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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 106 / 272
small molecule | CAS: 52328-98-0

Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin. It is a novel anti-androgen that enhances androgen receptor degradation.

Kategori:
AlkanesBenzene DerivativesCatechols +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 131-11-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgrochemicalsAntiparasitic Products, Insecticides and Repellents +9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 524-84-5

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse po…

Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 61-50-7

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an an…

Kategori:
AminesAntidepressive AgentsBiogenic Amines +13
Target Protein:
5-hydroxytryptamine receptor 6Sigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetindene Approved DB08801
small molecule | CAS: 5636-83-9

Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +13
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimetofrine DB13494
small molecule | CAS: 22950-29-4

Deskripsi belum tersedia.

Kategori:
Adrenergic and Dopaminergic AgentsAlcoholsAmines +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Diminazene DB03608
small molecule | CAS: 536-71-0

Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Az…

Kategori:
AmidinesAnti-Infective AgentsAntiparasitic Agents +4
Target Protein:
HTH-type transcriptional regulator QacRSerine protease 1Diamine oxidase [copper-containing] +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dimiracetam DB13018
small molecule | CAS: 126100-97-8

Dimiracetam has been used in trials studying the treatment of AIDS, Neuropathy, and Acquired Immunodeficiency Syndrome.

Waktu Paruh-
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Dinaciclib DB12021
small molecule | CAS: 779353-01-4

Dinaciclib has been used in trials studying the treatment of rrMM, rrCLL, rrDLBCL, Solid Tumors, and Solid Neoplasm, among others.

Kategori:
Cyclin-Dependent Kinases, antagonists & inhibitorsHeterocyclic Compounds, Fused-RingPyridines
Target Protein:
Cyclin-dependent kinase 9Cyclin-dependent kinase 2Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 311768-81-7

Dinalbuphine sebacate is under investigation in clinical trial NCT02468128 (A Study of Intramuscular Sebacoyl Dinalbuphine Ester for Post-Hemorrhoidectomy Pain Management).

Waktu Paruh-
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Genetik -
small molecule | CAS: 97-00-7

Dinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.

Kategori:
AntigensBenzene DerivativesBiological Factors +14
Target Protein:
Methylated-DNA--protein-cysteine methyltransferaseGlutathione S-transferase P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dinoprost tromethamine Approved DB01160
small molecule | CAS: 38562-01-5

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or …

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAngiography +11
Target Protein:
Prostaglandin F2-alpha receptorProstacyclin receptor
Waktu ParuhThe half-life of di…
Vol. Distribusi-
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Genetik -
Dinoprostone Approved DB00917
small molecule | CAS: 363-24-6

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, t…

Kategori:
AutacoidsBiological FactorsDinoprostone, antagonists & inhibitors +19
Target Protein:
Prostaglandin F2-alpha receptorProstaglandin E2 receptor EP2 subtypeProstaglandin E2 receptor EP1 subtype +3
Waktu ParuhLess than 5 minutes.
Vol. Distribusi-
Klirens-
Genetik -
Dinutuximab Approved DB09077
biotech | CAS: 1363687-32-4

Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
GD2 disialoganglioside
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe mean volume of …
KlirensThe clearance is 0.…
Genetik -
Dioctyldimonium Approved DB13970
small molecule | CAS: 20256-55-7

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Diodone DB13568
small molecule | CAS: 300-37-8

Deskripsi belum tersedia.

Kategori:
Compounds used in a research, industrial, or household settingContrast MediaDiagnostic Uses of Chemicals +5
Waktu Paruh-
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Genetik -
Diosmetin DB11259
small molecule | CAS: 520-34-3

Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits [A27231]. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic and anti-in…

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Cytochrome P450 1B1Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
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Diosmin Approved DB08995
small molecule | CAS: 520-27-4

Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease.[A232885] Diosmin is a bioflavonoid …

Kategori:
BenzopyransCapillary Stabilizing AgentsChromones +15
Target Protein:
Aryl hydrocarbon receptor
Waktu ParuhDiosmin half-life r…
Vol. DistribusiA pharmacokinetic s…
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Xanthine dehydrogenase/oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dioxybenzone Approved DB11221
small molecule | CAS: 131-53-3

Dioxybenzone, or benzophenone-8, is an organic compound derived from [DB01878] that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525].

Kategori:
Benzene DerivativesKetonesSunscreen Agents
Target Protein:
Sex hormone-binding globulin
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 94-37-1

Deskripsi belum tersedia.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseStandardized Chemical Allergen
Target Protein:
Aldehyde dehydrogenase family 3 member A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diperodon DB11513
small molecule | CAS: 101-08-6

Deskripsi belum tersedia.

Waktu Paruh-
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Diphemanil Approved DB13720
small molecule | CAS: 15394-62-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnti-Asthmatic Agents +9
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphenadione DB13347
small molecule | CAS: 82-66-6

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCytochrome P-450 CYP3A Substrates +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphencyprone DB12173
small molecule | CAS: 886-38-4

Diphencyprone has been used in trials studying the treatment and basic science of Melanoma, Ultraviolet Rays, Immunosuppression, Neoplasm Metastasis, and Hypersensitivity, Delayed, among others.

Kategori:
Cycloparaffins
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Diphenhydramine Approved DB01075
small molecule | CAS: 58-73-1

Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, …

Kategori:
Agents producing tachycardiaAminesAminoalkyl Ethers +41
Target Protein:
Histamine N-methyltransferaseHistamine H1 receptorMuscarinic acetylcholine receptor M2
Waktu ParuhThe elimination hal…
Vol. DistribusiDiphenhydramine is …
KlirensValues for plasma c…
Genetik -
Diphenidol Approved DB01231
small molecule | CAS: 972-02-1

Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntiemetics +6
Target Protein:
Muscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1 +1
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
Diphenoxylate Approved DB01081
small molecule | CAS: 915-30-0

A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medica…

Kategori:
Alimentary Tract and MetabolismAnalgesicsAntidiarrheals +11
Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
Waktu Paruh12-14 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 117-34-0

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicPhenylacetates
Target Protein:
Cathepsin B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphenylguanidine Approved DB14191
small molecule | CAS: 102-06-7

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen. Sensitivity to di…

Kategori:
AmidinesCell-mediated ImmunityIncreased Histamine Release +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diphthamide DB03223
small molecule | CAS: 75645-22-6

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins
Target Protein:
Elongation factor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 499-83-2

Deskripsi belum tersedia.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingEnzyme Inhibitors +3
Target Protein:
4-hydroxy-tetrahydrodipicolinate reductase4-hydroxy-tetrahydrodipicolinate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipipanone DB01491
small molecule | CAS: 467-83-4

Deskripsi belum tersedia.

Kategori:
Ketones
Waktu Paruh-
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Genetik -
Dipivefrin Approved DB00449
small molecule | CAS: 52365-63-6

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +24
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-2A adrenergic receptor +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipraglurant DB12733
small molecule | CAS: 872363-17-2

Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).

Target Protein:
Metabotropic glutamate receptor 5
Waktu Paruh-
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Genetik -
Diprenorphine DB01548
small molecule | CAS: 14357-78-9

A narcotic antagonist similar in action to naloxone. It is used to remobilize animals after etorphine neuroleptanalgesia and is considered a specific antagonist to etorphine. [PubChem]

Kategori:
AlkaloidsCentral Nervous System AgentsHeterocyclic Compounds, Fused-Ring +6
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63065-88-3

Dipropyl-4-hydroxytryptamine is the 4-hydroxyl analog of dipropyltryptamine (DPT). Dipropyl-4-hydroxytryptamine was first synthesized by Alexander Shulgin. This agent and its properties haven't been fully elucidated.

Waktu Paruh-
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Genetik -
Dipyridamole Approved DB00975
small molecule | CAS: 58-32-2

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Kategori:
AnticoagulantsAntiplatelet agentsBlood and Blood Forming Organs +17
Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AcGMP-specific 3',5'-cyclic phosphodiesterase3',5'-cyclic-AMP phosphodiesterase 4A +3
Waktu Paruh40 minutes
Vol. Distribusi* 1 to 2.5 L/kg
Klirens* 2.3-3.5 mL/min/kg
Genetik -
Dipyrithione Approved DB11327
small molecule | CAS: 3696-28-4

Dipyrithione, a bactericidal and fungicidal pyrithione derivate, was formulated as Crimanex anti-dandruff shampoo, but is no longer available.[L2611] It is currently used as a pesticide, and not used in any FDA approved drug products.[A32829] Interestingl…

Target Protein:
Nitric oxide synthase, inducibleProstaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipyrocetyl DB13839
small molecule | CAS: 486-79-3

Deskripsi belum tersedia.

Kategori:
AnalgesicsAntiinflammatory and Antirheumatic ProductsMusculo-Skeletal System +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diridavumab DB12607
biotech | CAS: 1393659-46-5

Cr6261 is under investigation in clinical trial NCT02016066 (A Study to Assess the Safety, Pharmacokinetics and Immunogenicity of Diridavumab in Japanese Healthy Participants).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Dirithromycin DB00954
small molecule | CAS: 62013-04-1

Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
23S ribosomal RNA
Waktu ParuhThe mean plasma hal…
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2163074-23-3

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dirlotapide DB11399
small molecule | CAS: 481658-94-0

Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, _Slentrol_, and is not intended for human use.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Microsomal triglyceride transfer protein large subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dirocaftor DB16143
small molecule | CAS: 2137932-23-9

Dirocaftor is under investigation in clinical trial NCT03251092 (Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Diroximel fumarate Approved DB14783
small molecule | CAS: 1577222-14-0

Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life.[A176474] It is the main cause of neurological disability not caused by trauma in the young a…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsDicarboxylic Acids +3
Target Protein:
Neuronal acetylcholine receptor subunit alpha-10
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensNo clearance inform…
Genetik -
small molecule | CAS: 130114-83-9

Disaccharide tripeptide glycerol dipalmitoyl is under investigation in clinical trial NCT00003667 (Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 2136633-23-1

Disitamab vedotin is an antibody-drug conjugate drug targeting human epidermal growth factor receptor 2 (HER2). It is currently being investigated for cancers.[A254721]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibody-drug Conjugates +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Disitertide DB12953
biotech | CAS: 272105-42-7

Disitertide has been used in trials studying the treatment of Skin Fibrosis.

Target Protein:
Transforming growth factor beta-1 proprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Disomotide DB17469
biotech | CAS: 181477-43-0

Disomotide is a synthetic peptide cancer vaccine.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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