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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 105 / 236
Fluciclovine (18F) Approved DB13146
small molecule | CAS: 222727-39-1

Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging.[A31384] The structure of fluciclovine allows it to be uptaken by the tumoral cel…

Kategori:
CycloparaffinsDiagnostic RadiopharmaceuticalsPositron Emitting Activity +2
Target Protein:
Neutral amino acid transporter B(0)Y+L amino acid transporter 1Cationic amino acid transporter 3 +5
Waktu ParuhFluciclovine is a c…
Vol. DistribusiThe compartmental v…
KlirensFluciclovine renal …
Genetik -
Fluclorolone DB13856
small molecule | CAS: 3693-38-7

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids, Dermatological Preparations +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluclorolone acetonide Approved DB08973
small molecule | CAS: 3693-39-8

Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.

Kategori:
Adrenal Cortex HormonesCorticosteroidsFused-Ring Compounds +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flucloxacillin Approved DB00301
small molecule | CAS: 5250-39-5

Antibiotic analog of [cloxacillin].

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +17
Target Protein:
Penicillin-binding protein 1A
Waktu Paruh0.75–1 hour
Vol. Distribusi-
Klirens-
Genetik -
Fluconazole Approved DB00196
small molecule | CAS: 86386-73-4

Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same …

Kategori:
14-alpha Demethylase InhibitorsAgents causing hyperkalemiaAnti-Infective Agents +29
Target Protein:
Lanosterol 14-alpha demethylase
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe apparent volume…
KlirensThis drug is mainly…
Genetik -
Flucytosine Approved DB01099
small molecule | CAS: 2022-85-7

A fluorinated cytosine analog that is used as an antifungal agent.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +17
Target Protein:
DNAThymidylate synthaseDNA (cytosine-5)-methyltransferase 1
Waktu Paruh2.4 to 4.8 hours.
Vol. Distribusi-
Klirens-
Genetik -
Fludarabine Approved DB01073
small molecule | CAS: 21679-14-1

Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.

Kategori:
Adenine NucleotidesAntimetabolitesAntineoplastic Agents +22
Target Protein:
DNAAdenosine deaminaseDeoxycytidine kinase +2
Waktu Paruh20 hours
Vol. Distribusi-
Klirens* 117-145 mL/min [p…
Genetik -
Fludeoxyglucose DB15107
small molecule | CAS: 29702-43-0

Fludeoxyglucose is under investigation in clinical trial NCT03262389 (Comparison of F-18 FDG and C-11 Acetate PET in Multiple Myeloma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fludiazepam DB01567
small molecule | CAS: 3900-31-0

Fludiazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a scheduled drug in the U.S., but is approved for use in Japan.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +11
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Translocator proteinGamma-aminobutyric acid receptor subunit alpha-2 +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fludrocortisone Approved DB00687
small molecule | CAS: 127-31-1

Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary e…

Kategori:
11-Hydroxycorticosteroids17-HydroxycorticosteroidsAdrenal Cortex Hormones +18
Target Protein:
Androgen receptorMineralocorticoid receptorGlucocorticoid receptor
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe apparent volume…
KlirensPopulation pharmaco…
Genetik -
Flufenamic acid Approved DB02266
small molecule | CAS: 530-78-9

An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)

Kategori:
Acids, CarbocyclicAminobenzoatesAnti-Inflammatory Agents +8
Target Protein:
Androgen receptorProstaglandin G/H synthase 2Prostaglandin G/H synthase 1 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flufenoxuron DB15006
small molecule | CAS: 101463-69-8

Flufenoxuron is under investigation in clinical trial NCT00922870 (Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock).

Kategori:
AmidesBenzene Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluindione Approved DB13136
small molecule | CAS: 957-56-2

Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for the treatment of Bloo…

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCytochrome P-450 CYP2C9 Substrates +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flumazenil Approved DB01205
small molecule | CAS: 78755-81-4

Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benz…

Kategori:
AntidotesBenzazepinesBenzodiazepine Antagonist +9
Target Protein:
Translocator proteinGamma-aminobutyric acid receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit alpha-2 +5
Waktu ParuhInitial distributio…
Vol. Distribusi* 0.9 to 1.1 L/kg
Klirens* 1 L/hr/kg [health…
Genetik -
Flumecinol DB18178
small molecule | CAS: 56430-99-0

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesEnzyme Induction, drug effects
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flumedroxone DB13610
small molecule | CAS: 15687-21-5

Deskripsi belum tersedia.

Kategori:
AnalgesicsAntimigraine PreparationsCorticosteroid Derivatives +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flumequine DB08972
small molecule | CAS: 42835-25-6

Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flumethasone Approved DB00663
small molecule | CAS: 2135-17-3

Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect …

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +17
Target Protein:
Glucocorticoid receptorSteroid hormone receptor ERR2Estrogen-related receptor gamma +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flunarizine Approved DB04841
small molecule | CAS: 52468-60-7

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an …

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAnticonvulsants +24
Target Protein:
Voltage-dependent P/Q-type calcium channel subunit alpha-1AVoltage-dependent T-type calcium channel subunit alpha-1GVoltage-dependent T-type calcium channel subunit alpha-1H +3
Waktu Paruh18 days
Vol. Distribusi-
Klirens-
Genetik -
Flunixin DB11518
small molecule | CAS: 38677-85-9

Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form. Flunixin is regulated in the United States by the Food and Drug …

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flunoxaprofen DB13317
small molecule | CAS: 66934-18-7

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluocinolone DB12553
small molecule | CAS: 807-38-5

Fluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization.

Kategori:
Fused-Ring CompoundsPregnadienesPregnanes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluocinolone acetonide Approved DB00591
small molecule | CAS: 67-73-2

Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.[T357] It has been used extensively in dermatological preparations and it has also been investigated thorou…

Kategori:
Adrenal Cortex HormonesAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnti-Inflammatory Agents +23
Target Protein:
Glucocorticoid receptorAnnexin A1Annexin A2 +4
Waktu ParuhThe reported half-l…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Fluocinonide Approved DB01047
small molecule | CAS: 356-12-7

A topical glucocorticoid used in the treatment of eczema.

Kategori:
Adrenal Cortex HormonesAnti-Allergic AgentsAnti-Inflammatory Agents +24
Target Protein:
Steroid hormone receptor ERR1Steroid hormone receptor ERR2Estrogen-related receptor gamma +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluocortin DB13223
small molecule | CAS: 33124-50-4

Fluocortin has been studied as a corticosteroid for treatment of dermatitis and eczema Spain [A174817].

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids, Dermatological Preparations +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluocortolone Approved DB08971
small molecule | CAS: 152-97-6

Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.

Kategori:
Adrenal Cortex HormonesAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnti-Inflammatory Agents +29
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 29205-06-9

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorescein Approved DB00693
small molecule | CAS: 2321-07-5

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA f…

Kategori:
BSEP/ABCB11 SubstratesColoring AgentsColouring Agents +21
Target Protein:
Organic anion transporter 3Immunoglobulin kappa variable 2-30DNA
Waktu Paruh-
Vol. Distribusi* 0.5 L/kg
Klirens* renal cl=1.75 mL/…
Genetik -
Fluorescin DB07764
small molecule | CAS: 518-44-5

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoride ion Approved DB11257
small molecule | CAS: 16984-48-8

Having a chemical formula of F?, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties. It is considered a trace element. Fluoride ions are found in various minerals but are only present in trace amounts in water. Its vario…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoride ion F-18 Approved DB09398
small molecule | CAS: 67862-54-8

Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intra…

Kategori:
Diagnostic RadiopharmaceuticalsRadioactive Diagnostic AgentRadiopharmaceutical Activity +1
Waktu Paruh110 min.
Vol. Distribusi0.5-0.7 L/Kg
KlirensRenal clearance for…
Genetik -
Fluorine F-18 DB13134
small molecule | CAS: 13981-56-1

Fluorine-18 is under investigation in clinical trial NCT00870974 (A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions).

Kategori:
IsotopesRadioisotopes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7574-44-9

Fluoroacetic acid F-18 is under investigation in clinical trial NCT01320787 (18-F-Fluoroacetate as PET Imaging Agent).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 864084-85-5

Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).

Kategori:
Compounds used in a research, industrial, or household settingDiagnostic Uses of ChemicalsFluorine Radioisotopes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 407582-13-2

Deskripsi belum tersedia.

Kategori:
AlcoholsAminesAmino Alcohols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 865838-26-2

Fluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosidesPyrimidine Nucleosides +2
Target Protein:
DNA (cytosine-5)-methyltransferase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoroestradiol F-18 Approved DB15690
small molecule | CAS: 94153-53-4

Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions.[L14096] The ability to image ER-positive tumors _in vivo_ is advantageous in that, while helping to visualize tum…

Kategori:
Estradiol CongenersEstranesEstrogens +10
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. DistribusiAs fluoroestradiol …
KlirensFluoroestradiol F-1…
Genetik -
small molecule | CAS: 160388-43-2

Fluorofuranylnorprogesterone F-18 is under investigation in clinical trial NCT02455453 (Assessment of Functional Status of Estrogen Receptors in Breast Cancer by Positron Emission Tomography).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluorometholone Approved DB00324
small molecule | CAS: 426-13-1

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Kategori:
Adrenal Cortex HormonesAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnti-Acne Preparations +32
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104613-87-8

Fluoromisonidazole F-18 is under investigation in clinical trial NCT01507428 (Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluoxetine Approved DB00472
small molecule | CAS: 54910-89-3

Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).[A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to ma…

Kategori:
Agents that reduce seizure thresholdAminesAnticholinergic Agents +47
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2CNeuronal acetylcholine receptor subunit alpha-2 +4
Waktu ParuhThe half life of fl…
Vol. DistribusiThe volume of distr…
KlirensThe clearance value…
Genetik -
Fluoxymesterone Approved DB01185
small molecule | CAS: 76-43-7

An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.

Kategori:
3-Oxoandrosten (4) DerivativesAnabolic AgentsAndrogens +11
Target Protein:
Androgen receptorEstrogen receptorGlucocorticoid receptor +1
Waktu Paruh9.2 hours
Vol. Distribusi-
Klirens-
Genetik -
Flupentixol Approved DB00875
small molecule | CAS: 2709-56-0

Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is pro…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +35
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 2A +5
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensFollowing oral admi…
Genetik -
Fluprednidene DB08970
small molecule | CAS: 2193-87-5

Fluprednidene is a corticosteroid.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids, Dermatological Preparations +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluprednisolone Approved DB09378
small molecule | CAS: 53-34-9

A synthetic glucocorticoid with anti-inflammatory properties.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 570-36-5

Deskripsi belum tersedia.

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fluralaner DB11414
small molecule | CAS: 864731-61-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurandrenolide Approved DB00846
small molecule | CAS: 1524-88-5

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +16
Target Protein:
Steroid hormone receptor ERR1Steroid hormone receptor ERR2Estrogen-related receptor gamma +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2802-11-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flurazepam Approved DB00690
small molecule | CAS: 17617-23-1

A benzodiazepine derivative used mainly as a hypnotic.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +22
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean apparent h…
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5201–5250 dari 11778
Sebelumnya Halaman 105 / 236 Berikutnya