Digital Pharmacy - Dashboard Peneliti

(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol DB08285

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2Cyclin-A2

Waktu Paruh-

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(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE DB07081

small molecule

Deskripsi belum tersedia.

Target Protein:

Dipeptidyl peptidase 4

Waktu Paruh-

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(2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE DB07092

small molecule

Deskripsi belum tersedia.

Target Protein:

Dipeptidyl peptidase 4

Waktu Paruh-

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(2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE DB07135

small molecule

Deskripsi belum tersedia.

Target Protein:

Dipeptidyl peptidase 4

Waktu Paruh-

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(5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine DB02963

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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(5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol DB06983

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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(5R,6S,7S,8S)-5-hydroxymethyl-6,7,8-trihydroxy-tetrazolo[1,5-A]piperidine DB02294

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-galactosidase

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(5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE DB07595

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE DB08354

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

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2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE DB08360

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

Waktu Paruh-

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2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE DB08353

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

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3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide DB07179

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine DB07698

small molecule

Deskripsi belum tersedia.

Target Protein:

Serine/threonine-protein kinase haspin

Waktu Paruh-

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3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine DB08535

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine DB07210

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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3-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amine DB08536

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

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3-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine DB08539

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE DB08345

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

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4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE DB07687

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

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4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide DB01888

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol DB08770

small molecule

Deskripsi belum tersedia.

Target Protein:

Adenosine receptor A1Adenosine receptor A2bAdenosine receptor A2a

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4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE DB07686

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE DB07685

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

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4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE DB07688

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2Cyclin-A2

Waktu Paruh-

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5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine DB07065

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine DB08531

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine DB08534

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE DB07794

small molecule

Deskripsi belum tersedia.

Target Protein:

Mitogen-activated protein kinase 1

Waktu Paruh-

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5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile DB08139

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine DB08008

small molecule

Deskripsi belum tersedia.

Target Protein:

Dihydroorotate dehydrogenase (quinone), mitochondrial

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5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE DB08140

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

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6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM DB08504

small molecule

Deskripsi belum tersedia.

Target Protein:

Dipeptidyl peptidase 4

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Atuliflapon DB19029

small molecule | CAS: 2041075-86-7

Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-severe Uncontrolled Asthma).

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Bexagliflozin Approved DB12236

small molecule | CAS: 1118567-05-7

Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge.[A256413…

Kategori:

Alimentary Tract and MetabolismBenzene DerivativesBlood Glucose Lowering Agents +16

Target Protein:

Sodium/glucose cotransporter 2

Waktu ParuhBexagliflozin has a…

Vol. DistribusiBexagliflozin has a…

KlirensPopulation pharmaco…

Genetik -

DPA-714 F-18 DB19189

small molecule | CAS: 958233-09-5

Deskripsi belum tersedia.

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DSM-265 DB12397

small molecule | CAS: 1282041-94-4

DSM265 has been used in trials studying the prevention and treatment of Malaria.

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Empagliflozin Approved DB09038

small molecule | CAS: 864070-44-0

Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.[A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other …

Kategori:

Alimentary Tract and MetabolismBCRP/ABCG2 SubstratesBenzene Derivatives +16

Target Protein:

Sodium/glucose cotransporter 2

Waktu ParuhThe apparent termin…

Vol. DistribusiThe estimated appar…

KlirensApparent oral clear…

Genetik -

Enavogliflozin DB18970

small molecule | CAS: 1415472-28-4

Enavogliflozin is under investigation in clinical trial NCT06399835 (Enavogliflozin vs. Pioglitazone on Glucose and Atherosclerosis).

Kategori:

Heterocyclic Compounds, Fused-Ring

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Epinastine Approved DB00751

small molecule | CAS: 80012-43-7

Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic respon…

Kategori:

Acid ReducersAntidepressive AgentsCentral Nervous System Depressants +27

Target Protein:

Histamine H1 receptorHistamine H2 receptorAlpha-1A adrenergic receptor +3

Waktu Paruh12 hours

Vol. Distribusi-

Klirens* 56 L/hr [patients…

Genetik -

FK352B DB06484

small molecule | CAS: 143881-08-7

FK352B is a adenosine A1 antagonist that is developed for the treatment of dialysis-induced hypotension.

Target Protein:

Adenosine receptor A1

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Gartisertib DB18770

small molecule | CAS: 1613191-99-3

Deskripsi belum tersedia.

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KER-047 DB19111

small molecule | CAS: 2248154-85-8

KER-047 is under investigation in clinical trial NCT05927012 (A Study to Evaluate the Safety and Preliminary Efficacy of a Response-guided Dose Titration of KER-047 in the Treatment of Functional IDA (Iron Deficiency Anemia).).

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LDN-193189 DB18051

small molecule | CAS: 1062368-24-4

Deskripsi belum tersedia.

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Luvixasertib DB19200

small molecule | CAS: 1610759-22-2

Luvixasertib is under investigation in clinical trial NCT05251714 (CFI-402257, a Potent and Selective TTK Inhibitor, in Solid Tumors and With Fulvestrant in Breast Cancer).

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N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE DB08340

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

Waktu Paruh-

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N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine DB08538

small molecule

Deskripsi belum tersedia.

Target Protein:

Cyclin-dependent kinase 2

Waktu Paruh-

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N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB08056

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein kinase Lck

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N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine DB08057

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein kinase Lck

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N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB08055

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein kinase Lck

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N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE DB08362

small molecule

Deskripsi belum tersedia.

Target Protein:

Casein kinase II subunit alpha

Waktu Paruh-

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