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin. It is a novel anti-androgen that enhances androgen receptor degradation.

Kategori:
AlkanesBenzene DerivativesCatechols +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 524-84-5

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse po…

Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 61-50-7

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an an…

Kategori:
AminesAntidepressive AgentsBiogenic Amines +13
Target Protein:
5-hydroxytryptamine receptor 6Sigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetofrine DB13494
small molecule | CAS: 22950-29-4

Deskripsi belum tersedia.

Kategori:
Adrenergic and Dopaminergic AgentsAlcoholsAmines +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetotiazine Approved DB08967
small molecule | CAS: 7456-24-8

Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.

Kategori:
AnalgesicsAntimigraine PreparationsHeterocyclic Compounds, Fused-Ring +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimiracetam DB13018
small molecule | CAS: 126100-97-8

Dimiracetam has been used in trials studying the treatment of AIDS, Neuropathy, and Acquired Immunodeficiency Syndrome.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinaciclib DB12021
small molecule | CAS: 779353-01-4

Dinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others.

Kategori:
Cyclin-Dependent Kinases, antagonists & inhibitorsHeterocyclic Compounds, Fused-RingPyridines
Target Protein:
Cyclin-dependent kinase 9Cyclin-dependent kinase 2Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 311768-81-7

Dinalbuphine sebacate is under investigation in clinical trial NCT02468128 (A Study of Intramuscular Sebacoyl Dinalbuphine Ester for Post-Hemorrhoidectomy Pain Management).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 97-00-7

Dinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.

Kategori:
AntigensBenzene DerivativesBiological Factors +14
Target Protein:
Methylated-DNA--protein-cysteine methyltransferaseGlutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinoprost Approved DB12789
small molecule | CAS: 551-11-1

Dinoprost has been investigated in Headache.

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAutacoids +11
Target Protein:
Prostaglandin F2-alpha receptorThromboxane A2 receptorProstaglandin E2 receptor EP1 subtype +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinoprost tromethamine Approved DB01160
small molecule | CAS: 38562-01-5

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or …

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAngiography +11
Target Protein:
Prostaglandin F2-alpha receptorProstacyclin receptor
Waktu ParuhThe half-life of di…
Vol. Distribusi-
Klirens-
Genetik -
Dinoprostone Approved DB00917
small molecule | CAS: 363-24-6

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, t…

Kategori:
AutacoidsBiological FactorsDinoprostone, antagonists & inhibitors +19
Target Protein:
Prostaglandin F2-alpha receptorProstaglandin E2 receptor EP2 subtypeProstaglandin E2 receptor EP1 subtype +3
Waktu ParuhLess than 5 minutes.
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Arginase-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinutuximab Approved DB09077
biotech | CAS: 1363687-32-4

Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
GD2 disialoganglioside
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe mean volume of …
KlirensThe clearance is 0.…
Genetik -
Dioctyldimonium Approved DB13970
small molecule | CAS: 20256-55-7

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diosmetin DB11259
small molecule | CAS: 520-34-3

Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits [A27231]. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic and anti-in…

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Cytochrome P450 1B1Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diosmin Approved DB08995
small molecule | CAS: 520-27-4

Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease.[A232885] Diosmin is a bioflavonoid …

Kategori:
BenzopyransCapillary Stabilizing AgentsChromones +15
Target Protein:
Aryl hydrocarbon receptor
Waktu ParuhDiosmin half-life r…
Vol. DistribusiA pharmacokinetic s…
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Xanthine dehydrogenase/oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dioxybenzone Approved DB11221
small molecule | CAS: 131-53-3

Dioxybenzone, or benzophenone-8, is an organic compound derived from [DB01878] that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525].

Kategori:
Benzene DerivativesKetonesSunscreen Agents
Target Protein:
Sex hormone-binding globulin
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Selenium Compounds
Target Protein:
Subtilisin BPN'
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphemanil Approved DB13720
small molecule | CAS: 15394-62-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnti-Asthmatic Agents +9
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphenadione DB13347
small molecule | CAS: 82-66-6

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCytochrome P-450 CYP3A Substrates +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphencyprone DB12173
small molecule | CAS: 886-38-4

Diphencyprone has been used in trials studying the treatment and basic science of Melanoma, Ultraviolet Rays, Immunosuppression, Neoplasm Metastasis, and Hypersensitivity, Delayed, among others.

Kategori:
Cycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5451–5500 dari 14063
Sebelumnya Halaman 110 / 282 Berikutnya