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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 108 / 282
small molecule | CAS: 3148-72-9

Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others.

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Diaminopyrimidine oxide Approved DB18756
small molecule | CAS: 74638-76-9

Diaminopyrimidine oxide is a compound similar to [minoxidil] which is used to aid in hair growth.

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Diamorphine Approved DB01452
small molecule | CAS: 561-27-3

Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal sta…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +16
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor +1
Waktu ParuhIn humans, administ…
Vol. DistribusiData regarding the …
KlirensSome studies have d…
Genetik -
Diampromide DB01502
small molecule | CAS: 552-25-0

Deskripsi belum tersedia.

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Dianexin DB15000
biotech | CAS: 1352413-49-0

Dianexin is under investigation in clinical trial NCT00615966 (Phase 2 Study of the Safety of Diannexin in Kidney Transplant Recipients).

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small molecule | CAS: 23261-20-3

Dianhydrogalactitol has been used in trials studying the treatment of GBM, Glioma, Glioblastoma, Brain Cancer, and Glioblastoma Multiforme.

Kategori:
AlcoholsAlkylating DrugsAntineoplastic Agents +6
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Dianicline DB12125
small molecule | CAS: 292634-27-6

Dianicline has been used in trials studying the treatment of Smoking, Smoking Cessation, and Tobacco Use Cessation.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Neuronal acetylcholine receptor subunit alpha-4Neuronal acetylcholine receptor subunit beta-2
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DiaPep 277 DB06651
small molecule | CAS: 179822-83-4

DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60(437-460).

Kategori:
Acid Anhydride HydrolasesAdenosine TriphosphatasesAmino Acids, Peptides, and Proteins +10
Target Protein:
60 kDa heat shock protein, mitochondrial
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Diatrizoate Approved DB00271
small molecule | CAS: 117-96-4

A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.

Kategori:
Acids, CarbocyclicAlcoholsAmino Sugars +17
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DiaVacs DB18512
biotech

DiaVacs is a CD40/CD80/CD86 modified autologous dendritic cell therapy

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Diazepam Approved DB00829
small molecule | CAS: 439-14-5

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disor…

Kategori:
Adjuvants, AnesthesiaAnestheticsAnesthetics, General +40
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhDiazepam has a biph…
Vol. DistribusiIn young healthy ma…
KlirensThe clearance of di…
Genetik -
Diazepinomicin DB12420
small molecule | CAS: 733035-26-2

Diazepinomicin has been used in trials studying the treatment of Glioblastoma Multiforme. It is a proprietary first-in-class small molecule with the potential to treat multiple solid tumours like the well known chemotherapeutics, doxorubicin and mitomycin C. …

Kategori:
Heterocyclic Compounds, Fused-RingTerpenes
Target Protein:
Translocator protein
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Diaziquone DB17174
small molecule | CAS: 57998-68-2

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsAzirinesCompounds used in a research, industrial, or household setting +4
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Diazolidinylurea Approved DB14173
small molecule | CAS: 78491-02-8

Deskripsi belum tersedia.

Kategori:
AmidesCell-mediated ImmunityIncreased Histamine Release +1
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Diazoxide Approved DB01119
small molecule | CAS: 364-98-7

Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activ…

Kategori:
Antihypertensive AgentsArteriolar Smooth Muscle, Agents Acting OnBenzothiadiazines +12
Target Protein:
ATP-sensitive inward rectifier potassium channel 11Mitochondrial ATP synthase F1 domain
Waktu ParuhFollowing oral admi…
Vol. DistribusiThe apparent volume…
KlirensIn subjects with no…
Genetik -
Dibekacin Approved DB13270
small molecule | CAS: 34493-98-6

Dibekacin is an aminoglycoside antibiotic marketed in Japan [L5623].

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +11
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Dibenzepin Approved DB13225
small molecule | CAS: 4498-32-2

Dibenzepin is approved for use in Europe.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +11
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small molecule

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-Ring
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small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin K
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Dibotermin alfa Approved DB11639
biotech | CAS: 246539-15-1

Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of th…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBone Morphogenetic Proteins +7
Target Protein:
Bone morphogenetic protein receptor type-2Bone morphogenetic protein receptor type-1A
Waktu ParuhWhen injected intra…
Vol. Distribusi-
KlirensAt the site of impl…
Genetik -
small molecule | CAS: 29096-93-3

At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the si…

Kategori:
BenzoquinonesQuinones
Target Protein:
Cytochrome fCytochrome b6-f complex subunit 5Cytochrome b6-f complex subunit 6 +5
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Dibunate DB13796
small molecule | CAS: 14992-58-6

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
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small molecule | CAS: 84-74-2

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAntiparasitic Products, Insecticides and RepellentsCompounds used in a research, industrial, or household setting +4
Target Protein:
Transient receptor potential cation channel subfamily A member 1
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small molecule | CAS: 141-03-7

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. Scabicides, Insecticides and RepellentsInsecticides and Repellents
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Dichlorobenzene Approved DB14046
small molecule | CAS: 25321-22-6

Dichlorobenzene refers to any of, or a mixture of, three isomers consisting of benzene in which two of the hydrogen atoms are replaced by chlorine atoms: ortho-, meta-, and paradichlorobenzene. It is a constituent of the ear-wax removal product Cerumol.

Kategori:
Benzene DerivativesCytochrome P-450 CYP2E1 SubstratesCytochrome P-450 Substrates
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Dichlorobenzyl alcohol Approved DB13269
small molecule | CAS: 1777-82-8

Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections.[A33047] Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada…

Kategori:
AlcoholsAnti-Infective Agents, LocalBenzene Derivatives +3
Target Protein:
Sodium channel protein
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
small molecule | CAS: 59-61-0

Dichloroisoproterenol has been used in trials studying the treatment and basic science of Insulin Resistance and Polycystic Ovary Syndrome.

Kategori:
AlcoholsAminesAmino Alcohols +5
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
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Dichlorophen DB11396
small molecule | CAS: 97-23-4

Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from dogs and cats.

Kategori:
AnthelminticsAnti-Infective AgentsAnticestodal Agents +9
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Dichlorvos DB11397
small molecule | CAS: 62-73-7

Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the _organophosphate_ class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products from insect infestations. The compound has been available…

Kategori:
AgrochemicalsAnthelminticsAnti-Infective Agents +13
Target Protein:
SerotransferrinCholinesterase
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Dichromate Approved DB14182
small molecule | CAS: 13907-47-6

Deskripsi belum tersedia.

Kategori:
CausticsChromatesChromium Compounds +4
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Diclazuril DB11398
small molecule | CAS: 101831-37-2

Diclazuril is a coccidiostat.

Kategori:
Anti-Infective AgentsAntiparasitic AgentsAntiprotozoals +1
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Diclofenac Approved DB00586
small molecule | CAS: 15307-86-5

Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain sign…

Kategori:
Acetic Acid Derivatives and Related SubstancesAcids, CarbocyclicAgents causing angioedema +58
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhThe terminal half-l…
Vol. DistribusiDiclofenac has a to…
KlirensDiclofenac has a pl…
Genetik -
Diclofenamide Approved DB01144
small molecule | CAS: 120-97-8

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

Kategori:
AmidesAntiglaucoma Preparations and MioticsCarbonic Anhydrase Inhibitors +11
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 1Carbonic anhydrase 4 +2
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Diclofop-methyl DB13918
small molecule | CAS: 51338-27-3

Herbicide for control of wild oat & foxtails in cereal crops.

Kategori:
Benzene DerivativesEthersPhenols +1
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Dicloxacillin Approved DB00485
small molecule | CAS: 3116-76-5

One of the penicillins which is resistant to penicillinase.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +13
Target Protein:
Penicillin-binding protein 3Penicillin-binding protein 1bPenicillin-binding protein 2a +3
Waktu ParuhThe elimination hal…
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Dicoumarol Approved DB00266
small molecule | CAS: 66-76-2

Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.

Kategori:
4-HydroxycoumarinsAnticoagulantsBenzopyrans +13
Target Protein:
Vitamin K epoxide reductase complex subunit 1NAD(P)H dehydrogenase [quinone] 1Quinone oxidoreductase
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Dicyclomine Approved DB00804
small molecule | CAS: 77-19-0

Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L796…

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +14
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe volume of distr…
KlirensData regarding the …
Genetik -
Didanosine Approved DB00900
small molecule | CAS: 69655-05-6

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +24
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyproteinPurine nucleoside phosphorylase
Waktu Paruh30 minutes in plasm…
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Didecyldimethylammonium Approved DB04221
small molecule | CAS: 20256-56-8

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsAntiseptics and Disinfectants +4
Target Protein:
Phospholipid membraneCyclopropane mycolic acid synthase 2
Waktu Paruh-
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small molecule | CAS: 4097-22-7

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntihypertensive AgentsAntimetabolites +18
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small molecule

Didesmethylrocaglamide is a naturally-occurring derivative of [rocaglamide] and belongs to a class of anti-cancer phytochemicals referred to as "rocaglamides" derived from plants of the genus _Aglaia_.[A186760] While traditionally used for their insecticidal …

Target Protein:
Prohibitin 1Prohibitin-2
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Didox DB12948
small molecule | CAS: 69839-83-4

Didox has been used in trials studying the supportive care of Gastric Cancer.

Kategori:
AminesAntineoplastic AgentsEnzyme Inhibitors +3
Target Protein:
Ribonucleoside-diphosphate reductase large subunitRibonucleoside-diphosphate reductase subunit M2Ribonucleoside-diphosphate reductase subunit M2 B
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Dienestrol Approved DB00890
small molecule | CAS: 13029-44-2

Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dr…

Kategori:
Benzene DerivativesBenzyl CompoundsBenzylidene Compounds +12
Target Protein:
Estrogen receptorSex hormone-binding globulin
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small molecule | CAS: 24705-61-1

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesBenzyl CompoundsBenzylidene Compounds +5
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Dienogest Approved DB09123
small molecule | CAS: 65928-58-7

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17?-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with eth…

Kategori:
Adrenal Cortex HormonesAntineoplastic AgentsAntineoplastic Agents, Hormonal +29
Target Protein:
Progesterone receptorAndrogen receptor
Waktu ParuhElimination half-li…
Vol. DistribusiThe apparent volume…
KlirensThe metabolic clear…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Estrogen receptorNuclear receptor coactivator 2
Waktu Paruh-
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Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphotriesterase
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Genetik -
small molecule | CAS: 3762-25-2

Deskripsi belum tersedia.

Kategori:
Organophosphorus Compounds
Target Protein:
Parathion hydrolaseParathion hydrolase
Waktu Paruh-
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Genetik -
Diethyl ether DB13598
small molecule | CAS: 60-29-7

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +9
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Genetik -
small molecule | CAS: 762-04-9

Deskripsi belum tersedia.

Kategori:
Cholinesterase Inhibitors
Target Protein:
CholinesteraseDiacylglycerol acyltransferase/mycolyltransferase Ag85C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5351–5400 dari 14063
Sebelumnya Halaman 108 / 282 Berikutnya