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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 101 / 315
Conestat alfa Approved DB09228
biotech | CAS: 80295-38-1

C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the comple…

Kategori:
Amino Acids, Peptides, and ProteinsAngioedemas, Hereditary, drug therapyBlood and Blood Forming Organs +16
Target Protein:
Complement C1r subcomponentComplement C1s subcomponentPlasma kallikrein +4
Waktu Paruh-
Vol. Distribusi-
KlirensClearance was found…
Genetik -
Conivaptan Approved DB00872
small molecule | CAS: 210101-16-9

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopres…

Kategori:
Antidiuretic Hormone Receptor AntagonistsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Substrates +12
Target Protein:
Vasopressin V1a receptorVasopressin V2 receptor
Waktu Paruh5 hours
Vol. Distribusi-
Klirens-
Genetik -
Conjugated estrogens Approved DB00286
small molecule | CAS: 12126-59-9

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sul…

Kategori:
Agents causing angioedemaBCRP/ABCG2 SubstratesCOMT Substrates +26
Target Protein:
Estrogen receptor betaEstrogen receptor
Waktu ParuhThe median half-lif…
Vol. DistribusiThe physiological d…
KlirensThe reported normal…
Genetik -
Contulakin-G DB05950
small molecule | CAS: 229180-41-0

Contulakin-G is a broad spectrum non-opioid analgesic. It is the synthetic form of a natural peptide extracted from the venom of the Conus Geographus sea snail.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsPeptides +1
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copanlisib Approved DB12483
small molecule | CAS: 1032568-63-0

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exi…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +17
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform +1
Waktu ParuhThe geometric mean …
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
Copper Approved DB09130
small molecule | CAS: 7440-50-8

Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. Copper is commonly used in contraceptive intrauterine devices…

Kategori:
Copper-containing Intrauterine DeviceDecreased Embryonic ImplantationDecreased Sperm Motility +12
Target Protein:
Amyloid-beta precursor proteinAdenosylhomocysteinaseHistone H2B type 1-C/E/F/G/I +143
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper Cu-64 Approved DB13980
small molecule | CAS: 13981-25-4

Copper-64 is a radiopharmaceutical usually found in the +2 oxidation state as the complexes including the +1 state tend to be more unstable.[T604] It is used in molecular radiotherapy and positron emission tomography.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper gluconate Approved DB11246
small molecule | CAS: 527-09-3

Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practi…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Copper oxodotreotide Cu-64 Approved DB15873
small molecule | CAS: 1426155-87-4

Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over <sup>68</sup>Ga-labeled somatostatin analogs for positron emission tomography (PET).[A220348] Copper Cu 64 dotatate has a longer half-life and can be prod…

Kategori:
Amino Acids, Peptides, and ProteinsCopper RadioisotopesPeptides +4
Target Protein:
Somatostatin receptor type 2
Waktu ParuhThe half-life of Co…
Vol. Distribusi-
Klirens-
Genetik -
Copper usnate DB13830
small molecule

Deskripsi belum tersedia.

Kategori:
Genito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68341-09-3

Deskripsi belum tersedia.

Kategori:
SemicarbazidesSemicarbazonesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coprelotamab DB16380
biotech | CAS: 2348469-84-9

Coprelotamab is under investigation in clinical trial NCT04170595 (Clinical Study of Recombinant Anti-her2 Humanized Monoclonal Antibody for Injection).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coprogen DB01747
small molecule | CAS: 31418-71-0

Deskripsi belum tersedia.

Kategori:
AminesHydroxy AcidsHydroxylamines +1
Target Protein:
Iron(3+)-hydroxamate-binding protein FhuD
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2624-63-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingPorphyrinogensPorphyrins
Target Protein:
Uroporphyrinogen decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coptisine DB19308
small molecule | CAS: 3486-66-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsBenzylisoquinolinesBerberine Alkaloids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake veno…

Kategori:
Antivenins
Waktu ParuhThe formal prescrib…
Vol. DistribusiThe formal prescrib…
KlirensThe formal prescrib…
Genetik -
Coramitug DB19411
biotech | CAS: 2626841-92-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corcorus capsularis fiber Approved DB10711
biotech

Corcorus capsularis fiber is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cordycepin DB12156
small molecule | CAS: 73-03-0

Cordycepin has been used in trials studying the treatment of Leukemia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 73-04-1

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesDeoxyribonucleotidesHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Poly(A) polymerase alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corifollitropin alfa Approved DB09066
biotech | CAS: 195962-23-3

Corifollitropin alfa, also known as _Elonva_ is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with _a gonadotropin-releasing hormone (GnRH) anta…

Kategori:
Drugs that are Mainly Renally ExcretedFollicle Stimulating HormoneGenito Urinary System and Sex Hormones +9
Target Protein:
Follicle-stimulating hormone receptor
Waktu ParuhCorifollitropin alf…
Vol. DistribusiDistribution, metab…
Klirens0.13 L/h (0.10-0.18…
Genetik -
Corn Approved DB10572
biotech

Corn allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CoronaVac DB15806
biotech

CoronaVac, previously known as PiCoVacc, is a SARS-CoV-2 purified, inactivated, and adsorbed vaccine candidate developed by SinoVac Biotech Corporation[A219758]. It was developed by propagating the SARS-CoV-2 CN2 strain inside Vero Cells and inactivating it w…

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

The Coronavirus-Like Particle COVID-19 Vaccine is in development and testing through Meidcago in Quebec City, Canada. The vaccine was developed by creating SARS-Cov-2 virus-like particles (CoVLPs), which mimic the structure of the virus without carrying the g…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1312542-61-2

Corticorelin acetate has been investigated for the treatment of Brain Edema and Brain Tumor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 121249-14-7

Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pit…

Kategori:
Amino Acids, Peptides, and ProteinsDiagnostic AgentsHormones +9
Target Protein:
Corticotropin-releasing factor receptor 1Corticotropin-releasing factor receptor 2
Waktu ParuhPlasma half-lives f…
Vol. DistribusiThe mean volume of …
Klirens95 ± 11 L/m2/day
Genetik -
Corticosterone DB04652
small molecule | CAS: 50-22-6

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman&#39;s The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Kategori:
11-HydroxycorticosteroidsAdrenal Cortex HormonesAnti-Inflammatory Agents +11
Target Protein:
11-beta-hydroxysteroid dehydrogenase 1Glucocorticoid receptorNuclear receptor coactivator 1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corticotropin Approved DB01285
biotech | CAS: 12427-33-7

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Kategori:
Adrenal Cortex HormonesAdrenocorticotropic HormoneAmino Acids, Peptides, and Proteins +27
Target Protein:
Adrenocorticotropic hormone receptorCorticoliberin
Waktu ParuhAbout 15 minutes fo…
Vol. Distribusi-
Klirens-
Genetik -
Cortisone DB14681
small molecule | CAS: 53-06-5

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. (From Martindale, Th…

Kategori:
17-HydroxycorticosteroidsAdrenal Cortex HormonesAnti-Inflammatory Agents +21
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cortisone acetate Approved DB01380
small molecule | CAS: 50-04-4

Cortisone acetate was first isolate in 1935 and became more widely researched in 1949.[A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatolo…

Kategori:
17-HydroxycorticosteroidsAdrenal Cortex HormonesAdrenals +25
Target Protein:
Steroid hormone receptor ERR2Estrogen-related receptor gammaGlucocorticoid receptor +2
Waktu Paruh-
Vol. Distribusi-
KlirensData regarding the …
Genetik -
Cortivazol DB13003
small molecule | CAS: 1110-40-3

Cortivazol is under investigation in clinical trial NCT00804895 (Cluster Headache Cortivazol Injection (CHCI)).

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +15
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corydalis ambigua tuber Approved DB14279
biotech

Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Corylus americana pollen Approved DB10363
biotech

Corylus americana pollen is the pollen of the Corylus americana plant. Corylus americana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1272033-67-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsDiphtheria ToxinInactivated Pneumococcal Vaccine +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 308079-75-6

Deskripsi belum tersedia.

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBacterial Vaccines +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cosfroviximab DB17774
biotech | CAS: 1792982-57-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cosibelimab DB15770
biotech | CAS: 2216751-26-5

Deskripsi belum tersedia.

Kategori:
Immune Checkpoint Inhibitors
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cositecan DB05806
small molecule | CAS: 203923-89-1

Cositecan is the novel camptothecin derivative which is also known as Karenitecin. It has been developed for superior oral bioavailability and increased lactone stability. It is used to treat cancer.

Kategori:
Alkaloids
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cotadutide DB15194
small molecule | CAS: 1686108-82-6

Cotadutide is under investigation in clinical trial NCT03444584 (Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Subject With Type 2 Diabetes).

Kategori:
Amino Acids, Peptides, and Proteins
Target Protein:
Pro-glucagon
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
COTI-2 DB17507
small molecule | CAS: 1039455-84-9

Deskripsi belum tersedia.

Target Protein:
Cellular tumor antigen p53
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2246424-95-1

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector TherapiesAmino Acids, Peptides, and ProteinsGenetic Phenomena +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cotsiranib DB18404
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cotton Approved DB10707
biotech

Cotton allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cotton seed Approved DB10408
biotech

Cotton seed allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumaphos DB11390
small molecule | CAS: 56-72-4

This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a _dip_ or _wash_. Coumaphos is widely used for both farm and domestic animals to control ticks, …

Kategori:
AgrochemicalsAnthelminticsAnti-Infective Agents +22
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumarin DB04665
small molecule | CAS: 91-64-5

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBenzopyransCytochrome P-450 CYP2C9 Substrates +5
Target Protein:
Carbonic anhydrase 4Carbonic anhydrase 1Carbonic anhydrase 6 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumarin 120 DB08168
small molecule | CAS: 26093-31-2

Deskripsi belum tersedia.

Kategori:
BenzopyransCompounds used in a research, industrial, or household settingHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Peptidyl-prolyl cis-trans isomerase APeptidyl-prolyl cis-trans isomerase APeptidyl-prolyl cis-trans isomerase F, mitochondrial +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumermycin A1 DB13912
small molecule | CAS: 4434-05-3

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsBenzopyransCoumarins +5
Target Protein:
DNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CoVac-1 DB16429
biotech

Sponsored by the University Hospital Tuebingen in Germany, CoVac-1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of the S-protein[A226588]. It is being investigated in the clinical trial NCT04546841 (Safety …

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Covax-19™ DB15846
biotech

Covax-19™, a protein-based vaccine, was developed through partnership between APC and Vaxine. It uses an insect-cell-produced recombinant SARS-CoV-2 spike protein and Vaxine’s adjuvant, Advax-SM. This adjuvant is designed to circumvent high fevers, fatigue, a…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 5001–5050 dari 15718
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